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Specialty: Neurology
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Total 636 results found since Jan 2013.
Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models
Neural Plast. 2022 Feb 21;2022:3172861. doi: 10.1155/2022/3172861. eCollection 2022.ABSTRACTRecently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ 42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine models of Alzheimer's disease carrying the preseniline-1 (PS1) P117L mutation. We observed that DSBs could hardly decrease following RA treatment in the mutated cells compared to the wild-type cells. The activation of the amyloidogenic pathway is proposed in the former case as Aβ 42- ...
Source: Neural Plasticity - March 3, 2022 Category: Neurology Authors: Marcella M Authiat Emmanuelle Gruz-Gibelli Julien Colas Estelle Bianchi Marta Garcia-Arauzo Pascale Marin Fran çois R Herrmann Armand Savioz Source Type: research
Hemorrhage-Induced Sphingosine Kinase 1 Contributes to Ferroptosis-Mediated Secondary Brain Injury in Intracerebral Hemorrhage
In this study, transcriptional changes in ICH patients were assessed by microarray data, exposing Sphk1 as a highly upregulated gene during ICH. Furthermore, Sphk1 chemical inhibitors and siRNA were used to inhibit ICH-induced Sphk1 upregulation in in vivo and in vitro models, showing that Sphk1 inhibition after protects against ferroptosis and attenuates secondary brain injury and cell death. Mechanistically, this study unveiled that sphingosine kinase 1/sphingosine 1-phosphate/extracellular-regulated protein kinases/phosphorylated extracellular-regulated protein kinases (Sphk1/S1p/ERK/p-ERK) pathway is responsible for re...
Source: Molecular Neurobiology - February 26, 2022 Category: Neurology Source Type: research
The Mfn1- βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage
AbstractNeuronal injury following subarachnoid hemorrhage (SAH) has been shown to be associated with mitochondrial dysfunction and oxidative stress. βIIPKC, a subtype of protein kinase C (PKC), accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Here, we investigated the role of Mfn1-βIIPKC interaction in brain damage and neurological function in both in vivo and in vitro experimental SAH models. The expression of βIIPKC protein and the interaction of Mfn1-βIIPKC were found to be increased after OxyHb treatment in primary cultured cortical neurons and were also observed i...
Source: Translational Stroke Research - February 22, 2022 Category: Neurology Source Type: research
Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures
The objective of this study was to investigate the role of transient receptor potential vanilloid 4 (TRPV4) in 4-aminopyridine (4-AP)-induced seizures and the underlying mechanism. We also provide evidence for the role of Yes-associated protein (YAP) in seizures. 4-AP was administered to mice or primary cultured astrocytes. YAP-specific small interfering RNA (siRNA) was administered to primary cultured astrocytes. Mouse brain tissue and surgical specimens from epileptic patient brains were examined, and the results showed that TRPV4 was upregulated, while astrocytes were activated and polarized to the A1 phenotype. The lev...
Source: Neurotherapeutics - February 18, 2022 Category: Neurology Source Type: research
Forkhead Box 1(FoxO1) mediates psychological stress-induced neuroinflammation
CONCLUSION: RSDS induced a measurable inflammatory response in the blood and brain, and FoxO1 was demonstrated in vitro to aggravate stress-induced inflammation.PMID:34983317 | DOI:10.1080/01616412.2021.2022913
Source: Neurological Research - January 5, 2022 Category: Neurology Authors: Yuequan Zhu Xiaokun Geng Christopher Stone Sichao Guo Shabber Syed Yuchuan Ding Source Type: research
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease
In this study, we examined the expression of hexokinase 2 (HK2) and lactate dehydrogenase (LDH), the key enzymes in glycolysis, and lactate levels in the substantia nigra pars compacta (SNpc) of a MPTP-induced mouse model of PD and in MPP+-treated SH-SY5Y cells. We found that the expression of HK2 and LDHA and the lactate levels were markedly increased in the SNpc of MPTP-treated mice and in MPP+-treated SH-SY5Y cells. Exogenous lactate treatment led to the apoptosis of SH-SY5Y cells. Intriguingly, lactate production and the apoptosis of dopaminergic neurons were suppressed by the application of 3-bromopyruvic acid (3-Brpa...
Source: Neurobiology of Disease - January 1, 2022 Category: Neurology Authors: Jingyi Li Longmin Chen Qixiong Qin Danlei Wang Jingwei Zhao Hongling Gao Xiao Yuan Jing Zhang Yuan Zou Zhijuan Mao Yongjie Xiong Zhe Min Manli Yan Cong-Yi Wang Zheng Xue Source Type: research
Enhanced expression of Pentraxin-3 in glioblastoma cells correlates with increased invasion and IL8-VEGF signaling axis
In this study, we examined the role of PTX3 in GB growth, angiogenesis, and invasion using in vitro and in vivo GB models, proteomic profiling, molecular and biochemical approaches. Under in vitro conditions, PTX3 over-expression in U87 cells correlated with cell cycle progression, increased migratory potential, and proliferation under hypoxic conditions. Conditioned media containing PTX3 enhanced the angiogenic potential of endothelial cells. While silencing of PTX3 by siRNA decreased the proliferation, migration, and angiogenic potential of U87 cells in vitro. Importantly, PTX3 over-expression increased tumor growth, ang...
Source: Brain Research - December 15, 2021 Category: Neurology Authors: Umadevi V Wesley Ian Sutton Paul A Clark Katelin Cunningham Carolina Larrain John S Kuo Robert J Dempsey Source Type: research
