New drugs for difficult bugs: management of multidrug-resistant gram-negative infections in solid organ transplant recipients
Curr Opin Organ Transplant. 2021 Jun 18. doi: 10.1097/MOT.0000000000000890. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Multidrug-resistant Gram-negative bacteria remain a significant threat to patient and allograft survival. Management of these infections in solid organ transplant (SOT) recipients remains challenging due to a limited antimicrobial pipeline and reliance on novel agents, which have not been systematically evaluated in the transplant population.RECENT FINDINGS: Novel antimicrobials, including the second-generation β-lactam/β-lactamase inhibitors, cefiderocol, plazomicin and eravacycline, have ...
Source: Current Opinion in Organ Transplantation - June 21, 2021 Category: Transplant Surgery Authors: Stephanie M Pouch Source Type: research

Update on islet cell transplantation
Curr Opin Organ Transplant. 2021 Jun 18. doi: 10.1097/MOT.0000000000000891. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Chronic diabetes-related complications continue to exert a rapidly growing and unsustainable pressure on healthcare systems worldwide. In type 1 diabetes, glycemic control is particularly challenging, as intensive management substantially increase the risk of severe hypoglycemic episodes. Alternative approaches to address this issue are required. Islet cell transplantation offers the best approach to reduce hypoglycemic risks and glycemic lability, while providing optimal glycemic control. Although o...
Source: Current Opinion in Organ Transplantation - June 21, 2021 Category: Transplant Surgery Authors: Kevin Verhoeff Braulio A Marfil-Garza A M James Shapiro Source Type: research

Pediatric kidney transplantation, a technical update
Curr Opin Organ Transplant. 2021 Jun 18. doi: 10.1097/MOT.0000000000000898. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Pediatric kidney transplantation is the definitive therapy for infants and children suffering from renal failure. It is a distinct endeavor demanding specialized care for optimal results. This includes a dedicated preoperative workup accounting for unique predisposing urologic conditions, specialized surgical techniques, and careful hemodynamic monitoring and maintenance.RECENT FINDINGS: Historically, size-matched renal allografts from pediatric donors to pediatric recipients suffered from poor outco...
Source: Current Opinion in Organ Transplantation - June 21, 2021 Category: Transplant Surgery Authors: Kambiz Etesami Rachel Hogen Rachel Lestz Source Type: research

Expanding access to pancreas transplantation for type 2 diabetes mellitus
Curr Opin Organ Transplant. 2021 Jun 18. doi: 10.1097/MOT.0000000000000901. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The vast majority of cases of diabetes mellitus (DM) in the United States are classified as type 2 DM (T2DM). Restrictive listing criteria and uncertainty regarding outcomes have historically limited access to pancreas transplantation for individuals with T2DM, although it has been used with success in patients with type 1 DM (T1DM). This review summarizes several recent studies that have sought to clarify the indications, appropriate patient selection, and outcomes of pancreas transplantation in the...
Source: Current Opinion in Organ Transplantation - June 21, 2021 Category: Transplant Surgery Authors: Christina M Papageorge Alexandra C Bolognese Jon S Odorico Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

Pancreas transplantation
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000900. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To define recent changes and future directions in the practice of pancreas transplantation (PT). Two major events have occurred in the past 18 months: COVID-19 pandemic, and the first world consensus conference on PT. Several innovative studies were published after the consensus conference.RECENT FINDINGS: During COVID-19 pandemic PT activity decreased. COVID-19 in transplant recipients increases mortality rates, but data from kidney transplantation show that mortality might be higher in waitlisted pa...
Source: Current Opinion in Organ Transplantation - June 8, 2021 Category: Transplant Surgery Authors: Fabio Vistoli Emanuele F Kauffmann Ugo Boggi Source Type: research

