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Condition: Multidrug Resistance

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Total 957 results found since Jan 2013.

Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Conclusions Shikonin effectively upregulates the transcription of CYP isozymes, phase II detoxification enzymes, and phase III membrane transporters and this function is at least partially through activation of AhR and Nrf2. Moreover, Nrf2 activation is dependent on mitogen-activated protein kinases. Graphical abstract
Source: Journal of Ethnopharmacology - February 4, 2018 Category: Drugs & Pharmacology Source Type: research

Reversal effect of quercetin on multidrug resistance via FZD7/ β-catenin pathway in hepatocellular carcinoma cells
Conclusion : Overall, these data suggested the effectiveness of using quercetin, at least in part, via inhibiting FZD7 to combat chemoresistance and showed that quercetin could be developed into an efficient natural sensitizer for resistant human hepatocellular carcinoma. Graphical abstract
Source: Phytomedicine - March 20, 2018 Category: Drugs & Pharmacology Source Type: research

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Conclusion: Our findings show that stimulation of adenylyl cyclase causes a remarkable activation of cell surface adenosine receptors.Cell Physiol Biochem 2018;45:2516 –2528
Source: Cellular Physiology and Biochemistry - March 27, 2018 Category: Cytology Source Type: research

Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells.
This study investigates the role of Sirtuin 1 (SIRT1) in paclitaxel (PTX)-resistant CC lines. We used qPCR and Western blots to measure SIRT1 mRNA and protein expressions in 10 matched clinical cancer tissues. We compared the expression levels of SIRT1 between sensitive CC cell lines and PTX-resistant cell lines. Subsequently, we used SIRT1 siRNA to knockdown the expression of SIRT1, and then measured cell proliferation, cell apoptosis rate, cell cycle distribution, and expression levels of Bcl-2 and Bax in PTX-sensitive Hela cell line, PTX-resistant Hela and Sila-resistant cell lines. Finally, we detected the location and...
Source: Cellular and Molecular Biology - May 30, 2018 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

The action mechanism of lncRNA-HOTAIR on the drug resistance of non-small cell lung cancer by regulating Wnt signaling pathway.
Authors: Guo F, Cao Z, Guo H, Li S Abstract The action mechanism of long non-coding ribonucleic acid-homeobox transcript antisense ribonucleic acid (lncRNA-HOTAIR) in the regulation of the Wnt signaling pathway on the drug resistance of non-small cell lung cancer was investigated. Forty eight patients with non-small cell lung cancer, who were treated with cisplatin (DDP) as neoadjuvant chemotherapy, were selected from the specimen bank of the Department of Pathology of Peking Union Medical College Hospital. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the messenger RNA (mRNA) level of...
Source: Experimental and Therapeutic Medicine - May 30, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

ASAP Overcoming Multidrug Resistance by Codelivery of MDR1-Targeting siRNA and Doxorubicin Using EphA10-Mediated pH-Sensitive Lipoplexes: In Vitro and In Vivo Evaluation
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b01806
Source: ACS Applied Materials and Interfaces - June 13, 2018 Category: Materials Science Authors: Jiulong Zhang, Zhouqi Du, Shuang Pan, Menghao Shi, Jie Li, Chunrong Yang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao Source Type: research

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide.
Authors: Melamed JR, Morgan JT, Ioele SA, Gleghorn JP, Sims-Mourtada J, Day ES Abstract Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are deregulated in GBM, including Hedgehog (Hh) signaling. Here, we investigate suppression of Hh signaling as an adjuvant to TMZ using U87-MG and T98G cell lines as in vitro models of GBM. We found that silencing GLI1 with siRNA reduces cell metabolic activity by up to 30% in combination ...
Source: Oncotarget - June 27, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Long noncoding RNA cancer susceptibility candidate  9 promotes doxorubicin‑resistant breast cancer by binding to enhancer of zeste homolog 2.
Long noncoding RNA cancer susceptibility candidate 9 promotes doxorubicin‑resistant breast cancer by binding to enhancer of zeste homolog 2. Int J Mol Med. 2018 Aug 07;: Authors: Jiang B, Li Y, Qu X, Zhu H, Tan Y, Fan Q, Jiang Y, Liao M, Wu X Abstract The present study aimed to investigate the effect of the long noncoding RNA cancer susceptibility candidate 9 (CASC9) on doxorubicin (DOX)‑resistant breast cancer and to reveal the potential underlying mechanisms. The expression of CASC9 in breast cancer tissues and cell lines, in addition to drug‑resistant breast cancer cells (MCF‑7/DOX), was d...
Source: International Journal of Molecular Medicine - August 7, 2018 Category: Molecular Biology Authors: Jiang B, Li Y, Qu X, Zhu H, Tan Y, Fan Q, Jiang Y, Liao M, Wu X Tags: Int J Mol Med Source Type: research

