Resident liver progenitor cells: Proofs of their contribution to human liver regeneration
Publication date: Available online 14 March 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Nicolas Lanthier, Laurent SpahrSummaryWhether the epithelial cell response (named “ductular reaction”) observed in chronic situations is only a marker of severity of liver disease or plays a role in liver cell regeneration remains under debate. However, recent cell tracking experiments provide a robust argument for the differentiation of those cells in an animal model of chronic liver disease and indicate that the situation could be similar in humans (Deng et al. 2018). Thanks to three other...
Source: Clinics and Research in Hepatology and Gastroenterology - March 14, 2019 Category: Gastroenterology Source Type: research

Commentary to the paper entitled “Increased incidence of Campylobacter enteritis and their quinolone resistance between 2010 and 2015: Results of a French national observatory conducted in 21 general hospitals (CHG)”
Publication date: Available online 14 March 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Isabelle Kempf, Cécile Adam, Claire Chauvin (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 14, 2019 Category: Gastroenterology Source Type: research

MicroRNA-101 suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signaling pathway
ConclusionsMiR-101 has antifibrotic effects in experimental liver fibrosis, and downregulating the PI3K/Akt/mTOR signaling pathway may be one of its antifibrotic mechanisms. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Feasibility of domino liver transplantation from hyperhomocsyteinemia
In conclusion, our data suggest that liver transplantation for CBS deficiency can be effective, safe and beneficial. It is possible to be both safe and beneficial to use a CBS deficiency patient as a domino donor for salvage liver transplantation in a selective category of recipients. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Mixed adenoneuroendocrine carcinoma of the cecum
Publication date: Available online 8 March 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Fabio Carboni, Mario Valle, Andrea Russo (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Severe takotsubo cardiomyopathy following orthotopic liver transplantation: A case series
DiscussionIt is important to recognize TC as a potential complication following liver transplantation so as to detect cases earlier in the disease course and begin early goal-directed care. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Mast cell-mediated splanchnic cholestatic inflammation
ConclusionsIn cholestatic rats, Ketotifen improves liver function and ascites, and also reduces pro-inflammatory mediators in the splanchnic area. The decrease in connective tissue mast cells in the mesenteric lymphatic complex due to the administration of Ketotifen would lead to the improvement of the inflammatory splanchnic response, and consequently the abovementioned complications. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Incretin-based treatment in type 2 diabetes mellitus and risk of cholangiocarcinoma: Is it only adverse drug effect?
Publication date: Available online 1 March 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Gian Maria Barbato, Massimiliano Cadamuro, Luca Fabris (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - March 4, 2019 Category: Gastroenterology Source Type: research

Increased mortality in non-alcoholic fatty liver disease with chronic kidney disease is explained by metabolic comorbidities
Publication date: Available online 1 March 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Kristina Önnerhag, Karl Dreja, Peter M. Nilsson, Stefan LindgrenSummaryBackgroundThere is a close association between non-alcoholic fatty liver disease (NAFLD) and prevalent chronic kidney disease (CKD). Few longitudinal studies exist. No previous study has investigated to what extent CKD affects mortality in biopsy-proven NAFLD. Our aim was to investigate the long-term risk of developing CKD in biopsy-proven NAFLD and its effect on mortality.MethodsPatients with biopsy-proven NAFLD diagnosed in 197...
Source: Clinics and Research in Hepatology and Gastroenterology - March 1, 2019 Category: Gastroenterology Source Type: research

Meta-analysis of the association between MBOAT7 rs641738, TM6SF2 rs58542926 and nonalcoholic fatty liver disease susceptibility
ConclusionCC genotype of TM6SF2 rs58542926 was associated with a significantly lower risk of NAFLD, while MBOAT7 rs641738 was not related to NAFLD risks. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 27, 2019 Category: Gastroenterology Source Type: research

