Filtered By:
Specialty: Neurology

This page shows you your search results in order of date. This is page number 18.

Order by Relevance | Date

Total 636 results found since Jan 2013.

MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.
Abstract Previous studies have demonstrated that myeloid zinc finger 1 (MZF1) in the dorsal root ganglion (DRG) participates in neuropathic pain induced by chronic-constriction injury (CCI) via regulation of voltage-gated K+ channels (Kv). Emerging evidence indicates that transient receptor potential vanilloid 1 (TRPV1) is involved in the development and maintenance of neuropathic pain. Although it is known that the transcription of TRPV1 is regulated by Kruppel-like zinc-finger transcription factor 7 (Klf7)-and that the structure of TRPV1 is similar to that of Kv-few studies have systematically investigated the r...
Source: Neural Plasticity - October 6, 2019 Category: Neurology Authors: Xing F, Gu H, Niu Q, Fan X, Wang Z, Yuan J, Li Z, Xu JT, Zhang W Tags: Neural Plast Source Type: research

The Roles of Chemokine (C-X-C motif) Ligand 13 in Spinal Cord Ischemia-Reperfusion Injury in Rats.
In this study, we studied the role of chemokine (C-X-C motif) ligand 13 (CXCL13) in a rat model of SCII. We examined the time course and cellular distribution of CXCL13 protein in rats after SCII. The effects of siRNA targeting CXCL13 or C-X-C chemokine receptor type 5 (CXCR5) in SCII were also investigated. Neurological function, histological assessment, and disruption of the blood-spinal cord barrier (BSCB) were evaluated. The expression levels of CXCL13, CXCR5, phosphorylated extracellular signal-regulated kinase (p-ERK), caspase-3, interleukin 6 (IL-6), TNF-α, and IL-1β were determined. We found that SCII resulted in...
Source: Brain Research - October 3, 2019 Category: Neurology Authors: Chen F, Li X, Li Z, Zhou Y, Qiang Z, Ma H Tags: Brain Res Source Type: research

Traditional Chinese medicine, Kami-Shoyo-San protects ketamine-induced neurotoxicity in human embryonic stem cell-differentiated neurons through activation of brain-derived neurotrophic factor
Conclusion: Kami-Shoyo-San could protect ketamine-induced neurotoxicity, and the underlying mechanism may involve brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling pathway.
Source: NeuroReport - October 2, 2019 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Analgesic effect of resveratrol on colitis-induced visceral pain via inhibition of TRAF6/NF- κB signaling pathway in the spinal cord.
In conclusion, our results suggest that RSV exerts the effects of antinociception on colitis-induced visceral hyperalgesia through inhibition of spinal TRAF6/NF-κB signaling pathway and the production of inflammatory mediators in the spinal cord, suggesting a new application of RSV for the treatment of visceral pain. PMID: 31536729 [PubMed - as supplied by publisher]
Source: Brain Research - September 15, 2019 Category: Neurology Authors: Lu Y, Xu HM, Han Y, Zhang YL Tags: Brain Res Source Type: research

Dystroglycan is involved in the activation of ERK pathway inducing the change of AQP4 expression in scratch-injured astrocytes.
Abstract We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved in adhesion-mediated signaling in ERK/MAPK pathway. We hypothesize that after scratch, extracellular α-DG and transmembrane β-DG may act as the scaffold in scratch mechanical force activating ERK pathway which may regulate the expression of AQP4. Use ERK inhibitor and activator to confirm wh...
Source: Brain Research - July 22, 2019 Category: Neurology Authors: Zhang G, Ma P, Wan S, Xu J, Yang M, Qiu G, Zhuo F, Xu S, Huo J, Ju Y, Liu H Tags: Brain Res Source Type: research

AAV-mediated siRNA against TRPV1 reduces nociception in a rat model of bone cancer pain.
Conclusions: Knockdown of TRPV1 effectively ameliorated mechanical allodynia and thermal hyperalgesia induced by TCI. Our data demonstrated that modulate the expression of TRPV1 in the spinal cord could be a potential therapeutic approach for bone cancer pain. PMID: 31296147 [PubMed - as supplied by publisher]
Source: Neurological Research - July 13, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats.
Abstract Reperfusion exceeded time window may induce ischemia/reperfusion injury, increase hemorrhagic transformation, and deteriorate neurological outcomes in ischemic stroke models. However, the increasing clinical evidences supported that reperfusion even within 6-24 h may salvage ischemic tissue and improve neurological outcomes in selected large vessel occlusion patients, without inducing serious ischemia/reperfusion injury and hemorrhagic transformation. The underlying molecular mechanisms are less clear. In present study, we demonstrated that delayed recanalization at 3 days after permanent middle cereb...
Source: Experimental Neurology - July 7, 2019 Category: Neurology Authors: Zheng W, Matei N, Pang J, Luo X, Song Z, Tang J, Zhang JH Tags: Exp Neurol Source Type: research

