Comment on “Diagnostic Value of Serum Amylase Levels Indicating Computed Tomography–Defined Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis”
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

DNA Damage Repair Defects and Survival Outcomes for Patients With Resected Pancreatic Ductal Adenocarcinoma
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The Role of Daily Physical Activity on Pancreatic Cancer Survival: A Retrospective Cohort Study
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Sclerosing Epithelioid Mesenchymal Neoplasm of the Pancreas: Case Report and Literature Review of the Morphologic Characteristics
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Acute and Severe Acute Pancreatitis and the Effect of Cannabis in States Before and After Legalization Compared With States Without Legalized Cannabis
Conclusions The trend of AP and SAP increased during the study period, but this was not correlated to cannabis use. Cannabis users had lower hospitalization costs and hospital stay. The effects of other confounders such as cannabis dose and delivery methods, alcohol, tobacco, and others need to be studied further as use increases. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Hypoxia Promotes Pancreatic Cancer Cell Dedifferentiation to Stem-Like Cell Phenotypes With High Tumorigenic Potential by the HIF-1α/Notch Signaling Pathway
Conclusions Hypoxia promoted PC cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential by activating HIF-1α/Notch signaling pathway, indicating a novel role in regulating PC progression. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Thromboembolic Complications in the First Year After Acute Pancreatitis Diagnosis
This study aimed to quantify the prevalence of venous thromboembolic (VTE) events in patients with pancreatitis requiring hospitalization and its impact on outcomes. Methods Adult patients admitted from 2011 to 2018 for pancreatitis were identified. Every admission for pancreatitis in the first year after diagnosis was evaluated for a VTE (pulmonary embolism, deep vein thrombosis, or mesenteric vessel thrombosis) within 30 days of discharge. Characteristics of patients who developed a thromboembolic event were compared with those who did not. Results There were 4613 patients with pancreatitis identified, 301 ...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Predictors of Poor Pathological Response to Neoadjuvant Gemcitabine Plus S-1 Chemotherapy in Patients With Pancreatic Ductal Adenocarcinoma
Conclusions Serum carcinoembryonic antigen and C-reactive protein to albumin ratio are associated with Evans I disease in patients with PDAC who receive NAC-GS. Patients who meet both predictors may not be optimal candidates for NAC-GS. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Liver Metastasis–Directed Ablative Radiotherapy in Pancreatic Cancer Offers Prolonged Time Off Systemic Therapy in Selected Patients: Data From a Multi-institutional Retrospective Study
Objectives We evaluated the outcomes of metastatic pancreatic cancer (MPC) patients who underwent liver metastases (LMs)–directed ablative radiotherapy (RT) and sought to characterize patients with more favorable prognosis. Methods A retrospective analysis of 76 MPC patients who underwent ablative RT (median dose, 50 Gy) to LM at 3 academic centers between 2008 and 2018 was performed. Endpoints were local control (LC), progression-free survival, and overall survival (OS) since RT. Results Median follow-up was 10.9 months. Liver metastases were metachronous in 68%. Before RT, LM was responsive/stable...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Patients With Coronavirus Disease 2019 Interstitial Pneumonia Exhibit Pancreatic Hyperenzymemia and Not Acute Pancreatitis
Conclusions The presence of pancreatic hyperenzymemia in a patient with COVID-19 requires the management of these patients be guided by clinical evaluation and not merely by evaluation of the biochemical results. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Sex-Based Differences in Prognosis of Patients With Gastroenteropancreatic-Neuroendocrine Neoplasms: A Population-Based Study
Objectives The aim of this study was to assess sex-based differences in prognosis of a contemporary cohort of gastroenteropancreatic-neuroendocrine neoplasm (GEP-NEN) patients. Methods Surveillance, Epidemiology, and End Results database was accessed, and cases with GEP-NENs were selected. Rates of GEP-NEN diagnosis from 1975 to 2016 for both male patients and female patients were reviewed. Survival outcomes of GEP-NEN patients diagnosed from 2010 to 2014 were determined through Kaplan-Meier estimates and multivariable Cox regression analysis. Overall survival analyses were stratified by stage and histology. ...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Prognostic Implications of the Immune Tumor Microenvironment in Patients With Pancreatic and Gastrointestinal Neuroendocrine Tumors
Objectives The aim of this study was to characterize the tumor microenvironment of patients with gastroenteropancreatic neuroendocrine tumors relative to progression-free survival (PFS). Methods Immune profiling for CD3, CD8, programmed death-1/programmed death-ligand 1, and indoleamine 2,3-dioxygenase expression in 2 cohorts of gastroenteropancreatic neuroendocrine tumors: patients with short PFS ( (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Blood Leukocyte Signaling Pathways as Predictors of Severity of Acute Pancreatitis
Conclusions Leukocyte STAT3, STAT1, STAT6, and NF-κΒ phosphorylations are potential predictors of AP severity. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

