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Total 526 results found since Jan 2013.
Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p
This study aimed to investigate the role of the long non-coding RNA (lncRNA) LINC00342-207 (LINC00342) in the development and progression of primary hepatocellular carcinoma (HCC). Forty-two surgically resected HCC tissues and corresponding paracancerous tissues were collected from October 2019 to December 2020 and examined for lncRNA LINC00342, microRNA (miR)-19a-3p, miR-545-5p, miR-203a-3p, cell cycle protein D1 (CyclinD1/CCND1), murine double minute 2 (MDM2), and fibroblast growth factor 2 (FGF2) expression. The disease-free survival and overall survival of patients with HCC were followed up. HCC cell lines and the norm...
Source: Biochemical Genetics - July 3, 2023 Category: Genetics & Stem Cells Authors: Zong-Xi Yao Jun-Hao Tu Yu-Lin Liu Xiao-Feng Xue Lei Qin Source Type: research
Linc-ROR Regulates < em > POU5F1 < /em > and < em > SOX2 < /em > by Competitively Binding miR-145-5p to Affect the Proliferation and Migration of Gastric Cancer Cells
In this study, in situ hybridization revealed that long intergenic non-protein coding RNA-regulator of reprogramming (linc-ROR) was highly expressed in gastric cancer cells and was mainly cytoplasmic-positive. Cell counting kit-8 (CCK-8), plate colony formation, wound healing, and Transwell assay revealed that linc-ROR knockdown impedes the growth, proliferation, and migration of gastric cancer cells, while linc-ROR overexpression promoted gastric cancer cell growth, migration, and colony formation ability. Combined with previous studies, the molecular mechanism axis of linc-ROR/miR-145-5-5p/POU5F1/SOX2 was verified. The e...
Source: Cell Transplantation - June 12, 2023 Category: Cytology Authors: Xiuchong Yu Xinyi Ma Yangtao Jia Xinxin Wu Zhilong Yan Source Type: research
Novel therapeutic strategies for autoimmune and inflammatory rheumatic diseases
Drug Discov Today. 2023 May 8:103612. doi: 10.1016/j.drudis.2023.103612. Online ahead of print.ABSTRACTDrugs of unknown mechanisms of action are no longer being developed because we have largely capitalized on our improved understanding of the immunopathogenesis of immune-mediated inflammatory diseases (IMIDs) to develop therapeutic monoclonal antibodies (mAbs) and targeted treatments. These therapies have profoundly revolutionized the care of IMIDs. However, because of the heterogeneity of IMIDs and the redundancy of the targeted molecular pathways, some patients with IMIDs might not respond to a specific targeted drug or...
Source: Drug Discovery Today - May 10, 2023 Category: Drugs & Pharmacology Authors: Renaud Felten Philippe Mertz Eden Sebbag Marc Scherlinger Laurent Arnaud Source Type: research
Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway
In conclusion, our study revealed that Mettl14 plays a critical role in the development and suppressive function of iTregs in vitro and could thus serve as a regulatory element for stabilizing iTregs in cell-based therapy.PMID:37121553 | DOI:10.1016/j.imlet.2023.04.008
Source: Immunology Letters - April 30, 2023 Category: Allergy & Immunology Authors: Yanzhuo Liu Yinglin Yuan Zili Zhou Xiaomei Jiang Shu He Fan Wei Yuanyuan Cui Lu Yang Gaoping Zhao Source Type: research
Bone marrow-mesenchymal stem cells alleviate microglial Pyroptosis after intracerebral hemorrhage in rat by secreting C1q/tumor necrosis factor-related protein 3
CONCLUSION: BMSCs can inhibit neuroinflammation by inhibiting microglial pyroptosis, thus alleviate ICH symptoms, likely by suppressing the Syk signaling pathway while promoting the PI3K/AKT signaling pathway activation through producing CTRP3.PMID:36958593 | DOI:10.1016/j.expneurol.2023.114387
Source: Experimental Neurology - March 23, 2023 Category: Neurology Authors: Qinghua Wang Jifeng Piao Yulong Li Huiru Tu Dingyi Lv Libin Hu Run Zhang Zhenzhong Zhong Source Type: research
Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk
Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide. While HPV infection can be cleared by an adequate immune response, immunocompromised individuals can develop persistent, treatment-refractory, and progressive disease. Primary immunodeficiencies (PIDs) associated with HPV-related disease include inborn errors of GATA, EVER1/2, and CXCR4 mutations, resulting in defective cellular function. People living with secondary immunodeficiency (e.g. solid-organ transplants recipients of immunosuppression) an...
Source: Frontiers in Immunology - March 7, 2023 Category: Allergy & Immunology Source Type: research
Lipopolysaccharide and lipoteichoic acid regulate the PI3K/AKT pathway through osteopontin/integrin β3 to promote malignant progression of non-small cell lung cancer
CONCLUSIONS: This study provides a theoretical basis for further exploration of the influence of lung microbiota on NSCLC and the optimization of LC treatment in the future.PMID:36794132 | PMC:PMC9922606 | DOI:10.21037/jtd-22-1825
Source: Journal of Thoracic Disease - February 16, 2023 Category: Respiratory Medicine Authors: Miao Zhang Yi Sun Yan Zhang Zhen Wang Zhao-Yi Wang Xi-Yue Ming Zhen-Dong Guo Source Type: research