The solid organ transplant recipient with SARS-CoV-2 infection
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000888. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The COVID-19 pandemic is a major challenge to global health, particularly among vulnerable populations. Here, we describe the emerging epidemiology and relevant data on treatment options for COVID-19. We discuss the implications of current knowledge for solid organ transplant (SOT) recipients.RECENT FINDINGS: Risk factors and outcomes of COVID-19 among SOT recipients remain uncertain, but recent data suggest similar outcomes to the general population. Case reports of donor-derived SARS-CoV-2 infection...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Justin C Laracy Benjamin A Miko Marcus R Pereira Source Type: research

Mycobacterium tuberculosis in solid organ transplant donors and recipients
Curr Opin Organ Transplant. 2021 Jun 7. doi: 10.1097/MOT.0000000000000885. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Due to impaired immune response, solid organ transplant (SOT) recipients are susceptible to tuberculosis (TB) and its subsequent morbidity and mortality. Current prevention strategies, diagnostic and treatment approach to TB infection in donors and recipients were reviewed in this article.RECENT FINDINGS: Screening of latent tuberculosis infection (LTBI) in donors and recipients is the cornerstone of TB-preventive strategy in recipients and requires an assessment of TB risk factors, TB-specific immuni...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Maricar Malinis Alan Koff Source Type: research

Emerging fungal pathogens in solid organ transplantation
Curr Opin Organ Transplant. 2021 Jun 4. doi: 10.1097/MOT.0000000000000889. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review examines recent cases and updated literature on emerging or newly resistant fungal infections in solid organ transplantation.RECENT FINDINGS: Candida auris, a newly described candida capable of drug resistance and persistence in the environment, is a growing concern with both published cases on donor-derived transmission and a hospital outbreak involving liver transplant recipients. Infections with non-albicans candida species are also increasing in incidence in SOT recipients, leading to ...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Aaron Mishkin Source Type: research

Equity of access to renal transplantation: a European perspective
Curr Opin Organ Transplant. 2021 Jun 4. doi: 10.1097/MOT.0000000000000895. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Renal transplantation offers the chance for patients with end-stage renal disease (ESRD) to have a significantly longer, healthier and better quality life compared with remaining on dialysis. Inequities have been demonstrated at multiple points in the transplantation pathway. In this review, the factors contributing to inequity in access to renal transplantation will be explored from a European perspective.RECENT FINDINGS: Despite improvements in patient assessment and revision of organ-offering schem...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Diana A Wu Gabriel C Oniscu Source Type: research

Intraoperative salvage and liver re-transplantation on ECMO
Curr Opin Organ Transplant. 2021 Jun 4. doi: 10.1097/MOT.0000000000000894. Online ahead of print.NO ABSTRACTPMID:34074942 | DOI:10.1097/MOT.0000000000000894 (Source: Current Opinion in Organ Transplantation)
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Rachel Hogen Arash Motamed Craig Baker Yuri Genyk Juliet Emamaullee Source Type: research

The solid organ transplant recipient with SARS-CoV-2 infection
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000888. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The COVID-19 pandemic is a major challenge to global health, particularly among vulnerable populations. Here, we describe the emerging epidemiology and relevant data on treatment options for COVID-19. We discuss the implications of current knowledge for solid organ transplant (SOT) recipients.RECENT FINDINGS: Risk factors and outcomes of COVID-19 among SOT recipients remain uncertain, but recent data suggest similar outcomes to the general population. Case reports of donor-derived SARS-CoV-2 infection...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Justin C Laracy Benjamin A Miko Marcus R Pereira Source Type: research

Mycobacterium tuberculosis in solid organ transplant donors and recipients
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000885. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Due to impaired immune response, solid organ transplant (SOT) recipients are susceptible to tuberculosis (TB) and its subsequent morbidity and mortality. Current prevention strategies, diagnostic and treatment approach to TB infection in donors and recipients were reviewed in this article.RECENT FINDINGS: Screening of latent tuberculosis infection (LTBI) in donors and recipients is the cornerstone of TB-preventive strategy in recipients and requires an assessment of TB risk factors, TB-specific immuni...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Maricar Malinis Alan Koff Source Type: research

