4 co-delivery of tnf- α sirna and il-22 via a nanoparticle-in-hydrogel system exerts synergistic therapeutic effects against ulcerative colitis

Combination therapy is an emerging approach for treating ulcerative colitis (UC). During the development of UC, TNF- α acts as the major pro-inflammatory cytokine while interleukin-22 (IL-22) plays an important role in preventing mucosal damage. In the present study, we loaded TNF-α siRNA (siTNF) into galactosylated polymeric nanoparticles (NPs). The resultant Gal-siTNF-NPs had a desirable diameter (~261 nm), narrow size distribution and a slightly negative zeta potential (~‒12 mV). These NPs successful mediated the targeted delivery of siTNF to macrophages and efficiently inhibited the expression of TNF-α.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical and Research Challenges Source Type: research

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Conclusions: IBD causes a significant burden to the Finnish healthcare system. This study provides a detailed characterization of the cost landscape of IBD and contributes to optimizing treatment strategies and healthcare resource use in the biosimilar era. PMID: 31203693 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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Source: Inflammation - Category: Allergy & Immunology Source Type: research
In this study, microRNA-24 was found to be elevated in colonic biopsies and blood samples from ulcerative colitis (UC) patients compared to healthy controls. In the colon of UC patients, microRNA-24 is localized to intestinal epithelial cells which prompted an investigation of intestinal epithelial barrier function.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research
AbstractDefective spleen function increases susceptibility to bacterial infections which can be prevented by vaccine prophylaxis. Splenic hypofunction can be found in a number of autoimmune disorders; however, no data are available regarding autoimmune atrophic gastritis (AAG), autoimmune enteropathy (AIE) and autoimmune liver disease (AILD). Peripheral blood samples from patients with AAG (n = 40), AIE (n = 3) and AILD (n = 40) were collected. Patients affected by autoimmune disorders already known to be associated with splenic hypofunction, i.e. coeliac disease (CD) and ulcerativ...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that comprises ulcerative colitis (UC) and Crohn ’s disease (CD). IBD involves the ileum, rectum, and colon, and common clinical...
Source: Chinese Medicine - Category: Complementary Medicine Authors: Tags: Review Source Type: research
This study aims to characterize one specific lncRNA, CDKN2B-AS1 whose expression was downregulated in UC patients.Main methodsUC biopsies were used to determine the levels of linear and circular CDKN2B-AS1 relative to healthy controls. In situ hybridization was used to determine the localization of CKDN2B-AS1 in the colon. The intestinal epithelial cell line, Caco-2, was used to study the effects of shRNA mediated loss of CDKN2B-AS1. Transepithelial electrical resistance was used to measure barrier function. An RT-PCR array, immunoblots and immunohistochemistry were used to determine tight junction proteins that CDKN2B-AS1...
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONS: Dose escalation and treatment switching of biologics may be considered as indicators of suboptimal therapy suggesting a lack of long-term remission and response under current therapies. PMID: 31192706 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSION: a treat-to-target strategy to achieve mucosal healing and deep remission is currently accepted by a substantial number of Portuguese gastroenterologists. PMID: 31190548 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
ConclusionsIBD ’s burden on the quality of life of patients and intricate functional background presents us constantly with new challenges. Our data and methodology provide researchers with new insights to a specific population, but also, to possible differentiation markers of disease classification and progress ion. This work, not only provides new insights into the interplay among IBD risk variants and their related signaling pathways, elucidates the mechanisms underlying IBD and its clinical sequelae, but also, introduces a generalized bioinformatics-based methodology which can be applied to studies of d ifferent disorders.
Source: Gut Pathogens - Category: Microbiology Source Type: research
Publication date: Available online 14 June 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Anna Claudia Romeo, Marco Ventimiglia, Valeria Dipasquale, Ambrogio Orlando, Michele Citrano, Salvatore Pellegrino, Salvatore Accomando, Mario Cottone, Claudio RomanoSummaryBackgroundBiological therapies have modified the disease course of pediatric inflammatory bowel disease (IBD) and are routinely used in clinical practice. Our observational study aims to evaluate effectiveness and safety of biologics in IBD.MethodClinical benefit and safety data of 93 children with IBD, receiving biologics (Infliximab...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
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