National Trends of Hospitalizations in Cystic Fibrosis Highlight a Need for Pediatric to Adult Transition Clinics
Objectives We hypothesized that hospitalizations in cystic fibrosis (CF) would reflect the development of age-related comorbidities. Methods A retrospective analysis was performed using the Nationwide Inpatient Sample (2002–2017). Hospitalizations for which the principal diagnosis was CF were analyzed regarding age at discharge and presence of comorbidities. Trends were assessed for significance using the Cochran-Armitage test. Results The mean age of patients hospitalized for CF increased from 19.7 years in 2002 to 23.0 years in 2017 (P = 0.017). Several comorbidities are more than 10 times more pr...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Identification of a Risk Profile for New-Onset Diabetes After Acute Pancreatitis
Conclusions These population-level variables predictive of developing AP-related DM can potentially identify patients who may benefit from closer follow-up, intensive education, and implementation of preventative strategies. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Patterns of Palliative Chemotherapy and Survival in Patients With Pancreatic Cancer Focusing on Age: A Nationwide Real-World Danish Registry Study
Objectives The aim of this study was to identify patterns of palliative chemotherapy (CTh) and the associated overall survival (OS) in patients with pancreatic cancer, with specific focus on age. Methods Between May 1, 2011, and April 30, 2016, 4260 patients were registered in the Danish Pancreatic Cancer Database. The 1715 patients receiving palliative CTh were retrieved. Age was grouped into less than 70, 70 to less than 75, and 75 years or more. Results Of the 1715 patients receiving first-line CTh, 586 (34%) underwent second-line CTh and 151 (9%) third-line CTh. First-line gemcitabine resulted in a si...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Endoscopic Pancreatic Drainage Improves Exocrine Pancreatic Function in Patients With Unresectable Pancreatic Cancer: A Double-Blind, Prospective, Randomized, Single-Center, Interventional Study
Conclusions Biliopancreatic and not biliary endoscopic drainage is associated with a significant improvement of exocrine pancreatic function in patients with unresectable pancreatic cancer. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Caenorhabditis elegans as a Diagnostic Aid for Pancreatic Cancer
Conclusions N-NOSE has sufficient sensitivity and specificity for use in clinical practice, and it holds great potential as a diagnostic aid for pancreatic cancer, especially for early-stage pancreatic cancer. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Prophylactic Antibiotics Do Not Prevent Infectious Complications of Endoscopic Ultrasound Fine-Needle Aspiration of Pancreatic Cysts: A Systematic Review and Meta-Analysis
In conclusion, the rate of infectious complications is very low, and antibiotic prophylaxis does not seem to confer any additional benefit in their prevention. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research

Diet and Exercise Interventions in Patients With Pancreatic Cancer: A Scoping Review
Diet and exercise interventions may help reverse malnutrition and muscle wasting common in pancreatic cancer. We performed a scoping review to identify the knowledge gaps surrounding diet and exercise interventions. We searched PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature, Embase, ProQuest Theses and Dissertations, and Google Scholar using the umbrella terms of “pancreatic cancer,” “diet/nutrition,” and “exercise.” Included were articles reporting on ambulatory adults with diagnosed pancreatic cancer. Excluded were studies examining prevention and/or risk, ani...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research

