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Condition: Multidrug Resistance

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Total 957 results found since Jan 2013.

Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans.
Abstract Lifespan extension is an all systems encompassing event. Involvement of reduced insulin/IGF1 signalling is well worked out, first in the model organism Caenorhbaditis elegans followed by other systems including humans. But the role of neuronal component in lifespan extension is not well understood due to the refractory nature of neurons to small RNA interference (sRNAi) in C. elegans. Earlier, we have demonstrated that an antihypertensive drug, reserpine, extends lifespan through modulation of neurotransmitter release, especially, acetylcholine, in C. elegans. Intriguingly, the reserpine mediated lifespan...
Source: Journal of Biosciences - November 30, 2016 Category: Biomedical Science Authors: Saharia K, Kumar R, Gupta K, Mishra S, Subramaniam JR Tags: J Biosci Source Type: research

CLIC1 induces drug resistance in human choriocarcinoma through positive regulation of MRP1.
In conclusion, our results suggest that CLIC1 may serve as a critical mediator of chemoresistance in human choriocarcinoma JeG3 cells. The CLIC1-mediated chemoresistance is achieved through positive regulation of MRP1. Depletion of either CLIC1 or its downstream MRP1 may be a promising therapeutic strategy concerning reversing the chemo-resistance in human choriocarcinoma JeG3 cells. PMID: 27983917 [PubMed - as supplied by publisher]
Source: Oncology Research - December 18, 2016 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity Cell Biology
Nitric oxide (NO) is integral to macrophage cytotoxicity against tumors due to its ability to induce iron release from cancer cells. However, the mechanism for how activated macrophages protect themselves from endogenous NO remains unknown. We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1). These prior studies also showed that MRP1 and GSTP1 protect tumor cells against NO cytotoxicity, which parallels their roles i...
Source: Journal of Biological Chemistry - December 29, 2016 Category: Chemistry Authors: Hiu Chuen Lok, Sumit Sahni, Patric J. Jansson, Zaklina Kovacevic, Clare L. Hawkins, Des R. Richardson Tags: Cell Biology Source Type: research

Role of 14-3-3 Sigma in over-expression of P-gp by Rifampin and Paclitaxel stimulation through interaction with PXR.
In this study, we presented the role of 14-3-3σ to activate CK2-Hsp90β-PXR-MDR1 pathway on rifampin and paclitaxel treated LS174T cells and in vivo LS174T cell-xenografted nude mouse model. Following several in vitro and in vivo experiments, rifampin and paclitaxel were found to be stimulated the CK2-Hsp90β-PXR-MDR1 pathway. Of the proteins in this pathway, Pregnane X receptor (PXR) is a representative transcription factor of multidrug resistance protein 1 (MDR1). We constructed FLAG-PXR-LS174T stable cell lines and discovered 22 proteins that interacted with PXR on rifampin treatment. Among them, Hsp90β and 14-3-3σ w...
Source: Cellular Signalling - January 6, 2017 Category: Cytology Authors: Kim SW, Hasanuzzaman M, Cho M, Kim NH, Choi HY, Han JW, Park HJ, Oh JW, Shin JG Tags: Cell Signal Source Type: research

Targeting BCRP/ABCG2 by RNA interference enhances the chemotherapy sensitivity of human colon cancer side population cells
This study isolated side population (SP) cells from a colon cancer cell line (Colo-320) and examined their self-renewal and differentiation abilities. Compared to non-SP (NSP) cells, SP colon cancer cells were more tumorigenicin vivo and exhibited more invasive characteristics and a greater ability to form colonies. Additionally, more cells were in G0/G1 phase and more highly expressed the multidrug resistance protein BCRP/ABCG2. We achieved enhanced chemotherapy sensitivity by transfecting SP cells with a hairpin-like, small interfering RNA (siRNA) eukaryotic expression plasmid targeting BCRP/ABCG2.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 1, 2017 Category: Research Source Type: research

Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance
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Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 10, 2017 Category: Biotechnology Authors: Miao Yu Shangcong Han Zhongai Kou Jialing Dai Jiao Liu Chen Wei Yitong Li Lutao Jiang Yong Sun Source Type: research

Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901.
In conclusion, we suggest that GAS contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1. PMID: 28498440 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - May 4, 2017 Category: Cancer & Oncology Authors: Zhuang K, Zhang L, Zhang X, Tang H, Zhang J, Yan Y, Han K, Guo H Tags: Int J Oncol Source Type: research

