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Total 636 results found since Jan 2013.

Delayed manipulation of regeneration within injured peripheral axons
Neurobiol Dis. 2021 May 1:105383. doi: 10.1016/j.nbd.2021.105383. Online ahead of print.ABSTRACTWhile several new translational strategies to enhance regrowth of peripheral axons have been identified, combined approaches with different targets are rare. Moreover, few have been studied after a significant delay when growth programs are already well established and regeneration-related protein expression has waned. Here we study two approaches, Rb1 (Retinoblastoma 1) knockdown that targets overall neuron plasticity, and near nerve insulin acting as a growth factor. Both are validated to boost regrowth only at the outset of r...
Source: Neurobiology of Disease - May 4, 2021 Category: Neurology Authors: P Komirishetty K Zubkow A Areti H Ong D W Zochodne Source Type: research

Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway
In this study, we explored whether quercetin plays an anti-depressant role via regulation of FoxG1 signaling in mice and revealed the potential mechanisms. To explore the antidepressant effects of quercetin, mice were subjected to behavioral tests after a chronic unpredictable mild stress (CUMS) exposure. We found that chronic quercetin treatment (15 mg/kg, 30 mg/kg) obviously restored the weight loss of mice caused by CUMS and alleviated CUMS-induced depression-like behaviors, such as increased sucrose consumption, improved locomotor activity and shorten immobility time. In addition, to clarify the relationship between qu...
Source: Behavioural Brain Research - March 22, 2021 Category: Neurology Authors: Zhong-Xuan Ma Ru-Yi Zhang Wen-Juan Rui Zhi-Qing Wang None Xia-Feng Source Type: research

Acute hepatic porphyrias for the neurologist: current concepts and perspectives
Conclusions: This review article highlights the main biochemical, pathophysiological, clinical, and therapeutic aspects of acute hepatic porphyrias in clinical practice.RESUMO Introdu ção: As porfirias hepáticas agudas representam um grupo de doenças metabólicas hereditárias complexas em expansão, decorrentes de erros inatos do metabolismo, envolvendo a via de biossíntese do grupamento heme. Objetivo: realizar revisão dos principais aspectos clínicos e terapêuticos as sociados com as porfirias hepáticas agudas. Métodos: Os autores realizaram ampla revisão não-sistemática sobre conceitos atuais e conheciment...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Cholesterol synthesis inhibition promotes axonal regeneration in the injured central nervous system.
Abstract Neuronal regeneration in the injured central nervous system is hampered by multiple extracellular proteins. These proteins exert their inhibitory action through interactions with receptors that are located in cholesterol rich compartments of the membrane termed lipid rafts. Here we show that cholesterol-synthesis inhibition prevents the association of the Neogenin receptor with lipid rafts. Furthermore, we show that cholesterol-synthesis inhibition enhances axonal growth both on inhibitory -myelin and -RGMa substrates. Following optic nerve injury, lowering cholesterol synthesis with both drugs and siRNA-...
Source: Neurobiology of Disease - January 9, 2021 Category: Neurology Authors: Shabanzadeh AP, Charish J, Tassew NG, Farhani N, Feng J, Qin X, Sugita S, Mothe AJ, Wälchli T, Koeberle PD, Monnier PP Tags: Neurobiol Dis Source Type: research

Blocking the Spinal Fbxo3/CARM1/K + Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief
AbstractMany epigenetic regulators are involved in pain-associated spinal plasticity. Coactivator-associated arginine methyltransferase 1 (CARM1), an epigenetic regulator of histone arginine methylation, is a highly interesting target in neuroplasticity. However, its potential contribution to spinal plasticity –associated neuropathic pain development remains poorly explored. Here, we report that nerve injury decreased the expression of spinal CARM1 and induced allodynia. Moreover, decreasing spinal CARM1 expression by Fbxo3-mediated CARM1 ubiquitination promoted H3R17me2 decrement at the K+ channel promoter, thereby caus...
Source: Neurotherapeutics - January 7, 2021 Category: Neurology Source Type: research

Effect of Ras-guanine nucleotide release factor 1-mediated H-Ras/ERK signaling pathway on glioma.
CONCLUSION: Ras-GRF1 was upregulated in glioma tissues and correlated with its malignancy and prognosis. Silencing Ras-GRF1, through mediating H-Ras/ERK pathway, may suppress the growth and metastasis of glioma. PMID: 33412149 [PubMed - as supplied by publisher]
Source: Brain Research - January 4, 2021 Category: Neurology Authors: Pan YH, Chen J, Sun C, Ma JF, Li X Tags: Brain Res Source Type: research

Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1 α pathway in a cuprizone-induced mouse model of demyelination.
Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1α pathway in a cuprizone-induced mouse model of demyelination. Exp Neurol. 2020 Dec 30;:113593 Authors: Liu Y, Fan H, Li X, JingLiu, Qu X, Wu X, Liu M, Liu Z, Yao R Abstract Increasing evidence has demonstrated that the Nod-like receptor pyrin domain containing 3 (Nlrp3) inflammasome overactivated during demyelinating disorders. It has been implicated that transient receptor potential type 4 (Trpv4) is regarded as a polymodal ionotropic receptor that plays an important role in a multitude of pathological conditions, including inflammation. The aim of ...
Source: Experimental Neurology - December 30, 2020 Category: Neurology Authors: Liu Y, Fan H, Li X, JingLiu, Qu X, Wu X, Liu M, Liu Z, Yao R Tags: Exp Neurol Source Type: research