Reply to Comment on Zeng et al, Spatial Distribution of Pancreatic Stones in Chronic Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Mathematical Model and Study Design Could Be Optimized in Spatial Distribution Analysis of Pancreatic Stones
No abstract available (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Reply to: The Relationship of Acute Pancreatitis and Pancreatic Cancer
No abstract available (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The Relationship of Acute Pancreatitis and Pancreatic Cancer
No abstract available (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Gastric Emptying and Distal Gastrectomy Independently Enhance Postprandial Glucagon-Like Peptide-1 Release After a Mixed Meal and Improve Glycemic Control in Subjects Having Undergone Pancreaticoduodenectomy
Conclusions Following PD, the postprandial GLP-1 release seems to be enhanced by rapid gastric emptying and to improve insulin sensitivity. Partial gastrectomy versus pylorus preservation enhanced the release of GLP-1, conceivably because of greater distal bowel exposure to undigested nutrients. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Correlation of DOTATOC Uptake and Pathologic Grade in Neuroendocrine Tumors
Conclusions Our analysis demonstrates an inverse correlation between Ki-67 PI and SUVmax in NETs. Somatostatin receptor–PET provides additional information that can help guide management of NETs. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Significance of Lymph Node Metastasis in Resectable Well-differentiated Pancreatic Neuroendocrine Tumor
Conclusions World Health Organization 2017 classification was the most independent prognostic factor in patients with resectable well-differentiated PanNETs. Patients with G2 and higher-grade tumors require lymph node dissection to improve prognosis. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Diagnostic and Management Challenges in Vasoactive Intestinal Peptide Secreting Tumors: A Series of 15 Patients
Conclusions The management of VIPomas is challenging requiring the application of multiple treatment modalities. Patients who underwent surgical treatment with curative intent appear to have higher survival rate. Central registration and larger prospective studies are required to evaluate the effect of currently employed therapies in these patients. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Differences in Pancreatic Cancer Incidence Rates and Temporal Trends Across Asian Subpopulations in California (1988–2015)
Conclusions Significant heterogeneity of PanCan incidence in disaggregated Asian Americans is a novel finding. These results fill a gap regarding PanCan burden in Asian Americans and underscore the importance of disaggregating ethnic populations in cancer research. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Alternate Week Gemcitabine and Capecitabine: An Effective Treatment for Patients With Pancreatic Adenocarcinoma
Conclusions Alternate week schedule of fixed dose rate gemcitabine and capecitabine was active and tolerable for advanced pancreatic adenocarcinoma. Overall survival and PFS were comparable to first-line treatments. Importantly, adverse effects appear less severe than first-line treatments. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Comparisons of Outcomes of Real-World Patients With Advanced Pancreatic Cancer Treated With FOLFIRINOX Versus Gemcitabine and Nab-Paclitaxel: A Population-Based Cohort Study
Conclusions Our results showed that real-world patients with advanced pancreatic cancer treated with FOLFIIRNOX or GnP had comparable survival with different safety profile. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Induction Therapy in Localized Pancreatic Cancer
Conclusions In patients with BRPC who undergo resection after induction treatment, the OS was significantly better than in patients with RPC. Neoadjuvant treatment should be considered for all localized PDACs. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

The Importance of a Conjoint Analysis of Tumor-Associated Macrophages and Immune Checkpoints in Pancreatic Cancer
Objectives Tumor-associated macrophages are dominant players in establishing the inmmunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC). Immune checkpoint inhibitor monotherapy has achieved limited clinical effectiveness. To date, the interaction of macrophages and checkpoint regulators and their correlation with clinicopathologic characteristics in PDAC have been largely unavailable. Methods Macrophages and immune checkpoint expression were assessed by immunohistochemistry from 80 PDAC samples. Clinicopathologic features and the prognostic value of each marker were evaluated. In vitro changes ...
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Endogenous Gastrin Collaborates With Mutant KRAS in Pancreatic Carcinogenesis
Conclusions This study supports the mitogenic role of gastrin in activation of KRAS during pancreatic carcinogenesis. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Acute Recurrent and Chronic Pancreatitis as Initial Manifestations of Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator–Related Disorders
Conclusions Cystic fibrosis or CFTR-RD can present as ARP/CP. Complete diagnostic testing for CFTR-RD in patients with ARP/CP will broaden treatment options and help to identify comorbid illness. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

The Surveillance Patterns of Incidentally Detected Pancreatic Cysts Vary Widely and Infrequently Adhere to Guidelines
Conclusions Although guidelines recommend that surgically fit patients with incidental cysts undergo surveillance, most patients receive no follow-up. When follow-up occurs, surveillance patterns vary widely and infrequently conform to guidelines. Interventions to reduce care variation require study. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Impact of Changes in the American Joint Committee on Cancer Staging Manual, Eighth Edition, for Pancreatic Ductal Adenocarcinoma
Conclusions The newly adopted pT stage protocol for PDAC is clinically relevant, ensures a more equal distribution among different stages, and allows for a significant prognostic stratification. In contrast, the new pN classification (pN1 and pN2) based on the number of positive lymph nodes failed to show survival differences and remains controversial. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

