Factors associated with non adherence to a gluten free diet in adult with celiac disease: A survey assessed by BIAGI score
Publication date: Available online 12 February 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Zelnik Yovel Dana, Berezovsky lena, Richter Vered, Shirin Haim, Broide EfratSummaryIntroductionThe cornerstone of the recommended treatment for Celiac disease (CeD) is a lifelong strict gluten-free diet (GFD). We aimed to identify prospectively the demographic, clinical, social and psychological profile associated with non-adherence to a GFD in adult CeD patients in Israel.MethodsAn anonymous online questionnaire was sent via the Israeli Celiac association and through social networks. Only CeD patien...
Source: Clinics and Research in Hepatology and Gastroenterology - February 13, 2020 Category: Gastroenterology Source Type: research

Does adipose tissue inflammation drive the development of non-alcoholic fatty liver disease in obesity?
Publication date: Available online 7 February 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Adryana Cordeiro, Raquel Costa, Nelson Andrade, Cláudia Silva, Natalia Canabrava, Maria João Pena, Ilda Rodrigues, Sara Andrade, Andrea RamalhoSummaryObesity, an increasingly common problem in modern societies, is associated with acquired metabolic disturbances. In this perspective, the development of insulin resistance is now recognized to be initiated by inflammation of the adipose tissue, but the events that lead to this inflammation are still vague. Furthermore, visceral adipose tiss...
Source: Clinics and Research in Hepatology and Gastroenterology - February 8, 2020 Category: Gastroenterology Source Type: research

Pancreatic anti-GP2 and anti-Saccharomyces cerevisiae antibodies in ruminants with paratuberculosis: A better understanding of the immunopathogenesis of Crohn's disease
ConclusionASCA are present in a significant proportion of ruminants with ptb and correlate with anti-GP2 antibody positivity, a finding further supporting the notion that Crohn's disease and ptb share common immunological mechanisms of antigen-driven loss of self-tolerance. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 6, 2020 Category: Gastroenterology Source Type: research

Early esophageal signet ring cell carcinoma: A contraindication to endoscopic resection?
ConclusionEndoscopic resection of early esophageal SRCC is neither histologically complete, nor curative in the majority of cases. These data argue against upfront endoscopic resection when SRCC is evidenced on esophageal biopsies. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 6, 2020 Category: Gastroenterology Source Type: research

Mesenteric infiltrative desmoid tumor bordering the pancreas and mimicking liposarcoma
Publication date: Available online 31 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Su Lim Lee, Jae Im Lee, Kyung Jin Seo (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 1, 2020 Category: Gastroenterology Source Type: research

In vitro high-throughput drug sensitivity screening with patient-derived primary cells as a guide for clinical practice in hepatocellular carcinoma—A retrospective evaluation
ConclusionHigh-throughput drug sensitivity screening can be successfully used to screen chemotherapeutic drugs for efficacy against HCC and the efficacious drugs can be used in postoperative adjuvant chemotherapy of HCC patients. This treatment paradigm is safe and reliable, and improves survival compared with empirical chemotherapy. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 1, 2020 Category: Gastroenterology Source Type: research

Editorial board
Publication date: February 2020Source: Clinics and Research in Hepatology and Gastroenterology, Volume 44, Issue 1Author(s): (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 30, 2020 Category: Gastroenterology Source Type: research

Transient elastography for assessment of fibrosis and steatosis of liver grafts from brain-death donors
Publication date: Available online 25 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Wen-Yi Liu, Jian-Hong Wang, Yuan Guo, Xin Wang, Xiao-Dong Wu, Chuan-Shen Xu, Yang Zhao, Yun-Jin ZangSummaryBackgroundAn objective and accurate evaluation of liver grafts is required to improve the prognosis of liver transplant recipients and to increase the number of available liver grafts.AimTo compare outcomes using FibroScan with that of pathology in liver grafts from brain-dead donors (DBD).MethodsLiver grafts from 52 DBD were examined using ultrasound (US), FibroScan before liver transplantation ...
Source: Clinics and Research in Hepatology and Gastroenterology - January 26, 2020 Category: Gastroenterology Source Type: research