Emerging fungal pathogens in solid organ transplantation
Curr Opin Organ Transplant. 2021 Jun 4. doi: 10.1097/MOT.0000000000000889. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review examines recent cases and updated literature on emerging or newly resistant fungal infections in solid organ transplantation.RECENT FINDINGS: Candida auris, a newly described candida capable of drug resistance and persistence in the environment, is a growing concern with both published cases on donor-derived transmission and a hospital outbreak involving liver transplant recipients. Infections with non-albicans candida species are also increasing in incidence in SOT recipients, leading to ...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Aaron Mishkin Source Type: research

Equity of access to renal transplantation: a European perspective
Curr Opin Organ Transplant. 2021 Jun 4. doi: 10.1097/MOT.0000000000000895. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Renal transplantation offers the chance for patients with end-stage renal disease (ESRD) to have a significantly longer, healthier and better quality life compared with remaining on dialysis. Inequities have been demonstrated at multiple points in the transplantation pathway. In this review, the factors contributing to inequity in access to renal transplantation will be explored from a European perspective.RECENT FINDINGS: Despite improvements in patient assessment and revision of organ-offering schem...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Diana A Wu Gabriel C Oniscu Source Type: research

Intraoperative salvage and liver re-transplantation on ECMO
Curr Opin Organ Transplant. 2021 Jun 4. doi: 10.1097/MOT.0000000000000894. Online ahead of print.NO ABSTRACTPMID:34074942 | DOI:10.1097/MOT.0000000000000894 (Source: Current Opinion in Organ Transplantation)
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Rachel Hogen Arash Motamed Craig Baker Yuri Genyk Juliet Emamaullee Source Type: research

The solid organ transplant recipient with SARS-CoV-2 infection
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000888. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The COVID-19 pandemic is a major challenge to global health, particularly among vulnerable populations. Here, we describe the emerging epidemiology and relevant data on treatment options for COVID-19. We discuss the implications of current knowledge for solid organ transplant (SOT) recipients.RECENT FINDINGS: Risk factors and outcomes of COVID-19 among SOT recipients remain uncertain, but recent data suggest similar outcomes to the general population. Case reports of donor-derived SARS-CoV-2 infection...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Justin C Laracy Benjamin A Miko Marcus R Pereira Source Type: research

Mycobacterium tuberculosis in solid organ transplant donors and recipients
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000885. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Due to impaired immune response, solid organ transplant (SOT) recipients are susceptible to tuberculosis (TB) and its subsequent morbidity and mortality. Current prevention strategies, diagnostic and treatment approach to TB infection in donors and recipients were reviewed in this article.RECENT FINDINGS: Screening of latent tuberculosis infection (LTBI) in donors and recipients is the cornerstone of TB-preventive strategy in recipients and requires an assessment of TB risk factors, TB-specific immuni...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Maricar Malinis Alan Koff Source Type: research

Emerging fungal pathogens in solid organ transplantation
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000889. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review examines recent cases and updated literature on emerging or newly resistant fungal infections in solid organ transplantation.RECENT FINDINGS: Candida auris, a newly described candida capable of drug resistance and persistence in the environment, is a growing concern with both published cases on donor-derived transmission and a hospital outbreak involving liver transplant recipients. Infections with non-albicans candida species are also increasing in incidence in SOT recipients, leading to ...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Aaron Mishkin Source Type: research

Equity of access to renal transplantation: a European perspective
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000895. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Renal transplantation offers the chance for patients with end-stage renal disease (ESRD) to have a significantly longer, healthier and better quality life compared with remaining on dialysis. Inequities have been demonstrated at multiple points in the transplantation pathway. In this review, the factors contributing to inequity in access to renal transplantation will be explored from a European perspective.RECENT FINDINGS: Despite improvements in patient assessment and revision of organ-offering schem...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Diana A Wu Gabriel C Oniscu Source Type: research

Intraoperative salvage and liver re-transplantation on ECMO
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000894. Online ahead of print.NO ABSTRACTPMID:34074942 | DOI:10.1097/MOT.0000000000000894 (Source: Current Opinion in Organ Transplantation)
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Rachel Hogen Arash Motamed Craig Baker Yuri Genyk Juliet Emamaullee Source Type: research