Identification of plasma miR-148a as a noninvasive biomarker for hepatocellular carcinoma
Publication date: Available online 27 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Juqiang Han, Jiarui Li, Yun Qian, Wenpeng Liu, Jiguang Liang, Zhigang Huang, Shuai Wang, Caiyan ZhaoSummaryBackgroundThe detection of microRNA (miRNA) markers in plasma is a potential strategy for hepatocellular carcinoma (HCC) screening. The aim of this study was to characterize miR-148a in the peripheral plasma as a non-invasive biomarker for the diagnosis of HCC.Methods and methodsQuantification of miR-148a was performed on 346 plasma samples, including 155 patients with HCC, 96 patients with live...
Source: Clinics and Research in Hepatology and Gastroenterology - February 27, 2019 Category: Gastroenterology Source Type: research

Clinical presentations of Hepatitis E: A clinical review with representative case histories
Publication date: Available online 23 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Abhishek Chauhan, Gwilym Webb, James FergusonSummaryHepatitis E virus (HEV) typically causes an acute, self-limiting hepatitis and is among the commonest cause of such presentations. Hepatitis E viral infection is also increasingly recognized as a cause of chronic hepatitis amongst the immunocompromised, particularly amongst solid organ transplant recipients. Chronic HEV infection remains an underdiagnosed disease and chronic infection can lead to rapidly progressive liver fibrosis and cirrhosis. Thi...
Source: Clinics and Research in Hepatology and Gastroenterology - February 25, 2019 Category: Gastroenterology Source Type: research

Domino liver transplantation: the risk of disease recurrence
Publication date: Available online 14 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Filoména Conti, Fanny Mochel, Yvon Calmus (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 15, 2019 Category: Gastroenterology Source Type: research

Clinical and psychological characteristics of patients with globus
Publication date: Available online 14 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Michel Bouchoucha, Noëlle Girault-Lidvan, Maria Hejnar, Florence Mary, Gheorges Airinei, Robert BenamouzigSummaryBackground/aimsPsychological factors are involved in many functional gastrointestinal disorders including globus. The aim of the present study was to assess the clinical and psychological correlates associated with globus.Patients and methods707 patients (69% female, 45.2 ± 16.5 years, BMI 27.2 ± 11.7 kg/m2) filled an MMPI-2 questionnai...
Source: Clinics and Research in Hepatology and Gastroenterology - February 14, 2019 Category: Gastroenterology Source Type: research

Predictive criteria of response to endoscopic treatment for severe strictures in primary sclerosing cholangitis
ConclusionMRC, together with biochemical features, may contribute to identify the PSC patients who are likely to be improved after ET for severe strictures of extrahepatic bile ducts. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 14, 2019 Category: Gastroenterology Source Type: research

Non-alcoholic fatty liver disease causes dissociated changes in metabolic liver functions
Publication date: Available online 13 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Peter Lykke Eriksen, Michael Sørensen, Henning Grønbæk, Stephen Hamilton-Dutoit, Hendrik Vilstrup, Karen Louise ThomsenSummaryBackgroundNon-alcoholic fatty liver disease (NAFLD) is a major health concern affecting 25% of the world’s population. It is generally held that a fatty liver does not influence liver function, but quantitative measurements of metabolic liver functions have not been systematically performed. We aimed to study selected hepatocellular metabolic function...
Source: Clinics and Research in Hepatology and Gastroenterology - February 13, 2019 Category: Gastroenterology Source Type: research

Cold guillotine of adherent clot in delayed post-polypectomy bleeding
Publication date: Available online 7 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Vincent Zimmer (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 8, 2019 Category: Gastroenterology Source Type: research

Editorial board
Publication date: February 2019Source: Clinics and Research in Hepatology and Gastroenterology, Volume 43, Issue 1Author(s): (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 6, 2019 Category: Gastroenterology Source Type: research

Psychosocial outcome and resilience after paediatric liver transplantation in young adults
ConclusionsOur results demonstrate psychological stability and high self-esteem of young patients, as well as good integration into society and a high degree of normality during daily life after LT. Adherence rates are lower than anticipated and do not correlate with patients’ understanding of their medical condition. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 6, 2019 Category: Gastroenterology Source Type: research

Is laparoscopy contraindicated for advanced gallbladder cancer?
Publication date: Available online 5 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Jun-Ke Wang, Zhen-Ru Wu, Hai-Jie Hu, Fu-Yu Li (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 6, 2019 Category: Gastroenterology Source Type: research

