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Total 636 results found since Jan 2013.

Autocrine motility factor receptor promotes the malignancy of glioblastoma by regulating cell migration and invasion
CONCLUSION: This study suggests that AMFR could be used as a therapeutic strategy for the clinical treatment of glioblastoma.PMID:37703903 | DOI:10.1080/01616412.2023.2257463
Source: Neurological Research - September 13, 2023 Category: Neurology Authors: Yao Zhang Xiuping Wang Guanghui Chen Yajing Lu Qiang Chen Source Type: research

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
In this study, electrophysiological properties of chloride current in primary cultured neurons were characterized using low chloride solution, 4,4 ′-diisothiocyano-2,2′-stilbenedisulfonic acid, and SLC26A11-specific siRNA under physiological conditions or ATP-depleted conditions. In vivo effect of SLC26A11 was evaluated on a rat stroke reperfusion model. We found that SLC26A11 mRNA in primary cultured neurons was upregulated as early as 6  h after oxygen glucose deprivation, and later, the protein level was elevated accordingly. Blockade of SLC26A11 activity could reduce chloride entry and attenuate hypoxia-induced ne...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research

Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
ConclusionOur study elucidates a novel signaling cascade wherein adiponectin stimulates TG Cav3.2 channels via adipoR1 coupled to a novel CK2 α-dependent PKCβ1. This process induces neuronal hyperexcitability and pain hypersensitivity. Insight into adipoR-Cav3.2 signaling in sensory neurons provides attractive targets for pain treatment.
Source: The Journal of Headache and Pain - August 25, 2023 Category: Neurology Source Type: research

Knockdown of long non-coding RNA LINC00941 suppressed cell proliferation, colony-formation, and migration of human glioblastoma cell lines
CONCLUSIONS: LINC00941 is overexpressed in GBM, exhibiting important roles in cell proliferation and survival, migration and invasion.PMID:37587895 | DOI:10.5114/fn.2023.126894
Source: Folia Neuropathologica - August 17, 2023 Category: Neurology Authors: Yuan Wang Shuwei Wang Haibo Wang Di Zhao Haoliang Zhang Huan Liu Jianzhong Cui Kaijie Wang Source Type: research