GSE109717 Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
Contributors : Shilpi Chandra ; James Gray ; William B Kiosses ; Archana Khurana ; Kaori Hitomi ; Catherine M Crosby ; Ashu Chawla ; Zheng Fu ; Meng Zhao ; Natacha Veerapen ; Stewart K Richardson ; Steven A Porcelli ; Gurdyal Besra ; Amy R Howell ; Sonia Sharma ; Bjoern Peters ; Mitchell KronenbergSeries Type : Expression profiling by arrayOrganism : Mus musculusInvariant natural killer T cells (iNKT cells) are activated by lipid antigens presented by CD1d, but the pathway leading to lipid antigen presentation remains incompletely characterized. Here we show a whole genome siRNA screen to elucidate the CD1d presentation pa...
Source: GEO: Gene Expression Omnibus - September 14, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Role of DDX53 in taxol-resistance of cervix cancer cells in  vitro.
In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated. In taxol-resistant HelaTR cells, DDX53 was significantly increased as compared to the parental HeLa cells. HelaTR cells also showed upregulation of multidrug resistant gene MDR1, invasive characteristics and decreased apoptosis. In addition, increased autophagy level was observed in HelaTR cells. Overexpression of DDX53 in HeLa and SiHa markedly led to greater resistance to taxol and cisplatin, whereas knockdown of DDX53 in HelaTR cells restored sensitivity, demonstrating that DDX53 regulated taxol resistance in cervix cancer cell...
Source: Biochemical and Biophysical Research communications - November 22, 2018 Category: Biochemistry Authors: Park SY, Kim WJ, Byun JH, Lee JJ, Jeoung D, Park ST, Kim Y Tags: Biochem Biophys Res Commun Source Type: research

Non-steroidal anti-inflammatory drugs increase MRP4 expression in an endometriotic epithelial cell line in a PPARa dependent manner.
CONCLUSIONS: MRP4 expression was increased in cells treated with NSAIDs and the nuclear receptor PPARa is involved. Elevated PGE2 levels in cell supernatants correlate with its increased transport by MRP4 after NSAID treatment. More importantly, we provide evidence that in endometriotic epithelial cells aspirin and non-aspirin NSAIDs treatments alter gene expression. PMID: 30556891 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 18, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells
ConclusionsOur findings show GAS5 contributes to regulation of the apoptosis, cell cycle, homeostasis of reactive oxygen species, and redox balance in MM cells, and suggest that reduced GAS5 expression contributes to disease progression in MM patients.
Source: Journal of Cancer Research and Clinical Oncology - December 19, 2018 Category: Cancer & Oncology Source Type: research

An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.
This study uncovers a novel function of pre-mRNA m6A as a determinant of mutant protein expression in cancer cells heterozygously carrying the TP53 R273H mutation. Suppressing both RNA methylation and ceramide glycosylation might constitute an efficacious and specific approach for targeting TP53 missense mutations coding for a G>A transition, thereby improving cancer treatments. PMID: 30578766 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - December 19, 2018 Category: Drugs & Pharmacology Authors: Uddin MB, Roy KR, Hosain SB, Khiste SK, Hill RA, Jois SD, Zhao Y, Tackett AJ, Liu YY Tags: Biochem Pharmacol Source Type: research

Caged-xanthone from Cratoxylum formosum ssp. pruniflorum inhibits malignant cancer phenotypes in multidrug-resistant human A549 lung cancer cells through down-regulation of NF- κB.
Caged-xanthone from Cratoxylum formosum ssp. pruniflorum inhibits malignant cancer phenotypes in multidrug-resistant human A549 lung cancer cells through down-regulation of NF-κB. Bioorg Med Chem. 2018 Dec 31;: Authors: Kaewpiboon C, Boonnak N, Yawut N, Kaowinn S, Chung YH Abstract Our recent study reported that multidrug-resistant (MDR) human A549 lung cancer cells (A549RT-eto) with the elevated expression of NF-κB showed epithelial-mesenchymal transition (EMT), increasing spheroid formation and elevating the expression levels of stemness-related factors, including Oct4, Nanog, Sox2, Bmi1, and Klf4...
Source: Bioorganic and Medicinal Chemistry - December 31, 2018 Category: Chemistry Authors: Kaewpiboon C, Boonnak N, Yawut N, Kaowinn S, Chung YH Tags: Bioorg Med Chem Source Type: research

Enhanced expression of ten ‐eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P‐glycoprotein expression
This study demonstrated that TET1 expression reverses gemcitabine resistance in CCA accompanied by a reduction in P ‐gp expression. Thus, TET1 may be a promising target to overcome the chemoresistance in CCA. AbstractIncreasing evidence revealed that ten ‐eleven translocation 1 (TET1) plays an important role in tumorigenesis and chemoresistance, but its functions in gemcitabine resistance in cholangiocarcinoma (CCA) remain unknown. This study aims to investigate the effect of TET1 on gemcitabine resistance in CCA and the possible effect on P‐gly coprotein (P‐gp) expression encoded by multidrug resistance (MDR) gene...
Source: Cancer Medicine - February 19, 2019 Category: Cancer & Oncology Authors: Chuanxu Wang, Hua Ye, Lei Zhang, Yayu Cheng, Shifeng Xu, Ping Zhang, Zijie Zhang, Jimin Bai, Fangkang Meng, Lin Zhong, Guangjun Shi, Hao Li Tags: ORIGINAL RESEARCH Source Type: research