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Specialty: Gastroenterology

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Total 496 results found since Jan 2013.

Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma < em > via < /em > the PI3K/AKT pathway
CONCLUSION: Our study suggests for the first time that DDX51 promotes cancer cell proliferation by regulating the PI3K/AKT pathway; thus, DDX51 might be a therapeutic target for ESCC.PMID:35125830 | PMC:PMC8790558 | DOI:10.3748/wjg.v28.i4.464
Source: World Journal of Gastroenterology - February 7, 2022 Category: Gastroenterology Authors: Dong-Xin Hu Qi-Feng Sun Lin Xu Hong-Da Lu Fan Zhang Zhen-Miao Li Ming-Yan Zhang Source Type: research

Silencing HBV transcription with SMC5/6: has a path been found?
Chronic hepatitis B virus (HBV) infection is maintained by the viral nuclear covalently closed circular DNA (cccDNA) that is the transcriptional template for HBV’s mRNAs. The cccDNA is durable during current therapies, but a functional cure for HBV infections will require stable, off-treatment silencing of any cccDNA remaining in the body after treatment cessation.1 The cccDNA is silenced naturally during infection by binding of the structural maintenance of chromosome 5/6 (SMC5/6) complex to the cccDNA, and HBV antagonises this silencing with the HBx protein that binds to SMC5/6 and triggers its proteasomal degradat...
Source: Gut - January 11, 2022 Category: Gastroenterology Authors: Tavis, J., Chauhan, R. Tags: Gut Commentary Source Type: research

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo
Conclusion These results reveal that therapeutics abrogating all HBV transcripts including HBx promote epigenetic suppression of the HBV minichromosome, whereas strategies protecting the human hepatocytes from reinfection are needed to maintain cccDNA silencing.
Source: Gut - January 11, 2022 Category: Gastroenterology Authors: Allweiss, L., Giersch, K., Pirosu, A., Volz, T., Muench, R. C., Beran, R. K., Urban, S., Javanbakht, H., Fletcher, S. P., Lütgehetmann, M., Dandri, M. Tags: Open access, Gut Hepatology Source Type: research

Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease
CONCLUSION: FGL1 can induce intestinal inflammation by activating the canonical NF-κB signalling pathway, and it may be considered a potential biomarker and therapeutic target for CD.PMID:34629811 | PMC:PMC8475002 | DOI:10.3748/wjg.v27.i35.5946
Source: World Journal of Gastroenterology - October 11, 2021 Category: Gastroenterology Authors: Xue-Liang Sun Li-Chao Qiao Jing Gong Ke Wen Zhi-Zhong Xu Bo-Lin Yang Source Type: research