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Specialty: Gastroenterology

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Total 496 results found since Jan 2013.

β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice.
CONCLUSION: β-arrestin 2 can protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation. PMID: 29375207 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Jiang MP, Xu C, Guo YW, Luo QJ, Li L, Liu HL, Jiang J, Chen HX, Wei XQ Tags: World J Gastroenterol Source Type: research

ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells.
Conclusions: To the best of our knowledge, this study provides the first evidence that the absence of SMYD3 could inhibit the migration, invasion, and proliferation of gastric cancer cells and halt cells in G2/M phase via the ATM-CHK2/p53-Cdc25C pathway. These findings indicated that SMYD3 plays crucial roles in the proliferation, migration, and invasion of gastric cancer cells and may be a useful therapeutic target in human gastric carcinomas. PMID: 29302370 [PubMed]
Source: Journal of Gastric Cancer - January 7, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

4 co-delivery of tnf- α sirna and il-22 via a nanoparticle-in-hydrogel system exerts synergistic therapeutic effects against ulcerative colitis
Combination therapy is an emerging approach for treating ulcerative colitis (UC). During the development of UC, TNF- α acts as the major pro-inflammatory cytokine while interleukin-22 (IL-22) plays an important role in preventing mucosal damage. In the present study, we loaded TNF-α siRNA (siTNF) into galactosylated polymeric nanoparticles (NPs). The resultant Gal-siTNF-NPs had a desirable diameter (～261 nm), narrow size distribution and a slightly negative zeta potential (～‒12 mV). These NPs successful mediated the targeted delivery of siTNF to macrophages and efficiently inhibited the expression of TNF-α.
Source: Gastroenterology - January 1, 2018 Category: Gastroenterology Authors: Bo Xiao, Emilie Viennois, Tim L. Denning, Didier Merlin Tags: Clinical and Research Challenges Source Type: research

Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.
CONCLUSION: The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Sun W, Wu HY, Chen S Tags: World J Gastroenterol Source Type: research

Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer
ConclusionsSPOP could down-regulate MMP2 expression in CRC, and this regulation is mediated by inhibiting SP1 phosphorylation and nuclear translocation through PI3K/Akt signaling pathway. Our findings in this study provide understanding of MMP2 regulation in CRC and may also shed lights on the development of anti-CRC treatments.
Source: Digestive Diseases and Sciences - December 19, 2017 Category: Gastroenterology Source Type: research

Effect of heme oxygenase-1 on the protection of ischemia reperfusion injury of bile duct in rats after liver transplantation
Conclusion Our study demonstrated that overexpression of HO-1 in donor liver can ameliorate the damage to bile duct and liver, and improved liver function, suggesting HO-1 might be a new therapeutic target in the treatment of IRI after liver transplantation.
Source: Clinics and Research in Hepatology and Gastroenterology - December 16, 2017 Category: Gastroenterology Source Type: research

miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1.
CONCLUSION: This study demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1. PMID: 29290651 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Liu XL, Cao HX, Wang BC, Xin FZ, Zhang RN, Zhou D, Yang RX, Zhao ZH, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research

Palmitate induces fat accumulation by activating C/EBP β-mediated G0S2 expression in HepG2 cells.
CONCLUSION: Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPβ-mediated G0S2 expression. PMID: 29209111 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 21, 2017 Category: Gastroenterology Authors: Zhao NQ, Li XY, Wang L, Feng ZL, Li XF, Wen YF, Han JX Tags: World J Gastroenterol Source Type: research

