Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. Gemcitabine is the standard chemotherapy for patients with metastatic pancreatic adenocarcinoma (MPA). Randomized clinical trials evaluating intensified chemotherapies including FOLFIRINOX and nab-paclitaxel plus gemcitabine (NAB+GEM) have shown improvement in survival. Here, we have evaluated the efficacy of intensified chemotherapy versus gemcitabine monotherapy in real-life settings across Europe. (Source: Pancreatology)
Source: Pancreatology - October 15, 2018 Category: Gastroenterology Authors: Muhammad Ahsan Javed, Georg Beyer, Nha Le, Alessio Vinci, Helen Wong, Daniel Palmer, Robert D. Morgan, Angela Lamarca, Richard A. Hubner, Juan W. Valle, Salma Alam, Sumsur Chowdhury, Yuk Ting Ma, Livia Archibugi, Gabriele Capurso, Patrick Maisonneuve, Alb Source Type: research

Characterization of long-term prognosis in acute pancreatitis: An explorative analysis
Severity classification systems of acute pancreatitis (AP) assess inpatient morbidity and mortality without predicting outpatient course of AP. To provide appropriate outpatient care, determinants of long-term prognosis must also be identified. The aim of this study was to define clinical groups that carry long-term prognostic significance in AP. (Source: Pancreatology)
Source: Pancreatology - October 8, 2018 Category: Gastroenterology Authors: Mohannad Abou Saleh, Dharani Guttikonda, Vijit Chouhan, Ashwinee Natu, Michael Enzerra, Raj Paspulati, David Ngendahimana, Bayan Alsuleiman, Lorna Kang, Emad Mansoor, Brooke Glessing, Amitabh Chak, Tyler Stevens, Peter J. Lee Source Type: research

From the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis
In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. (Source: Pancreatology)
Source: Pancreatology - October 6, 2018 Category: Gastroenterology Authors: J. Enrique Dominguez-Munoz, Asbj ørn M. Drewes, Björn Lindkvist, Nils Ewald, László Czakó, Jonas Rosendahl, J. Matthias Löhr, HaPanEU/UEG Working Group Source Type: research

Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome
Despite the recent introduction of new drugs and the development of innovative multi-target treatments, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains very poor. Even when PDAC is resectable, the rate of local or widespread disease recurrence remains particularly high. Currently, reliable prognostic biomarkers of recurrence are lacking. We decided to explore the potential usefulness of pancreatic developmental regulators as biomarkers of PDAC relapse. (Source: Pancreatology)
Source: Pancreatology - October 4, 2018 Category: Gastroenterology Authors: Erica Dugnani, Valeria Sordi, Silvia Pellegrini, Raniero Chimienti, Ilaria Marzinotto, Valentina Pasquale, Daniela Liberati, Gianpaolo Balzano, Claudio Doglioni, Michele Reni, Alessandra Gandolfi, Massimo Falconi, Vito Lampasona, Lorenzo Piemonti Source Type: research

Acute pancreatitis: Trends in outcomes and the role of acute kidney injury in mortality- A propensity-matched analysis
To assess national trends of AP (acute pancreatitis) admissions, outcomes, prevalence of AKI (acute kidney injury) in AP, and impact of AKI on inpatient mortality. (Source: Pancreatology)
Source: Pancreatology - October 4, 2018 Category: Gastroenterology Authors: Kalpit Devani, Paris Charilaou, Dhruvil Radadiya, Bhaumik Brahmbhatt, Mark Young, Chakradhar Reddy Source Type: research

Organotypic slice cultures of pancreatic ductal adenocarcinoma preserve the tumor microenvironment and provide a platform for drug response
/Objective: The conventional models currently used to evaluate various anti-tumor therapeutic agents are not sufficient for representing human pancreatic ductal adenocarcinoma (PDA), which has a unique tumor microenvironment. We aimed to produce an organotypic slice culture model from human PDA that resembles the in  vivo situation and to evaluate the responses of PDA slices to established cytotoxic drugs. (Source: Pancreatology)
Source: Pancreatology - October 3, 2018 Category: Gastroenterology Authors: Chae Yoon Lim, Jae Hyuck Chang, Won Sun Lee, Kang Min Lee, Young Chul Yoon, Jeana Kim, Il Young Park Source Type: research

Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
At present, pancreatic ductal adenocarcinoma (PDAC) is a fetal disease lack of effective prognostic and therapeutic methods resulting in high mortality. The Notch signaling has been demonstrated being up- or down-regulated in many cancers, but the effects in pancreatic ductal adenocarcinoma are still controversial. Moreover, the available cases in an individual study are of small samples. Therefore, it is essential to define the effect of Notch signaling in pancreatic ductal adenocarcinoma with larger samples. (Source: Pancreatology)
Source: Pancreatology - October 1, 2018 Category: Gastroenterology Authors: Jianbin Ye, Junjie Wen, Yunshan Ning, Yan Li Source Type: research

Early removal of metal stents in walled off pancreatic necrosis
Endoscopic transmural drainage is the preferred drainage route for walled off necrosis (WON) with larger diameter transmural tract dilatation and placement of multiple plastic stents being advocated to achieve effective drainage of solid necrotic material [1]. Development of dedicated fully covered large diameter metal stents made the management of WON with significant solid debris easier. These stents are easy to deploy with high rate technical success. Also, direct endoscopic necrosectomy (DEN) can be easily performed through the large calibre stent [2]. (Source: Pancreatology)
Source: Pancreatology - October 1, 2018 Category: Gastroenterology Authors: Surinder Singh Rana, Ravi Sharma, Rajesh Gupta Source Type: research

Systemic chemotherapy in combination with liver-directed therapy improves survival in patients with pancreatic adenocarcinoma and synchronous liver metastases
We investigated whether the combination of systemic chemotherapy (SCT) and liver-directed therapy (LDT) was superior to chemotherapy alone for patients with pancreatic adenocarcinoma and synchronous liver metastases (PACLM). (Source: Pancreatology)
Source: Pancreatology - September 29, 2018 Category: Gastroenterology Authors: Huaqiang Ouyang, Weidong Ma, Ti Zhang, Fang Liu, Lujun Zhao, Minghui Fang, Manman Quan, Zhanyu Pan Source Type: research

Diagnosis and management of pancreatic cancer in adults: A summary of guidelines from the UK National Institute for Health and Care Excellence
To enable standardisation of care of pancreatic cancer patients and facilitate improvement in outcome, the United Kingdom's National Institute for Health and Care Excellence (NICE) developed a clinical guideline for the diagnosis and management of pancreatic cancer in adults. Systematic literature searches, systematic review and meta-analyses were undertaken. Recommendations were drafted on the basis of the group's interpretation of the best available evidence of clinical and cost effectiveness. (Source: Pancreatology)
Source: Pancreatology - September 28, 2018 Category: Gastroenterology Authors: Derek O'Reilly, Linyun Fou, Elise Hasler, James Hawkins, Susan O'Connell, Ferruccio Pelone, Mark Callaway, Fiona Campbell, Margred Capel, Richard Charnley, Pippa Corrie, Dawn Elliot, Lesley Goodburn, Anna Jewell, Suzanne Joharchi, Laura McGeeney, Somnath Source Type: research

Relationship between somatostatin and interleukin-6: A cross-sectional study in patients with acute pancreatitis
The aim of the analysis is to determine dynamic changes in somatostatin (SS) and interleukin-6 (IL-6) concentrations during in acute pancreatitis (AP). (Source: Pancreatology)
Source: Pancreatology - September 28, 2018 Category: Gastroenterology Authors: Mariola Sliwinska-Mosson, Grzegorz Marek, Zygmunt Grzebieniak, Halina Milnerowicz Source Type: research

Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer
Aberrantly expressed mucin glycoproteins (MUC) play important roles in pancreatic ductal adenocarcinoma (PDAC), yet their use as a diagnostic aid in fine-needle aspiration biopsy (FNAB) is poorly documented. The aim of this study was to investigate the rationale and feasibility of mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) expression profiling by RT-PCR for diagnostic applications in cytology. (Source: Pancreatology)
Source: Pancreatology - September 27, 2018 Category: Gastroenterology Authors: Milosz Wiktorowicz, Damian Mlynarski, Radoslaw Pach, Romana Tomaszewska, Jan Kulig, Piotr Richter, Marek Sierzega Source Type: research