The solid organ transplant recipient with SARS-CoV-2 infection
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000888. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The COVID-19 pandemic is a major challenge to global health, particularly among vulnerable populations. Here, we describe the emerging epidemiology and relevant data on treatment options for COVID-19. We discuss the implications of current knowledge for solid organ transplant (SOT) recipients.RECENT FINDINGS: Risk factors and outcomes of COVID-19 among SOT recipients remain uncertain, but recent data suggest similar outcomes to the general population. Case reports of donor-derived SARS-CoV-2 infection...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Justin C Laracy Benjamin A Miko Marcus R Pereira Source Type: research

Mycobacterium tuberculosis in solid organ transplant donors and recipients
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000885. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Due to impaired immune response, solid organ transplant (SOT) recipients are susceptible to tuberculosis (TB) and its subsequent morbidity and mortality. Current prevention strategies, diagnostic and treatment approach to TB infection in donors and recipients were reviewed in this article.RECENT FINDINGS: Screening of latent tuberculosis infection (LTBI) in donors and recipients is the cornerstone of TB-preventive strategy in recipients and requires an assessment of TB risk factors, TB-specific immuni...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Maricar Malinis Alan Koff Source Type: research

Emerging fungal pathogens in solid organ transplantation
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000889. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review examines recent cases and updated literature on emerging or newly resistant fungal infections in solid organ transplantation.RECENT FINDINGS: Candida auris, a newly described candida capable of drug resistance and persistence in the environment, is a growing concern with both published cases on donor-derived transmission and a hospital outbreak involving liver transplant recipients. Infections with non-albicans candida species are also increasing in incidence in SOT recipients, leading to ...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Aaron Mishkin Source Type: research

Equity of access to renal transplantation: a European perspective
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000895. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Renal transplantation offers the chance for patients with end-stage renal disease (ESRD) to have a significantly longer, healthier and better quality life compared with remaining on dialysis. Inequities have been demonstrated at multiple points in the transplantation pathway. In this review, the factors contributing to inequity in access to renal transplantation will be explored from a European perspective.RECENT FINDINGS: Despite improvements in patient assessment and revision of organ-offering schem...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Diana A Wu Gabriel C Oniscu Source Type: research

Intraoperative salvage and liver re-transplantation on ECMO
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000894. Online ahead of print.NO ABSTRACTPMID:34074942 | DOI:10.1097/MOT.0000000000000894 (Source: Current Opinion in Organ Transplantation)
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Rachel Hogen Arash Motamed Craig Baker Yuri Genyk Juliet Emamaullee Source Type: research

The solid organ transplant recipient with SARS-CoV-2 infection
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000888. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The COVID-19 pandemic is a major challenge to global health, particularly among vulnerable populations. Here, we describe the emerging epidemiology and relevant data on treatment options for COVID-19. We discuss the implications of current knowledge for solid organ transplant (SOT) recipients.RECENT FINDINGS: Risk factors and outcomes of COVID-19 among SOT recipients remain uncertain, but recent data suggest similar outcomes to the general population. Case reports of donor-derived SARS-CoV-2 infection...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Justin C Laracy Benjamin A Miko Marcus R Pereira Source Type: research

Mycobacterium tuberculosis in solid organ transplant donors and recipients
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000885. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Due to impaired immune response, solid organ transplant (SOT) recipients are susceptible to tuberculosis (TB) and its subsequent morbidity and mortality. Current prevention strategies, diagnostic and treatment approach to TB infection in donors and recipients were reviewed in this article.RECENT FINDINGS: Screening of latent tuberculosis infection (LTBI) in donors and recipients is the cornerstone of TB-preventive strategy in recipients and requires an assessment of TB risk factors, TB-specific immuni...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Maricar Malinis Alan Koff Source Type: research

Emerging fungal pathogens in solid organ transplantation
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000889. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review examines recent cases and updated literature on emerging or newly resistant fungal infections in solid organ transplantation.RECENT FINDINGS: Candida auris, a newly described candida capable of drug resistance and persistence in the environment, is a growing concern with both published cases on donor-derived transmission and a hospital outbreak involving liver transplant recipients. Infections with non-albicans candida species are also increasing in incidence in SOT recipients, leading to ...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Aaron Mishkin Source Type: research

