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Specialty: Gastroenterology

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Total 496 results found since Jan 2013.

Hepatic miR-181b-5p Contributes to Glycogen Synthesis Through Targeting EGR1
ConclusionWe demonstrated that miR-181b-5p contributes to glycogen synthesis by targeting EGR1, thereby regulating PTEN expression to mediate hepatic insulin resistance.
Source: Digestive Diseases and Sciences - January 9, 2019 Category: Gastroenterology Source Type: research

Hepatitis C Virus Entry into Macrophages/Monocytes Mainly Depends on the Phagocytosis of Macrophages
ConclusionsHCV entry into macrophages mainly depends on phagocytosis of macrophages.
Source: Digestive Diseases and Sciences - December 10, 2018 Category: Gastroenterology Source Type: research

Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes.
Authors: Maués JHDS, Ribeiro HF, Pinto GR, Lopes LO, Lamarão LM, Pessoa CMF, Moreira-Nunes CFA, de Carvalho RM, Assumpção PP, Rey JA, Burbano RMR Abstract MYC is an oncogene responsible for excessive cell growth in cancer, enabling transcriptional activation of genes involved in cell cycle regulation, metabolism, and apoptosis, and is usually overexpressed in gastric cancer (GC). By using siRNA and Next-Generation Sequencing (NGS), we identified MYC-regulated differentially expressed Genes (DEGs) in three Brazilian gastric cancer cell lines representing the histological subtypes of GC (diffuse, intestinal, and ...
Source: Canadian Journal of Gastroenterology - November 11, 2018 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer
ConclusionsThese results suggest that NIS regulates tumor progression by affecting IFN signaling, and that its strong expression is related to a worse prognosis in patients with GC. These results provide an insight into the role of NIS as a mediator and/or a biomarker for GC.
Source: Gastric Cancer - September 6, 2018 Category: Gastroenterology Source Type: research

MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway
ConclusionThe tumor suppressor miR-449a suppresses HCC tumorigenesis by repressing the c-Met/ERK pathway.
Source: Hepatobiliary and Pancreatic Diseases International - August 11, 2018 Category: Gastroenterology Source Type: research

Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure.
CONCLUSION: Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. PMID: 30090006 [PubMed - in process]
Source: World Journal of Gastroenterology - August 7, 2018 Category: Gastroenterology Authors: Zhang RZ, Zeng XH, Lin ZF, Ming-Fu, Tong YL, Lui VC, Tam PK, Lamb JR, Xia HM, Chen Y Tags: World J Gastroenterol Source Type: research

MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/c-Met pathway
ConclusionThe tumor suppressor miR-449a suppresses HCC tumorigenesis by repressing the c-Met/ERK pathway.
Source: Hepatobiliary and Pancreatic Diseases International - July 26, 2018 Category: Gastroenterology Source Type: research

Effect of heme oxygenase-1 on the protection of ischemia reperfusion injury of bile duct in rats after liver transplantation
ConclusionOur study demonstrated that overexpression of HO-1 in donor liver can ameliorate the damage to bile duct and liver, and improved liver function, suggesting HO-1 might be a new therapeutic target in the treatment of IRI after liver transplantation.
Source: Clinics and Research in Hepatology and Gastroenterology - July 10, 2018 Category: Gastroenterology Source Type: research

P90-RSK as a synthetic lethal target in pancreatic cancer - molecular characterization and therapeutic inhibition
Objectives Pancreatic cancer continues to be the cancer entity with the worst prognosis among all solid tumors associated with a 5-year survival of 5-8%. Combined chemotherapeutic regimes provide only survival benefits for a few months and are not equally suited for all patients with advanced pancreatic cancer. Targeted approaches have largely failed. A marginal clinical benefit was seen for an EGFR inhibitior, erlotinib, in combination with chemotherapy. Using a kinome-wide small-interfering RNA (siRNA)-based loss of function screen, we recently identified the kinase RPS6KA2, also known as p90 ribosomal S6 kinase RSK3, as...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Jan Riedel, Nada Milosevic, Jens von Kries, Marc Nazare, Heidi Griesmann, Patrick Michl Tags: 4. Experimental pancreatitis and cell biology II Source Type: research

Notch Signaling Pathway Is Inhibited in the Development of Barrett's Esophagus: An In Vivo and In Vitro Study.
Conclusions: Both hydrochloric acid and deoxycholic acid could suppress Notch signaling pathway in esophageal epithelial cells, and inhibited Notch signaling has important functions in the development of Barrett's esophagus. PMID: 29785394 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - May 24, 2018 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Filaggrin and tight junction proteins are crucial for IL-13-mediated esophageal barrier dysfunction.
Abstract Eosinophilic esophagitis (EoE) is an allergy-mediated disease that is accompanied by IL-13 overexpression and an impaired esophageal barrier. Filaggrin (FLG) and tight junction (TJ) proteins are considered to contribute to epithelial barrier function. However, their functional involvement in EoE has not been elucidated. Here, we aimed to determine the IL-13-mediated barrier dysfunction and expression of TJ-related proteins in EoE, and to characterize interactions among TJ-related proteins involved in the barrier function of the esophageal epithelium. Biopsy specimens from EoE patients were analyzed. Prima...
Source: Am J Physiol Gastroi... - May 10, 2018 Category: Gastroenterology Authors: Wu L, Oshima T, Li M, Tomita T, Fukui H, Watari J, Miwa H Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Fish oil alleviates liver injury induced by intestinal ischemia/reperfusion via AMPK/SIRT-1/autophagy pathway.
CONCLUSION: Our study indicates that FO may protect the liver against intestinal I/R induced injury through the AMPK/SIRT-1/autophagy pathway. PMID: 29467553 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 21, 2018 Category: Gastroenterology Authors: Jing HR, Luo FW, Liu XM, Tian XF, Zhou Y Tags: World J Gastroenterol Source Type: research

Hepatitis C virus core protein-induced miR-93-5p up-regulation inhibits interferon signaling pathway by targeting IFNAR1.
CONCLUSION: HCV-1b core protein-induced miR-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR-93-5p-IFNAR1 axis regulates STAT1 phosphorylation. This axis may be a potential therapeutic target for HCV-1b infection. PMID: 29375208 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: He CL, Liu M, Tan ZX, Hu YJ, Zhang QY, Kuang XM, Kong WL, Mao Q Tags: World J Gastroenterol Source Type: research