Impact of preoperative sarcopenia on postoperative outcomes following pancreatic resection: A systematic review and meta-analysis
Morphometric analysis of sarcopenia has garnered interest due to its putative role in predicting outcomes following surgery for a variety of pathologies, including resection for pancreatic disease. However, there are no standard recommendations on whether sarcopenia is a clinically relevant predictor of outcomes in this setting. The aim of this study was to review the prognostic impact of preoperatively diagnosed sarcopenia on postoperative outcomes following pancreatic resection. (Source: Pancreatology)
Source: Pancreatology - September 27, 2018 Category: Gastroenterology Authors: Chathura BB. Ratnayake, Benjamin PT. Loveday, Shailesh V. Shrikhande, John A. Windsor, Sanjay Pandanaboyana Source Type: research

Artificial neural network algorithm model as powerful tool to predict acute lung injury following to severe acute pancreatitis
The aim of this study is to predict the risk of severe acute pancreatitis (SAP) associated with acute lung injury (ALI) by artificial neural networks (ANNs) model. (Source: Pancreatology)
Source: Pancreatology - September 26, 2018 Category: Gastroenterology Authors: Yang Fei, Kun Gao, Wei-qin Li Source Type: research

Management of pregnancy-associated pancreatic cystic tumors: Review of the literature and results of a Pancreas Club Inc. Survey
Management of patients with pregnancy-associated cyst pancreatic cystic tumors (PA-PCT) is complicated by lack of large series. (Source: Pancreatology)
Source: Pancreatology - September 26, 2018 Category: Gastroenterology Authors: Sara Iacopi, Carlo Lombardo, Francesca Menonna, Salvatore Mazzeo, Davide Caramella, Gabriella Amorese, Fabio Vistoli, Ugo Boggi Source Type: research

Lymphadenectomy in pancreatic neuroendocrine neoplasms: Why are we still debating?
Pancreatic Neuroendocrine Neoplasms (PNEN) are rare tumours exhibiting very heterogeneous behaviour. For these reasons, studies with high level of evidence are lacking. Whether lymphadenectomy should be performed for PNEN is a matter of debate. In this review, we perform a critical analysis of the available literature regarding the clinical significance of lymphnode metastases, the importance of lymphadenectomy, and the implications on disease-specific survival. (Source: Pancreatology)
Source: Pancreatology - September 19, 2018 Category: Gastroenterology Authors: F. Ausania, P. Senra del Rio Source Type: research

Dilemma of elevated CA 19-9 in biliary pathology
Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker which has been extensively evaluated and widely utilized primarily in diagnosing and prognosticating pancreaticobiliary malignancies. Levels may be significantly influenced and elevated in cases of benign biliary conditions however, especially in obstructive jaundice, thereby posing difficulty in distinguishing between benign and malignant cholestasis. A myriad of studies have focused on elucidating proper use and interpretation of CA 19-9 in pancreatic cancer as well as in the setting of cholestasis. (Source: Pancreatology)
Source: Pancreatology - September 18, 2018 Category: Gastroenterology Authors: Adrianne Tsen, Mary Barbara, Laura Rosenkranz Source Type: research

Diagnosis, treatment and long-term outcome of autoimmune pancreatitis in Sweden
Autoimmune pancreatitis (AIP) is a pancreatic inflammatory process characterized by a strong inflammatory cell infiltration and two histopathologically distinct subtypes: type 1 and type 2. Diagnosis is often challenging and requires a combination of clinical, laboratory and imaging data. AIP can mimic pancreatic tumours leading to unnecessary resections if not correctly diagnosed. Short- and long-term outcomes of AIP have been poorly investigated so far and no large series have been previously reported from Sweden. (Source: Pancreatology)
Source: Pancreatology - September 13, 2018 Category: Gastroenterology Authors: Miroslav Vujasinovic, Roberto Valente, Pia Maier, Victoria von Beckerath, Stephan L. Haas, Urban Arnelo, Marco Del Chiaro, Nikolaos Kartalis, Raffaella Maria Pozzi-Mucelli, Carlos Fernandez-Moro, Caroline Sophie Verbeke, Jingru Yu, Weimin Ye, J. Matthias Source Type: research

Portal encasement: Significant CT findings to diagnose local recurrence after pancreaticoduodenectomy for pancreatic cancer
To demonstrate the utility of portal encasement as a criterion for early diagnosis of local recurrence (LR) after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). (Source: Pancreatology)
Source: Pancreatology - September 10, 2018 Category: Gastroenterology Authors: Tamaki Noie, Yasushi Harihara, Masaaki Akahane, Junichi Kazaoka, Astuki Nagao, Shoichi Sato, Kazuteru Watanabe, Satoshi Nara, Kaoru Furushima, Ryuji Yoshioka, Yukinori Yamagata, Emiko Takeshita, Takashi Okuyama, Shinichi Sameshima, Masatoshi Oya Source Type: research

Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria: Proposal of a modified Yonsei criteria score
In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. (Source: Pancreatology)
Source: Pancreatology - September 3, 2018 Category: Gastroenterology Authors: Seoung Yoon Rho, Mi Jin Yun, Chang Moo Kang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee Source Type: research

Comparison between groove carcinoma and groove pancreatitis
The pancreatoduodenal groove (anatomical groove) is a potential space bordered by the head of the pancreas, duodenum, and common bile duct. Discerning between groove carcinoma (GC) and groove pancreatitis (GP) is often difficult, but clinically important. We retrospectively analyzed and compared the findings of computed tomography (CT), laboratory tests, and endoscopic ultrasound-fine needle aspiration (EUS-FNA) for GC and GP. (Source: Pancreatology)
Source: Pancreatology - August 29, 2018 Category: Gastroenterology Authors: Jae Hyuck Jun, Sung Koo Lee, So Yeon Kim, Dong Hui Cho, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Myung-Hwan Kim Source Type: research

Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis
The paper presents the international guidelines for imaging evaluation of chronic pancreatitis. The following consensus was obtained: Computed tomography (CT) is often the most appropriate initial imaging modality for evaluation of patients with suspected chronic pancreatitis (CP) depicting most changes in pancreatic morphology. CT is also indicated to exclude other potential intraabdominal pathologies presenting with symptoms similar to CP. However, CT cannot exclude a diagnosis of CP nor can it be used to exclusively diagnose early or mild disease. (Source: Pancreatology)
Source: Pancreatology - August 28, 2018 Category: Gastroenterology Authors: Jens Br øndum Frøkjær, Fatih Akisik, Ammad Farooq, Burcu Akpinar, Anil Dasyam, Asbjørn Mohr Drewes, Ingfrid S. Haldorsen, Giovanni Morana, John P. Neoptolemos, Søren Schou Olesen, Maria Chiara Petrone, Andrea Sheel, Tooru Shimosoegawa, David C. Whitc Source Type: research

The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair
Cantharidin is an inhibitor of protein phosphatase 2  A (PP2A), and has been frequently used in clinical practice. In our previous study, we proved that cantharidin could arrest cell cycle in G2/M phase. Since cells at G2/M phase are sensitive to radiotherapy, in the present study, we investigated the radiotherapy-sesitization effect of cantharidin and the potential mechanisms involved. (Source: Pancreatology)
Source: Pancreatology - August 24, 2018 Category: Gastroenterology Authors: Meng-Dan Xu, Shu-Ling Liu, Bei-Bei Zheng, Jing Wu, Meng-Yao Wu, Yan Zhang, Fei-Ran Gong, Min Tao, Junning Zhang, Wei Li Source Type: research

Overexpression of GP73 promotes cell invasion, migration and metastasis by inducing epithelial-mesenchymal transition in pancreatic cancer
Pancreatic cancer is one of the most difficult clinical cases to diagnose with a very low 5-year survival rate of 5%, regardless of the advances made in both the medical and surgical treatment of the disease. One of the contributing factors for the high mortality rate seen of pancreatic cancer patients is the lack of effective chemotherapies, which is believed to be due to drug-resistance. Based on recent evidence, epithelial-mesenchymal transition (ETM) of pancreatic cancer cells has been found to be associated with the development of drug resistance and an increase in cell invasion. (Source: Pancreatology)
Source: Pancreatology - August 23, 2018 Category: Gastroenterology Authors: Yin-Xue Song, Zhi-Chao Xu, Hui-Ling Li, Pei-Lei Yang, Jun-Kai Du, Jing Xu Source Type: research

Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer
The transient receptor potential TRPM8 ion channel is required for cellular proliferation in pancreatic epithelia and adenocarcinoma. To elucidate the mechanism that mediates the function of TRPM8, we examined its role in the proliferation and invasion of pancreatic cancer (PC) cells. TRPM8 expression increased in both the PC tissues and cell lines; a high TRPM8 expression was correlated with poorer prognosis in patients with PC. In PC cell lines, PACN-1 and BxPC-3, Ca2+ influxes could be evoked by TRPM8; the sensitivity of PC cells to gemcitabine was increased, while the proliferation and invasion of PC cells were suppres...
Source: Pancreatology - August 22, 2018 Category: Gastroenterology Authors: JieFeng Liu, GuoHuang Hu, YuJing Gong, QianLe Yu, Bin He, WangHao Li, ZhiGuo He, WenJie Hao, ZiChao He, YiPing Liu Source Type: research

An audit of percutaneous drainage for acute necrotic collections and walled off necrosis in patients with acute pancreatitis
Percutaneous catheter drainage (PCD) is used as a first step in the management of symptomatic fluid collections in patients with acute pancreatitis (AP). We aimed to compare the outcome of patients with acute necrotic collection (ANC) and those with walled-off necrosis (WON), who had undergone PCD as a part of management of AP. (Source: Pancreatology)
Source: Pancreatology - August 20, 2018 Category: Gastroenterology Authors: Bipadabhanjan Mallick, Narendra Dhaka, Pankaj Gupta, Ajay Gulati, Sarthak Malik, Saroj K. Sinha, Thakur D. Yadav, Vikas Gupta, Rakesh Kochhar Source Type: research

Pancreatic cystosis in patients with cystic fibrosis: A qualitative systematic review
Patients with cystic fibrosis (CF) and a CFTR gene mutation may present with a variety of pancreatic disorders. The presence of multiple macrocysts (>1  cm) replacing the entire pancreatic parenchyma is termed pancreatic cystosis. Lack of clear data makes clinical decision making challenging and controversial. The aim of this review is to perform a qualitative systematic analysis of the literature with intention to evaluate management plans. (Source: Pancreatology)
Source: Pancreatology - August 17, 2018 Category: Gastroenterology Authors: Chirag S. Desai, Jennifer Shurney, Rebecca McCall, Khalid M. Khan, Todd H. Baron Source Type: research

RCAN1 is a marker of oxidative stress, induced in acute pancreatitis
To date, there still is a lack of specific acute pancreatitis markers and specifically an early marker that can reliably predict disease severity. The inflammatory response in acute pancreatitis is mediated in part through oxidative stress and calcineurin-NFAT (Nuclear Factor of Activated T-cells) signaling, which is inducing its own negative regulator, regulator of calcineurin 1 (RCAN1). Caerulein induction is a commonly used in vivo model of experimental acute pancreatitis. Caerulein induces CN-NFAT signaling, reactive oxygen species and inflammation. (Source: Pancreatology)
Source: Pancreatology - August 16, 2018 Category: Gastroenterology Authors: K. Jessica Norberg, Salvatore Nania, Xuan Li, Hui Gao, Peter Szatmary, Ralf Segersv ärd, Stephan Haas, Annika Wagman, Urban Arnelo, Robert Sutton, Rainer L. Heuchel, J. Matthias Löhr Source Type: research

RNA sequence analysis reveals pathways and candidate genes associated with liver injury in a rat pancreatitis model
The morbidity and mortality associated with acute pancreatitis (AP) are largely attributable to abnormalities that occur in distant organs, such as liver and lungs. Pancreatitis-associated liver injury (PALI) remains a serious and even fatal complication during the progression of AP. However, the exact pathophysiological mechanism is still unclear. (Source: Pancreatology)
Source: Pancreatology - August 15, 2018 Category: Gastroenterology Authors: Qian Wang, Shuanghong Lei, Yi Wang, Chaoxu Liu, Gang Wang Source Type: research

Endoscopic ultrasound appearance of pancreatic serotonin-staining neuroendocrine neoplasms
The pancreatic localization of serotonin-staining neuroendocrine neoplasms is extremely rare. This is a retrospective study aimed at analyzing the endoscopic ultrasound appearance of pancreatic serotoninoma. (Source: Pancreatology)
Source: Pancreatology - August 11, 2018 Category: Gastroenterology Authors: Sara Massironi, Stefano Partelli, Maria C. Petrone, Alessandra Zilli, Dario Conte, Massimo Falconi, Paolo G. Arcidiacono Source Type: research

