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Specialty: Gastroenterology
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Total 496 results found since Jan 2013.
Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease
CONCLUSION: FGL1 can induce intestinal inflammation by activating the canonical NF-κB signalling pathway, and it may be considered a potential biomarker and therapeutic target for CD.PMID:34629811 | PMC:PMC8475002 | DOI:10.3748/wjg.v27.i35.5946
Source: World Journal of Gastroenterology - October 11, 2021 Category: Gastroenterology Authors: Xue-Liang Sun Li-Chao Qiao Jing Gong Ke Wen Zhi-Zhong Xu Bo-Lin Yang Source Type: research
The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer
ConclusionsATP1A1 appears to regulate tumor progression by altering IFN signaling, and high ATP1A1 expression levels were associated with poor postoperative survival in GC patients. The present results provide novel insights into the function of ATP1A1 as a mediator and/or biomarker of GC.
Source: Gastric Cancer - October 11, 2021 Category: Gastroenterology Source Type: research
Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA
ConclusionHigh ACYP1 expression could influence the prognosis of cHCC-iCCA, HCC, and iCCA patients. In vitro ACYP1 expression influences the tumor growth and cell viability in both HCC and iCCA by regulating anti-apoptosis proteins.
Source: Digestive Diseases and Sciences - October 9, 2021 Category: Gastroenterology Source Type: research
LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway
ConclusionsThe present results indicate that LRRC8A functions as a mediator of and/or biomarker for GC.
Source: Gastric Cancer - August 5, 2021 Category: Gastroenterology Source Type: research
The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer
ConclusionsATP1A1 appears to regulate tumor progression by altering IFN signaling, and high ATP1A1 expression levels were associated with poor postoperative survival in GC patients. The present results provide novel insights into the function of ATP1A1 as a mediator and/or biomarker of GC.
Source: Gastric Cancer - July 12, 2021 Category: Gastroenterology Source Type: research
LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway
ConclusionsThe present results indicate that LRRC8A functions as a mediator of and/or biomarker for GC.
Source: Gastric Cancer - April 16, 2021 Category: Gastroenterology Source Type: research
Novel treatment options for acute hepatic porphyrias
Purpose of review
Acute hepatic porphyrias (AHP) are a group of rare diseases that are characterized by episodic acute neurovisceral pain episodes caused by abnormal accumulation of the neurotoxic porphyrin precursor delta-aminolevulinic acid (ALA). Patient with frequent recurrent acute attacks have been difficult to treat and these patients sometimes require liver transplantation. Recent developments in small interfering RNA (siRNA)-based therapy led to the development of an effective prophylactic treatment for patients with frequent recurrent attacks. This review will describe treatment options for AHP and highlight ...
Source: Current Opinion in Gastroenterology - April 9, 2021 Category: Gastroenterology Tags: LIVER: Edited by Don C. Rockey Source Type: research
Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPAR γ/PGC-1α/HNF-4α in Hep3B Cells
CONCLUSIONS: Atorvastatin induces FXR and CYP7A1 activation as a result of sequential action of PPARγ-PGC-1α-HNF-4α in human hepatocytes. We propose that atorvastatin enhances solubility of cholesterol in bile by simultaneously activating of FXR and CYP7A1.PMID:33686046 | DOI:10.4166/kjg.2020.156
Source: Korean J Gastroenter... - March 9, 2021 Category: Gastroenterology Authors: Jin Lee Eun Mi Hong Jang Han Jung Se Woo Park Sang Pyo Lee Dong Hee Koh Hyun Joo Jang Sea Hyub Kae Source Type: research
