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Specialty: Gastroenterology

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Total 496 results found since Jan 2013.

Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to colorectal visceral pain in adult mice with neonatal maternal deprivation
CONCLUSIONS: This study suggested that overexpression of Rab27a increased exosome secretion in ACC neurons, thus contributing to visceral hyperalgesia in NMD mice.PMID:37529842 | DOI:10.1152/ajpgi.00029.2023
Source: Am J Physiol Gastroi... - August 2, 2023 Category: Gastroenterology Authors: Qian Sun Rui-Xia Weng Jia-Hui Li Yong-Chang Li Ji-Tian Xu Rui Li Xiaomin Lu Guang-Yin Xu Source Type: research

Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts anti-tumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis
RNA N6-Methyladenosine (m6A) reader protein YTHDF1 has been implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in nonalcoholic steatohepatitis-associated HCC (NASH-HCC), remains unknown. Here, we investigated the functional role and molecular mechanism of YTHDF1 on NASH-HCC and its interplay with tumor immune microenvironment.
Source: Journal of Hepatology - July 15, 2023 Category: Gastroenterology Authors: Lina Wang, Lefan Zhu, Cong Liang, Xiang Huang, Ziqin Liu, Jihui Huo, Ying Zhang, Yifan Zhang, Lili Chen, Hongzhi Xu, Xiaoxing Li, Lixia Xu, Ming Kuang, Chi Chun Wong, Jun Yu Source Type: research

Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis
RNA N6-methyladenosine (m6A) reader protein YTHDF1 has been implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non-alcoholic steatohepatitis-associated HCC (NASH-HCC), remains unknown. Here, we investigated the functional role of YTHDF1 in NASH-HCC and its interplay with the tumor immune microenvironment.
Source: Journal of Hepatology - July 15, 2023 Category: Gastroenterology Authors: Lina Wang, Lefan Zhu, Cong Liang, Xiang Huang, Ziqin Liu, Jihui Huo, Ying Zhang, Yifan Zhang, Lili Chen, Hongzhi Xu, Xiaoxing Li, Lixia Xu, Ming Kuang, Chi Chun Wong, Jun Yu Tags: Research Article Source Type: research

Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Conclusion YTHDF1 impairs antitumour immunity via an m6A-p65-CXCL1/CXCR2 axis to promote CRC and serves as a therapeutic target in immune checkpoint blockade therapy.
Source: Gut - July 6, 2023 Category: Gastroenterology Authors: Bao, Y., Zhai, J., Chen, H., Wong, C. C., Liang, C., Ding, Y., Huang, D., Gou, H., Chen, D., Pan, Y., Kang, W., To, K. F., Yu, J. Tags: Open access, Gut Colon Source Type: research

Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways
CONCLUSION: Our results suggest that calcitriol may be employed as an adjuvant therapy for hepatic fibrosis and that NS3TP1 is a unique, prospective therapeutic target in hepatic fibrosis.PMID:37274069 | PMC:PMC10237113 | DOI:10.3748/wjg.v29.i18.2798
Source: World Journal of Gastroenterology - June 5, 2023 Category: Gastroenterology Authors: Liu Shi Li Zhou Ming Han Yu Zhang Yang Zhang Xiao-Xue Yuan Hong-Ping Lu Yun Wang Xue-Liang Yang Chen Liu Jun Wang Pu Liang Shun-Ai Liu Xiao-Jing Liu Jun Cheng Shu-Mei Lin Source Type: research