Cancers, Vol. 11, Pages 1330: Transport-Mediated Oxaliplatin Resistance Associated with Endogenous Overexpression of MRP2 in Caco-2 and PANC-1 Cells

In conclusion, oxaliplatin is a substrate of MRP2 with possibly two binding sites, and silencing MRP2 increased oxaliplatin accumulation and cytotoxicity in two widely available gastrointestinal tumour lines (PANC-1 and Caco-2).

Source: Cancers - September 7, 2019 Category: Cancer & Oncology Authors: Riya Biswas Piyush Bugde Ji He Fabrice Merien Jun Lu Dong-Xu Liu Khine Myint Johnson Liu Mark McKeage Yan Li Tags: Article Source Type: research