Liver and kidney function in refractory heart failure: The narrow gate to achieve post-transplant survival
Publication date: Available online 5 February 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Marco Masetti, Luciano PotenaSummarySubstantial evidence is underscoring the importance of a combined assessment of liver and kidney function in patients with refractory heart failure, to stratify early post- heart transplant risk: multi-organ dysfunction, while identifying sickest patients on the list is also associated with a high risk of post transplant complications. In this issue of the Journal, Dr. Lebray provides an analysis of combined kidney and liver function patients undergoing heart transp...
Source: Clinics and Research in Hepatology and Gastroenterology - February 6, 2019 Category: Gastroenterology Source Type: research

Early high levels of regulatory T cells and T helper 1 may predict the progression of recurrent hepatitis C after liver transplantation
ConclusionThese findings suggest that Treg, induced by a multifactorial process, which could include a strong Th1 response itself, may play a role in suppressing the early antiviral response, leading to a severe recurrence of hepatitis C. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 1, 2019 Category: Gastroenterology Source Type: research

Pre-treatment with FK506 reduces hepatic ischemia-reperfusion injury in rats
ConclusionFK506 pre-treatment could lessen hepatic ischemia-reperfusion injury through up-regulating the expression of HIF-1α and HO-1, and inhibiting nuclear translocation of NFAT3 in liver tissues. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 1, 2019 Category: Gastroenterology Source Type: research

Intraductal deployment of two fully covered metallic stents for anastomotic strictures following living donor liver transplantation
Publication date: Available online 29 January 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Ben Warner, Deepak Joshi, Michael Heneghan, Parthi Srinivasan, Andreas Prachalias, Phillip Harrison (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 30, 2019 Category: Gastroenterology Source Type: research

Incidence and characteristics of young-onset colorectal cancer in the United States: An analysis of SEER data collected from 1988 to 2013
Publication date: Available online 24 January 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Weibing Wang, Wenbin Chen, Jianjiang Lin, Qinsong Shen, Xile Zhou, Caizhao LinSummaryBackgroundThe incidence of colorectal cancer (CRC) has significantly increased in adults 
Source: Clinics and Research in Hepatology and Gastroenterology - January 25, 2019 Category: Gastroenterology Source Type: research

Cap-assisted underwater endoscopic mucosal resection of an anorectal mucosal prolapse polyp
Publication date: Available online 23 January 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Vincent Zimmer, Bert Bier (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 24, 2019 Category: Gastroenterology Source Type: research

Correlation between the DEPDC5 rs1012068 polymorphism and the risk of HBV-related hepatocellular carcinoma
ConclusionsThere was a significant correlation between DEPDC5 rs1012068A/C and HBV-related HCC in the Han Chinese population. A to C mutation increased the risk of the developing of HBV-related HCC. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 23, 2019 Category: Gastroenterology Source Type: research

HBsAg levels as a guide for finite treatment duration of chronic hepatitis B
Publication date: Available online 19 January 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Dzhamal Abdurakhmanov, Elhan Ibragimov, Teona Rozina, Elena Nikulkina, Natalya Mazurchik (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 20, 2019 Category: Gastroenterology Source Type: research

Combined heart and liver transplantation: State of knowledge and outlooks
Publication date: Available online 8 January 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Pascal Lebray, Shaida VarnousSummaryVarious types of liver impairment have been described in patients with end-stage heart failure who are awaiting heart transplantation. The liver impairment may be severe, characterized by a high model for end-stage liver disease (MELD) Score and/or the presence of ascites, both of which are associated with a high risk of failure after single heart transplantation. A liver function assessment is therefore necessary before registration on the heart transplant list, mor...
Source: Clinics and Research in Hepatology and Gastroenterology - January 9, 2019 Category: Gastroenterology Source Type: research

HCV-infected dialysis patients: History is changing
Publication date: Available online 4 January 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Lucia Parlati, Stanislas Pol (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 5, 2019 Category: Gastroenterology Source Type: research

