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Condition: Asthma

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Total 404 results found since Jan 2013.

KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
CONCLUSION: KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma, and may be a potential target for asthma treatment. PMID: 29156524 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 15, 2017 Category: Drugs & Pharmacology Authors: Geng G, Du Y, Dai J, Tian D, Xia Y, Fu Z Tags: Biomed Pharmacother Source Type: research

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma.
CONCLUSIONS: These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma. PMID: 29178675 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Interleukin-22 attenuates double-stranded RNA-induced upregulation of PD-L1 in airway epithelial cells via a STAT3-dependent mechanism.
Abstract Double-stranded RNA derived from viruses induces host immune responses. PD-L1, also known as B7-H1, is an immune-checkpoint molecule associated with the escape of viruses from host immune systems, which plays a role in the persistence of viral infection, resulting in exacerbations of underlying diseases such as asthma and chronic obstructive pulmonary disease. Interleukin (IL)-22 is produced from various immune cells and has protective properties on mucosal tissue. The binding of IL-22 to IL-22 receptor induces STAT3 activation. We investigated the effect of IL-22 on the expression in airway epithelial ce...
Source: Biochemical and Biophysical Research communications - November 30, 2017 Category: Biochemistry Authors: Seki N, Kan-O K, Matsumoto K, Fukuyama S, Hamano S, Tonai K, Ota K, Inoue H, Nakanishi Y Tags: Biochem Biophys Res Commun Source Type: research

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome.
Abstract Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase rele...
Source: International Journal of Molecular Medicine - December 5, 2017 Category: Molecular Biology Authors: Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW, Hsu YL Tags: Int J Mol Med Source Type: research

HMGB1 ‐induced asthmatic airway inflammation through GRP75‐mediated enhancement of ER–Mitochondrial Ca2+ transfer and ROS increased
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 2, 2018 Category: Biochemistry Authors: Lv Yanhua, Li Yanli, Zhang Dandan, Zhang Anbing, Guo Weihong, Zhu Shunfang Tags: Article Source Type: research

HMGB1 ‐induced asthmatic airway inflammation through GRP75‐mediated enhancement of ER‐mitochondrial Ca2+ transfer and ROS increased
Abstract Imbalanced T‐helper (TH)1/Th2 response contributes significantly to asthma pathogenesis. Our study indicated that HMGB1 play an important role in the release of Th2‐associated cytokines of asthma. However, the specific mechanism about HMGB1‐induced imbalanced TH1/Th2 response is not known. In vivo, an OVA‐induced asthma mouse model was set up and mice treated with anti‐HMGB1 IgG. The mice treated with the anti‐HMGB1 IgG ameliorated airway hyper‐reactivity, disruption of Th1/Th2 balance and the upregulation of GRP75 induced by OVA. In vitro, the exposure of normal human bronchial epithelial cells to H...
Source: Journal of Cellular Biochemistry - January 25, 2018 Category: Biochemistry Authors: Yanhua Lv, Yanli Li, Dandan Zhang, Anbing Zhang, Weihong Guo, Shunfang Zhu Tags: RESEARCH ARTICLE Source Type: research

High-fat-diet induces airway hyperresponsiveness partly through activating CD38 signaling pathway.
This study aimed to detect the effect of CD38 signaling pathway on the AHR of overweight/obese mice. The HFD-fed mice exhibited a significantly higher baseline airway resistance (Rn), and the increasing rates of Rn responded to increasing doses of methacholine compared with the LFD-fed mice. High-fat-diet increased CD38 expressions both in lung tissues and primary cultured ASMCs. Besides, preincubation with TNF-α led to a higher expression of CD38 protein and increased intracellular calcium in ASMC of the HFD-fed mice. Furthermore, CD38 gene knockdown through transfection of CD38 siRNA decreased the concentration of intra...
Source: International Immunopharmacology - February 1, 2018 Category: Allergy & Immunology Authors: Chong L, Zhang W, Yu G, Zhang H, Zhu L, Li H, Shao Y, Li C Tags: Int Immunopharmacol Source Type: research

MID1 –PP2A complex functions as new insights in human lung adenocarcinoma
ConclusionsWe demonstrated that the MID1 –PP2A complex plays an important role in lung adenocarcinoma, influencing cell cycle progression, proliferation and apoptosis. Our findings showed a novel molecular mechanism of lung tumorigenesis that may provide new insights for anti-tumor therapies.
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research

TRPC3 overexpression and intervention in airway smooth muscle of ovalbumin-induced hyperresponsiveness and remodeling.
Abstract Transient receptor potential canonical channel 3 (TRPC3) proteins function as non-voltage-gated Ca2+ -permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression and airway hyperresponsiveness and remodeling in ovalbumin-induced asthmatic Kunming mice. Mice were sensitized and challenged by ovalbumin to establish asthmatic model. Hematoxylin-eosin staining, hydroxyproline assay and isometric tracheal ring force measurement were used to evaluate airway remodeling and hyperresponsiveness in asthmatic m...
Source: Cell Biology International - April 6, 2018 Category: Cytology Authors: Xu BM, Zhang JH, Wang JL, Xiao JH Tags: Cell Biol Int Source Type: research

