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Specialty: Gastroenterology

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Total 496 results found since Jan 2013.

High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition.
CONCLUSION: The functional inhibition between Parp1 and Sirt1 leads to HMGB1 hyperacetylation, which leads to its translocation from the nucleus to the cytoplasm and finally outside the cell. PMID: 31576091 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 27, 2019 Category: Gastroenterology Authors: Ye TJ, Lu YL, Yan XF, Hu XD, Wang XL Tags: World J Gastroenterol Source Type: research

Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.
CONCLUSION: Overall, our data demonstrate the oncogenic role of circPIP5K1A-miR-1273a axis in regulation of colon cancer development, which provides a novel insights into colon cancer pathogenesis. PMID: 31558874 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 20, 2019 Category: Gastroenterology Authors: Zhang Q, Zhang C, Ma JX, Ren H, Sun Y, Xu JZ Tags: World J Gastroenterol Source Type: research

Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF- κB signaling pathways.
CONCLUSION: AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-κB pathway. Therefore, AITC is a potential therapeutic agent for NAFLD. PMID: 31558861 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 13, 2019 Category: Gastroenterology Authors: Li CX, Gao JG, Wan XY, Chen Y, Xu CF, Feng ZM, Zeng H, Lin YM, Ma H, Xu P, Yu CH, Li YM Tags: World J Gastroenterol Source Type: research

Downregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6
ConclusionsDownregulation of NR2F2-AS1 induces G1 arrest of CRC cells by downregulating CDK6.
Source: Digestive Diseases and Sciences - August 19, 2019 Category: Gastroenterology Source Type: research

Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma.
CONCLUSION: We provide new evidence that TROP2 is epigenetically down-regulated and operates as a negative regulator of cell proliferation and migration in liver fluke-associated CCA. PMID: 31320172 [PubMed]
Source: Annals of Hepatology - July 21, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Association of HOTAIR with the Diagnosis and Prognosis of Gastric Cancer and Its Effect on the Proliferation of Gastric Cancer Cells.
Conclusion: The present study demonstrated that HOTAIR was highly expressed in GC tissues and may serve as a potential diagnostic and prognostic biomarker for GC. And HOTAIR promoted GC cell proliferation. PMID: 31281803 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - July 11, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

EZH2 Regulates Intestinal Inflammation and Necroptosis Through the JNK Signaling Pathway in Intestinal Epithelial Cells
ConclusionOur data suggest that EZH2 plays an important role in the development of intestinal inflammation and necroptosis. Hence, EZH2 could be a potential therapeutic target for IBD.
Source: Digestive Diseases and Sciences - July 3, 2019 Category: Gastroenterology Source Type: research

Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor- κB signaling pathway.
CONCLUSION: NLRC5 may play a key role in the development and reversal of hepatic fibrosis through the NF-κB signaling pathway, and it is expected to be one of the clinical therapeutic targets. PMID: 31293340 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - June 27, 2019 Category: Gastroenterology Authors: Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, Gao B Tags: World J Gastroenterol Source Type: research

Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways
ConclusionThis study supports PTPRD as a tumor suppressor and could be served as a marker for prognostic of GC. Silencing PTPRD could be a potential therapeutic in GC.
Source: Digestive Diseases and Sciences - April 29, 2019 Category: Gastroenterology Source Type: research

Effect of bacterial flagellin on thiamin uptake by human and mouse pancreatic acinar cells: Inhibition mediated at the level of transcription of THTR-1 and 2.
Abstract Thiamin (vitamin B1) is essential for normal cellular metabolism and function. Pancreatic acinar cells (PACs) obtain thiamin from circulation, via a specific carrier-mediated process that involves the plasma membrane thiamin transporters -1 and -2 (THTR-1 and THTR-2; products of SLC19A2 and SLC19A3 genes, respectively). There is nothing known about the effect of bacterial products/toxins on thiamin uptake by PACs. We addressed this issue in the current investigation by examining the effect of the bacterial flagellin on physiological and molecular parameters of the thiamin uptake by PACs. We used human pri...
Source: Am J Physiol Gastroi... - March 27, 2019 Category: Gastroenterology Authors: Srinivasan P, Anandam KY, Ramesh V, Geltz ET, Said HM Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway
ConclusionsCircular RNA ciRS-7 plays an oncogene role in PDAC, partly by targeting miR-7 and regulating the EGFR/STAT3 signaling pathway.
Source: Hepatobiliary and Pancreatic Diseases International - March 10, 2019 Category: Gastroenterology Source Type: research

Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury.
CONCLUSION: USP22 is correlated with promoting intestinal cell proliferation and accelerating intestinal tissue regeneration after intestinal I/R injury and may serve as a potential target for therapeutic development for tissue repair during intestinal I/R injury. PMID: 30809082 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 21, 2019 Category: Gastroenterology Authors: Ji AL, Li T, Zu G, Feng DC, Li Y, Wang GZ, Yao JH, Tian XF Tags: World J Gastroenterol Source Type: research

Effects of Tec Tyrosine Kinase Inhibition on the Inflammatory Response of Severe Acute Pancreatitis-Associated Acute Lung Injury in Mice
ConclusionsTec tyrosine kinase plays a key role in PALI, and is therefore a potential target for clinical treatment.
Source: Digestive Diseases and Sciences - February 14, 2019 Category: Gastroenterology Source Type: research

Osteopontin Protects Colonic Mucosa from Dextran Sodium Sulfate-Induced Acute Colitis in Mice by Regulating Junctional Distribution of Occludin
ConclusionsOur study showed that OPN is essential for maintaining the tight junction complex by allowing occludin to localize at tight junctions. This could constitute additional evidence that OPN plays a crucial role in intestinal mucosal protection.
Source: Digestive Diseases and Sciences - February 1, 2019 Category: Gastroenterology Source Type: research

Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
CONCLUSION: HuR mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer. Further studies are needed to assess the underlying mechanisms. PMID: 30670910 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z Tags: World J Gastroenterol Source Type: research