Equity of access to renal transplantation: a European perspective
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000895. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Renal transplantation offers the chance for patients with end-stage renal disease (ESRD) to have a significantly longer, healthier and better quality life compared with remaining on dialysis. Inequities have been demonstrated at multiple points in the transplantation pathway. In this review, the factors contributing to inequity in access to renal transplantation will be explored from a European perspective.RECENT FINDINGS: Despite improvements in patient assessment and revision of organ-offering schem...
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Diana A Wu Gabriel C Oniscu Source Type: research

Intraoperative salvage and liver re-transplantation on ECMO
Curr Opin Organ Transplant. 2021 Jun 1. doi: 10.1097/MOT.0000000000000894. Online ahead of print.NO ABSTRACTPMID:34074942 | DOI:10.1097/MOT.0000000000000894 (Source: Current Opinion in Organ Transplantation)
Source: Current Opinion in Organ Transplantation - June 2, 2021 Category: Transplant Surgery Authors: Rachel Hogen Arash Motamed Craig Baker Yuri Genyk Juliet Emamaullee Source Type: research

The time is now: antimicrobial stewardship in solid organ transplantation
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000886. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To provide a summary of complications of antimicrobials and opportunities for antimicrobial stewardship (AS) in solid organ transplant (SOT) patient care.RECENT FINDINGS: Personalized, precision antimicrobial prescribing in SOT aiming to avoid negative consequences of antimicrobials is essential to improving patient outcomes. The positive impact AS efforts in transplant care has been recognized and bespoke activities tailored to special interests of transplant patients and providers are evolving. Str...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Jonathan M Hand Source Type: research

Recurrent glomerulonephritis after kidney transplantation: a practical approach
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000887. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review will provide a practical approach in the assessment of kidney failure patients with primary glomerulonephritides (GN) being considered for kidney transplantation, focusing on high-risk subtypes of immunoglobulin A nephropathy, focal segmental glomerulosclerosis, idiopathic membranous glomerulonephritis and membranoproliferative glomerulonephritis.RECENT FINDINGS: Recurrent glomerulonephritis remains one of the most common causes of allograft loss in kidney transplant recipients. Although ...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Laura De Souza Janelle Prunster Doris Chan Aron Chakera Wai H Lim Source Type: research

The time is now: antimicrobial stewardship in solid organ transplantation
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000886. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To provide a summary of complications of antimicrobials and opportunities for antimicrobial stewardship (AS) in solid organ transplant (SOT) patient care.RECENT FINDINGS: Personalized, precision antimicrobial prescribing in SOT aiming to avoid negative consequences of antimicrobials is essential to improving patient outcomes. The positive impact AS efforts in transplant care has been recognized and bespoke activities tailored to special interests of transplant patients and providers are evolving. Str...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Jonathan M Hand Source Type: research

Recurrent glomerulonephritis after kidney transplantation: a practical approach
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000887. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review will provide a practical approach in the assessment of kidney failure patients with primary glomerulonephritides (GN) being considered for kidney transplantation, focusing on high-risk subtypes of immunoglobulin A nephropathy, focal segmental glomerulosclerosis, idiopathic membranous glomerulonephritis and membranoproliferative glomerulonephritis.RECENT FINDINGS: Recurrent glomerulonephritis remains one of the most common causes of allograft loss in kidney transplant recipients. Although ...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Laura De Souza Janelle Prunster Doris Chan Aron Chakera Wai H Lim Source Type: research

The time is now: antimicrobial stewardship in solid organ transplantation
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000886. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To provide a summary of complications of antimicrobials and opportunities for antimicrobial stewardship (AS) in solid organ transplant (SOT) patient care.RECENT FINDINGS: Personalized, precision antimicrobial prescribing in SOT aiming to avoid negative consequences of antimicrobials is essential to improving patient outcomes. The positive impact AS efforts in transplant care has been recognized and bespoke activities tailored to special interests of transplant patients and providers are evolving. Str...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Jonathan M Hand Source Type: research