The Effect of Perioperative Blood Transfusion on Long-Term Survival Outcomes After Surgery for Pancreatic Ductal Adenocarcinoma: A Systematic Review
Conclusions Imprecision, unmeasured confounding, small effect sizes, and overall low quality of the available literature result in uncertainty regarding the effect of transfusion on recurrence-free survival, disease-specific survival, and overall survival in patients undergoing surgery for pancreatic cancer. Randomized trials are needed to determine if there is a causal relationship between transfusion and survival after pancreatic resection. (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research

Pancreas Academy: A Conference-Based Approach for Improving Education in Pancreatic Diseases
The Collaborative Alliance for Pancreatic Education and Research developed Pancreas Academy as a lecture-based conference with the goal of providing practical guidance in the diagnosis and management of pancreatic diseases for health care providers. Since its inception in 2017, attendance at Pancreas Academy has steadily grown every year, with trainees accounting for the largest proportion of attendees. The proportion of advanced practice providers and pediatric specialists attending the conference, although relatively low, has also risen each year. Despite the growth in the conference, this report highlights the need for ...
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Conference Report Source Type: research

A Case of Metastatic VIPoma With Complete Response to Peptide Radionuclide Receptor Therapy
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Endoscopic Ultrasound for Evaluation of Pancreatic Duct “Cutoff” Identified on Magnetic Resonance Imaging Improves the Diagnostic Yield of Occult Malignancy
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Association Between Thyroid Disorders and Pancreatic Cancer Risk: A Nationwide Population-Based Case-Control Study
No abstract available (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Portal Annular Pancreas With Common Hepatic Artery Trajectory Abnormality: A Case Report and Review of the Literature
Portal annular pancreas (PAP) is a rare congenital pancreatic anomaly, in which the uncinate process of the pancreas fuses to the body of pancreas behind the portal vein. Here, we report a case of PAP with common hepatic arterial anomaly, which was identified during surgery. A 57-year-old man who had branch type intraductal papillary mucinous neoplasm in the head of the pancreas developed a nodule in the cystic lesion. We planned pylorus preserving pancreaticoduodenectomy. The common hepatic artery from the celiac artery passing behind the portal vein was revealed in preoperative examinations. During surgery, we discovered...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Case Report Source Type: research

Optimal Timing of Endoscopic Intervention After Extracorporeal Shock-Wave Lithotripsy in the Treatment of Chronic Calcified Pancreatitis
Conclusions The interval between ESWL and ERCP in chronic calcified pancreatitis patients with prior ERCP is not relevant, while delaying endoscopic intervention is recommended in those with native papilla. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures
Conclusions Novel Hsp90 inhibitors can be developed as antipancreatic cancer agents. Their chemical structures are simpler, and they are likely to exhibit lower side effects than the much more complex inhibitors used as controls. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Long Noncoding RNA CERS6-AS1 Accelerates the Proliferation and Migration of Pancreatic Cancer Cells by Sequestering MicroRNA-15a-5p and MicroRNA-6838-5p and Modulating HMGA1
Conclusions CERS6-AS1 enhanced HMGA1 expression to contribute to the progression of PC by sequestering miR-15a-5p and miR-6838-5p. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Vagotomy and Splenectomy Reduce Insulin Secretion and Interleukin-1β
Conclusions The absence of the spleen attenuated or blocked the effects of VAG on adiposity, triglycerides and glucose homeostasis, suggesting a synergistic effect of both on metabolism. The vagus nerve and spleen modulate the presence of interleukin-1β in β cells, possibly because of the reduction of glucose-induced insulin secretion, indicating a bidirectional flow between autonomous neural firing and the spleen, with repercussions for the endocrine pancreas. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Genetic Variants in Patients With a Family History of Pancreatic Cancer: Impact of Multigene Panel Testing
Conclusions Genetic testing of individuals with a FH of pancreatic cancer represents an opportunity to identify individuals who may be candidates for pancreatic surveillance. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Comparison of Treatment Outcomes Between Gemcitabine With Nab-Paclitaxel and Modified FOLFIRINOX for First-Line Chemotherapy in Metastatic and Recurrent Pancreatic Cancer: Propensity Score Matching
Conclusions Gemcitabine with nab-paclitaxel had a higher disease control rate and lower rates of severe anorexia and diarrhea in our propensity-matched population. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Lack of Improvement in Insulin Sensitivity After Pancreas Transplantation in Recipients With a High Level of Calcineurin Inhibitors
Conclusions Unlike β-cell function and glucose control, insulin sensitivity did not significantly improve until posttransplant 1 year after pancreas transplantation regardless of the type of DM or the degree of pretransplant insulin sensitivity. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