New observations on the utility of CA19-9 as a biomarker in Lewis negative patients with pancreatic cancer
This study was to examine serum CA19-9 levels in patients with pancreatic cancer according to Lewis status. (Source: Pancreatology)
Source: Pancreatology - August 9, 2018 Category: Gastroenterology Authors: Guopei Luo, Zhiyao Fan, He Cheng, Kaizhou Jin, Meng Guo, Yu Lu, Chao Yang, Kun Fan, Qiuyi Huang, Jiang Long, Liang Liu, Jin Xu, Renquan Lu, Quanxing Ni, Andrew L. Warshaw, Chen Liu, Xianjun Yu Source Type: research

The diagnostic value of Rosemont and Japanese diagnostic criteria for ‘indeterminate’, ‘suggestive’, ‘possible’ and ‘early’ chronic pancreatitis
Longitudinal data are lacking to support consensus criteria for diagnosing early chronic pancreatitis. (Source: Pancreatology)
Source: Pancreatology - August 7, 2018 Category: Gastroenterology Authors: Andrea RG. Sheel, Ryan D. Baron, Ioannis Sarantitis, Jayapal Ramesh, Paula Ghaneh, Michael GT. Raraty, Vincent Yip, Robert Sutton, Michael R. Goulden, Fiona Campbell, Ammad Farooq, Priya Healey, Richard Jackson, Christopher M. Halloran, John P. Neoptolemo Source Type: research

Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38  MAPK and ERS inhibition
To investigate the effects of quercetin on intestinal barrier disruption and inflammationin acute necrotizing pancreatitis (ANP) in rats, and its possible mechanism. (Source: Pancreatology)
Source: Pancreatology - August 6, 2018 Category: Gastroenterology Authors: Zheng Junyuan, Xu Hui, Huang Chunlan, Fan Junjie, Mei Qixiang, Lu Yingying, Lou Lihong, Wang Xingpeng, Zeng Yue Source Type: research

Patients with pancreatic cystic neoplasms can benefit from management of multidisciplinary team: Experience from a Chinese academic center
Pancreatic cystic neoplasms (PCNs) are a spectrum of neoplasms that can be benign or malignant. The accuracy of diagnosis is critical for this disease since different types of PCNs are treated differently using various modalities. The use of a multidisciplinary team (MDT) has been shown to improve the management and outcomes of various diseases. We aimed to determine the performance of MDT in the management of PCNs. (Source: Pancreatology)
Source: Pancreatology - August 1, 2018 Category: Gastroenterology Authors: Yiwen Chen, Chengxiang Guo, Qi Zhang, Yinang Shen, Yuwei Li, Xiang Li, Xueli Bai, Tingbo Liang Source Type: research

Functions of the CXC ligand family in the pancreatic tumor microenvironment
Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. (Source: Pancreatology)
Source: Pancreatology - August 1, 2018 Category: Gastroenterology Authors: Nien-Hung Lee, Mehrdad Nikfarjam, Hong He Source Type: research

Endoscopic ultrasound elastography in the diagnosis of pancreatic masses: A meta-analysis
Endoscopic ultrasound (EUS) elastography is a novel non-invasive technique that can be used for distinguishing benign from malignant pancreatic masses. However, the studies have reported widely varied sensitivities and specificities. A meta-analysis was performed to assess the performance of EUS elastography for the differentiation of benign and malignant pancreatic masses. (Source: Pancreatology)
Source: Pancreatology - July 30, 2018 Category: Gastroenterology Authors: Binglan Zhang, Fuping Zhu, Pan Li, Shishi Yu, Yajing Zhao, Minmin Li Source Type: research

Progression to pancreatic ductal adenocarcinoma from pancreatic intraepithelial neoplasia: Results of a simulation model
To gain insight into the natural history and carcinogenesis pathway of Pancreatic Intraepithelial Neoplasia (PanIN) lesions by building a calibrated simulation model of PanIN progression to pancreatic ductal adenocarcinoma (PDAC) (Source: Pancreatology)
Source: Pancreatology - July 28, 2018 Category: Gastroenterology Authors: Mary Linton B Peters, Andrew Eckel, Peter P. Mueller, Angela C. Tramontano, Davis T. Weaver, Anna Lietz, Chin Hur, Chung Yin Kong, Pari V. Pandharipande Source Type: research

