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Condition: Multidrug Resistance

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Total 957 results found since Jan 2013.

Pregnane X receptors regulate CYP2C8 and P ‐glycoprotein to impact on the resistance of NSCLC cells to Taxol
Abstract Cytochrome P450 2C8 (CYP2C8) is one of the enzymes that primarily participate in producing metabolisms of medications and P‐glycoprotein (P‐gp) has been regarded as one of the important molecules in chemotherapeutically induced multidrug resistance (MDR). In addition, the pregnane X receptor (PXR) is involved in regulating both CYP2C8 and P‐gp. We aim to research the effect of PXR on Taxol‐resistant non–small‐cell lung cancer (NSCLC cells) via regulating CYP2C8 and P‐gp. NSCLC cells were treated with SR12813, LY335979, or PXR siRNA. Cell counting kit (CCK‐8) assay was used to detect cell vitality. ...
Source: Cancer Medicine - November 21, 2016 Category: Cancer & Oncology Authors: Yan Chen, Wandan Huang, Feiyu Chen, Guoping Hu, Fenglei Li, Jianhua Li, Aiguo Xuan Tags: Original Research Source Type: research

Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss
ConclusionsInhibition of CDK4 by palbociclib can enhance paclitaxel sensitivity in both Rb-positive and Rb-negative MDR ovarian cancer cells by increasing apoptosis. CDK4 may serve as a promising target in the treatment of ovarian cancer.
Source: Cellular Oncology - February 26, 2017 Category: Cancer & Oncology Source Type: research

Chemotherapy With Si-Rna And Anti-Cancer Drugs.
Abstract To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agents exhibit multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene. It is a well known fact that intake of more drugs can le...
Source: Current Drug Delivery - May 18, 2017 Category: Drugs & Pharmacology Authors: Kaur K, Rath G, Chandra S, Singh R, Goyal AK Tags: Curr Drug Deliv Source Type: research

LIM kinase 1 serves an important role in the multidrug resistance of osteosarcoma cells.
Authors: Yang JZ, Huang LH, Chen R, Meng LJ, Gao YY, Ji QY, Wang Y Abstract Multidrug resistance (MDR) is a major challenge for the management of the majority of cancers. The precise molecular mechanisms of MDR remain elusive. In a previous study, a multidrug resistant osteosarcoma model [MG63/vincristine (VCR)] was established by intermittent exposure of MG63 cells to gradually increasing concentrations of VCR. These cells exhibited cross-resistance to multiple structurally and mechanistically unrelated chemotherapeutic agents. The development of MDR was associated with increased expression of LIM kinase 1 (LIMK1)...
Source: Oncology Letters - February 3, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions
In this study, we explored the hypothesis by which AL reversed 5-Fu or DDP resistance in gastric cancer and the underlying molecular mechanism. Here, in vitro, the drug-resistant cancer cells were incubated to AL or DDP alone or the combination of AL and DDP. Then, MTT, colony formation, Hoechst 33258, flow cytometry and western blot analysis were used to investigate the effects of AL in the regulation of drug-resistance gastric cancer cells. The results indicated that AL treatment markedly re-sensitizes the drug resistant cells (SGC-7901/5-Fu and SGC-7901/DDP) to cytotoxicity of 5-Fu or DDP. Molecular mechanism analysis i...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions.
In this study, we explored the hypothesis by which AL reversed 5-Fu or DDP resistance in gastric cancer and the underlying molecular mechanism. Here, in vitro, the drug-resistant cancer cells were incubated to AL or DDP alone or the combination of AL and DDP. Then, MTT, colony formation, Hoechst 33258, flow cytometry and western blot analysis were used to investigate the effects of AL in the regulation of drug-resistance gastric cancer cells. The results indicated that AL treatment markedly re-sensitizes the drug resistant cells (SGC-7901/5-Fu and SGC-7901/DDP) to cytotoxicity of 5-Fu or DDP. Molecular mechanism analysis i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2018 Category: Drugs & Pharmacology Authors: Guo XF, Liu JP, Ma SQ, Zhang P, Sun WD Tags: Biomed Pharmacother Source Type: research

Reversal of Multidrug Resistance in an Epirubicin-Resistant Gastric Cancer Cell Subline
Conclusions: ABCB1 knockdown decreased EPI efflux and increased EPI sensitivity in AGS/EPI cells. This result provides a novel strategy for targeted gene therapy to reverse EPI resistance in gastric cancer. PMID: 29801407 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - May 31, 2018 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Up-regulation of P-gp via NF- κB activation confers protection against oxidative damage in the retinal pigment epithelium cells.
In conclusion, P-gp can provide moderate cytoprotection for the human RPE cells by ameliorating the mitochondrial dysfunction and NF-κB activation may be a potential regulator of P-gp expression response to oxidative stress. PMID: 30496729 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - November 26, 2018 Category: Opthalmology Authors: Feng Q, Yang W, Gao Z, Ruan X, Zhang Y Tags: Exp Eye Res Source Type: research