Cold Stimuli Facilitate Inflammatory Responses Through Transient Receptor Potential Melastatin 8 (TRPM8) in Primary Airway Epithelial Cells of Asthmatic Mice
AbstractBronchial asthma is a chronic inflammatory airway disease that can be aggravated by cold air. However, its mechanism remains largely unknown. As a thermo-sensing cation channel, transient receptor potential melastatin 8 (TRPM8) can be activated by cold stimuli (8 –22 °C) and cooling agents. Whereas TRPM8 activation leads to enhanced expression of inflammatory cytokines and mucus hypersecretion in human bronchial epithelial cell lines, no previous study has examined its role in regulating the cold-induced inflammatory responses and its mechanism in asthma tic airway epithelium. Airway epithelial cells were isola...
Source: Inflammation - April 9, 2018 Category: Allergy & Immunology Source Type: research

MID1-PP2A complex functions as new insights in human lung adenocarcinoma.
CONCLUSIONS: We demonstrated that the MID1-PP2A complex plays an important role in lung adenocarcinoma, influencing cell cycle progression, proliferation and apoptosis. Our findings showed a novel molecular mechanism of lung tumorigenesis that may provide new insights for anti-tumor therapies. PMID: 29450633 [PubMed - indexed for MEDLINE]
Source: Clinical Lung Cancer - May 1, 2018 Category: Cancer & Oncology Authors: Zhang L, Li J, Lv X, Guo T, Li W, Zhang J Tags: J Cancer Res Clin Oncol Source Type: research

Bromodomain protein BRD4 is increased in human placentas from women with early-onset preeclampsia
In conclusion, these findings suggest BRD4 may play a central role in propagating inflammation and endothelial dysfunction associated with the pathophysiology of early-onset preeclampsia.
Source: Reproduction - May 10, 2018 Category: Reproduction Medicine Authors: Liong, S., Barker, G., Lappas, M. Tags: Research Source Type: research

Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of chronic myeloid leukemia cells through apoptosis.
Authors: Zovko A, Yektaei-Karin E, Salamon D, Nilsson A, Wallvik J, Stenke L Abstract The clinical outcome for patients with chronic myeloid leukemia (CML) has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs). However, their curative potential appears limited, probably as a consequence of TKI-resistant leukemic stem cells (LSCs) that persist as a result of aberrant pathways independent of the well-established oncoprotein Bcr-Abl. One such pathway involves signaling through leukotrienes (LTs), bioactive compounds that have been suggested to play a role in several other malignancies. ...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sphingosine-1-phosphate induces airway smooth muscle cells proliferation, migration and contraction by modulating Hippo signaling effector YAP.
Abstract Sphingosine-1-phosphate (S1P), a bioactive lipid, has been shown to be elevated in the airways of individuals with asthma and modulates the airway smooth muscle cells (ASMCs) functions, yet its underlying molecular mechanisms are not completely understood. The aim of the present study is to address this issue. S1P induced yes-associated protein (YAP) de-phosphorylation and nuclear localization via S1PR2/3/Rho-associated protein kinase (ROCK) pathway, and this in turn increased forkhead box M1 (FOXM1) and cyclin D1 expression leading to ASMCs proliferation, migration and contraction. Pre-treatment of cells...
Source: Am J Physiol Lung Ce... - July 12, 2018 Category: Respiratory Medicine Authors: Liu L, Zhai C, Pan Y, Zhu Y, Shi W, Wang J, Yan X, Su X, Song Y, Gao L, Li M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Th1 Cytokines, TNF α and IFNγ, Promote Corticosteroid Resistance in Developing Human Airway Smooth Muscle.
Th1 Cytokines, TNFα and IFNγ, Promote Corticosteroid Resistance in Developing Human Airway Smooth Muscle. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 18;: Authors: Britt RD, Thompson MA, Sasse SK, Pabelick CM, Gerber AN, Prakash YS Abstract Corticosteroids are commonly used to manage wheezing and asthma in pediatric populations. Although corticosteroids are effective in alleviating airway diseases, some children with more moderate-severe asthma phenotypes show corticosteroid (CS) resistance and exhibit significant airflow obstruction, persistent inflammation, and more frequent exacerbations. Previo...
Source: Am J Physiol Lung Ce... - October 18, 2018 Category: Respiratory Medicine Authors: Britt RD, Thompson MA, Sasse SK, Pabelick CM, Gerber AN, Prakash YS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research