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Condition: Multidrug Resistance

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Total 957 results found since Jan 2013.

Enzyme-sensitive nanoparticles, smart TAT and cetuximab conjugated immunoliposomes to overcome multidrug resistance in breast cancer cells
Toxicol Appl Pharmacol. 2022 Mar 18:115989. doi: 10.1016/j.taap.2022.115989. Online ahead of print.ABSTRACTDue to recent advances in the field of small molecule-based drugs, designing an efficient siRNA delivery system seems essential. Here, modified sets of lipids conjugated with cell-penetrating TAT peptide, MMP2 enzyme-sensitive moiety, and cetuximab antibodies against the EGF receptor were synthesized, purified and verified on HPLC, TLC, SEM, and DLS analyses. Different cellular and molecular experiments were designed to evaluate the transfection efficiency, targeting properties, and functions, including cytotoxicity a...
Source: Toxicology and Applied Pharmacology - March 22, 2022 Category: Toxicology Authors: Mohsen Safaei Pegah Khosravian Sedighe Kazemi Sheykhshabani Gashtasb Mardani Fatemeh Elahian Seyed Abbas Mirzaei Source Type: research

Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1
Conclusions: This study demonstrates that drug resistance can be effectively reversed in adriamycin-resistant breast carcinoma cells through delivery of siRNAs targeting ETS1.
Source: Cancer Cell International - March 7, 2014 Category: Cancer & Oncology Authors: Jinrong WeiYong ZhouGuo-Qin JiangDong Xiao Source Type: research

Reversal of multidrug resistance in breast cancer MCF-7/ADR cells by h-R3-siMDR1-PAMAM complexes
In this study, anti-EGFR antibody h-R3 was designed to self-assembled h-R3-siRNA-PAMAM-complexes (HSPCs) via electrostatic interactions for siRNA delivery. The physicochemical characterization, cell uptake, MDR1 silencing efficiency, cell migration, cell growth and cell apoptosis were investigated. The HSPCs presented lower cytotoxicity, higher cellular uptake and enhanced endosomal escape ability. Also, HSPCs encapsulating siMDR1 knockdowned 99.4% MDR1 gene with up to ∼6 times of enhancement compared to naked siMDR1, increased the doxorubicin accumulation, down-regulated P-glycoprotein (P-gp) expression and suppressed c...
Source: International Journal of Pharmaceutics - July 25, 2016 Category: Drugs & Pharmacology Source Type: research

Notch1 is associated with the multidrug resistance of hypoxic osteosarcoma by regulating MRP1 gene expression.
In this study, to further evaluate the role of hypoxia and Notch1 on drug resistance of OS, we investigated the influence of inhibiting Notch1 pathway by Notch1 small interference RNA (siRNA) on human MG-63 OS cells in hypoxia. Our data showed that hypoxia promoted OS cell proliferation, induced the G0/G1-S-G2/M phase transition, and increased multidrug resistance of human OS cells. Western blot analysis suggested that hypoxia increased the expression of HIF-1α, Notch1, and multidrug resistance protein-1 (MRP1) in human OS cells. Notch1 siRNA inhibits proliferation and increases apoptosis of hypoxic OS cells. Finally, the...
Source: Neoplasma - July 28, 2016 Category: Cancer & Oncology Authors: Li C, Guo D, Tang B, Zhang Y, Zhang K, Nie L Tags: Neoplasma Source Type: research

Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF- κB gene transcription.
CONCLUSION: Metformin via silencing NF-κB signaling could effectively reverse MDR of HCC cells by down-regulating MDR1/P-gp expression. PMID: 27621764 [PubMed]
Source: World Journal of Hepatology - September 15, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Guggulsterone sensitized drug-resistant human hepatocarcinoma cells to doxorubicin through a Cox-2/P-gp dependent pathway.
Abstract Previous researches indicated that cyclooxygenase-2 (Cox-2) might be involved in P-glycoprotein (P-gp)-mediated multidrug resistance in hepatocellular carcinoma cells. Doxorubicin-resistant hepatocellular carcinoma PLC/PRF/5 cells (PLC/PRF/5R) and HepG2 (HepG2R) cells were developed in the present study. The modulatory effect of guggulsterone on Cox-2 and P-gp in PLC/PRF/5R and HepG2R cells was investigated. Cells proliferation, Cox-2 and P-gp expression, and prostaglandin E2 release were examined using MTT, flow cytometry, western blot and ELISA assays. Small interfering RNA (siRNA) targeted against Cox-...
Source: European Journal of Pharmacology - March 23, 2017 Category: Drugs & Pharmacology Authors: Xu HB, Fu J, Huang F, Yu J Tags: Eur J Pharmacol Source Type: research

Wip1 gene silencing enhances the chemosensitivity of human colon cancer cells.
Authors: Xia ZS, Wu D, Zhong W, Lu XJ, Yu T, Chen QK Abstract Colon cancer is one of the most common cancers in the world. Multidrug resistance is one of the main reasons for failure of therapy in patients with advanced colon cancer. In previous studies, multiple methods were investigated to reverse the multidrug resistance of colon cancer cells. However, to date, no clinical method has been identified to be satisfactory. Therefore, successful reversal of drug resistance in colon cancer cells still requires new therapeutic strategies or pharmaceuticals. Wild-type p53-induced phosphatase (Wip1), a member of the 2C t...
Source: Oncology Letters - August 9, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cancers, Vol. 11, Pages 1330: Transport-Mediated Oxaliplatin Resistance Associated with Endogenous Overexpression of MRP2 in Caco-2 and PANC-1 Cells
In conclusion, oxaliplatin is a substrate of MRP2 with possibly two binding sites, and silencing MRP2 increased oxaliplatin accumulation and cytotoxicity in two widely available gastrointestinal tumour lines (PANC-1 and Caco-2).
Source: Cancers - September 7, 2019 Category: Cancer & Oncology Authors: Riya Biswas Piyush Bugde Ji He Fabrice Merien Jun Lu Dong-Xu Liu Khine Myint Johnson Liu Mark McKeage Yan Li Tags: Article Source Type: research

Expressions of CD44, PCNA and MRP1 in lung cancer tissues and their effects on proliferation and invasion abilities of lung cancer cell line 95D
CONCLUSION: CD44, PCNA and MRP1, which may be involved in the regulation of the proliferation and invasion abilities of lung cancer cells, may serve as new molecular targeting markers for the diagnosis and treatment of lung cancer.PMID:33721434
Source: Journal of B.U.ON. - March 15, 2021 Category: Cancer & Oncology Authors: Xudong Chen Jinlin Sun Yansen Wang Source Type: research