Identification of DJ ‐1 as a contributor to multidrug resistance in human small‐cell lung cancer using proteomic analysis
Summary Proteomic approaches have been proven to provide an important tool in identifying drug resistance‐associated proteins. The aim of this study was to investigate the protein profiling of drug resistance‐related proteins in small‐cell lung cancer (SCLC) by proteomic analysis. The proteomic profiling was performed by two‐dimensional fluorescence difference gel electrophoresis (2D‐DIGE) coupled with MALDI‐TOF‐TOF of SCLC in the multidrug‐resistant cell line H69AR and its parental cell line H69. A total of 11 proteins were identified to be >2‐fold up‐or downregulated between the two cell lines. DJ...
Source: International Journal of Experimental Pathology - June 5, 2017 Category: Pathology Authors: Hongyi Gao, Yuchun Niu, Man Li, Shun Fang, Linlang Guo Tags: Original Article Source Type: research

ΔNp73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report
ConclusionsOur data support a role for ΔNp73 in the multidrug-resistance of breast cancer and melanoma cells.
Source: Cellular Oncology - July 4, 2017 Category: Cancer & Oncology Source Type: research

Increased EGFR expression induced by a novel oncogene, CUG2, confers resistance to doxorubicin through Stat1-HDAC4 signaling
ConclusionTaken together, we conclude that CUG2-induced EGFR upregulation confers doxorubicin resistance to lung (cancer) cells through Stat1-HDAC4 signaling.
Source: Cellular Oncology - August 3, 2017 Category: Cancer & Oncology Source Type: research

In vitro studies of phospholipid-modified PAMAM-siMDR1 complexes for the reversal of multidrug resistance in human breast cancer cells
In this study, we designed a new carrier system loaded with a functional siRNA targeting MDR1 gene to reverse multi-drug resistance (MDR) in human breast cancer MCF-7/ADR cells. Phospholipid-modified PAMAM-siMDR1 complexes were designed on the external decoration of polyamidoamine (PAMAM) with phospholipid (PL) and the electrostatical interaction between PAMAM and siMDR1 to form hybrid nanocomplexes (PL-dendriplexes). Compared with siMDR1 and dendriplexes (PAMAM-siMDR1), this delivery system represented higher gene silencing efficiency, enhanced cellular uptake of siMDR1, decreased p-gp expression, raised cellular accumula...
Source: International Journal of Pharmaceutics - August 5, 2017 Category: Drugs & Pharmacology Source Type: research

Identification of 2,4-dihydroxy-5-pyrimidinyl imidothiocarbomate as a novel inhibitor to Y box binding protein-1 (YB-1) and its therapeutic actions against breast cancer.
In this study, we determined that DPI was toxic to breast cancer cell lines as individual drug as well as in combination with DOX. Moreover, immunofluorescence and confocal studies showed that DPI decreases DOX induced YB-1 nuclear translocation and increases DOX accumulation in breast cancer cell line. A G1/G0 phase cell cycle arrest and apoptosis was also induced by DPI. Moreover, DPI modulated YB-1 downstream targets such as p53, caspase-3, CDK-1 which are involved in cell cycle progression and apoptosis. Further, metastatic functional analysis revealed that DPI inhibits cell adhesion, migration, invasion in aggressive ...
Source: European Journal of Pharmaceutical Sciences - September 12, 2017 Category: Drugs & Pharmacology Authors: Gunasekaran VP, Nishi K, Sivakumar D, Sivaraman T, Mathan G Tags: Eur J Pharm Sci Source Type: research

Activation of insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17 β-D-glucuronide-induced cholestasis in rats.
In conclusion, the activation of IGF-1R is a key factor in the alteration of canalicular transporter function and localization induced by E17G, and its activation follows that of GPR30 and precedes that of PI3K/Akt. PMID: 29090346 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - October 31, 2017 Category: Toxicology Authors: Barosso IR, Miszczuk GS, Ciriaci N, Andermatten RB, Maidagan PM, Razori V, Taborda DR, Roma MG, Crocenzi FA, Sánchez Pozzi EJ Tags: Arch Toxicol Source Type: research

Increase in CIP2A expression is associated with cisplatin chemoresistance in gastric cancer.
CONCLUSIONS: Our results suggested that CIP2A oncoprotein plays an important role in DDP resistance of GC and could serve as a novel therapeutic target for the treatment of GC patients with DDP resistance. PMID: 29103022 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - November 6, 2017 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research