Filtered By:
Procedure: Transplants
This page shows you your search results in order of date. This is page number 17.
Order by Relevance | Date
Total 526 results found since Jan 2013.
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling
This study aimed to explore the role of Toll-like receptors 2 (TLR2) in Ang II-induced cardiac remodeling. We investigated the effect of TLR2 deficiency on Ang II-induced cardiac remodeling by utilizing TLR2 knockout mice, bone marrow transplantation models, and H9C2 cells. Though TLR2 deficiency had no effect on body weight change, cardiac Ang II content and blood pressure, it significantly ameliorated cardiac hypertrophy, fibrosis and inflammation, as well as improved heart function. Further bone marrow transplantation studies showed that TLR2-deficiency in cardiac cells but not bone marrow-derived cells prevented Ang II...
Source: Translational Research : the journal of laboratory and clinical medicine - March 2, 2021 Category: Laboratory Medicine Authors: Shiju Ye Ke Lin Gaojun Wu Ming-Jiang Xu Peiren Shan Weijian Huang Yi Wang Guang Liang Source Type: research
Tumor Suppressor Gene XEDAR Promotes Differentiation and Suppresses Proliferation and Migration of Gastric Cancer Cells Through Upregulating the RELA/LXR α Axis and Deactivating the Wnt/β-Catenin Pathway
Cell Transplant. 2021 Jan-Dec;30:963689721996346. doi: 10.1177/0963689721996346.ABSTRACTX-linked ectodermal dysplasia receptor (XEDAR) is a new member of the tumor necrosis factor receptor (TNFR) family that induces cell death. The purpose of this study is to determine the tumor-suppressive potential of XEDAR in the development and differentiation of gastric cancer (GC). XEDAR levels were analyzed in human GC tissues and adjacent normal tissues by immunohistochemistry (IHC), quantitative real-time reverse transcription PCR (RT-qPCR), and Western blot analysis. We found that XEDAR expression was significantly downregulated ...
Source: Cell Transplantation - February 27, 2021 Category: Cytology Authors: Xinwu Zhang Di Zhang Xiaoli Sun Shunle Li Yun Sun Hongjun Zhai Source Type: research
CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma
In this research, we analyze a relationship between CD44 expression and responsiveness to Bev and elucidate the role of CD44 in anti ‐VEGF therapy. These results indicate CD44 will be a useful biomarker for predicting responsiveness to bevacizumab and may serve as a therapeutic target in both primary and recurrent GBMs. AbstractAntiangiogenic therapy with bevacizumab (Bev), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is a common treatment for recurrent glioblastoma (GBM), but its survival benefit is limited. Resistance to Bev is thought to be a major cause of ineffectiveness on Bev therapy....
Source: Cancer Medicine - February 5, 2021 Category: Cancer & Oncology Authors: Masahiro Nishikawa,
Akihiro Inoue,
Takanori Ohnishi,
Hajime Yano,
Yonehiro Kanemura,
Shohei Kohno,
Shiro Ohue,
Saya Ozaki,
Shirabe Matsumoto,
Satoshi Suehiro,
Yawara Nakamura,
Seiji Shigekawa,
Hideaki Watanabe,
Riko Kitazawa,
Junya Tanaka,
Tags: ORIGINAL RESEARCH Source Type: research
Regulation of temozolomide resistance in glioma cells via the RIP2/NF- κB/MGMT pathway.
CONCLUSION: We report that the RIP2/NF-κB/MGMT signaling pathway is involved in the regulation of TMZ resistance. Interference with NF-κB or MGMT activity could constitute a novel strategy for the treatment of RIP2-positive TMZ-resistant glioma.
PMID: 33460245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 18, 2021 Category: Neuroscience Authors: Hu YH, Jiao BH, Wang CY, Wu JL Tags: CNS Neurosci Ther Source Type: research
Ultrasound ‑targeted microbubble destruction‑mediated Galectin‑7‑siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats.
In conclusion, the present study demonstrated that UTMD‑mediated Galectin‑7‑siRNA treatment could enhance the homing ability of BMSCs, thus alleviating AMI in rats.
PMID: 33416139 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - December 23, 2020 Category: Molecular Biology Authors: Wei X, Zheng Y, Zhang W, Tan J, Zheng H Tags: Int J Mol Med Source Type: research
GSE160062 FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling bulk RNA-seq
Conclusions: Taken together, this data indicates that FGF9 is an important regulator of SSC proliferation, operating through p38 MAPK phosphorylation and upregulating Etv5 and Bcl6b in turn.
Source: GEO: Gene Expression Omnibus - October 26, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE160061 FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling single-cell RNA-seq
Conclusions: Taken together, this data indicates that FGF9 is an important regulator of SSC proliferation, operating through p38 MAPK phosphorylation and upregulating Etv5 and Bcl6b in turn.
Source: GEO: Gene Expression Omnibus - October 26, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine
Conclusion: This study provides novel methods for the construction of stem cell microenvironments and experimental models of HF regeneration for the treatment of hair loss.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Peng Chen, Yong Miao, Feifei Zhang, Junfei Huang, Yuxin Chen, Zhexiang Fan, Lunan Yang, Jin Wang, Zhiqi Hu Tags: Research Paper Source Type: research
The role of machine perfusion in liver xenotransplantation
Purpose of review
To review the role of machine perfusion in advancing the study and clinical application of liver xenotransplantation to liver transplantation.
Recent findings
Recent multicenter trial has shown the benefits of normothermic machine perfusion (NMP) in the assessment and selection of suitable allografts for liver transplantation, especially marginal liver allografts. Advances in ex-vivo therapeutic intervention with proof-of-concept studies demonstrating successful ex-vivo genetic modification of donor allografts and blockade of gene expression with siRNA.
Summary
Xenotransplantation and NMP are two ...
Source: Current Opinion in Organ Transplantation - September 10, 2020 Category: Surgery Tags: XENOTRANSPLANTATION: Edited by Parsia A. Vagefi Source Type: research
IGF-1R stimulation alters microglial polarization via TLR4/NF- κB pathway after cerebral hemorrhage in mice.
In this study, we examined the impact of insulin-like growth factor-1 (IGF-1) secreted by NSCs on microglial polarization following ICH in adult C57BL/6 mice. Mouse models of ICH were established by collagenase injection. ICH mice received NSC transplantation after one hour. Firstly, the changes of microglial polarization in cerebral tissues of ICH mice were detected by immunofluorescence and ELISA. Secondly, the molecular mechanism underlying the microglial polarization was evaluated repeatedly with the application of IGF-1R siRNA and IGF-1R-mediated inhibition. We assessed the brain water content and behavioral deficits ...
Source: Brain Research Bulletin - August 28, 2020 Category: Neurology Authors: Sun Z, Wu K, Gu L, Huang L, Zhuge Q, Yang S, Wang Z Tags: Brain Res Bull Source Type: research