Activation of GPR30 with G1 attenuates neuronal apoptosis via src/EGFR/stat3 signaling pathway after subarachnoid hemorrhage in male rats.
CONCLUSION: G1 reduced EBI through attenuating neuronal apoptosis after SAH in male rats, partly via activating src/EGFR/stat3/signaling pathway. G1 may provide a promising therapeutic strategy for SAH patients. PMID: 31295444 [PubMed - as supplied by publisher]
Source: Experimental Neurology - July 7, 2019 Category: Neurology Authors: Peng J, Zuo Y, Huang L, Okada T, Liu S, Zuo G, Zhang G, Tang J, Xia Y, Zhang JH Tags: Exp Neurol Source Type: research

Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors
AbstractChronic stress induces persistent depressive behaviors. Stress-induced transcriptional alteration over the homeostatic range in stress hormone –sensitive brain regions is believed to underlie long-lasting depressive behaviors. However, the detailed mechanisms by which chronic stress causes those adaptive changes are not clearly understood. In the present study, we investigated whether epigenetic changes regulate stress-induced depressive behaviors. We found that chronic stress in mice downregulates the epigenetic factors HDAC2 and SUV39H1 in the hippocampus. A series of follow-up analyses including ChIP assay and...
Source: Molecular Neurobiology - July 1, 2019 Category: Neurology Source Type: research

Correction to: lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia
In the original version of this article “lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia”, which we have published in Mol Neurobiol (2017) 54:511–523.
Source: Molecular Neurobiology - June 25, 2019 Category: Neurology Source Type: research

RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats.
The objective of this study was to explore the protective role of RvD1 through reducing inflammation after HI and to study the contribution of Ras-related C3 botulinum toxin substrate 1 (Rac1)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) pathways in RvD1-mediated protection. Rat pups (10-day old) were subjected to HI or sham surgery. RvD1 was administrated by intraperitoneal injection 1 h after HI. FPR2 small interfering ribonucleic acid (siRNA) and Rac1 activation CRISPR were administered prior to RvD1 treatment to elucidate the possible mechanisms. Time course expression of FPR2 by Western blot ...
Source: Experimental Neurology - June 23, 2019 Category: Neurology Authors: Liu W, Huang J, Doycheva D, Gamdzyk M, Tang J, Zhang JH Tags: Exp Neurol Source Type: research

TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.
Abstract TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS). Previous studies have demonstrated that loss of TDP-43 function leads to intracellular accumulation of non-coding repetitive element transcripts and double-stranded RNA (dsRNA). These events could cause immune activation and contribute to the neuroinflammation observed in ALS, but this possibility has not been investigated. Here, we knock down TDP-43 in primary rat astrocytes via siRNA, and we use RNA-seq, immunofluorescence, and immunoblotting to show th...
Source: Neurobiology of Disease - June 19, 2019 Category: Neurology Authors: LaRocca TJ, Mariani A, Watkins LR, Link CD Tags: Neurobiol Dis Source Type: research

FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage
AbstractNeuronal apoptosis is a common and critical pathology following subarachnoid hemorrhage (SAH). We investigated the anti-apoptotic property of fibroblast growth factor (FGF)-2 after SAH in rats. A total of 289 rats underwent endovascular perforation to induce SAH or sham operation. Three dosages (3, 9, or 27  μg) of recombinant FGF-2 (rFGF-2) or vehicle was administered intranasally to rats 30 min after SAH induction. The pan-FGF receptor (FGFR) inhibitor PD173074 or vehicle was administered intracerebroventricularly (i.c.v.) 1 h before modeling, in addition to rFGF-2 treatment. Small interfering ri bonucleic ac...
Source: Molecular Neurobiology - June 14, 2019 Category: Neurology Source Type: research

Sprouty2 —a Novel Therapeutic Target in the Nervous System?
AbstractClinical trials applying growth factors to alleviate symptoms of patients with neurological disorders have largely been unsuccessful in the past. As an alternative approach, growth factor receptors or components of their signal transduction machinery may be targeted directly. In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. Among them are the Sprouty proteins which mainly act as inhibitors of growth factor-dependent neuronal and glial signaling pathways. In this review, we summarize the role of Sprouties in the lesioned ce...
Source: Molecular Neurobiology - May 7, 2019 Category: Neurology Source Type: research

P2Y4/TSP-1/TGF- β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid. Brain Res Bull. 2019 Apr 18;: Authors: Zhang Y, Zhu W, Yu H, Yu J, Zhang M, Pan X, Gao X, Wang Q, Sun H Abstract Epilepsy is accompanied by angiogenesis and blood-brain barrier (BBB) disruption. The transforming growth factor-β1 (TGF-β1)/phosphorylated small mothers against decapentaplegic 2 and 3 (pSmad2/3)/vascular endothelial growth factor (VEGF) pathway, activated by thrombospondin-1 (TSP-1), which is further regulated by Y type P2 purinergic receptor activity, may participate in angiogenesis. W...
Source: Brain Research Bulletin - April 17, 2019 Category: Neurology Authors: Zhang Y, Zhu W, Yu H, Yu J, Zhang M, Pan X, Gao X, Wang Q, Sun H Tags: Brain Res Bull Source Type: research