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Condition: Asthma

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Total 404 results found since Jan 2013.

LSC - 2019 - RNA degradation is a deficient antiviral mechanism in the asthmatic airway epithelium
Conclusions: Our data suggest that decreased UPF1 levels in asthma BECs contribute to impaired antiviral immunity and RV-induced exacerbations in asthma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wong, T., Rynne, J., Howarth, P. H., Edwards, M. R., Martinez-Nunez, R. T. Tags: Respiratory infections Source Type: research

Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Asthmatics.
CONCLUSIONS: We demonstrate that NOTCH3 is a regulator of MUC5AC production. Increased NOTCH3 signaling in the asthmatic airway epithelium may therefore be an underlying driver of excess MUC5AC production. PMID: 31922915 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - January 9, 2020 Category: Respiratory Medicine Authors: Reid AT, Nichol KS, Chander-Veerati P, Moheimani F, Kicic A, Stick SM, Bartlett NW, Grainge CL, Wark PAB, Hansbro PM, Knight DA Tags: Am J Respir Cell Mol Biol Source Type: research

Epithelial PI3K- δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners.
CONCLUSIONS: The results of this study suggest that PI3K-δ-isoform can promote HDM-induced allergic airway inflammation via NLRP3 inflammasome-dependent response as well as via NLRP3 inflammasome-independent epithelial cell activation. PMID: 32009326 [PubMed]
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline
Publication date: Available online 8 February 2020Source: Life SciencesAuthor(s): Linlin Han, Nannan Song, Xiaomin Hu, Afang Zhu, Xin Wei, Jinmin Liu, Shiying Yuan, Weike Mao, Xiangdong ChenAbstractAimsAlthough resistin-like molecule β (RELM-β) is involved in the pathological processes of various lung diseases, such as pulmonary inflammation, asthma and fibrosis, its potential roles in hypoxic pulmonary arterial hypertension (PAH) remain largely unknown. The study aims to investigate whether RELM-β contributes to hypoxia-induced excessive proliferation of human pulmonary artery smooth muscle cells (PASMCs) and to explor...
Source: Life Sciences - February 9, 2020 Category: Biology Source Type: research

Dual role of RACK1 in airway epithelial mesenchymal transition and apoptosis.
Abstract Airway epithelial apoptosis and epithelial mesenchymal transition (EMT) are two crucial components of asthma pathogenesis, concomitantly mediated by TGF-β1. RACK1 is the downstream target gene of TGF-β1 shown to enhancement in asthma mice in our previous study. Balb/c mice were sensitized twice and challenged with OVA every day for 7 days. Transformed human bronchial epithelial cells, BEAS-2B cells were cultured and exposed to recombinant soluble human TGF-β1 to induced apoptosis (30 ng/mL, 72 hours) and EMT (10 ng/mL, 48 hours) in vitro, respectively. siRNA and pharmacological inhibitors were use...
Source: J Cell Mol Med - February 16, 2020 Category: Molecular Biology Authors: Pu Y, Liu YQ, Zhou Y, Qi YF, Liao SP, Miao SK, Zhou LM, Wan LH Tags: J Cell Mol Med Source Type: research

Inhibition of PI3K δ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells
Viral infections of the airway can exacerbate respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), and accelerate disease progression. Phosphoinositide 3-kinase (PI3K)δ, a class 1A PI3K, has been studied as a potential target for achieving anti-oncogenic and anti-inflammatory effects. However, the role of PI3Kδ in antiviral responses is poorly understood. Using a synthetic double-stranded RNA poly I:C and a selective PI3Kδ inhibitor IC87114, we investigated the role of PI3Kδ signaling in poly I:C-induced expression of the T lymphocyte-inhibitory molecule programmed death 1 ligand 1 (PD-...
Source: Frontiers in Immunology - March 10, 2020 Category: Allergy & Immunology Source Type: research

Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation.
Abstract Sensitivity to allergenic fungi (Alternaria alternata) is associated with acute, severe asthma attacks. Antigen presenting cells (APCs) in the lung sense environmental perturbations that induce cellular stress and metabolic changes and are critical for allergic airway inflammation. However, the mechanisms underlying such environmental sensing by APCs in the lung remains unclear. Here we show that acute Alternaria challenge rapidly induces neutrophil accumulation in airways, and alter expressions of Pyruvate Kinase (PKM2) and hypoxia-inducible factor -1α (Hif-1α) that correlates with proinflammatory medi...
Source: Immunobiology - June 30, 2020 Category: Allergy & Immunology Authors: Jaiswal AK, Makhija S, Stahr N, Sandey M, Suryawanshi A, Mishra A Tags: Immunobiology Source Type: research

TMEM16A Mediated Mucus Production in Human Airway Epithelial Cells.
We examined this question using BCi-NS1 cells, a human airway basal cell line that maintains multipotent differentiation capacity, and the two human airway epithelial cell lines, Calu-3 and CFBE. The data demonstrate that exposure of airway epithelial cells to IL-8 and IL-13, two cytokines known to be enhanced in CF and asthma, respectively, leads to increase in mucus production. Expression of MUC5AC was fully dependent on expression of TMEM16A, as shown by siRNA-knockdown of TMEM16A. In addition, different inhibitors of TMEM16A attenuated IL-13 induced mucus production. Interestingly, in CFBE cells expressing F508delCFTR,...
Source: American Journal of Respiratory Cell and Molecular Biology - October 7, 2020 Category: Molecular Biology Authors: Cabrita I, Benedetto R, Wanitchakool P, Lerias J, Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K Tags: Am J Respir Cell Mol Biol Source Type: research