Protocol digest of randomized phase II study of modified FOLFIRINOX versus gemcitabine plus nab-paclitaxel combination therapy for locally advanced pancreatic cancer: Japan clinical oncology group study (JCOG1407)
A randomized phase II selection design trial comparing FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer started in July 2016. (Source: Pancreatology)
Source: Pancreatology - July 27, 2018 Category: Gastroenterology Authors: Junki Mizusawa, Akira Fukutomi, Hiroshi Katayama, Hiroshi Ishii, Tatsuya Ioka, Takuji Okusaka, Hideki Ueno, Makoto Ueno, Masafumi Ikeda, Nobumasa Mizuno, Masato Ozaka, Haruhiko Fukuda, Junji Furuse, Hepatobiliary and Pancreatic Oncology Group of the Japan Source Type: research

Increased risk of candidemia in patients with necrotising pancreatitis infected with candida species
Candida infections are frequent in necrotising pancreatitis. Candidemia is associated with very high mortality and its risk due to infected pancreatic necrosis is unknown. So we aimed to assess potential risk factors and the risk of candidemia in necrotising pancreatitis. (Source: Pancreatology)
Source: Pancreatology - July 15, 2018 Category: Gastroenterology Authors: Sebastian Rasch, Ulrich Mayr, Veit Phillip, Roland M. Schmid, Wolfgang Huber, Hana Alg ül, Tobias Lahmer Source Type: research

Genomic testing for pancreatic cancer in clinical practice as real-world evidence
Precision medicine guided by comprehensive genome sequencing represents a potential treatment strategy for pancreatic cancer. However, clinical sequencing for pancreatic cancer entails several practical difficulties. We have launched an in-house clinical sequencing system and started genomic testing for patients with cancer in clinical practice. We have analyzed the clinical utility of this system in pancreatic cancer. (Source: Pancreatology)
Source: Pancreatology - July 15, 2018 Category: Gastroenterology Authors: Hideyuki Hayashi, Shigeki Tanishima, Kyoko Fujii, Ryo Mori, Yasunobu Okamura, Emmy Yanagita, Ryosuke Matsuoka, Toraji Amano, Ichiro Kinoshita, Yoshito Komatsu, Hirotoshi Dosaka-Akita, Hiroshi Nishihara Tags: Original Article Source Type: research

Dietary oleic acid is inversely associated with pancreatic cancer – Data from food diaries in a cohort study
This study aims to clarify the relationship between dietary oleic acid intake and the risk of developing PDA using nutritional information from food diaries plus published serum biomarker data from HbA1c. (Source: Pancreatology)
Source: Pancreatology - July 10, 2018 Category: Gastroenterology Authors: Paul JR. Banim, Robert Luben, Kay-Tee Khaw, Andrew R. Hart Source Type: research

Knockdown of AGR2 induces cell apoptosis and reduces chemotherapy resistance of pancreatic cancer cells with the involvement of ERK/AKT axis
Pancreatic cancer (PC), an aggressive human malignancy, presents with a striking resistance to chemotherapy. Interesting, AGR2 has been found to be upregulated in various cancers and has been found to promote the dissemination of PC cells. Thereby, a series of in-vitro experiments were performed to investigate the relationship between AGR2 and the ERK/AKT axis, and to explore whether it affects PC cells. (Source: Pancreatology)
Source: Pancreatology - July 7, 2018 Category: Gastroenterology Authors: Qing-Guo Liu, Yan-Ju Li, Lan Yao Source Type: research

The prevalence of pancreatic morphological abnormalities detected by digital autopsy
Chronic pancreatitis (CP) is a chronic condition characterized by irreversible fibrosis of the pancreatic parenchyma, accompanied by calcification and dilatation of the main pancreatic duct (MPD) and its branches [1]. A more recent proposal for a new mechanistic definition consensus suggests that ‘common features of established and advanced CP may include pancreatic atrophy, duct distortion and strictures and calcifications’ [2]. These pancreatic morphological abnormalities (PMA) are identifiable on computed tomography (CT) which is recommended when CP is suspected [3]. (Source: Pancreatology)
Source: Pancreatology - July 6, 2018 Category: Gastroenterology Authors: Jennifer A. Campbell, JamesN.S. Hampton, Matthias L öhr, Chris Howard, David S. Sanders, Andrew D. Hopper Source Type: research