New-Onset Diabetes Mellitus After Chronic Pancreatitis Diagnosis: A Systematic Review and Meta-analysis
Conclusions This systematic review identified a clinically relevant risk of new-onset DM after CP diagnosis. Therefore, patients should be informed of the risk of DM and monitored. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Surgical and Oncological Outcomes of Laparoscopic Versus Open Pancreaticoduodenectomy in Patients With Pancreatic Duct Adenocarcinoma
In conclusion, LPD was found to be a suitable alternative to OPD in selected PDAC patients with respect to both surgical and oncological outcomes. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Review Source Type: research

The Distributional Characteristic and Growing Trend of Pancreatic Cancer in China: Erratum
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Erratum Source Type: research

The First Report of Total Pancreatectomy and Islet Cell Autotransplantation for Pancreatic Cystosis in Patient With Cystic Fibrosis
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Autoimmune Pancreatitis Masquerading as Celiac Disease
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

High Serum Serotonin Test Results Caused by Traumatic Vascular Access Due to Difficult Veins
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Outcomes After Differing Surgical Strategies in Patients With Small Pancreatic Neuroendocrine Tumors
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Proceedings of the Japan Pancreas Society, 2018, Suizo, the Journal of the Japan Pancreas Society, Volume 33, 2018, Naohiro Sata, MD, PhD, Editor-in-Chief
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Abstract Source Type: research

The Impact of Cannabis Consumption on Mortality, Morbidity, and Cost in Acute Pancreatitis Patients in the United States: A 10-Year Analysis of the National Inpatient Sample
Conclusions Cannabis-exposed hospitalized patients with AP had lower age-adjusted, mortality, morbidity, and hospitalization-cost than non–cannabis-exposed patients. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Low Serum Trypsin Levels Predict Deep Pancreatic Cannulation Failure During Endoscopic Retrograde Cholangiopancreatography in Patients With Symptomatic Obstructive Chronic Pancreatitis
Conclusions Low serum trypsin levels independently predict DPC failure during ERCP in patients with symptomatic obstructive CP. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Benefit of Gemcitabine/Nab-Paclitaxel Rescue of Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma After Early Failure of FOLFIRINOX
Conclusions When patients do not respond to neoadjuvant FOLFIRINOX, early switch to GA should be considered. Future efforts should be directed toward identifying markers that will allow correct choice of initial therapy rather than attempting to rescue patients who respond poorly to first-line therapy. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Neutrophil-to-Lymphocyte Ratio as a Predictor of Invasive Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas
Conclusions Neutrophil-to-lymphocyte ratio was significantly higher in patients with IPMN-associated invasive carcinoma as compared with patients with noninvasive disease; however, NLR was not helpful in differentiating between high- and low-grade lesions. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Does Neoadjuvant Chemotherapy Change the Role of Regional Lymphadenectomy in Pancreatic Cancer Survival?
The objective of this study was to evaluate the role of lymph node (LN) dissection and staging in outcomes of patients with pancreatic adenocarcinoma (PDAC) who underwent neoadjuvant chemotherapy (NAC). Methods National Cancer Database was queried for patients with stages I to III PDAC diagnosed between 2004 and 2014. Overall survival (OS) was derived from Kaplan-Meier methods, and Cox-regression model was used to evaluate associations between the number of LN examined, number of positive nodes, and LN ratio with OS. Results A total 35,599 patients were included, 3395 (9%) underwent NAC, 19,865 (56%) received adjuvan...
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Characteristics and Outcomes of Pancreatic Cancer by Histological Subtypes
Conclusions The study systematically summarizes characteristics and behaviors of primary pancreatic cancer by histological subtypes, which can facilitate the management of pancreatic cancer. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Predicting Successful Catheter Drainage in Patients With Pancreatic Fistula After Pancreatoduodenectomy
The objective of this study was to identify predictors for successful minimally invasive catheter drainage (ie, survival without relaparotomy) for pancreatic fistula after pancreatoduodenectomy. Methods Included were consecutive patients undergoing catheter drainage as first intervention for pancreatic fistula after pancreatoduodenectomy (2005–2013) in 9 Dutch centers. Possible prognostic factors for successful catheter drainage (ie, survival without relaparotomy) were selected using Akaike information criterion. Results Included were 227 patients after 2196 pancreatoduodenectomies. Primary catheter drainage wa...
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Deep Learning to Classify Intraductal Papillary Mucinous Neoplasms Using Magnetic Resonance Imaging
Conclusions The deep learning protocol showed accuracy comparable to current radiographic criteria. Computer-aided frameworks could be implemented as aids for radiologists to identify high-risk IPMN. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Pancreatobiliary Versus Head and Neck Manifestations in Immunoglobulin G4–related Disease: Distinct Subsets of the Same Disease?
Objectives We compared the clinical profiles and organ manifestations of the commonly encountered immunoglobulin G4–related diseases (IgG4-RDs) on either side of the diaphragm: head and neck (HN) versus pancreatobiliary (PB) in IgG4-RD. Methods From the Mayo Clinic, Rochester, database, we identified 53 HN and 88 PB IgG4-RD based on the first affected organ manifestation. Results Compared with HN IgG4-RD, subjects with PB IgG4-RD were likely to be older (median, 64.8 vs 50.2 years; P (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Ki-67 Index of 5% is Better Than 2% in Stratifying G1 and G2 of the World Health Organization Grading System in Pancreatic Neuroendocrine Tumors
Objective The World Health Organization (WHO) grading system for the stratification of G1 and G2 pancreatic neuroendocrine tumors (pNETs) using an optimal Ki-67 index cutoff is still controversial. The present study aimed at finding one optimal Ki-67 cutoff value that distinguishes G1 and G2 tumors by analyzing the prognosis of patients with pNET in our center. Methods Data from 84 patients with pNET undergoing surgical resection in The First Affiliated Hospital of Sun Yat-sen University between March 2003 and October 2015 were retrospectively analyzed. Results The 5-year overall survival rate was 74.2%. Univariate...
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Per Oral Pancreatoscopy Identification of Main-duct Intraductal Papillary Mucinous Neoplasms and Concomitant Pancreatic Duct Stones: Not Mutually Exclusive
Conclusions Per-oral pancreatoscopy may identify MD-IPMN as an etiology for patients with presumed idiopathic chronic calcific pancreatitis and associated dilated pancreatic duct. Larger prospective studies are needed to validate these findings. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Heme Oxygenase-1 Polymorphism Is Associated With the Development of Necrotic Acute Pancreatitis Via Vascular Cell Adhesion Molecule-1 and the E-Selectin Expression Regulation Pathway
Conclusion Polymorphism of the GT repeats in the HO-1 promoter region may be a risk factor for developing acute necrotizing pancreatitis due to deregulation of the immune response. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Frequency of Appropriate Use of Pancreatic Enzyme Replacement Therapy and Symptomatic Response in Pancreatic Cancer Patients
Conclusions Of the 89% of PC patients prescribed PERT, 65% were prescribed PERT appropriately with all meals and snacks. Overall compliance with PERT administration guidelines was low (50% [105/208]). Improvement in symptoms significantly correlated with appropriate use of PERT. Increase in PC patient and provider education about appropriate PERT usage and administration is warranted. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer
The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. The content covers both nongenic and genetically engineered models across multiple species (large and small). Recommendations for choosing the appropriate model as well as how to conduct and present results are provided. (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Reviews Source Type: research

