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Condition: Multidrug Resistance

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Total 957 results found since Jan 2013.

Interleukin-6: A Critical Cytokine in Cancer Multidrug Resistance.
Abstract Multidrug resistance (MDR) is a phenomenon through which tumor cells develop resistance against the cytotoxic effects of various structurally and mechanistically unrelated chemotherapeutic agents. The most consistent feature in MDR is overexpression and/or overactivity of ATP-dependent drug efflux transporters. Other mechanisms such as overexpression of drug-detoxifying enzymes and alterations in pro-survival or pro-death signaling pathways are also responsible for MDR. Inflammatory mediators including interleukin-6 (IL-6) play important roles in various events during inflammation and are also involved in...
Source: Current Pharmaceutical Design - November 24, 2015 Category: Drugs & Pharmacology Authors: Ghandadi M, Sahebkar A Tags: Curr Pharm Des Source Type: research

Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells
Publication date: 1 April 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 140 Author(s): Jijin Gu, Junguo Hao, Xiaoling Fang, Xianyi Sha Generally, the major obstacles for efficient gene delivery are cellular internalization and endosomal escape of nucleic acid such as plasmid DNA (pDNA) or small interfering RNA (siRNA). We previously developed Pluronic P123 modified polypropyleneimine (PPI)/pDNA (P123-PPI/pDNA) polyplexes as a gene delivery system. The results showed that P123-PPI/pDNA polyplexes revealed higher transfection efficiency than PPI/pDNA polyplexes in multidrug resistant breast cancer cells. A...
Source: Colloids and Surfaces B: Biointerfaces - January 11, 2016 Category: Biochemistry Source Type: research

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters.
CONCLUSION: The amino acid transporters located at the apical side of the syncytiotrophoblast (STB) manage uptake of MeHg. Mercury conjugated to glutathione (GSH) is effluxed via MRP1 localized to the basal side of the STB. The findings can well explain why mercury is transported primarily towards the fetal side. PMID: 26740192 [PubMed - as supplied by publisher]
Source: Toxicology - December 28, 2015 Category: Toxicology Authors: Straka E, Ellinger I, Balthasar C, Scheinast M, Schatz J, Szattler T, Bleichert S, Saleh L, Knöfler M, Zeisler H, Hengstschläger M, Rosner M, Salzer H, Gundacker C Tags: Toxicology Source Type: research

CD56 and RUNX1 isoforms in AML prognosis and their therapeutic potential
Publication date: Available online 12 December 2015 Source:Hematology/Oncology and Stem Cell Therapy Author(s): Syed Z.A. Zaidi, Ibraheem H. Motabi, Ali Al-Shanqeeti Neural cell adhesion molecule (NCAM/CD56) expression in acute myeloid leukemia (AML) has been associated with extramedullary leukemia, multidrug resistance, shorter remission and survival. Recently, Bloomfield et al. published a succinct review of issues surrounding the AML prognostication and current therapeutics. However, we want to reiterate the prognostic value and therapeutic potential of CD56 that is frequently expressed in AML as was also reported ...
Source: Hematology Oncology and Stem Cell Therapy - March 7, 2016 Category: Cancer & Oncology Source Type: research

Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia.
This study indicated that α(1,2)-fucosyltransferase involved in the development of MDR of CML cells probably through FUT1 regulated the activity of EGFR/MAPK signaling pathway and the expression of P-gp. PMID: 26986216 [PubMed - as supplied by publisher]
Source: Oncology Reports - March 19, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma.
Authors: Kataoka J, Shiraha H, Horiguchi S, Sawahara H, Uchida D, Nagahara T, Iwamuro M, Morimoto H, Takeuchi Y, Kuwaki K, Onishi H, Nakamura S, Takaki A, Nouso K, Yagi T, Yamamoto K, Okada H Abstract Runt-related transcription factor 3 (RUNX3) is known to function as a tumor suppressor in gastric cancer and other types of cancers, including hepatocellular carcinoma (HCC). However, its role has not been fully elucidated. In the present study, we aimed to evaluate the role of RUNX3 in HCC. We used the human HCC cell lines Hep3B, Huh7 and HLF; RUNX3 cDNA was introduced into Hep3B and Huh7 cells, which were negative f...
Source: Oncology Reports - March 19, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Don´t trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface
While investigating placental mercury transport, we validated specificity of commercial antibodies against four candidate transporters (Large neutral amino acids transporter (LAT)1, LAT2, 4F2 cell-surface antigen heavy chain (4F2hc), and multidrug resistance-associated protein (MRP)2) by immunoblotting and small interfering RNA (siRNA)-mediated protein knockdown. An anti-4F2hc- and one anti-LAT1-antibody were specific. Another anti-LAT1-antibody reacted with LAT2. Two anti-LAT2-antibodies detected mainly albumin in placental lysates.
Source: Placenta - April 18, 2016 Category: Reproduction Medicine Authors: Isabella Ellinger, Waranya Chatuphonprasert, Martin Reiter, Agnes Voss, Jost Kemper, Elisabeth Straka, Matthias Scheinast, Harald Zeisler, Hans Salzer, Claudia Gundacker Tags: Technical note Source Type: research

Don't trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface
While investigating placental mercury transport, we validated specificity of commercial antibodies against four candidate transporters (Large neutral amino acids transporter (LAT)1, LAT2, 4F2 cell-surface antigen heavy chain (4F2hc), and multidrug resistance-associated protein (MRP)2) by immunoblotting and small interfering RNA (siRNA)-mediated protein knockdown. An anti-4F2hc- and one anti-LAT1-antibody were specific. Another anti-LAT1-antibody reacted with LAT2. Two anti-LAT2-antibodies detected mainly albumin in placental lysates.
Source: Placenta - April 18, 2016 Category: Reproduction Medicine Authors: Isabella Ellinger, Waranya Chatuphonprasert, Martin Reiter, Agnes Voss, Jost Kemper, Elisabeth Straka, Matthias Scheinast, Harald Zeisler, Hans Salzer, Claudia Gundacker Tags: Technical note Source Type: research

