Role of Transthoracic Lung Ultrasonography in Acute Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Drug-Induced Pancreatitis in a Pediatric Patient Following Acetaminophen Overdose
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

PlasmaLyte Improves Patient Outcomes Compared With Normal Saline in the Treatment of Acute Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Validation of the Novel Eighth Edition of American Joint Committee on Cancer Staging Manual: An In-depth Analysis for Nonfunctional Pancreatic Neuroendocrine Neoplasms
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Surgical Treatment of Pancreaticoduodenal Artery Aneurysm Due to Median Arcuate Ligament Syndrome for Which Intraoperative Doppler Ultrasonography Was BeneficialA Case Report
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

A Case of Immunoglobulin G4–Related Autoimmune Pancreatitis With Extreme Hypergammaglobulinemia
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Utility of DNA Profiling From Main Pancreatic Duct Fluid by Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography to Screen for Malignant Potential
Conclusions Endoscopic MPD fluid sampling may yield genetic data to improve diagnosis and risk stratification. In our surgical cohort, LOH was the sole predictor of invasive pathology. Endoscopic ultrasound-guided fine-needle aspiration of MPD fluid, when possible, is preferred because of superior safety profile. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Diazoxide Preconditioning of Nonhuman Primate Pancreas Improves Islet Isolation Outcomes by Mitochondrial Protection
Conclusions This study showed a strong mitochondrial protection of DZ on nonhuman primate islets against ischemia-reperfusion injury that provides strong evidence for its clinical application in islet and pancreas transplantation. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Characteristics of Lung Metastasis as an Initial Recurrence Pattern After Curative Resection of Pancreatic Cancer
Objectives Understanding the disparity in clinical course because of differences in initial recurrence patterns could lead to a more accurate estimation of prognosis and optimal treatment. Methods Patients who underwent resection for pancreatic cancer between January 2003 and December 2016 were identified from a prospective database. We analyzed the association between clinicopathological information or survival outcomes and initial recurrence patterns. Results The most frequent recurrence pattern was locoregional recurrence (n = 84, 31.3%), followed by simultaneous multiple recurrences (n = 65, 24.2%), liver metas...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Dynamic Change of β to α Ratio in Islets of Chinese People With Prediabetes and Type 2 Diabetes Mellitus
Conclusions The islet β to α ratio increased in PreD individuals because of a relative α-cell loss and β-cell compensation and decreased after T2D onset because of both β-cell loss and α-cell reexpansion. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Adenosquamous Carcinoma of the Pancreas Comprise a Heterogeneous Group of Tumors With the Worst Outcome: A Clinicopathological Analysis of 25 Cases Identified in 562 Pancreatic Carcinomas Resected With Curative Intent
Conclusions Adenosquamous carcinoma of the pancreas comprises a group of neoplasms in which stage and adverse morphological features contribute to its bad prognosis. Further work must be pursued to improve detection and treatment options to reduce mortality. Specifically, differences in biology might become a target for the development of possible therapies. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Extrapancreatic Nerve Plexus Invasion on Imaging Predicts Poor Survival After Upfront Surgery for Anatomically Resectable Pancreatic Cancer
This study aimed to analyze the risk factors for poor survival of the patients with anatomically resectable pancreatic ductal adenocarcinoma (PDAC), focusing on detailed computed tomography (CT) findings of tumor extent to the peripancreatic tissue. Methods The study included 192 patients who underwent upfront pancreaticoduodenectomy for anatomically resectable PDAC. Preoperative CT images were rereviewed by an experienced radiologist for the pattern of tumor extension to the surrounding tissue: biliary, duodenal, serosal, retroperitoneal, portal venous, arterial, extrapancreatic nerve plexus, and other-organ invasion. ...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Analysis of 102 Fully Robotic Pancreaticoduodenectomies: Clinical and Financial Outcomes
Objectives The value of robotic pancreaticoduodenectomy (RPD) remains undefined. The aim of this retrospective study was to compare and assess clinical outcomes and financial variables of patients undergoing RPD versus open pancreaticoduodenectomy (OPD) at a single high-volume center. Methods The study design is a retrospective analysis of a prospectively maintained database of consecutive PD patients from 2013 to 2019. Clinical variables and total hospital charges were evaluated as an unadjusted and adjusted intention-to-treat analysis. Results A total of 156 patients (54 OPD, 102 RPD) were identified. In the RPD ...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Role of Static and Dynamic Intra-abdominal Pressure Monitoring in Acute Pancreatitis: A Prospective Study on Its Impact
Conclusion Determination of static IAP is an easy, useful, and inexpensive method to determine and predict the mortality of acute pancreatitis. Prevention and/or early detection of intra-abdominal hypertension helps in reducing the mortality in acute pancreatitis. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Establishment of a 7-miRNA–Based Risk Score System for Predicting Prognosis of Pancreatic Cancer
Conclusions The findings of this study suggest that the 7-miRNA–based risk score system is a promising prognostic model for pancreatic cancer. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

