Concomitant Insulinoma and Glucagonoma in Solitary Cystic Pancreatic Lesion in a Young Male Patient
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Long-Term Survival With Nanoliposomal Irinotecan in Pancreatic Cancer
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Clinical Utility of Pancreatic Cancer Circulating Tumor DNA in Predicting Disease Progression, Prognosis, and Response to Chemotherapy
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Acute Pancreatitis in the Setting of Hepatitis E Virus (Genotype 3) Infection and Compound CLDN2-PRSS1 Risk Variants
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Complete Agenesis of the Dorsal Pancreas as a Rare Manifestation of a Chromosomal Anomaly: A Case Report
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Pancreatic Intraductal Papillary Mucinous Neoplasm–Derived Cancer, Mucinous Cystic Neoplasm–Derived Cancer, and Adenocarcinoma: National Survival Outcomes
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Effectiveness of Routine Computed Tomography After Pancreaticoduodenectomy With Regards to Postoperative Pancreatic Fistula
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Chronic Asymptomatic Hyperenzymemia of the Pancreas Suggestive of the Presence of Undiagnosed Sjögren Syndrome
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Anticoagulation Versus No Anticoagulation for Splanchnic Venous Thrombosis Secondary to Acute Pancreatitis: Do We Really Need to Treat the Incidental Findings?
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Comment on “Acupuncture for Pain in Chronic Pancreatitis A Single-Blinded Randomized Crossover Trial”
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Comments on “Chromogranin A in the Follow-up of Gastroenteropancreatic Neuroendocrine Neoplasms: Is It Really Game Over? A Systematic Review and Meta-analysis”
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

High Frequency of Multiple Imaging Studies During the Diagnostic Workup for Pancreatic Ductal Adenocarcinoma
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Acute Phase Response and Postprocedural Evaluation of Open and Laparoscopic Cryoablation Procedures in Porcine Pancreases
Conclusions Cryoablation of the pancreas was experimentally practicable without severe complications under direct or laparoscopic vision. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Efficacy of Early Percutaneous Catheter Drainage in Acute Pancreatitis of Varying Severity Associated With Sterile Acute Inflammatory Pancreatic Fluid Collection
Conclusions Early PCD may improve the prognosis of SAP with drainable sterile AIPFCs by reducing the OR, IR, and mortality. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Immunological Gene Signature Associated With the Tumor Microenvironment of Pancreatic Cancer After Neoadjuvant Chemotherapy
Conclusions Neoadjuvant chemotherapy may suppress regulatory T cells and B-cell function in the PDAC microenvironment. The 11 identified genes could be useful for predicting the efficacy of NAC and could be therapeutic targets for PDAC. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Pancreatic Angiopathy Associated With Islet Amyloid and Type 2 Diabetes Mellitus
Objectives Type 2 diabetes (T2D) is histopathologically characterized by islet amyloid and is closely connected with vascular complications. Here, we explore the presence of pancreatic angiopathy (PA) associated with islet amyloid and T2D. Methods From a total of 172 autopsy cases who had a history of T2D diagnosis, we randomly selected 30 T2D autopsy cases with islet amyloid (DA+) in comparison with islet amyloid-free (DA−) 30 T2D cases and 60 nondiabetic (ND) controls. Amyloid deposits and PA including atherosclerosis of pancreatic interlobar arteries, arterial calcification, atheroembolism, hyaline arterioscl...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Adipose Tissue From Type 1 Diabetes Mellitus Patients Can Be Used to Generate Insulin-Producing Cells
Objectives We aimed to determine whether responsive insulin-producing cells (IPCs) could be generated from adipose-derived stem cells (ADSCs) isolated from patients with type 1 diabetes mellitus (T1DM). Methods We isolated ADSCs from adipose tissue of 4 patients (one patient with T1DM and 3 nondiabetic patients), who underwent surgery and differentiated them into IPCs with using a 2-step xeno-antigen free, 3-dimensional culture method. Characteristics of isolated ADSCs, in vitro cell quality, programmed cell death ligand-1 (PDL-1) expression, and transplantation into streptozotocin induced diabetic nude mice were inve...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Efficacy and Safety of Early Systemic Anticoagulation for Preventing Splanchnic Thrombosis in Acute Necrotizing Pancreatitis
Objectives Splanchnic venous thrombosis (SVT) is a relevant complication in patients with acute necrotizing pancreatitis. So far, no specific treatment for preventing development of SVT exists, and the effect of systemic anticoagulation (SAC) is unclear. Methods Patients with acute necrotizing pancreatitis admitted to our center within 7 days from onset of abdominal pain were screened. In the historic group, during which period, most patients received no SAC. Patients in the study group received SAC therapy considering the risk of deep vein thrombosis and SVT. The primary outcome measure was the incidence of SVT. Res...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Serum Exo-EphA2 as a Potential Diagnostic Biomarker for Pancreatic Cancer
Conclusions Novel findings suggest that serum Exo-EphA2 is a potential early diagnostic biomarker complementing CA 19-9 and CA 242 in PC. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