KRAS in Cyst Fluid Obtained by Endoscopic Ultrasound–Fine-Needle Aspiration in Pancreatic Cystic Lesions: A Systematic Review and Meta-analysis
To evaluate the diagnostic accuracy of KRAS mutation in pancreatic cystic fluid and compare it with carcinoembryonic antigen and cytology, we identified studies with cyst fluid obtained by endoscopic ultrasound prior to surgery. We classified cysts as malignant, premalignant, and benign. A random-effects model was used for quantitative meta-analysis. Pooled sensitivities, specificities, and summary receiver operating characteristic curve analysis were conducted. We analyzed 16 studies, with 3429 patients, including 731 referred for surgery. Carcinoembryonic antigen was better for clinically significant cysts (premalignant ...
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Reviews Source Type: research

Next-Generation Sequencing in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is lethal, and the majority of patients present with locally advanced or metastatic disease that is not amenable to cure. Thus, with surgical resection being the only curative modality, it is critical that disease is identified at an earlier stage to allow the appropriate therapy to be applied. Unfortunately, a specific biomarker for early diagnosis has not yet been identified; hence, no screening process exists. Recently, high-throughput screening and next-generation sequencing (NGS) have led to the identification of novel biomarkers for many disease processes, and work has commence...
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Reviews Source Type: research

The 49th Annual Meeting of the American Pancreatic Association in Collaboration With the International Association of Pancreatology
No abstract available (Source: Pancreas)
Source: Pancreas - June 20, 2019 Category: Gastroenterology Tags: Conference Report Source Type: research

A Systematic Review of the Etiology, Diagnosis, and Treatment of Hemosuccus Pancreaticus
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

A Systemic Inflammation Response Index Could be a Predictive Factor for mFOLFIRINOX in Metastatic Pancreatic Cancer
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Diffusion-Weighted Magnetic Resonance Imaging and 18-Fluorodeoxglucose Positron Emission Tomography With Computed Tomography for Evaluating Malignancy of Branch Duct and Mixed Type Intraductal Papillary Mucinous Neoplasms of the Pancreas
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Significance and Prognostic Value of Red Blood Cell Distribution as a Severity Index for Patients Diagnosed as Having Acute Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

FAM111B Mutation Is Associated With Pancreatic Cancer Predisposition
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Intrapancreatic Accessory Spleen Along With Hepatic Adenomas Mimicking Pancreatic Neuroendocrine Tumor Associated With Liver Metastasis
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Rapunzel Syndrome: A Rare Case Requiring Surgical Management of Acute Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Multiple Endocrine Neoplasia Type 1–Related Acute Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research