High Fractions of Large Islets in Human Islet Preparations Detrimentally Affect Posttransplant Outcomes in Streptozotocin-Induced Diabetic Immunodeficient Mice
Conclusions The fraction of large islets is a sensitive predictor of human islet transplantation outcomes in diabetic mice. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Report on the Short Endoscopic Exocrine Pancreatic Function Test in Children and Young Adults
Conclusions Short ePFT assesses pancreatic acinar function in a reliable and clinically meaningful way in patients. Diagnostic yield of endoscopy increased substantially albeit with increased sedation time. By S-ePFT ductal function, cytokines and proteomics can also be assessed. (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Clinical Utility of Histological and Radiological Evaluations of Tumor Necrosis for Predicting Prognosis in Pancreatic Cancer
Objectives Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the prognostic potential of histological and radiological evaluations of necrosis. Methods We investigated histological necrosis in 221 patients, who underwent surgery for PDAC, and classified its size as small (≤5 mm) or large (>5 mm). We also evaluated poorly enhanced areas on preoperative computed ...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

The Risk of Vitamin D Deficiency, Osteoporosis, and Fractures in Acute Pancreatitis
Objectives A few past studies have found increased utilization of 25-hydroxyvitamin D and prevalence of osteoporosis in acute pancreatitis (AP). Our aim was to obtain a survey of bone diseases after a sentinel episode of AP. Methods A database (Explorys), an aggregate of electronic health record from 26 integrated United States healthcare systems, was queried. A cohort of patients with a Systematized Nomenclature of Medicine—Clinical Terms diagnosis of AP between 2014 and 2019, after excluding patients with selected medical conditions and medications that are associated with poor bone health, was identified. The...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Pancreatoduodenectomy With Arterial Resection for Locally Advanced Pancreatic Cancer of the Head: A Systematic Review
The development of increasingly effective chemotherapy regimens and increasing tumor necrosis is allowing radical pancreatectomy to be re-evaluated. This systematic review examines the outcome of patients with locally advanced cancer of the pancreatic head after pancreatectomy with arterial resection. Electronic searches were performed on PubMed and Medline databases between January 2000 and December 2018. The end points were to determine the safety and overall survival after arterial resection in pancreatectomy. Thirteen studies with 467 patients were included. Celiac, hepatic, mesenteric, and splenic arteries were resect...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

The Diverse Involvement of Cigarette Smoking in Pancreatic Cancer Development and Prognosis
Despite extensive research in the pathogenesis, early detection, and therapeutic approaches of pancreatic ductal adenocarcinoma (PDAC), it remains a devastating and incurable disease. As the global incidence and prevalence of PDAC continue to rise, there is a pressing need to place strong emphasis on its prevention. Although it is widely recognized that cigarette smoking, a potentially modifiable risk factor, has been linked to PDAC development, its contribution to prognosis is still uncertain. Moreover, the mechanistic pathways of PDAC progression secondary to smoking are various and lack a summative narration. Herein, we...
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

American Pancreatic Association Frank Brooks Symposium: Fifty Years of Pancreatic Cell Biology
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Conference Report Source Type: research

Radioligand Theranostics in the Management of Neuroendocrine Tumors
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2020 Category: Gastroenterology Tags: Editorial Source Type: research