A Low Total Psoas Muscle Area Index Is a Strong Prognostic Factor in Metastatic Pancreatic Cancer
Objectives The total psoas area index (TPI) is an emerging alternative to the total skeletal muscle area index as a prognostic factor but has never been evaluated in metastatic pancreatic cancer (mPC). Methods Areas were manually recorded, as previously described. Sex-specific cutoffs were identified by optimum stratification of TPI using log-rank χ2 statistic associated with mortality to define sarcopenic psoas. Progression-free survival (PFS) and overall survival (OS) were the primary objectives. Two period groups were used as internal validation. Results During the period study, 79 patients were tr...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Comparison Between Lumen-Apposing Metal Stents and Plastic Stents in Endoscopic Ultrasound–Guided Drainage of Pancreatic Fluid Collection: A Meta-analysis and Systematic Review
This study aimed to explore efficacy and safety between LAMSs (lumen-apposing metal stents) and DPPSs (double-pigtail plastic stents) in endoscopic ultrasound–guided drainage for pancreatic fluid collections. Methods Electronic databases were searched to identify relevant studies published until July 20, 2020. Results Fifteen studies were identified in this study. Endoscopic ultrasound–guided drainage with LAMS has higher clinical success (90.01% vs 82.56%) (odds ratio [OR], 2.44; 95% confidence interval [CI], 1.79–3.33; P (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Effects of High-Fat Diet on Carcinogen-Induced Pancreatic Cancer and Intestinal Microbiota in C57BL/6 Wild-Type Mice
Conclusions Our results revealed that high-fat diet changed the composition of the gut microbiota and was involved in carcinogen-induced pancreatic cancer progression. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Autoimmune Pancreatitis: A Critical Analysis of the Surgical Experience in an Era of Modern Diagnostics
Objective The aim of this study was to critically analyze the surgical experience of managing autoimmune pancreatitis (AIP) in an era of modern diagnostics and compare these patients with those who were managed conservatively. Methods Two prospectively maintained databases were used to retrospectively identify patients with AIP who were either managed conservatively or underwent pancreatectomy. Results Eighty-eight patients were included in the study, of which 56 (63.6%) underwent resection and 32 (36.4%) were managed conservatively. Patients who underwent resection were more likely to present with jaundi...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Diagnostic Accuracy of Computed Tomography Scores in Chronic Pancreatitis
Conclusions Both CT scores had similar, moderate accuracies for diagnosing CP. The limitation in diagnostic accuracy makes CT ineligible as a single method to diagnose CP, supporting that the diagnostic process for CP needs to incorporate other imaging methods and/or markers for better diagnostics. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Quality Gaps in Management of Acute Pancreatitis: A Tertiary Care Center Experience
Conclusions Adherence to guidelines for management of AP is inadequate, and nonuniformity exists across different services within the same institution. There is a need for quality improvement initiatives. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor
Conclusions The favorable safety profile and patient outcomes suggest Auxora may be an appropriate early treatment for patients with AP and SIRS. Clinical development will continue in a randomized, controlled, blinded, dose-ranging study. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Survival Outcomes of Acinar Cell Pancreatic Cancer: A National Cancer Database Analysis
The objective of this study is to evaluate the benefit of chemotherapy in the adjuvant setting in resected ACPC and in the palliative setting for metastatic ACPC. Methods Data were obtained from all US hospitals that contributed to the National Cancer Database between 2004 and 2014. Cases were identified using the histology code 8550. Results A total of 593 patients with ACPC were identified. The mean age was 64.4 years (range, 18–90 years), with a male preponderance (72.8%, n = 432). Localized stage disease comprised 52.3% (n = 310) of patients. Among localized ACPC patients, 88.0% (n = 191) underwent ...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Direct Effects of Lipopolysaccharide on Human Pancreatic Cancer Cells
Conclusions The exposure of PDAC cells to LPS led to differential gene expression. A top canonical pathway was PI3K/Akt/mTOR, a known oncogenic driver. Our findings provided evidence that LPS can directly induce differential gene expression in PDAC cells. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms and Improved Prognostic Stratification With the New World Health Organization 2019 Classification: A Validation Study From a Single-Institution Retrospective Analysis
Objectives There is a pressing need to develop clinical management pathways for grade 3 (G3) gastroenteropancreatic neuroendocrine neoplasms (GEP NEN). Methods We performed a retrospective study on patients with metastatic G3 GEP NEN. The relationship between baseline characteristics and progression-free survival and overall survival was analyzed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards model. Results We included 142 patients (74 well-differentiated neuroendocrine tumors [WDNETs], 68 poorly differentiated neuroendocrine carcinoma...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Comparison of Nausea and Vomiting Associated With Amino Acid Formulations Coinfused With Peptide Receptor Radionuclide Therapy: Commercial Parenteral Nutrition Formulas Versus Compounded Arginine/Lysine
Objectives Positively charged amino acids (AA) such as arginine/lysine are coinfused with radiolabeled somatostatin analogs to reduce rates of nephrotoxicity. In the phase 3 NETTER-1 trial, commercial AA formulations were used in association with 177Lu–DOTA-0-Tyr3-Octreotate (DOTATATE). These formulations were also used in an early-access program (EAP) before regulatory approval of 177Lu-DOTATATE. Our program transitioned to compounded l-arginine 2.5%/l-lysine 2.5% in 0.9% NaCl after commercial approval of 177Lu-DOTATATE. We sought to compare rates of nausea/vomiting with arginine/lysine versus commercial parente...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Recurrence Patterns After Surgical Resection of Gastroenteropancreatic Neuroendocrine Tumors: Analysis From the National Comprehensive Cancer Network Oncology Outcomes Database
Conclusions R0 resection was associated with variable risk of recurrence across subtypes. Further research to inform refinement of guidelines for the appropriate duration of surveillance after R0 resection is needed. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

