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Condition: Asthma

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Total 404 results found since Jan 2013.

TIPE2 Inhibits the Expression of Asthma-Related Inflammatory Factors in Hyperstretched Bronchial Epithelial Cells Through the Wnt/ β-Catenin Pathway
In this study, we found that TIPE2 was poorly expressed in hyperstretched human bronchial ep ithelial cells (BEAS-2B). TIPE2 overexpression also significantly suppressed the stretch-induced secretion of asthma-related inflammatory factors (TNF-α, TSLP, MMP-9, and VEGF). In contrast, TIPE2 inhibition significantly promoted the secretion of TNF-α, TSLP, MMP-9, and VEGF. Furthermore, overexp ression of TIPE2 remarkably inhibited the activation of Wnt/β-catenin in hyperstretched BEAS-2B cells, while siTIPE2 activated Wnt/β-catenin in hyperstretched BEAS-2B cells. Further analysis showed that the Wnt/β-catenin signal inhib...
Source: Inflammation - February 9, 2017 Category: Allergy & Immunology Source Type: research

Connexin43 Controls the Myofibroblastic Differentiation of Bronchial Fibroblasts from Asthmatic Patients.
Abstract Pathologic accumulation of myofibroblasts in asthmatic bronchi is regulated by extrinsic stimuli and by the intrinsic susceptibility of bronchial fibroblasts to transforming growth factor-β (TGF-β). The specific function of gap junctions and connexins in this process remained unknown. Here, we investigated the role of connexin (Cx)43 in TGF-β-induced myofibroblastic differentiation of fibroblasts derived from bronchoscopic biopsies of asthmatic patients and non-asthmatic donors. Asthmatic fibroblasts expressed considerably higher levels of Cx43 and were more susceptible to TGF-β1-induced myofibroblast...
Source: Am J Respir Cell Mol... - February 27, 2017 Category: Respiratory Medicine Authors: Paw M, Borek I, Wnuk D, Ryszawy D, Piwowarczyk K, Kmiotek K, Wójcik-Pszczoła KA, Pierzchalska M, Madeja Z, Sanak M, Błyszczuk P, Michalik M, Czyż J Tags: Am J Respir Cell Mol Biol Source Type: research

Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells
In conclusion, these data suggest that dexamethasone increases MKP-1 expression and th is results in the suppression of p38 MAPK signaling leading to the inhibition of cytokine production in human bronchial epithelial cells. These results point to the role of MKP-1 as an important factor in the therapeutic effects of glucocorticoids in the treatment of inflammatory lung diseases.
Source: Inflammation Research - March 14, 2017 Category: Research Source Type: research

O-Aminobenzoyl-S-Nitrosoglutathione: a Fluorogenic, Cell Permeable, Pseudo-Substrate for S-Nitrosoglutathione Reductase.
Abstract S-nitrosoglutathione reductase (GSNOR) is a multifunctional enzyme. It can catalyze NADH-dependent reduction of S-nitrosoglutathione (GSNO); as well as NAD(+)-dependent oxidation of hydroxymethylglutathione (HMGSH; an adduct formed by the spontaneous reaction between formaldehyde and glutathione). While initially recognized as the enzyme that is involved in formaldehyde detoxification, increasing amount of research evidence has shown that GSNOR also plays a significant role in nitric oxide mediated signaling through its modulation of protein S-nitrosothiol abundance via transnitrosation reactions with GSN...
Source: Free Radical Biology and Medicine - April 15, 2017 Category: Biology Authors: Sun BL, Palmer L, Alam SR, Adekoya I, Brown-Steinke K, Periasamy A, Mutus B Tags: Free Radic Biol Med Source Type: research

Autophagy Plays a Role in FSTL1-induced EMT and Airway Remodeling in Asthma.
In this study, we hypothesized that Follistatin-like 1(FSTL1) promotes EMT and airway remodeling by intensifying autophagy. Using transmission electron microscopy (TEM), double membrane autophagosomes were detected in the airways of patients and mice. More autophagosomes were in asthmatic patients and OVA-challenged mice compared to healthy control. The expression of FSTL1 and Beclin1 were upregulated in the airways of asthmatic patients and OVA-challenged mice, accompany with airway EMT and remodeling. In OVA-challenged Fstl1+/- mice, the degree of airway remodeling and autophagy were decreased compared to control mice. T...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 4, 2017 Category: Cytology Authors: Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma
In this study, we hypothesized that Follistatin-like 1 (FSTL1) promotes EMT and airway remodeling by intensifying autophagy. With the use of transmission electron microscopy (TEM), double-membrane autophagosomes were detected in the airways of patients and mice. More autophagosomes were in patients with asthma and OVA-challenged mice compared with healthy controls. The expression of FSTL1 and beclin-1 was upregulated in the airways of patients with asthma and OVA-challenged mice, accompanied by airway EMT and remodeling. In OVA-challenged Fstl1+/– mice, the degree of airway remodeling and autophagy was decreased comp...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2017 Category: Respiratory Medicine Authors: Liu, T., Liu, Y., Miller, M., Cao, L., Zhao, J., Wu, J., Wang, J., Liu, L., Li, S., Zou, M., Xu, J., Broide, D. H., Dong, L. Tags: RESEARCH ARTICLE Source Type: research