The Epidemiology of Pancreatic Cancer and the Association With Acetylsalicylic Acid in the United States: A Population-Based Study
Conclusions This is the largest population-based study evaluating the epidemiology of PaC. We observed a protective association of ASA on a subgroup of patients with PaC and chronic pancreatitis. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Acute Pancreatitis in Celiac Disease: Has the Inpatient Prevalence Changed and Is It Associated With Worse Outcomes?
Objectives Studies suggest that adults diagnosed with celiac disease (CD) are at higher risk of developing acute pancreatitis (AP). The aim of this study is to explore the relationship between CD and AP in terms of inpatient prevalence, mortality, morbidity, and resource utilization in the past decade. Methods Retrospective cohort study using the Nationwide Inpatient Sample (2007–2016). The primary outcome was the occurrence of AP in CD patients. Secondary outcomes were the trend in AP cases in CD patients, and mortality, morbidity, length of stay, and total hospital charges and costs. Results Of 337,201 CD p...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Impact of the Human Immunodeficiency Viruses Status on Outcomes in Patients Hospitalized With Acute Pancreatitis: A Propensity-Matched Analysis
Conclusions Patients admitted for AP with AIDS have worse outcomes. On the contrary, aHIV status was not only associated with better outcomes when compared with AIDS, but to HIV-negative status as well. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Syndecan-1 and KRAS Gene Expression Signature Associates With Patient Survival in Pancreatic Cancer
Conclusions SDC1 interplays with KRAS, and targeting both KRAS and SDC1 in combination may be more beneficial to pancreatic cancer patients. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Real-world Evidence of Diffusion-weighted Imaging Combined With Magnetic Resonance Cholangiopancreatography for Pancreatic Tumor Screening: A Cross-Sectional Diagnostic Accuracy Study
Conclusions Diffusion-weighted imaging was more sensitive than magnetic resonance cholangiopancreatography, whereas those used in combination resulted in increased sensitivity. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Inflammatory Bowel Diseases Elevate the Risk of Developing Acute Pancreatitis: A Meta-analysis
Objectives Increasing data suggest that acute pancreatitis (AP) occurs more frequently among patients with inflammatory bowel diseases (IBDs) than in the non-IBD population; however, currently no comprehensive meta-analysis is available. Methods Systematic literature search was conducted in 4 major databases. We included observational studies sampling from the general population. Basic study characteristics and crude incidences of AP were extracted. Pooled odds ratios (ORs) with 95% confidence interval (CIs) were calculated using the random-effects model. Subgroups were set up by Crohn disease and ulcerative colitis. ...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Safety and Feasibility of Electrochemotherapy of the Pancreas in a Porcine Model
Conclusions This study shows that ECT with bleomycin is feasible and safe in the pancreatic parenchyma. Clinical studies are needed to evaluate the efficacy of ECT in pancreatic cancer. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

A 5-Year Retrospective Cohort Study: Epidemiology, Etiology, Severity, and Outcomes of Acute Pancreatitis
Conclusions Biliary disease was the predominant etiology of AP in southern Sichuan of China, and hypertriglyceridemia ranked second. The proportion of hypertriglyceridemic AP and mixed etiology AP gradually increased, whereas idiopathic AP decreased. There were different etiology proportion of AP according age, sex, and severity. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

SMAD4-Expressing Pancreatic Ductal Adenocarcinomas Have Better Response to Neoadjuvant Therapy and Significantly Lower Lymph Node Metastasis Rates
Conclusions Further characterization of the role of SMAD4 within the context of neoadjuvant therapy will lead to improved personalized therapeutic strategies. (Source: Pancreas)
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Reviews on Current Liquid Biopsy for Detection and Management of Pancreatic Cancers
Pancreatic cancer is the fourth leading cause of cancer death in the United States. Pancreatic cancer presents dismal clinical outcomes in patients, and the incidence of pancreatic cancer has continuously increased to likely become the second most common cause of cancer-related deaths by as early as 2030. One of main reasons for the high mortality rate of pancreatic cancer is the lack of tools for early-stage detection. Current practice in detecting and monitoring therapeutic response in pancreatic cancer relies on imaging analysis and invasive endoscopic examination. Liquid biopsy–based analysis of genetic alteratio...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Therapeutic Potentials of MicroRNAs for Curing Diabetes Through Pancreatic β-Cell Regeneration or Replacement
MicroRNAs are a type of noncoding RNAs that regulates the expression of target genes at posttranscriptional level. MicroRNAs play essential roles in regulating the expression of different genes involved in pancreatic development, β-cell mass maintenance, and β-cell function. Alteration in the level of miRNAs involved in β-cell function leads to the diabetes. Being an epidemic, diabetes threatens the life of millions of patients posing a pressing demand for its urgent resolve. However, the currently available therapies are not substantial to cure the diabetic epidemic. Thus, researchers are trying to find new...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Differential Diagnosis of Diarrhea in Patients With Neuroendocrine Tumors
Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and exper...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Reviews Source Type: research