Efficacy of Checkpoint Inhibitors in Neuroendocrine Neoplasms: Mayo Clinic Experience
Conclusions Checkpoint inhibitor therapy shows limited activity in patients with NENs. Future studies should identify biomarkers that can help identify patients who are likely responders to immunotherapy. (Source: Pancreas)
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research

The Clinical Applicability of Primary Thromboprophylaxis in Ambulatory Patients With Pancreatic Cancer
Thromboembolism is a leading cause of death in ambulatory patients with cancer. Patients with pancreatic adenocarcinoma have a very high risk of developing venous thromboembolism, especially within the first 6 months of diagnosis. Although primary thromboprophylaxis could reduce this risk, there are unresolved questions concerning choice of agents for anticoagulation, duration of anticoagulation treatment, and criteria for patient selection. Furthermore, the current clinical guidelines on primary thromboprophylaxis in ambulatory patients with pancreatic cancer are ambiguous. This review seeks out to understand and critical...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: Review Source Type: research

The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma
This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the medical management and surveillance of metastatic and unresectable pheochromocytoma and paraganglioma held on October 2 and 3, 2019. The panelists consisted of endocrinologists, medical oncologists, surgeons, radiologists/nuclear medicine physicians, nephrologists, pathologists, and radiation oncologists. The panelists performed a literature review on a series of questions regarding the medical management of metastatic and unresectable pheochromocytoma and paraganglioma as well as questions regarding surveillance af...
Source: Pancreas - April 1, 2021 Category: Gastroenterology Tags: NANETS Guidelines Source Type: research

Low-Molecular-Weight Heparin Combined With Insulin Versus Insulin Alone in the Treatment of Hypertriglyceridemic Pancreatitis (LIHTGP Trial): Study Protocol for a Multicenter, Prospective, Single-Blind, Randomized Controlled Trial: Retraction
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2021 Category: Gastroenterology Tags: Retraction Source Type: research

A 3-Decade Analysis of Pancreatic Adenocarcinoma After Solid Organ Transplant: Erratum
No abstract available (Source: Pancreas)
Source: Pancreas - March 1, 2021 Category: Gastroenterology Tags: Errata Source Type: research