A new combination therapy for asthma using dual function dexamethsone-conjugated polyethylenimine and vitamin D binding protein siRNA
Gene Therapy, Published online: 28 August 2017; doi:10.1038/gt.2017.83
Source: Gene Therapy - August 28, 2017 Category: Genetics & Stem Cells Authors: M Choi J Gu M Lee T Rhim Source Type: research

Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation
Publication date: April 2018 Source:Redox Biology, Volume 14 Author(s): John D. Dickinson, Jenea M. Sweeter, Kristi J. Warren, Iman M. Ahmad, Xavier De Deken, Matthew C. Zimmerman, Steven L. Brody The airway epithelium is a broad interface with the environment, mandating well-orchestrated responses to properly modulate inflammation. Classically, autophagy is a homeostatic pathway triggered in response to external cellular stresses, and is elevated in chronic airway diseases. Recent findings highlight the additional role of autophagy in vesicle trafficking and protein secretion, implicating autophagy pathways in complex ce...
Source: Redox Biology - October 3, 2017 Category: Biology Source Type: research

TGF- β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3.
In this study, we set out to investigate the direct effects of TGF-β1 on human airway smooth muscle (HASM) cell shortening and hyperresponsiveness. The dynamics of AHR and single-cell excitation-contraction (E-C) coupling were measured in human precision-cut lung slices (hPCLS) and in isolated HASM cells using supravital microscopy and magnetic twisting cytometry (MTC), respectively. In hPCLS, overnight treatment with TGF-β1 significantly augmented basal and carbachol-induced bronchoconstriction. In isolated HASM cells, TGF-β1 increased basal and methacholine-induced cytoskeletal stiffness in a dose- and time-dependent ...
Source: American Journal of Respiratory Cell and Molecular Biology - October 6, 2017 Category: Molecular Biology Authors: Ojiaku CA, Cao G, Zhu W, Yoo EJ, Shumyatcher M, Himes BE, An SS, Panettieri RA Tags: Am J Respir Cell Mol Biol Source Type: research

IL-1 β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma.
IL-1β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma. Immunol Lett. 2017 Oct 12;192:20-26 Authors: Wu S, Li H, Yu L, Wang N, Li X, Chen W Abstract The manifest and important feature in respiratory diseases, including asthma and COPD (chronic obstructive pulmonary disease), is the increased numbers and hypersecretion of goblet cells and overexpression of mucins, especially Muc5ac. Many proinflammatory cytokines play important roles in goblet cell metaplasia and overproduction of Muc5ac. However, the effect of IL-1β on Muc5ac expression in asthma remains unknown. Here, we detected ...
Source: Immunology Letters - October 12, 2017 Category: Allergy & Immunology Authors: Wu S, Li H, Yu L, Wang N, Li X, Chen W Tags: Immunol Lett Source Type: research

Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma
Conclusion: Our results indicate the potential role of SIRT1 in regulating inflammation by modulation of IL-6 expression in an Akt-dependent manner during allergic asthma.Cell Physiol Biochem 2017;43:1950 –1960
Source: Cellular Physiology and Biochemistry - October 20, 2017 Category: Cytology Source Type: research

Transforming growth factor- β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1.
This article is protected by copyright. All rights reserved. PMID: 29071730 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - October 25, 2017 Category: Physiology Authors: Shaifta Y, MacKay CE, Irechukwu N, O'Brien KA, Wright DB, Ward JPT, Knock GA Tags: J Physiol Source Type: research

The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways.
In conclusion, the FFAR1 promoted airway smooth muscle cell proliferation and p70S6K phosphorylation through MEK/ERK and PI3K/Akt signaling pathways. PMID: 29097424 [PubMed - as supplied by publisher]
Source: Am J Physiol Lung Ce... - November 2, 2017 Category: Respiratory Medicine Authors: Matoba A, Matsuyama N, Shibata S, Masaki E, Emala CW, Mizuta K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma.
Authors: Chen H, Xu X, Cheng S, Xu Y, Xuefei Q, Cao Y, Xie J, Wang CY, Xu Y, Xiong W Abstract Asthma is a chronic T helper type 2 (Th2) cell-mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post-transcriptional level; their role in regulating allergic inflammatio...
Source: Experimental and Therapeutic Medicine - November 7, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

G α12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
Conclusions and ImplicationsGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - November 12, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research