Silencing of long non-coding RNA ANRIL inhibits the development of multidrug resistance in gastric cancer cells.
Authors: Lan WG, Xu DH, Xu C, Ding CL, Ning FL, Zhou YL, Ma LB, Liu CM, Han X Abstract The development of multidrug resistance (MDR) is a crucial cause of therapy failure in gastric cancer, which results in disease recurrence and metastasis. Long non-coding RNAs (lncRNAs) have been proven to be critical in carcinogenesis and metastasis of gastric cancer. However, little is known about the roles of ANRIL (antisense non-coding RNA in the INK4 locus) in gastric cancer MDR. The aim of our study is to identify the biological function of ANRIL in gastric cancer MDR. In our results, ANRIL was highly expressed in gastric c...
Source: Oncology Reports - April 30, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3
P-glycoprotein (P-gp) is encoded by the multidrug resistance (MDR1) gene and is well studied as a multi-drug resistance transporter. Peritoneal adhesion formation following abdominal surgery remains an important clinical problem. Here, we found that P-gp was highly expressed in human adhesion fibroblasts and promoted peritoneal adhesion formation in a rodent model. Knockdown of P-gp expression by intraperitoneal injection of MDR1-targeted siRNA significantly reduced both the peritoneal adhesion development rate and adhesion grades. Additionally, we found that operative injury up-regulated P-gp expression in peritoneal fibr...
Source: Theranostics - June 5, 2016 Category: Molecular Biology Authors: Lulu Deng, Qin Li, Guixian Lin, Dan Huang, Xuxin Zeng, Xinwei Wang, Ping Li, Xiaobao Jin, Haifeng Zhang, Chunmei Li, Lixin Chen, Liwei Wang, Shulin Huang, Hongwei Shao, Bin Xu, Jianwen Mao Tags: Research Paper Source Type: research

Profiling gene mutations, translocations, and multidrug resistance in pediatric acute lymphoblastic leukemia: a step forward to personalizing medicine
Abstract Precise risk stratification and tailored therapy in acute lymphoblastic leukemia (ALL) can lead to enhanced survival rates among children. Translocations and mutations along with multidrug resistance markers are important factors that determine therapeutic efficacy. Gene mutation profiling of patients at the time of diagnosis can offer accurate clinical decision-making. Multiplex PCR was used to screen for various translocations, mutations, and P-glycoprotein (P-gp) status in pediatric ALL samples. The roles of P-gp were analyzed at the transcriptional and translational levels by using real-time PCR and immunoblo...
Source: Medical Oncology - July 22, 2016 Category: Cancer & Oncology Source Type: research

Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cells.
In conclusion, inhibition of PXR-mediated pathways could be a novel means of augmenting sensitivity, or overcoming resistance to anticancer agents for ovarian cancer. PMID: 27572875 [PubMed - in process]
Source: International Journal of Oncology - August 31, 2016 Category: Cancer & Oncology Authors: Masuyama H, Nakamura K, Nobumoto E, Hiramatsu Y Tags: Int J Oncol Source Type: research

Doxorubicin and siRNA Codelivery via Chitosan-Coated pH-Responsive Mixed Micellar Polyplexes for Enhanced Cancer Therapy in Multidrug-Resistant Tumors
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.6b00776
Source: Molecular Pharmaceutics - November 8, 2016 Category: Drugs & Pharmacology Authors: Adeel Masood Butt, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Nor Azian Abdul Murad, Rahman Jamal and Prashant Kesharwani Source Type: research

Targeting autophagy augments the activity of DHA-E3 to overcome p-gp mediated multi-drug resistance.
In this study, we further evaluated the reversal effect of DHA-E3 on MDR and explored its mechanism of action in vitro. Our findings showed that DHA-E3 significantly potentiated the cytotoxicity of vincristine(VCR) and adriamycin(ADR) in the P-gp over-expressing KB/VCR and A02 cells. The mechanistic study found that DHA-E3 increased the intracellular accumulation of ADR and rhodamine-123 by directly inhibiting the drug-transport activity of P-gp. In the present study, we found that DHA-E3 not only reversed MDR, but also induced autophagy in MDR cancer cells. To determine whether DHA-E3-induced autophagy is an adaptive surv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 4, 2016 Category: Drugs & Pharmacology Authors: Xi G, Wang M, Sun B, Shaikh AS, Liu Y, Wang W, Lou H, Yuan H Tags: Biomed Pharmacother Source Type: research

The Zuo Jin Wan Formula Induces Mitochondrial Apoptosis of Cisplatin-Resistant Gastric Cancer Cells via Cofilin-1.
Authors: Tang QF, Sun J, Yu H, Shi XJ, Lv R, Wei HC, Yin PH Abstract Despite the status of cisplatin (DDP) as a classical chemotherapeutic agent in the treatment of cancer, the development of multidrug resistance often leads to a failure of DDP therapy. Here we found that phosphorylated cofilin-1 (p-cofilin-1) was overexpressed in the DDP-resistant human gastric cancer cell lines SGC7901/DDP and BGC823/DDP, relative to the respective parent cell lines (SGC7901 and BGC823), and that DDP induced the dephosphorylation of p-cofilin-1 in both parent lines but not in the DDP-resistant lines. However, we noted that the tr...
Source: Evidence-based Complementary and Alternative Medicine - November 24, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research