Assessment of liver fibrosis by transient elastography (Fibroscan®) in patients with A1AT deficiency
ConclusionsFibroscan® is an easy and repeatable tool which can be used in PiZZ patients to screen for the presence of significant liver fibrosis and to identify patients at higher risk to develop liver complications in the future and who may benefit from a closer surveillance. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 4, 2019 Category: Gastroenterology Source Type: research

Autoimmune hepatitis in patients with multiple sclerosis: The role of immunomodulatory treatment
ConclusionsThe differential diagnosis of hepatitis in MS patients should include AIH and in particular when immunomodulatory treatment has been preceded. Autoantibody testing and liver histology play fundamental role in establishing a prompt diagnosis of AIH in these patients. Treatment of AIH in patients with MS seems safe and efficient as complete or partial response was recorded in all of our patients. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 27, 2018 Category: Gastroenterology Source Type: research

Sofosbuvir directly promotes the clonogenic capability of human hepatocellular carcinoma cells
Publication date: Available online 26 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Jiaye Liu, Wanlu Cao, Buyun Ma, Meng Li, Maikel P. Peppelenbosch, Qiuwei Pan (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 27, 2018 Category: Gastroenterology Source Type: research

Interleukin-10 promoter gene polymorphisms are associated with the first major depressive episode in chronic hepatitis C patients
ConclusionsThis is the first study to demonstrate that the IL10 low producer ATA haplotype is associated with the first MDE in patients with CHC. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 25, 2018 Category: Gastroenterology Source Type: research

Erratum to “Cameron lesions: A still overlooked diagnosis. Case report and systematic review of literature” [Clin. Res. Hepatol. Gastroenterol. 42 (2018) 604–609]
Publication date: Available online 19 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): A. Zullo, R. Manta, V. De Francesco, G. Fiorini, E. Lahner, D. Vaira, B. Annibale (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 20, 2018 Category: Gastroenterology Source Type: research

Portal vein thrombosis and liver cirrhosis: Long-term anticoagulation is effective and safe
ConclusionsOur results confirm that anticoagulation allows a recanalization of PVT complicating cirrhosis in the majority of the cases, is associated with non-severe bleeding complications, and can be maintained for a long duration in order to avoid recurrence. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 19, 2018 Category: Gastroenterology Source Type: research

A 33-year-old man with jaundice, dyspnoea and fever
Publication date: Available online 14 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): M Van Haren, A Lenaerts, H Paridaens, P Machiels (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 15, 2018 Category: Gastroenterology Source Type: research

Synchronous neuroendocrine tumor and signet-ring cell carcinoma in the stomach
Publication date: Available online 12 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Fengxia He, Ling Nie (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 14, 2018 Category: Gastroenterology Source Type: research

Adenocarcinoma is not always the diagnosis – colon neoplasia in patient with long-standing ulcerative colitis under long-term prednisone maintenance therapy
Publication date: Available online 13 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): J.M. Costa, A.P. Rodrigues, D. Fernandes, F. Costeira, F. Vieira, R. Gonçalves, M. Teixeira, J.B. Soares (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 14, 2018 Category: Gastroenterology Source Type: research

Primary acinic cell carcinoma of the esophagus
Publication date: Available online 11 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Ling Nie, Qi Wang, Fanqing Meng (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 12, 2018 Category: Gastroenterology Source Type: research

The early prognostic value of inflammatory markers in patients with acute pancreatitis
Publication date: Available online 10 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Gaoli Liu, Jing Tao, Zhongchao zhu, Weixing WangSummaryObjectivesThe aim of this study was to compare the prognostic value of inflammation-based prognostic markers with the more mature scoring system BISAP in patients with AP and identify the best predictors.Patients and methodsWe retrospectively analysed the data of patients with AP who were treated in our hospital from January 2017 to March 2018 and compared the prognostic value of these inflammation-based prognostic markers with the BISAP score in...
Source: Clinics and Research in Hepatology and Gastroenterology - December 11, 2018 Category: Gastroenterology Source Type: research