Fat patch trimming as a novel adjunct for over-the-scope clip closure of colonic perforation
Publication date: Available online 24 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Vincent Zimmer (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 25, 2020 Category: Gastroenterology Source Type: research

Cholangioscopic characterization of a giant barrel-shaped bile duct stone
Publication date: Available online 24 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Vincent Zimmer (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 25, 2020 Category: Gastroenterology Source Type: research

Cap-assisted detection and characterization of a spurting deep duodenal vascular lesion
Publication date: Available online 24 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Vincent Zimmer (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 25, 2020 Category: Gastroenterology Source Type: research

Direct cholangioscopy for exposure and treatment of bile duct stone disease in a “megacholedochus”
Publication date: Available online 24 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Vincent Zimmer (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 25, 2020 Category: Gastroenterology Source Type: research

USP9X mRNA expression predicts clinical outcome for esophageal squamous cell carcinoma treated with cisplatin-based therapy
Publication date: Available online 23 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Bin Wei, Lijuan Xu, Hongxia Hui, Yuan Sun, Jingjing WuSummaryIntroductionCombination therapy with cisplatin is the conventional first-line treatment in patients with locally advanced or metastatic esophageal squamous cell carcinoma (ESCC). Ubiquitin-specific protease 9X (USP9X) has been shown to be associated with resistance to chemotherapy drugs in several cancers. The purpose of this study was to explore the predictive effects of USP9X on advanced ESCC patients treated with cisplatin-based regi...
Source: Clinics and Research in Hepatology and Gastroenterology - January 24, 2020 Category: Gastroenterology Source Type: research

Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease
ConclusionHaptoglobin bifucosylated tetra-antennary glycan is associated with the presence of HCC in patients with chronic liver disease including those without cirrhosis. Its combination with existing HCC biomarkers could improve the performance of standard AFP for HCC detection. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 19, 2020 Category: Gastroenterology Source Type: research

Evaluation of efficacy, safety and treatment-related outcomes of percutaneous radiofrequency ablation versus partial hepatectomy for small primary liver cancer meeting the Milan criteria: A systematic review and meta-analysis of randomized controlled trials
Publication date: Available online 17 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Chengjun Yu, Shengde Wu, Jie Zhao, Jiandong Lu, Tianxin Zhao, Yi Wei, Chunlan Long, Tao Lin, Dawei He, Guanghui WeiSummaryBackground and objectiveTo systematically evaluate the efficacy, safety, and treatment-related outcomes between percutaneous radiofrequency ablation (PtRFA) and partial hepatectomy (PH) for small primary liver cancer meeting the Milan criteria.MethodsA systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta...
Source: Clinics and Research in Hepatology and Gastroenterology - January 18, 2020 Category: Gastroenterology Source Type: research

Predictive factors for risk of hepatocellular carcinoma in immune inactive chronic hepatitis B
Publication date: Available online 17 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Seung In Seo, Hyoung Su Kim, Bo Kyung Yang, Jin Gu Kang, Woon Geon Shin, Jin Heon Lee, Hak Yang Kim, Myoung Kuk JangSummaryBackground and aimsThe risk factors for hepatocellular carcinoma (HCC) in immune inactive chronic hepatitis B (CHB) have not been clarified. The aim of this study was to investigate the predictive factors for HCC inimmune inactive CHB.MethodsA total of 337 patients in immune inactive CHB were consecutively enrolled in Kangdong Sacred Heart Hospital from 1995 to 2017. Univariate an...
Source: Clinics and Research in Hepatology and Gastroenterology - January 18, 2020 Category: Gastroenterology Source Type: research

Methylprednisolone-related liver injury: A descriptive study using the French pharmacovigilance database
DiscussionThe results suggest that IV MP causality should be considered in case of acute liver injury while data for oral MP is insufficient; systematic liver monitoring for high-dose IV MP may be recommended. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 15, 2020 Category: Gastroenterology Source Type: research