D-Dimer Could Be a Surrogate Postoperative Prognostic Marker of Resectable Pancreatic Cancer
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Trends and In-Hospital Outcomes of Neuroendocrine Neoplasms
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Factors Causing Abnormal Heart Failure After Successful Fluid Resuscitation on Acute Pancreatitis Patients
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Resection of Replaced Common Hepatic Artery in Locally Advanced Pancreatic Cancer: A Case Report and Analysis of Technical and Oncological Implications
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Nonfunctional Pancreatic Neuroendocrine Carcinoma With Isolated Retroperitoneal Metastasis: A Case Report and Literature Review
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Needle-Based Confocal Laser Endomicroscopy Examination of Autoimmune Pancreatitis With Cystic Lesions (With Video)
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Acute Pancreatitis in Patients With a Medical History of Type 2 Diabetes Mellitus: Clinical Findings and Magnetic Resonance Imaging Characteristics
Objective To determine the characteristics of type 2 diabetes mellitus (T2DM)–related acute pancreatitis (AP) on magnetic resonance imaging (MRI). Methods Retrospectively studied 262 patients with AP were admitted to our institution and underwent MRI. Diagnosis of T2DM-related AP was based on clinical manifestations, laboratory tests, and MRI. Pancreatic/peripancreatic changes were assessed on MRI. Results Fifty-three (20.2%) patients with T2DM-related AP and 209 (79.8%) with nondiabetic AP were enrolled. On MRI, a higher prevalence of necrotizing pancreatitis (P 30% (57.5% vs 29.2%; P = 0.006), hemorrhage (3...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Endoscopic Ultrasound–Guided Fine-Needle Aspiration Microhistology in Asymptomatic and Symptomatic Pancreatic Cystic Lesions
This study aimed to analyze the usefulness of endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) microhistology to detect malignancy in pancreatic cystic lesions (PCLs). Methods Patients with PCLs were identified and submitted to EUS-FNA from January 2010 to January 2017. The percentage of samples suitable for diagnostic classification by microhistology and the positive and negative likelihood ratios to detect malignancy in asymptomatic (APC) and symptomatic (SPC) PCLs were determined. Results Endoscopic ultrasound–guided fine-needle aspiration was performed in 510 patients. The resulting mater...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Nonaggressive Versus Aggressive Intravenous Fluid Therapy in Acute Pancreatitis With More Than 24 Hours From Disease Onset: A Randomized Controlled Trial
This study aimed to compare a “nonaggressive” hydration versus an “aggressive” hydration using Hartmann's solution in patients with acute pancreatitis (AP) with more than 24 hours from disease onset. Methods We included 88 patients with AP with more than 24 hours from disease onset, and were randomized into 2 groups. Group I (n = 45) received a nonaggressive hydration (Hartmann's solution at 1.5 mL kg−1 h−1 for the first 24 hours and 30 mL kg during the next 24 hours), and group II (n = 43) received an aggressive hydration (bolus of Hartmann's solution 20 mL kg, followed by an infusio...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

FOLFIRINOX for Advanced Pancreatic Cancer Patients After Nab-Paclitaxel Plus Gemcitabine Failure
Conclusions FOLFIRINOX has potential activity for patients with APC in whom GP failed. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Comparative Effectiveness of Pylorus-Preserving Versus Standard Pancreaticoduodenectomy in Clinical Practice
Objectives We compared risk-adjusted short- and long-term outcomes between standard pancreaticoduodenectomy (SPD) and a pylorus-preserving pancreaticoduodenectomy (PPPD). Methods The National Cancer Database was queried for the years 2004 to 2014 to identify patients with adenocarcinoma of the pancreatic head undergoing SPD and PPD. Margin status, lymph node yield, length of stay (LOS), 30- and 90-day mortality, and overall survival were compared. Results A total of 11,172 patients were identified, of whom 9332 (83.5%) underwent SPD and 1840 (16.5%) PPPD. There was no difference in patient age, sex, stage, tumor gr...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Endoscopic Ultrasound Criteria for Arterial Invasion in Pancreatic Cancer of the Body and Tail
Conclusions Different EUS criteria may be necessary for diagnosing arterial and portal venous invasions. Criterion (d) might be appropriate for diagnosing arterial invasion. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Risk Factors for Pancreatic Cancer and the Necessity of Long-Term Surveillance in Patients With Pancreatic Cystic Lesions
Conclusions Continuous surveillance is needed after 5-year observation, especially in LRG with our identified risk factors. For discontinuing surveillance, PCLs not presumed BD-IPMN at fifth year could be candidates. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

miR-375 Inhibits Autophagy and Further Promotes Inflammation and Apoptosis of Acinar Cells by Targeting ATG7
Conclusions We proved that miR-375 could inhibit autophagy and promote inflammation and the apoptosis of acinar cells through regulating ATG7. This study first proves that miR-375 modulates the development of SAP through targeting ATG7. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Alteration of Transforming Growth Factor β Signaling Pathway Predicts Worse Prognosis in Pancreatic Ductal Adenocarcinoma
Conclusions Inferior prognosis was observed in PDACs with mutations of TGF-β pathway. Genomic information could help screen out patients at risk after surgery, and adjuvant therapy might benefit this subgroup of PDACs. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Efficacy of Second-Line Chemotherapy in Extrapulmonary Neuroendocrine Carcinoma
Conclusions The efficacy of current second-line therapy in PD NEC is poor. No second-line regimen showed statistically significant superiority. Cisplatin was associated with longer OS regardless of second-line regimen or age. However, unmeasured confounders such as performance status or comorbidities may explain this effect. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