Recombinant Pyrin Domain Protein Attenuates Airway Inflammation and Alleviates Epithelial-Mesenchymal Transition by Inhibiting Crosstalk Between TGF β1 and Notch1 Signaling in Chronic Asthmatic Mice
In conclusion, RPYD reduces airway inflammation, improves airway remodeling and reduces EMT in chronic asthmatic mice by inhibiting the crosstalk between TGFβ1/smad3 and Jagged1/Notch1 signaling pathways.
Source: Frontiers in Physiology - October 23, 2020 Category: Physiology Source Type: research

Cbx4 Regulates RNA Binding Protein MEX-3B To Thymic stromal lymphopoietin Expression Sumoylation In Epithelium Of HDM-induced Allergic Inflammation
Conclusion: CBX4/MEX-3B/TSLP axis involved in TSLP-mediated airway inflammation,suggesting that targeting SUMO E3 ligase activity of CBX4 would be a novel target for the treatment of asthma.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: shixiu, l., Changhui, Y., Zicong, Z., Zili, Z., Jieyi, L., Shaoxi, C. Tags: Allergy and immunology Source Type: research

TNF α Induces Mitochondrial Fragmentation and Biogenesis in Human Airway Smooth Muscle.
TNFα Induces Mitochondrial Fragmentation and Biogenesis in Human Airway Smooth Muscle. Am J Physiol Lung Cell Mol Physiol. 2020 Nov 04;: Authors: Delmotte PF, Marin Mathieu N, Sieck GC Abstract In human airway smooth muscle (hASM), mitochondrial volume density is greater in asthmatic patients compared to normal controls. There is also an increase in mitochondrial fragmentation in hASM of moderate asthmatics associated with an increase in Drp1 and a decrease in Mfn2 expression, mitochondrial fission and fusion proteins, respectively. Pro-inflammatory cytokines such TNFα contribute to hASM hyperreacti...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 4, 2020 Category: Cytology Authors: Delmotte PF, Marin Mathieu N, Sieck GC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

GSE146017 Influence of CEBPD  on Glucocorticoid Response in Airway Smooth Muscle 
Contributor : Blanca E HimesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCCAAT/Enhancer Binding Protein D (CEBPD) is a transcription factor that regulates genes involved in immune and inflammatory responses. Based on our previous observation that CEBPD expression increases in airway smooth muscle (ASM) with glucocorticoid exposure, we sought to better understand its role in the ASM transcriptomic response to glucocorticoids via knockdown experiments.Primary human airway smooth muscle (ASM) cells from four non-asthma donors were transfected with 25pmol of siRNA non-targeting control...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Cellular Clocks in Hyperoxia Effects on Ca2+i Regulation in Developing Human Airway Smooth Muscle.
We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2. Disruption of the clock via siRNA-mediated PER1 or ARNTL knockdown alters store-operated calcium entry (SOCE) and [Ca2+]i response to histamine in hyperoxia. Effects of O2 on [Ca2+]i are rescued by driving expression of clock proteins, via effects on the Ca2+ channels IP3R and Orai1. These data reveal a functional fASM clock that modulates [Ca2+]i regulation, particularly in hyperoxia. Harnessing clock biology may be a novel therapeutic consideration for neonatal airway diseas...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 6, 2021 Category: Cytology Authors: Bartman CM, Matveyenko A, Pabelick CM, Prakash YS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

S1PR2 Inhibition Attenuates Allergic Asthma Possibly by Regulating Autophagy
This study is to investigate the role of Sphingosine-1-phosphate (S1P) in the asthma progression, and the involvement of autophagy. Airway remodeling mice were subjected to the HE, PAS, and Masson staining. Protein expression levels in the tissues, samples and model cells were detected with ELISA, Western blot analysis, and immunohistochemical/immunofluorescent analysis. The S1P2 receptor antagonist JTE-013 decreased the inflammatory cell infiltration and goblet cell production in asthmatic mice tissues. The IL-1, IL-4, IL-5 and serum IgE contents were decreased in bronchoalveolar lavage fluid, while the Beclin1 expression...
Source: Frontiers in Pharmacology - February 10, 2021 Category: Drugs & Pharmacology Source Type: research

The Degradation of Airway Epithelial Tight Junctions in Asthma Under High Airway Pressure Is Probably Mediated by Piezo-1
Full functioning of the airway physical barrier depends on cellular integrity, which is coordinated by a series of tight junction (TJ) proteins. Due to airway spasm, edema, and mucus obstruction, positive end-expiratory alveolar pressure (also termed auto-PEEP) is a common pathophysiological phenomenon, especially in acute asthma attack. However, the influence of auto-PEEP on small airway epithelial TJs is currently unclear. We performed studies to investigate the effect of extra pressure on small airway epithelial TJs and its mechanism. The results first confirmed that a novel mechanosensitive receptor, piezo-1, was highl...
Source: Frontiers in Physiology - April 1, 2021 Category: Physiology Source Type: research