TNF α Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis.
CONCLUSION: Our findings indicated that TNFα induces hepatic MRP4 expression through activation of the p38-E2F1-Nrf2 signaling pathway in human obstructive cholestasis. PMID: 31637886 [PubMed - in process]
Source: Yonsei Medical Journal - October 23, 2019 Category: Universities & Medical Training Authors: Lian W, Liu X, Chen W Tags: Yonsei Med J Source Type: research

Modulation of ABCG2 surface expression by Rab5 and Rab21 to overcome multi drug resistance in cancer cells.
Abstract 1. Human ABCG2 is a half transporter implicated in drug efflux and development of multidrug resistance (MDR) in cancer cells. Here we present the regulatory effects of early endocytic Rab GTPases, Rab5A and Rab21 on ABCG2.2. ABCG2 was stably expressed in MCF-7 cells (MCF-7/G2). Rab5A and Rab21 was manipulated in MCF-7/G2 cells by co expression or siRNA knockdown and their effect on ABCG2 mediated drug efflux was quantified using fluorescence microscopy.3. The ectopically expressed ABCG2 was predominantly confined to the plasma membrane and was capable of drug efflux. Expression of constitutively active Ra...
Source: Xenobiotica - January 12, 2020 Category: Research Authors: Yousaf M, Ali M Tags: Xenobiotica Source Type: research

Z-guggulsterone regulates MDR1 expression mainly through the pregnane X receptor-dependent manner in human brain microvessel endothelial cells.
Abstract Recently studies showed that pregnane X receptor (PXR) was expressed in human brain microvessel endothelial cells and coordinately induced multidrug resistance protein 1 (MDR1) expression. The present study aimed to investigate the regulatory effect of Z-guggulsterone on MDR1 in human brain microvessel endothelial cells, and explored whether it involved modulation of PXR. The results showed that Z-guggulsterone (30 μM) simultaneously inhibited the expression of PXR and MDR1 at 24 h in human brain-derived microvessel endothelial cells (hBDMECs). Meanwhile, the levels of PXR and MDR1 expression were si...
Source: European Journal of Pharmacology - February 18, 2020 Category: Drugs & Pharmacology Authors: Xu HB, Tang ZQ, Wang J, Kong PS Tags: Eur J Pharmacol Source Type: research

Enrichment of CD44 in Exosomes From Breast Cancer Cells Treated With Doxorubicin Promotes Chemoresistance
In conclusion, breast cancer cells could spread resistance capacity by the intercellular transfer of proteins, especially CD44, via exosomes.
Source: Frontiers in Oncology - July 13, 2020 Category: Cancer & Oncology Source Type: research

Bim downregulation by activation of NF- κB p65, Akt, and ERK1/2 is associated with adriamycin and dexamethasone resistance in multiple myeloma cells
In this study, we examined the MDR mechanism in adriamycin- and dexamethasone-resistant cells. RPMI8226/ADM, ARH-77/ADM, RPMI8226/DEX, and ARH-77/DEX cells exhibited enhanced nuclear factor κB (NF-κB) p65, Akt, and extracellular signal-regulated kinase 1/2 (ERK1/2) activation. Combination treatment with NF-κB p65, phosphoinositide 3-kinase (PI3K), and mitogen-activated protein kinase 1/2 (MEK1/2) inhibitors resensitized to adriamycin and dexamethasone via increased Bim expression. A lthough treatment with MDR1 or Survivin siRNA did not overcome adriamycin and dexamethasone resistance in RPMI8226/ADM and RPMI8226/DEX cel...
Source: Clinical and Experimental Medicine - November 30, 2022 Category: Research Source Type: research

Frizzled-3 suppression overcomes multidrug chemoresistance by Wnt/ β-catenin signaling pathway inhibition in hepatocellular carcinoma cells
This study aimed to identify a potential target in HCC chemotherapy. The FZD3 expression variant in HCC cell lines was detected by RT-qPCR and western blotting. The FZD3 expression in the early recurrent HCC group (RE group) and the non-early recurrent HCC group (non-RE group) was measured by RT-qPCR. Then, the 50% inhibitory concentrations (IC50) in HCC cell lines were studied by MTT assay. TOP/FOP FLASH luciferase assay was performed to measure TCF-binding activities. We found that FZD3 was upregulated in three HCC cell lines, and the FZD3 expression was significantly higher in the RE group than in the non-RE group (P = ...
Source: Journal of Chemotherapy - February 27, 2023 Category: Cancer & Oncology Authors: Zifan Meng Qing Liu Yanfei Liu Yuanming Yang Changfeng Shao Shaoqiang Zhang Source Type: research