Genetic Variants, Fat Malabsorption, and Ancestral Background in a Small Chronic Pancreatitis Cohort
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Successful Treatment for the Recurrent Liver Metastases of the Pancreatic Cancer by Multimodality Therapy
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Impact of the Duration of Organ Failure on Mortality in Patients With Acute Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Reply
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The Risk of Primary Open Necrosectomy Rather Than Secondary Open Necrosectomy for Necrotizing Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Minimally Invasive Approach for Pancreatic Solid Pseudopapillary Neoplasm and Initially Undiagnosed Slowly Progressing Liver Tumor: A Case Report
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Metastatic Risk in Pancreatic Neuroendocrine Tumors: An 18-Year Experience From Bogotá, Colombia—A Case Series
No abstract available (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Depression Before and After a Diagnosis of Pancreatic Cancer: Results From a National, Population-Based Study
Objectives The aim of this study was to evaluate depression in pancreatic cancer (PC) patients before and after a cancer diagnosis using a US-based healthcare database. We also sought to study the impact of treatment of depression in PC patients on all-cause mortality. Methods Pancreatic cancer patients with comorbid depression in Explorys (1999–2019) were compared with controls using odds ratios with 95% confidence intervals. Rates of depression diagnosed within 6 months, 1 year, and 3 years before and after a PC diagnosis were recorded. Patients who developed depression after a PC diagnosis were further catego...
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Proteomic Analysis of Cell Lines and Primary Tumors in Pancreatic Cancer Identifies Proteins Expressed Only In Vitro and Only In Vivo
Conclusions Our work offers a catalog of proteins detected in each of the PDAC cell lines, providing a useful guide for researchers seeking model systems for PDAC functional studies. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Currarino Syndrome: A Rare Condition With Potential Connection to Neuroendocrine Tumors
Conclusions In our patients with CS, the prevalence of NET is 11.53%. The coexistence of 2 rare conditions, CS and presacral NET, suggests that there may be an etiological connection. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Platelet Microparticles Regulate Neutrophil Extracellular Traps in Acute Pancreatitis
Conclusions The level of PMPs is a positive correlation with AP severity, which may be related to PMPs-NETs interaction. Platelet microparticles may be a potential predictor of severe AP and promising novel therapeutic target for AP. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Impact of a Prior Nonpancreatic Malignancy on Survival Outcomes of Patients With Stage IV Pancreatic Neuroendocrine Tumor: A Population-Based and Propensity Score Matching Study
Conclusions Stage IV PanNET patients with a history of a prior cancer had comparable survival outcomes with patients without such history. These patients could be candidates for clinical trials if otherwise appropriate, and aggressive and potentially curative therapies should be offered. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Symptom Burden of Nonresected Pancreatic Adenocarcinoma: An Analysis of 10,753 Patient-Reported Outcome Assessments
Conclusions The prevalence of severe symptoms in patients with nonresected PAC was high, but potentially modifiable. We identified vulnerable groups of patients that may benefit from focused interventions. This information is important for patient counseling and design of supportive care strategies. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Multimodal Device and Computer Algorithm–Based Monitoring of Pancreatic Microcirculation Profiles In Vivo
Conclusions We established a multimodal device and computer algorithm–based monitoring platform for visualizing integrated pancreatic microcirculation profiles. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Left Ventricular Assist Device Therapy and Acute Pancreatitis: Higher Incidence and Worse Clinical Outcomes
Conclusions Patients with LVAD have double risk of pancreatitis, worse clinical outcomes, and increased healthcare utilization. Studies elucidating the mechanisms behind pancreatic injury in advanced heart failure are suggested. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

The Effect of Age on Short- and Long-Term Outcomes in Patients With Pancreatic Ductal Adenocarcinoma Undergoing Laparoscopic Pancreaticoduodenectomy
Objective The aim of the study was to evaluate the effect of age on outcomes with pancreatic ductal adenocarcinoma (PDAC) undergoing laparoscopic pancreaticoduodenectomy (LPD). Methods We retrospectively collected clinical data of consecutive patients with PDAC undergoing LPD from January 2012 to April 2019. The patients were divided into 2 groups according to age at admission for LPD: younger than 70 and 70 years or older. Results A total of 147 patients were included ( (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research

Risk Factors for Acute Kidney Injury in Acute Pancreatitis: A 7-Year Retrospective Analysis of Patients in a Large Tertiary Hospital
Conclusions Hypertriglyceridemia, severity, etiology, and Acute Physiology and Chronic Health Evaluation II scores are independent risk factors for AKI in AP patients. Those patients have serious outcomes such as high rate of organ failure, pancreatic necrosis, and debridement of necrosis. (Source: Pancreas)
Source: Pancreas - August 22, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research