Takotsubo cardiomyopathy triggered by delirium tremens in a cirrhotic patient with acute-on-chronic liver failure: A case report
This report describes a singular case of Takotsubo cardiomyopathy precipitated by delirium tremens in a cirrhotic patient with acute-on-chronic liver failure. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 10, 2020 Category: Gastroenterology Source Type: research

The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis
ConclusionsUnlike other chronic liver diseases, carrying two MBOAT7 variant alleles does not seem to affect PSC patients negatively, but seems to have a positive effect on transplant-free survival. This study could help improve individual prognosis in PSC patients and give some new perspective on the involvement of the immune system in PSC. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 10, 2020 Category: Gastroenterology Source Type: research

What is the role of small bowel capsule endoscopy in established coeliac disease?
ConclusionsThis is the first study showing correlation between extent of disease and severity of duodenal histology, markers of malabsorption such as folate levels and vitamin B12 and complications of CD. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 10, 2020 Category: Gastroenterology Source Type: research

Erratum to “Systematic review of progressive familial intrahepatic cholestasis” [Clin. Res. Hepatol. Gastroenterol. 43 (2019) 20–36]
Publication date: Available online 8 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Alastair Baker, Nanda Kerkar, Lora Todorova, Binita M. Kamath, Roderick H.J. Houwen (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 9, 2020 Category: Gastroenterology Source Type: research

Effect of mycophenolic acid on inosine monophosphate dehydrogenase (IMPDH) activity in liver transplant patients
ConclusionMPA-levels and IMPDH-activity in liver transplanted patients allows individual risk assessment. Patients with higher IMPDH inhibition acquire more often viral infections. Insufficient IMPDH inhibition is associated with development of non-anastomotic bile duct strictures and reduced re-transplantation-free survival. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 9, 2020 Category: Gastroenterology Source Type: research

The MBOAT7 rs641738 variant in primary sclerosing cholangitis: A novel biomarker for prognostication
Publication date: Available online 7 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Harman K. Rahal, James H. Tabibian (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 9, 2020 Category: Gastroenterology Source Type: research

Real-world use of therapeutic drug monitoring of CT-P13 in patients with inflammatory bowel disease: A 12-month prospective observational cohort study
Publication date: Available online 8 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Nicolas Petitdidier, Laurent Beaugerie, Franck Carbonnel, Anne Bourrier, Xavier Treton, Sylvie Rajca, Georgia Malamut, Vered Abitbol, Matthieu Allez, Anne-Laure Pelletier, Lysiane Marthey, Pauline Jouet, Robert Benamouzig, Xavier Amiot, Yoram Bouhnik, Aurelien AmiotSummaryBackgroundWhether therapeutic drug monitoring (TDM) of infliximab should be implemented in daily practice is an ongoing controversy.AimsTo assess the real-world use of TDM in an observational multicentre cohort study with consecutive ...
Source: Clinics and Research in Hepatology and Gastroenterology - January 9, 2020 Category: Gastroenterology Source Type: research

Parvovirus B19 infection: A challenging cause of fulminant hepatitis
Publication date: Available online 6 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Nicolas Gille, Anne-Marie Roque-Afonso, Mylène Sebagh, Marika Rudler, Dominique Thabut, Jean-Charles Duclos-Vallée, Didier Samuel, Audrey Coilly (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 7, 2020 Category: Gastroenterology Source Type: research

Why and when to diagnose Behcet's disease in patients with Budd Chiari Syndrome?
Publication date: Available online 6 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Anne-Claire Desbois, Aurelie Plessier (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 7, 2020 Category: Gastroenterology Source Type: research

Hepatitis Delta recurrence post-liver transplantation in absence of detectable hepatitis B surface antigen and hepatitis B virus DNA in peripheral blood
Publication date: Available online 28 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Paul Rémi Petit, Patrick Borentain, Sarah Aherfi, René Gérolami, Philippe Colson (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 29, 2019 Category: Gastroenterology Source Type: research