Increased incidence of Campylobacter enteritis and their quinolone resistance between 2010 and 2015: Results of a French national observatory conducted in 21 general hospitals (CHG)
Publication date: Available online 7 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Marie Trompette, Laura Le Guilloux, Laurent Souply, Bernard Denis, Ahmed Tsouria, Hélène Garrec, Vincent Quentin, Jacques Vaucel, Christophe Locher, Georges Barjonet, Patrick Marthelet, Xavier Causse, Didier Poisson, Stéphane Nahon, Caroline Joubrel-Guyot, Denis Grasset, Pascal Pouedras, Christophe Renou, Anne-Lise Toyer, Arnaud BoruchowiczSummaryIntroductionIn Europe, the number of cases of Campylobacter enteritis and their quinolone resistance is increasing. The aims of this wor...
Source: Clinics and Research in Hepatology and Gastroenterology - December 8, 2018 Category: Gastroenterology Source Type: research

Epidemiology of Budd-Chiari syndrome: A systematic review and meta-analysis
ConclusionEvidence from meta-analyses of existing literature confirmed that BCS should be a rare vascular liver disease. BCS may not be more common in Asia than Europe. More epidemiological data in other countries should be warranted. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 8, 2018 Category: Gastroenterology Source Type: research

mTOR inhibitors in pediatric liver transplant recipients
ConclusionOur results suggest that mTORi can be used in pediatric LT recipients in different clinical situations, both to reinforce immunosuppressive therapy, and to reduce CNI and related toxicity. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 7, 2018 Category: Gastroenterology Source Type: research

Health-related quality of life in pre-adolescent liver transplant recipients with biliary atresia: A cross-sectional study
ConclusionsPre-adolescents who underwent LT as an infant with BA, self-report low HRQOL on both disease-specific and generic HRQOL tools. Further research targeting sports participation and simplifying immunosuppression may further optimize quality of life years restored by life-saving LT. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 7, 2018 Category: Gastroenterology Source Type: research

Targeting Mcl-1 inhibits survival and self-renewal of hepatocellular cancer stem-like cells
This study suggests that Mcl-1 is an essential factor for the survival and self-renewal of HCC CSLCs. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 6, 2018 Category: Gastroenterology Source Type: research

Abdominal ascites in children as the presentation of eosinophilic gastroenteritis: A surgeon's perspective
ConclusionsSurgeons should be aware of EG as a rare cause of ascites, even in a pediatric population and especially in children with strong histories of allergic diseases, peripheral blood eosinophilia, and/or family histories of EG. It is important to avoid unnecessary surgical intervention, because dietary control and methylprednisolone treatment are effective remedies. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 6, 2018 Category: Gastroenterology Source Type: research

Impact of physician experience and multidisciplinary team on clinical outcome in patients receiving sorafenib
Publication date: Available online 5 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Andrea Casadei Gardini, Emanuela Scarpi, Francesco Giuseppe Foschi, Giorgia Marisi, Marco Maltoni, Giovanni Luca Frassineti (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 5, 2018 Category: Gastroenterology Source Type: research

Baseline HBsAg levels associated with HBsAg loss in HBeAg-negative chronic hepatitis B infection with persistently normal alanine aminotransferase
Publication date: Available online 5 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Li Chen, Junjie Shi, Zhonghua Lu, Yun Ye, Xinbei Zhou, Youwen TanSummaryBackgroundWe aimed to assess the long-term outcomes of e antigen-negative chronic hepatitis B (CHB) infection with low hepatitis B virus (HBV) DNA level (
Source: Clinics and Research in Hepatology and Gastroenterology - December 5, 2018 Category: Gastroenterology Source Type: research

Long non-coding RNA LINC00472 suppresses hepatocellular carcinoma cell proliferation, migration and invasion through miR-93-5p/PDCD4 pathway
Publication date: Available online 3 December 2018Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Changyu Chen, Qiang Zheng, Weibiao Kang, Changjun YuSummaryHepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths. In the present study, we have demonstrated that long non-coding RNA (lncRNA) LINC00472 was low expressed in human HCC tissues and cell lines compared with adjacent non-tumor liver tissues and normal liver cell lines respectively. LINC00472 was also low expressed in HCC tissues from patients with metastasis compared with tiss...
Source: Clinics and Research in Hepatology and Gastroenterology - December 4, 2018 Category: Gastroenterology Source Type: research