CA 19 –9 predicts resectability of pancreatic cancer even in jaundiced patients
Surgical resection remains the only curative option for pancreatic adenocarcinoma. Despite recent improvements in medical imaging, unresectability is still often discovered at the time of surgery. It is essential to identify unresectable patients preoperatively to avoid unnecessary surgery. High serum CA 19-9 levels have been suggested as a marker of unresectability but considered inaccurate in patients with hyperbilirubinemia. (Source: Pancreatology)
Source: Pancreatology - July 3, 2018 Category: Gastroenterology Authors: Nicolas Santucci, Olivier Facy, Pablo Ortega-Deballon, Jean-Baptiste Lequeu, Paul Rat, Patrick Rat Source Type: research

The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration
Insulin, a key hormone produced by pancreatic beta cells precisely regulates glucose metabolism in vertebrates. In type 1 diabetes, the beta cell mass is destroyed, a process triggered by a combination of environmental and genetic factors. This ultimately results in absolute insulin deficiency and dysregulated glucose metabolism resulting in a number of detrimental pathophysiological effects. The traditional focus of treating type 1 diabetes has been to control blood sugar levels through the administration of exogenous insulin. (Source: Pancreatology)
Source: Pancreatology - June 20, 2018 Category: Gastroenterology Authors: Amitoj Singh, Yann Gibert, Karen M. Dwyer Tags: Review Article Source Type: research

Evaluation of local instillation of antibiotics in infected walled-off pancreatic necrosis
This study evaluates the efficacy of local instillation of antibiotics into WON. (Source: Pancreatology)
Source: Pancreatology - June 19, 2018 Category: Gastroenterology Authors: Mikkel Werge, Srdan Novovic, Stine Roug, Jenny Dahl Knudsen, Erik Feldager, Lise Lotte Gluud, Palle Norblad Schmidt Source Type: research

Ultrasonic/CT image fusion guidance facilitating percutaneous catheter drainage in treatment of acute pancreatitis complicated with infected walled-off necrosis
As the firs-line treatment for acute pancreatitis (AP) related infectious walled-off necrosis (WON), percutaneous catheter drainage (PCD) are usually accomplished under CT or US guidance, either of which has certain disadvantages. It is necessary to verify the clinical effects of using US and CT images fusion as guidance of PCD. (Source: Pancreatology)
Source: Pancreatology - June 15, 2018 Category: Gastroenterology Authors: Hui Zhang, Guang-yu Chen, Le Xiao, Xiao Ma, Li Shi, Tao Wang, Hong-tao Yan, Hong Zou, Qi Chen, Li-jun Tang, Wei-hui Liu Source Type: research

Measurement of copy number of ACTN4 to optimize the therapeutic strategy for locally advanced pancreatic cancer
The standard therapeutic strategy recommended for locally advanced pancreatic cancer (LAPC) is typically chemotherapy or chemoradiotherapy (CRT). Although the clinical benefit of chemotherapy alone versus CRT for LAPC has been compared in a number of clinical trials, the optimal therapy for LAPC remains unclear. Moreover, the clinical benefit derived from treatment in each clinical trial is a matter of controversy, and the superiority of one treatment over another has yet to be definitively demonstrated. (Source: Pancreatology)
Source: Pancreatology - June 13, 2018 Category: Gastroenterology Authors: Hirokazu Shoji, Nami Miura, Hideki Ueno, Kazufumi Honda Source Type: research

Improving the accuracy of pancreatic cancer clinical staging by exploitation of nanoparticle-blood interactions: A pilot study
Pancreatic ductal adenocarcinoma (PDAC) early diagnosis is   crucial  and new, cheap and user-friendly techniques for biomarker identification  are  needed. “Protein corona” (PC) is emerging a new bio-interface potentially useful in tumor early diagnosis. In a previous investigation, we showed that relevant differences between the  protein pat terns of  PCs formed on lipid NPs after exposure to PDAC and non-cancer plasma  samples exist. To extend that research, We performed this pilot study to investigate the effect of PDAC tumor size and distant metastases on PC composition. (Source: Pancreatology)
Source: Pancreatology - June 12, 2018 Category: Gastroenterology Authors: D. Caputo, M. Cartillone, C. Cascone, D. Pozzi, L. Digiacomo, S. Palchetti, G. Caracciolo, R. Coppola Source Type: research

Incidence and reasons of pancreatic resection in patients with asymptomatic serous cystadenoma
Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. (Source: Pancreatology)
Source: Pancreatology - June 8, 2018 Category: Gastroenterology Authors: Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccol ò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi Source Type: research