A Predictive Nomogram for Small Intestine Neuroendocrine Tumors
This study proposed a concise nomogram for SI-NETs using US population-based data. Methods Patients with SI-NETs (2004–2015) were selected from the Surveillance, Epidemiology, and End Results database. Variables selected were age, sex, race, tumor grade, primary tumor size, and TNM staging. Cox regression parameter estimates were used to generate nomogram scores. Results A total of 2734 patients were selected: 2050 for nomogram development and 684 for internal validation. Prognosticators, age (P 3 cm (P (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Aberration of ARID1A Is Associated With the Tumorigenesis and Prognosis of Sporadic Nonfunctional Pancreatic Neuroendocrine Tumors
Objective The genetic aberrations that underlie chromatin remodeling in sporadic nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) remain largely unknown. Here, we investigated the dysregulation of the switch/sucrose nonfermentable (SWI/SNF) component ARID1A and its correlation with clinicopathological features and prognosis. Methods We sequenced the exomes of sporadic NF-pNETs. Quantitative real-time polymerase chain reaction and immunohistochemistry were used to determine messenger RNA level and protein expression. Results The sporadic NF-pNETs harbored 264 somatic mutations in 228 different genes, most c...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Prognostic Factors Associated With Progression for Advanced-Stage/G1 and G2 Small-Bowel Neuroendocrine Tumors After Multimodal Therapy: Experience From a Tertiary Referral Center
Conclusions Age at diagnosis, perineural invasion, and elevated preoperative chromogranin level may play a prognostic role in PFS. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Efficacy of Recombinant Human-Soluble Thrombomodulin for Severe Acute Pancreatitis in a Rat Experimental Model
Conclusions Early administration of rTM prevents organ failure by maintenance of microcirculation and improves prognoses of SAP. (Source: Pancreas)
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Intraductal Tubulopapillary Neoplasm of the Pancreas and Bile Duct: A Review
Intraductal tubulopapillary neoplasms (ITPNs) of the pancreas and bile duct are contemporary entities. It is unclear on how to best manage patients with this diagnosis because little is known about its progression to cancer. This review provides an update on the current knowledge of ITPN of the pancreas and bile duct with an overview of clinical, radiological, histopathological, and molecular features, as well as the prognosis and management. Embase and Medline databases search were performed to identify studies that evaluated ITPN of the pancreas and bile duct. The infrequent exposure to this variant poses a diagnostic ch...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Roles of Autophagy and Pancreatic Secretory Trypsin Inhibitor in Trypsinogen Activation in Acute Pancreatitis
The focus of the review is on roles of autophagy and pancreatic secretory trypsin inhibitor (PSTI), an endogenous trypsin inhibitor, in trypsinogen activation in acute pancreatitis. Acute pancreatitis is a disease in which tissues in and around the pancreas are autodigested by pancreatic digestive enzymes. This reaction is triggered by the intrapancreatic activation of trypsinogen. Autophagy causes trypsinogen and cathepsin B, a trypsinogen activator, to colocalize within the autolysosomes. Consequently, if the resultant trypsin activity exceeds the inhibitory activity of PSTI, the pancreatic digestive enzymes are activate...
Source: Pancreas - April 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Liposomal Irinotecan + 5-FU/LV in Metastatic Pancreatic Cancer: Subgroup Analyses of Patient, Tumor, and Previous Treatment Characteristics in the Pivotal NAPOLI-1 Trial: Erratum
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2020 Category: Gastroenterology Tags: Errata Source Type: research

Aberrant Expression miR-196a is Associated With Abnormal Apoptosis, Invasion, and Proliferation of Pancreatic Cancer Cells: Erratum
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2020 Category: Gastroenterology Tags: Errata Source Type: research

Prevalence and Associated Factors of Abdominal Pain and Disability at 1-Year Follow-up After an Attack of Acute Pancreatitis: Erratum
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2020 Category: Gastroenterology Tags: Errata Source Type: research

Pancreatic Endometrioma Presenting With Spontaneous Hemorrhagic Rupture
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Primary Pancreatic Natural Killer/T-Cell Lymphoma
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research