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Specialty: Neurology
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Total 636 results found since Jan 2013.
4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway
Neurotoxicology. 2022 Apr 23:S0161-813X(22)00056-0. doi: 10.1016/j.neuro.2022.04.008. Online ahead of print.ABSTRACTProlonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival in different conditions. However, the role and mechanism of autophagy in sevoflurane-induced neurotoxicity were not fully elucidated. We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. Sevoflurane treatment significantly decrea...
Source: Neurotoxicology - April 26, 2022 Category: Neurology Authors: Jingjing Lv Hao Cheng Weidong Yao Can Liu Yongquan Chen Xiaoju Jin Zeyong Yang Yuanhai Li Source Type: research
Principles of translational gene therapy for neuromuscular diseases
This article describes the principles of precision gene therapy for neurogenetic diseases using examples of neuromuscular diseases.DISCUSSION: Various strategies of gene therapy have become established and are being tested in preclinical and clinical trials and evaluated as approved forms for long-term efficacy. The aim of every gene therapy is the modification or introduction of the target gene with initiation of a degradation of dysfunctional proteins. Various techniques, such as gene transfer, gene substitution or gene editing in vivo and ex vivo are now usable. For example, a modification of the pre-mRNA using antisens...
Source: Der Nervenarzt - April 6, 2022 Category: Neurology Authors: B Schoser Source Type: research
lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway
This study aimed to investigate the involvement of BDNF-AS in propofol-induced apoptosis in HT22 cells. HT22 cells were treated with various concentrations of propofol at different time points. BDNF-AS was silenced using BDNF-AS-targeting siRNA. TrkB was antagonized by the TrkB inhibitor, ANA-12. Flow cytometry, quantitative reverse-transcription PCR, and western blotting were performed to analyze apoptosis and the expression of genes and proteins, respectively. In propofol-treated HT22 cells, BDNF-AS was upregulated, and BDNF was downregulated in a time- and dose-dependent manner. BDNF-AS downregulation mediated by siRNA ...
Source: Molecular Neurobiology - March 26, 2022 Category: Neurology Source Type: research
The Angiogenesis Effects Of Electro-acupuncture Treatment Via Exosomal miR-210 In Cerebral Ischemia-Reperfusion Rats
CONCLUSION: EA treatment could active the HIF-1α/VEGF/Notch 1 signal pathway to facilitate angiogenesis after ischemic stroke via exosomal miR-210.PMID:35319370 | DOI:10.2174/1567202619666220321115412
Source: Current Neurovascular Research - March 23, 2022 Category: Neurology Authors: Shu-Ying Xu Chun-Li Zeng Si-Ming Ni Yong-Jun Peng Source Type: research
