Filtered By:
Procedure: Transplants
This page shows you your search results in order of date. This is page number 16.
Order by Relevance | Date
Total 526 results found since Jan 2013.
Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials
Donor organ shortage still remains a serious obstacle for the access of wait-list patients to kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand the number of transplants, the use of lower quality organs from older ECD or DCD donors has become an established routine but at the price of increased incidence of Primary Non-Function, Delay Graft Function and lower-long term graft survival. In the last years, several improvements have been made in the field of renal transplantation from surgical procedure to preservation strategies. To improve renal outcomes, research has focused on develo...
Source: Frontiers in Immunology - July 6, 2021 Category: Allergy & Immunology Source Type: research
Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels
In conclusion, ischemia-reperfusion injury can downregulate Sp1 mediated-folate transporter expression in tubular cells, which may reduce folate reabsorption and lead to low folate status.
Source: Frontiers in Immunology - June 4, 2021 Category: Allergy & Immunology Source Type: research
Curcumin Blunts IL-6 Dependent Endothelial ‐to‐Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation
Fibrosis contributes to graft loss in chronic renal allograft injury. Endothelial‐to‐mesenchymal transition (EndMT) plays an important role in the development of fibrosis following kidney transplantation. Autophagy plays an important role in the homeostasis of diverse cell types including endothelial cells. Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6–dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was ass...
Source: Frontiers in Immunology - May 28, 2021 Category: Allergy & Immunology Source Type: research
Transdermal Delivery of Adipocyte Phospholipase A2 siRNA using Microneedles to Treat Thyroid Associated Ophthalmopathy-Related Proptosis
This study sets the stage not only for future treatment of TAO-related proptosis using AdPLA siRNA, but also provides the foundation for targeted siRNA delivery by using microneedles.PMID:33880967 | DOI:10.1177/09636897211010633
Source: Cell Transplantation - April 21, 2021 Category: Cytology Authors: Guiqin Liu Yan Deng Yi Song Yi Sui Juan Cen Ziyu Shao Hu Li Tao Tang Source Type: research
Novel treatment options for acute hepatic porphyrias
Purpose of review
Acute hepatic porphyrias (AHP) are a group of rare diseases that are characterized by episodic acute neurovisceral pain episodes caused by abnormal accumulation of the neurotoxic porphyrin precursor delta-aminolevulinic acid (ALA). Patient with frequent recurrent acute attacks have been difficult to treat and these patients sometimes require liver transplantation. Recent developments in small interfering RNA (siRNA)-based therapy led to the development of an effective prophylactic treatment for patients with frequent recurrent attacks. This review will describe treatment options for AHP and highlight ...
Source: Current Opinion in Gastroenterology - April 9, 2021 Category: Gastroenterology Tags: LIVER: Edited by Don C. Rockey Source Type: research
Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis
Conclusion: Taken together, our research suggested that alternol increased TRAIL-mediated apoptosis via inhibiting antiapoptotic proteins and upregulating DR5 levels via ROS generation and the CHOP pathway.
Source: Frontiers in Pharmacology - March 25, 2021 Category: Drugs & Pharmacology Source Type: research
Klotho Regulates Epithelial-to-Mesenchymal Transition In Vitro via Wnt/ β-Catenin Pathway and Attenuates Chronic Allograft Dysfunction in a Rat Renal Transplant Model
CONCLUSIONS Our results show that Klotho has a significant protective role against EMT, renal allograft fibrosis, and CAD following kidney transplantation, which is mediated by inhibition of the Wnt/ß-catenin signaling pathway.PMID:33737505 | DOI:10.12659/AOT.930066
Source: Annals of Transplantation - March 19, 2021 Category: Transplant Surgery Authors: Xiaojun Li Pei Lu Xue-Feng Shao Ting Jiang Feng Liu Gang Li Source Type: research
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling
This study aimed to explore the role of Toll-like receptors 2 (TLR2) in Ang II-induced cardiac remodeling. We investigated the effect of TLR2 deficiency on Ang II-induced cardiac remodeling by utilizing TLR2 knockout mice, bone marrow transplantation models, and H9C2 cells. Though TLR2 deficiency had no effect on body weight change, cardiac Ang II content and blood pressure, it significantly ameliorated cardiac hypertrophy, fibrosis and inflammation, as well as improved heart function. Further bone marrow transplantation studies showed that TLR2-deficiency in cardiac cells but not bone marrow-derived cells prevented Ang II...
Source: Translational Research : the journal of laboratory and clinical medicine - March 2, 2021 Category: Laboratory Medicine Authors: Shiju Ye Ke Lin Gaojun Wu Ming-Jiang Xu Peiren Shan Weijian Huang Yi Wang Guang Liang Source Type: research