Jaundice 8 years after left hemi-hepatectomy for hepatocellular carcinoma
Publication date: Available online 26 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Si-Shu Yang, Xian Wu, Jiong Lu, Nan-Sheng Cheng (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 27, 2019 Category: Gastroenterology Source Type: research

Marked coagulopathy without liver disease or anticoagulation therapy
Publication date: Available online 26 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Kevin Jurgensmeier, Lee J. Hixson, David C. PfeifferSummarySymptomatic coagulopathies in celiac disease (CD) are rare. Here, we report a profound case of coagulopathy in a celiac. A 66-year old female without liver disease or anti-coagulation therapy presented with multiple ecchymoses, guaiac positive melanic stool, and a recent 4.5 kg weight loss. Laboratory values included hemoglobin, 3.8 g/dL; MCV, 66 fL; serum iron, 17 μg/dL; platelet count, 580 K/μL; white count, 14.2&n...
Source: Clinics and Research in Hepatology and Gastroenterology - December 27, 2019 Category: Gastroenterology Source Type: research

Survival according to recurrence patterns after resection for transplantable hepatocellular carcinoma in HBV endemic area: Appraisal of liver transplantation strategy
Publication date: Available online 20 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Chung Gyo Seo, Sun Young Yim, Soon Ho Um, Yoo Ra Lee, Yoo Jin Lee, Tae Hyung Kim, Hyun Gil Goh, Young Sun Lee, Sang Jun Suh, Na Yeon Han, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Ji Hoon Kim, Dong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik LeeSummaryBackground and aimsSince there is a shortage of liver donors, we investigated recurrence patterns and outcomes after liver resection (LR) to determine the feasibility of salvage liver transplantation (SLT).MethodsWe anal...
Source: Clinics and Research in Hepatology and Gastroenterology - December 21, 2019 Category: Gastroenterology Source Type: research

Resectable HCC: Should salvage liver transplantation for HCC be discussed de principe?
Publication date: Available online 18 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Claire Goumard, Olivier Scatton (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 19, 2019 Category: Gastroenterology Source Type: research

Gammadelta T cells as a predictor of surgical relapse of Crohn's disease
ConclusionsThe deficit of γδ T cells was related with the severity and the risk for surgical relapse in CD patients. Patients with CD3 + γδ deficit were more prone to surgery than patients without this deficit. These results suggest that γδ T cells could be used as markers of poor prognosis of CD following the diagnosis of the disease. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 19, 2019 Category: Gastroenterology Source Type: research

Efficacy and safety of endoscopic submucosal dissection for large gastric stromal tumors
ConclusionsESD is a feasible, safe, effective and minimally invasive approach for the resection of LGSTs. Tumors originating from the deep MP layer, located at the fundus and with an irregular shape were identified as risk factors for the development of complications. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 16, 2019 Category: Gastroenterology Source Type: research

Non-invasive fibrosis tests to predict complications in compensated post-hepatitis C cirrhosis
Publication date: Available online 12 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Jean-Pierre Zarski, Sandra David-Tchouda, Candice Trocme, Jennifer Margier, Antoine Vilotitch, Marie-Noelle Hilleret, Carole Cagnot, Valerie Boursier, Marianne Ziol, Angela Sutton, Richard Layese, Etienne Audureau, Francoise Roudot-Thoraval, Pierre NahonSummaryBackground and AimsMarkers predicting complications of post-hepatitis C cirrhosis are needed. We asked whether changes in noninvasive markers of fibrosis can predict liver-related complications.MethodsThis was a case-controlled study using a pr...
Source: Clinics and Research in Hepatology and Gastroenterology - December 13, 2019 Category: Gastroenterology Source Type: research

Multicystic schwannoma of the porta hepatis
Publication date: Available online 9 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Najat Mourra, Nikias Colignon, Ghazi Zaatari (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 9, 2019 Category: Gastroenterology Source Type: research

Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model
ConclusionCollectively, the evidences from this study demonstrated that active VD could alleviate the development of NAFLD through blocking the p53-p21 signaling pathway, which provided a novel nutritional therapeutic insight for NAFLD. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - December 5, 2019 Category: Gastroenterology Source Type: research

Obstructed membranous transformation of the inferior vena cava in patients with hepatic vein-type Budd-Chiari syndrome: A case series
Publication date: Available online 27 November 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Peng-Xu Ding, Chao Liu, Xin-Wei Han, Jia-Yin Ding, Gary Tse, Edward Wolfgang LeeSummaryBudd-Chiari syndrome (BCS) is a rare disease characterized by the obstruction of hepatic venous outflow due to occlusion of the hepatic vein (HV) or the inferior vena cava (IVC). The pathophysiology of IVC and HV membranous transformation, which can form in isolation or simultaneously, remains unclear in patients with combined-type BCS. Here we report three cases of patients with BCS demonstrating conversion from H...
Source: Clinics and Research in Hepatology and Gastroenterology - November 28, 2019 Category: Gastroenterology Source Type: research

Characteristics and outcome of primary Budd-Chiari syndrome due to Behçet's syndrome
ConclusionsThe prevalence of BS in Egyptian patients with BCS is considerably high. The clinical presentation of these patients was different from those without BS. Besides, the incidence of HCC was higher in patients with BS, whereas the mortality did not differ between the two groups. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - November 16, 2019 Category: Gastroenterology Source Type: research

Editorial board
Publication date: November 2019Source: Clinics and Research in Hepatology and Gastroenterology, Volume 43, Issue 6Author(s): (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - November 8, 2019 Category: Gastroenterology Source Type: research

Rectal perforation following fist fornication
Publication date: Available online 6 November 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Moussa Sylla, Pierlesky Elion Ossibi, Patrick Allimant, Sebastien Dan, Vincent De Parades (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - November 7, 2019 Category: Gastroenterology Source Type: research

Management of infections in patients with cirrhosis in the context of increasing therapeutic resistance: A systematic review
Publication date: Available online 6 November 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Manon Allaire, Jean-François Cadranel, Thi Thu Nga Nguyen, Armand Garioud, Honore Zougmore, Ratmony Heng, Claire Perignon, Isabelle Ollivier-Hourmand, Thông DaoSummaryPatients with cirrhosis are prone to develop bacterial infections, which consist in one of the major precursors of Acute-on-Chronic Liver Failure (ACLF) and are responsible for a high mortality rate. In recent years, the management of bacterial infections in patients with cirrhosis has become increasingly complicated due to ...
Source: Clinics and Research in Hepatology and Gastroenterology - November 7, 2019 Category: Gastroenterology Source Type: research

TIPS for management of portal-hypertension-related complications in patients with cirrhosis
Publication date: Available online 26 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Manon Allaire, Aurélie Walter, Olivier Sutter, Pierre Nahon, Nathalie Ganne-Carrié, Roland Amathieu, Jean-Charles NaultSummaryPortal hypertension is primarily due to liver cirrhosis, and is responsible for complications that include variceal bleeding, ascites and hepatorenal syndrome. The transjugular intrahepatic portosystemic shunt (TIPS) is a low-resistance channel between the portal vein and the hepatic vein, created by interventional radiology, that aims to reduce portal pressure. T...
Source: Clinics and Research in Hepatology and Gastroenterology - October 27, 2019 Category: Gastroenterology Source Type: research

Mutations and polymorphisms associated with iron overload in a series of 91 non-HFE haemochromatosis patients
Publication date: Available online 19 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Adrien Borgel, Jérôme Lamoril, Dimitri Tchernitchko (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - October 20, 2019 Category: Gastroenterology Source Type: research

