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Condition: Multidrug Resistance

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Total 957 results found since Jan 2013.

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells
Conclusions: Our results have indicated the treatment of cells involving use of the siRNA targeting efflux pumps could be a beneficial approach in the future.
Source: BMC Veterinary Research - Latest articles - June 17, 2013 Category: Veterinary Research Authors: Karol Paw¿owskiJoanna MuchaKinga MajchrzakTomasz MotylMagdalena Król Source Type: research

Glycolaldehyde induces cytotoxicity and increases glutathione and multidrug-resistance-associated protein levels in schwann cells.
Abstract Schwann cell injury is observed in diabetic neuropathy. It is speculated that glycolaldehyde (GA), a precursor of advanced glycation end products (AGEs), contributes to the pathogenesis and development of diabetic neuropathy. Here, we demonstrated for the first time that GA at near-physiological concentration decreased the viability of rat Schwann cells. In contrast, methylglyoxal, glyoxal, and 3-deoxyglucosone, all of which are AGE precursors, had no effects on cell viability. It is well known that methylglyoxal causes oxidative damage. In the present study, however, GA failed to induce reactive oxygen s...
Source: Biological and Pharmaceutical Bulletin - July 6, 2013 Category: Drugs & Pharmacology Authors: Sato K, Tatsunami R, Yama K, Tampo Y Tags: Biol Pharm Bull Source Type: research

Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle
Previous studies have identified differences in the expression of proteins that regulate myosin light chain phosphorylation and contraction in tonic and phasic smooth muscle. cGMP plays a critical role in smooth muscle relaxation and is important for optimal function of phasic and tonic smooth muscle. The intracellular cGMP levels are regulated by its hydrolysis via phosphodiesterase 5 (PDE5) and efflux via novel multidrug resistance protein 5 (MRP5). In the present study we tested the hypothesis that the differences in the phasic and tonic behavior of smooth muscles may be related to differences in mechanisms that termina...
Source: AJP: Gastrointestinal and Liver Physiology - August 15, 2013 Category: Gastroenterology Authors: Al-Shboul, O., Mahavadi, S., Sriwai, W., Grider, J. R., Murthy, K. S. Tags: NEUROREGULATION AND MOTILITY Source Type: research

Multidrug Resistance via Lysosomal P-glycoprotein Cell Biology
Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little work has focused on the contribution of Pgp expressed in intracellular organelles to drug resistance. This investigation describes an additional mechanism for understanding how lysosomal Pgp contributes to MDR. These studies were performed using Pgp-expressing MDR cells and their non-resistant counterparts. Using confocal microscopy and lysosomal fractionation, we demonstrated that intracellular Pgp was localized to LAMP2-stained lysosomes. I...
Source: Journal of Biological Chemistry - November 1, 2013 Category: Chemistry Authors: Yamagishi, T., Sahni, S., Sharp, D. M., Arvind, A., Jansson, P. J., Richardson, D. R. Tags: Cell Biology Source Type: research

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro
Abstract: Tumor resistance, especially that mediated by P-glycoprotein (P-gp) and β-III tubulin, is a major obstacle to the efficacy of most microtubule-targeting anticancer drugs in clinics. A novel semisynthetic taxane, 2-debenzoyl-2-(3-azidobenzyl)-10-propionyldocetaxel (Yg-3-46a) was shown to be highly cytotoxic to breast cancer cell lines MCF-7 and MCF/ADR which overexpressed P-gp via long term culture with doxorubicin, and cervical cancer cell lines Hela and Hela/βIII which overexpressed βIII-tubulin via stable transfection with TUBB3 gene. siRNA transfection experiments also confirmed that Yg-3-46a can circumvent...
Source: Cancer Letters - August 29, 2013 Category: Cancer & Oncology Authors: Pei Cai, Peihua Lu, Frances J. Sharom, Wei-Shuo Fang Tags: Research Articles Source Type: research

Role of homeobox gene A5 in multidrug resistance of human small cell lung cancer cells.
CONCLUSION: HOXA5 may play an important role in multidrug resistance of SCLC and can be a potential therapeutic target in clinical treatment of SCLC. PMID: 24273274 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2013 Category: Universities & Medical Training Authors: Xiao FM, Chen ZZ, Zeng XP, Bai YF, Guo LL, Li YF Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
In conclusion, our findings indicate the potential of the PBOX compounds in enhancing chemosensitivity in neuroblastoma. PMID: 24406249 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - January 6, 2014 Category: Drugs & Pharmacology Authors: Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM Tags: Biochem Pharmacol Source Type: research

Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1.
In conclusion, nickel induces a ROS-ceramide pathway to cause apoptotic cell death as well as activate adaptive survival responses, including upregulation of ABCB1, which improves cell survival by extruding proapoptotic (glucosyl)ceramides. PMID: 24448832 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - January 22, 2014 Category: Toxicology Authors: Dahdouh F, Raane M, Thévenod F, Lee WK Tags: Arch Toxicol Source Type: research

Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.
Abstract During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A (FERO), a novel furanocoumarin, shows toxicity toward A549RT-eto cells in a dose- and time‑dependent manner. FERO reduced the expression of NF-κB, leading to downregulation of P-glycoprotein (P-gp), encoded by MDR1, which eventually sensitized A549RT-eto cells to apoptosis. FERO specifically diminished transcription and promoter activity of MDR1 but did not inhibit the expression of other multidrug resistance genes MRP2 an...
Source: International Journal of Oncology - February 22, 2014 Category: Cancer & Oncology Authors: Kaewpiboon C, Surapinit S, Malilas W, Moon J, Phuwapraisirisan P, Tip-Pyang S, Johnston RN, Koh SS, Assavalapsakul W, Chung YH Tags: Int J Oncol Source Type: research

Vimentin silencing effect on invasive and migration characteristics of doxorubicin resistant MCF-7 cells.
In this study, MCF-7 cell line which is a model for human mammary carcinoma, and a doxorubicin resistant subline (MCF-7/Dox) were used. The resistant subline was previously obtained by stepwise selection in our laboratory. In the resistant cells, high levels of vimentin expression were observed. The main purpose of this study was to investigate changes in invasive and migration characteristics of MCF-7/Dox cell line, after transient silencing of vimentin gene by specific siRNA. PMID: 24612689 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 13, 2014 Category: Drugs & Pharmacology Authors: Tezcan O, Gündüz U Tags: Biomed Pharmacother Source Type: research

MGr1‐Ag/37LRP induces cell adhesion‐mediated drug‐resistance via FAK/PI3K and MAPK pathway in gastric cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - April 7, 2014 Category: Cancer & Oncology Authors: Li Sun, Lili Liu, Xiangqiang Liu, Yafang Wang, Mengbin Li, Liping Yao, Jianjun Yang, Genlin Ji, Changcun Guo, Yanglin Pan, Shuhui Liang, Biaoluo Wang, Jie Ding, Hongwei Zhang, Yongquan Shi Tags: Original Article Source Type: research

A Tamoxifen Derivative, N,N-Diethyl-2-4-(phenylmethyl) phenoxy Ethanamine, Selectively Targets P-glycoprotein-Positive Multidrug Resistant Chinese Hamster Cells.
In this study we examined the effects of DPPE alone on the growth of drug sensitive and P-gp positive CHO cell line. Our results demonstrate DPPE is selectively toxic to P-gp positive cells and the sensitivity to DPPE alone correlated with the levels of P-gp expression. Moreover, in MDR cells, DPPE-induced apoptosis was significantly reduced with Bcl2 overexpression and in the presence of P-gp ATPase inhibitor, PSC833. Furthermore, knockdown of P-gp expression in MDR cells with P-gp-siRNA reversed DPPE sensitivity and increased their sensitivity to doxorubicin and taxol but not to cisplatin. The addition of DPPE to membran...
Source: Biochemical Pharmacology - May 9, 2014 Category: Drugs & Pharmacology Authors: Georges E, Lian J, Laberge R Tags: Biochem Pharmacol Source Type: research

cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway
Multidrug resistance protein 4 (MRP4/ABCC4) has been established as an independent regulator of cyclic AMP (cAMP) levels particularly in vascular smooth muscle cells and in hematopoietic cells. Here, we assessed whether cAMP in turn regulates MRP4. A significant upregulation of MRP4 mRNA and protein by long-term treatment with cAMP-enhancing agents was observed in HeLa cells, smooth muscle cells, and megakaryoblastic leukemia M07e cells. This upregulation was not affected by inhibition of protein kinase A, but could be reverted by inhibitors and siRNA of an alternative cAMP-signaling route involving exchange proteins activ...
Source: Pharmacogenetics and Genomics - October 1, 2014 Category: Genetics & Stem Cells Tags: Rapid Communication Source Type: research

Glucosylceramide synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line.
Abstract Multidrug resistance (MDR) to chemotherapeutic agents is a major obstacle to curative treatment of cancer. In various types of cancers, overexpression of glucosylceramide synthase (GCS) has been observed to be associated with MDR, thus making GCS a target for reversal of resistance. Our previous work demonstrated that GCS and Bcl-2 are co-overexpressed in the K562/A02 leukemia multidrug-resistant cell line compared with its sensitive counterpart, K562. In the present study, we investigated the effects of GCS on apoptosis in K562/A02 and the associated molecular mechanisms. Our results indicate that the in...
Source: International Journal of Hematology - October 4, 2014 Category: Hematology Authors: Wang Q, Zou J, Zhang X, Mu H, Yin Y, Xie P Tags: Int J Hematol Source Type: research

MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule Cells
In conclusion, MDR1/Mdr1 participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.
Source: Toxicological Sciences - October 6, 2014 Category: Toxicology Authors: Wen, X., Gibson, C. J., Yang, I., Buckley, B., Goedken, M. J., Richardson, J. R., Aleksunes, L. M. Tags: Mechanisms Source Type: research