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Condition: Asthma
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Total 404 results found since Jan 2013.
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma
Biomed Pharmacother. 2021 May 26;140:111701. doi: 10.1016/j.biopha.2021.111701. Online ahead of print.ABSTRACTPatients with chronic obstructive asthma (COA) develop airflow obstruction caused by subepithelial fibrosis. Although a disintegrin and metalloproteinase 17 (ADAM17) has been implicated in lung inflammation and tissue fibrosis, its role in airway fibrosis in COA has not been explored. Here, we found marked overexpression of ADAM17, phosphorylated ADAM17, and connective tissue growth factor (CTGF) in human airway fibroblasts from COA patients, compared with those of normal subjects. Similarly, levels of ADAM17, CTGF...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 29, 2021 Category: Drugs & Pharmacology Authors: Jing-Yun Chen Wun-Hao Cheng Kang-Yun Lee Han-Pin Kuo Kian Fan Chung Chia-Ling Chen Bing-Chang Chen Chien-Huang Lin Source Type: research
HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway
CONCLUSION: HMSC-exos could inhibit the differentiation of Th2 cells via the regulation of the miR-146a-5p/SERPINB2 pathway. miR-146a-5p and SERPINB2 could be applied as potential targets for AR treatment.PMID:34095322 | PMC:PMC8140841 | DOI:10.1155/2021/6696525
Source: Journal of Immunology Research - June 7, 2021 Category: Allergy & Immunology Authors: Jing Zhou Yi Lu Wei Wu Yunhai Feng Source Type: research
TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts
This study assessed the effect of calcitriol on PRMT1-dependent fibroblast remodeling in human lung fibroblasts, and allergen-induced asthma in E3-rats. Fibroblasts were activated with thymic stromal lymphopoietin (TLSP); asthma was induced by ovalbumin inhalation in rats. The airway structure was assessed by immunohistology. Protein expression in fibroblasts and activation of the mitogen activated protein kinases were detected by Western-blotting. Transcription factor activation was determined by luciferase reporter assay. PRMT1 action was blocked by siRNA and PRMT-inhibition. Ovalbumin upregulated the expression of TSLP,...
Source: Biochimica et Biophysica Acta - June 20, 2021 Category: Biochemistry Authors: Ai Jin Xuemei Tang Weiqi Zhai Yuwen Li Qingzhu Sun Li Liu Xiaojun Yang Hui Ren Shemin Lu Source Type: research
Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling
Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print.ABSTRACTExaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors (GPCRs) causes airway hyperresponsiveness (AHR) in asthma. Activation of Gq-coupled GPCRs leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP3) and diacylglycerol (DAG). DAG signaling is terminated by the action of DAG kinase (DGK) that converts DAG into phosphatidic acid (PA). Our previous study demonstrated that DGKα and ζ isoform knockout mice are protected from the development of all...
Source: Mol Biol Cell - July 22, 2021 Category: Molecular Biology Authors: Pawan Sharma Santosh K Yadav Sushrut D Shah Elham Javed John M Lim Shi Pan Ajay P Nayak Reynold A Panettieri Raymond B Penn Taku Kambayashi Deepak A Deshpande Source Type: research