Skeletal status assessed by quantitative ultrasound and dual-energy X-ray absorptiometry in children with inflammatory bowel disease: A 2-year prospective study
Publication date: Available online 17 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Katarzyna Bąk-Drabik, Piotr Adamczyk, Agata Chobot, Wojciech PluskiewiczSummaryPurposeTo assess the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement and dual-energy X-ray absorptiometry (DXA) at baseline and after two years of adequate treatment of the IBD and bone protection medication.MethodsSixteen children (six boys) with IBD, aged 13.4 ± 2.4 years, were examined at baseline and two years later. DXA was used to asses b...
Source: Clinics and Research in Hepatology and Gastroenterology - October 18, 2019 Category: Gastroenterology Source Type: research

Characteristics of amino acid substitutions within the “a” determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs
Publication date: Available online 14 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Wei Hou, Zhixiao Huo, Yanan Du, Cindy Wang, Wing-Kin SynSummaryObjectivesSimultaneous positivity for both hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) is an atypical serological profile in chronic hepatitis B (CHB) patients. The exact mechanisms underlying the uncommon profile remains unclear. The aim of this study was to analyze the characteristics of amino acid substitutions within the “a” determinant region in a large cohort of CHB patients with coexistence of ...
Source: Clinics and Research in Hepatology and Gastroenterology - October 15, 2019 Category: Gastroenterology Source Type: research

Characterization of biopsy proven non-alcoholic fatty liver disease in healthy non-obese and lean population of living liver donors: The impact of uric acid
This study aimed to investigate prevalence and risk factors of biopsy proven NAFLD in a cluster of healthy non-obese and lean individuals.Methods and MaterialsIn a retrospective study, adult (> 18 years) apparently healthy individuals who had donated liver to pediatric patients between July 2012 and October 2018 were included. Non-obese and lean individuals were defined as BMI 
Source: Clinics and Research in Hepatology and Gastroenterology - October 12, 2019 Category: Gastroenterology Source Type: research

Mechanical hemolysis after transjugular intrahepatic portosystemic shunt can occur with covered stent
Publication date: Available online 11 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Jérôme Dumortier, Badis Menassel, Nicolas Benech, Gaspard Bertrand, Pierre-Jean Valette (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - October 12, 2019 Category: Gastroenterology Source Type: research

Three fluoropyrimidine-based regimens in routine clinical practice after nab-paclitaxel plus gemcitabine for metastatic pancreatic cancer: An AGEO multicenter study
Publication date: Available online 10 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Anne-Laure Pointet, David Tougeron, Simon Pernot, Astrid Pozet, Dominique Béchade, Isabelle Trouilloud, Nelson Lourenco, Vincent Hautefeuille, Christophe Locher, Nicolas Williet, Jérôme Desrame, Pascal Artru, Emilie Soularue, Bertrand Le Roy, Julien TaiebSummaryBackgroundA combination of nab-paclitaxel plus gemcitabine (N + G) has recently become a standard first-line treatment in patients with metastatic pancreatic adenocarcinoma (MPA), but there are currently no publish...
Source: Clinics and Research in Hepatology and Gastroenterology - October 12, 2019 Category: Gastroenterology Source Type: research

Pyogenic liver abscesses from Fusobacterium nucleatum in an immunocompetent host
Publication date: Available online 10 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Kanupriya Soni, Zachary Fricker, Michelle Theresa Long (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - October 12, 2019 Category: Gastroenterology Source Type: research

Vaccination in adult liver transplantation candidates and recipients
Publication date: Available online 10 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Florent Valour, Anne Conrad, Florence Ader, Odile LaunaySummaryIn patients with chronic liver disease and liver transplant recipients, cirrhosis-associated immune dysfunction syndrome and immunosuppressant drug regimens required to prevent graft rejection lead to a high risk of severe infections, associated with acute liver decompensation, graft loss and increased mortality. In addition to maintain their global health status, vaccination represents a major preventive measure against specific infectiou...
Source: Clinics and Research in Hepatology and Gastroenterology - October 12, 2019 Category: Gastroenterology Source Type: research