Recurrent glomerulonephritis after kidney transplantation: a practical approach
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000887. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review will provide a practical approach in the assessment of kidney failure patients with primary glomerulonephritides (GN) being considered for kidney transplantation, focusing on high-risk subtypes of immunoglobulin A nephropathy, focal segmental glomerulosclerosis, idiopathic membranous glomerulonephritis and membranoproliferative glomerulonephritis.RECENT FINDINGS: Recurrent glomerulonephritis remains one of the most common causes of allograft loss in kidney transplant recipients. Although ...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Laura De Souza Janelle Prunster Doris Chan Aron Chakera Wai H Lim Source Type: research

The time is now: antimicrobial stewardship in solid organ transplantation
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000886. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To provide a summary of complications of antimicrobials and opportunities for antimicrobial stewardship (AS) in solid organ transplant (SOT) patient care.RECENT FINDINGS: Personalized, precision antimicrobial prescribing in SOT aiming to avoid negative consequences of antimicrobials is essential to improving patient outcomes. The positive impact AS efforts in transplant care has been recognized and bespoke activities tailored to special interests of transplant patients and providers are evolving. Str...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Jonathan M Hand Source Type: research

Recurrent glomerulonephritis after kidney transplantation: a practical approach
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000887. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review will provide a practical approach in the assessment of kidney failure patients with primary glomerulonephritides (GN) being considered for kidney transplantation, focusing on high-risk subtypes of immunoglobulin A nephropathy, focal segmental glomerulosclerosis, idiopathic membranous glomerulonephritis and membranoproliferative glomerulonephritis.RECENT FINDINGS: Recurrent glomerulonephritis remains one of the most common causes of allograft loss in kidney transplant recipients. Although ...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Laura De Souza Janelle Prunster Doris Chan Aron Chakera Wai H Lim Source Type: research

The time is now: antimicrobial stewardship in solid organ transplantation
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000886. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To provide a summary of complications of antimicrobials and opportunities for antimicrobial stewardship (AS) in solid organ transplant (SOT) patient care.RECENT FINDINGS: Personalized, precision antimicrobial prescribing in SOT aiming to avoid negative consequences of antimicrobials is essential to improving patient outcomes. The positive impact AS efforts in transplant care has been recognized and bespoke activities tailored to special interests of transplant patients and providers are evolving. Str...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Jonathan M Hand Source Type: research

Recurrent glomerulonephritis after kidney transplantation: a practical approach
Curr Opin Organ Transplant. 2021 May 25. doi: 10.1097/MOT.0000000000000887. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review will provide a practical approach in the assessment of kidney failure patients with primary glomerulonephritides (GN) being considered for kidney transplantation, focusing on high-risk subtypes of immunoglobulin A nephropathy, focal segmental glomerulosclerosis, idiopathic membranous glomerulonephritis and membranoproliferative glomerulonephritis.RECENT FINDINGS: Recurrent glomerulonephritis remains one of the most common causes of allograft loss in kidney transplant recipients. Although ...
Source: Current Opinion in Organ Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Laura De Souza Janelle Prunster Doris Chan Aron Chakera Wai H Lim Source Type: research

Mechanical circulatory support in pre and postheart transplant period
This article discusses the use of temporary and durable devices and their deployment strategies in the pre and posttransplant period.RECENT FINDINGS: Recently temporary mechanical support devices have allowed us to improve survival to transplant as well as posttransplant. Early implementation of temporary devices both for stabilization of advanced HF patients being considered for transplant as well as those with posttransplant primary graft dysfunction (although utilization of extracorporeal membrane oxygenation has repeatedly shown to be associated with worse outcomes compared to the other devices discussed), is reflectiv...
Source: Current Opinion in Organ Transplantation - May 19, 2021 Category: Transplant Surgery Authors: Andrew R Kolodziej Gaurang N Vaidya Neeti Reddy Emma J Birks Source Type: research