Downregulation of LncRNA-RP11-317J10.2 promotes cell proliferation and invasion and predicts poor prognosis in colorectal cancer.
CONCLUSIONS: This study reveals a crucial role for lncRNA-RP11-317J10.2 in CRC growth and invasion via upregulation of cyclin D1 expression and suggests that expression of this lncRNA may be a potential prognostic biomarker for CRC. PMID: 29073791 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - October 28, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Predominance of regorafenib over sorafenib: restoration of membrane ‐bound MICA in hepatocellular carcinoma cells
ConclusionsThe clinical superiority of REG over SOR is partially attributable to reduced MICA shedding via transcriptional suppression of ADAM9 and ADAM10.
Source: Journal of Gastroenterology and Hepatology - October 21, 2017 Category: Gastroenterology Authors: Jun Arai, Kaku Goto, Anthony Stephanou, Yasushi Tanoue, Sayaka Ito, Ryosuke Muroyama, Yasuo Matsubara, Ryo Nakagawa, Sayuri Morimoto, Yoshimi Kaise, Lay Ahyoung Lim, Hitoshi Yoshida, Naoya Kato Tags: Hepatology Source Type: research

Sex Determining Region Y Box 9 Induces Chemoresistance in Pancreatic Cancer Cells by Induction of Putative Cancer Stem Cell Characteristics and Its High Expression Predicts Poor Prognosis
Objectives: Pancreatic cancer is a highly chemoresistant tumor and underlying mechanisms are not well understood. Sex determining region Y box 9 (Sox9) is a transcription factor playing important roles on maintenance of pluripotent cells during pancreatic organogenesis. The purpose of this study is to evaluate the roles of Sox9 in pancreatic cancer. Methods: The Sox9 expression was evaluated by immunohistochemical analysis. Effects of Sox9 inhibition by siRNA or shRNA on chemosensitivity, sphere formation, stem cell markers expression, and in vivo tumor formation rate were examined using pancreatic cancer cell lines. Res...
Source: Pancreas - October 19, 2017 Category: Gastroenterology Tags: Original Articles Source Type: research

Expression of annexin II in gastric carcinoma and its role in gastric cancer metastasis.
CONCLUSION: Annexin II is highly expressed in gastric cancer tissues, annexin II protein expression is related to tumor size, histological differentiation, TNM staging, lymph node metastasis and other clinical features were significantly correlated. Annexin II high expression can promote the invasion and metastasis of gastric cancer. PMID: 29097873 [PubMed - in process]
Source: World Journal of Gastroenterology - October 14, 2017 Category: Gastroenterology Authors: Han F, Shrestha S, Huang H, Lv HY, Nie C, Lin L, Lu ML Tags: World J Gastroenterol Source Type: research

Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide
Hydrogen sulfide (H2S), like nitric oxide (NO), causes smooth muscle relaxation, but unlike NO, does not stimulate soluble guanylyl cyclase (sGC) activity and generate cyclic guanosine 5'-monophosphate (cGMP). The aim of this study was to investigate the interplay between NO and H2S in colonic smooth muscle. In colonic smooth muscle from rabbit, mouse, and human, l-cysteine, substrate of cystathionine--lyase (CSE), or NaHS, an H2S donor, inhibited phosphodiesterase 5 (PDE5) activity and augmented the increase in cGMP levels, IP3 receptor phosphorylation at Ser1756 (measured as a proxy for PKG activation), and muscle relaxa...
Source: AJP: Gastrointestinal and Liver Physiology - October 1, 2017 Category: Gastroenterology Authors: Nalli, A. D., Bhattacharya, S., Wang, H., Kendig, D. M., Grider, J. R., Murthy, K. S. Tags: RESEARCH ARTICLE Source Type: research

LncRNA-CCAT1 Promotes Migration, Invasion, and EMT in Intrahepatic Cholangiocarcinoma Through Suppressing miR-152
ConclusionsOur results suggested that CCAT1 functions as an oncogenic lncRNA in ICC, which could serve as a potential diagnostic and therapeutic target for ICC patients.
Source: Digestive Diseases and Sciences - September 18, 2017 Category: Gastroenterology Source Type: research

Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells.
CONCLUSION: Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1. PMID: 28974890 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Lu CJ, He YF, Yuan WZ, Xiang LJ, Zhang J, Liang YR, Duan J, He YH, Li MY Tags: World J Gastroenterol Source Type: research