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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE185071 RNA-seq quantification in EPS15 knockdown and scramble-oligo controls in JEG3 cells
Conclusions: Our results provide some experimental evidence that EPS15 has transcriptomic consequences in human placenta-derived JEG3 cells.
Source: GEO: Gene Expression Omnibus - October 7, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE156389 Small RNA-Seq of HeLa cells treated with siTFIP11
Contributors : Denis Mottet ; Amandine Duchemin ; Tina O'Grady ; Sarah HanacheSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSmall RNA-Seq of HeLa cells treated with siTFIP11 or control siRNA to investigate the effect of TFIP11 knockdown on small RNA (snRNA, snoRNA, etc.) as part of a larger study on the function of TFIP11.
Source: GEO: Gene Expression Omnibus - September 22, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE156388 RNA-Seq of HeLa cells treated with siTFIP11
Contributors : Denis Mottet ; Amandine Duchemin ; Tina O'Grady ; Sarah HanacheSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-Seq of HeLa cells treated with siTFIP11 or control siRNA to investigate the effect of TFIP11 knockdown on mRNA as part of a larger study on the function of TFIP11.
Source: GEO: Gene Expression Omnibus - September 22, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE171446 RNA-Seq of HeLa cells treated with siDHX15
Contributors : Denis Mottet ; Amandine Duchemin ; Tina O'Grady ; Sarah HanacheSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-Seq of HeLa cells treated with siDHX15 or control siRNA to investigate the effect of DHX15 knockdown on mRNA as part of a larger study on the function of TFIP11 and DHX15.
Source: GEO: Gene Expression Omnibus - September 22, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE183926 Differentially expressed genes after transfection of siRNA in human cancer cell lines
Contributors : Naohiko Seki ; Kengo TanigawaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by siRNAs transfection in human cancer, lung squamous cell carcinoma cell lines were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - September 11, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE122739 Differential requirement for B-cell Receptor signaling during adhesion of different Mantle Cell Lymphoma cell lines to stromal cells
Conclusions: The results suggest that different MCL cell lines exhibit different signaling profiles and pathway dependencies during microenvironment interaction. In this study BCR signaling pathways were shown to be important for stromal cell adhesion of JeKo1 cells but not REC1 cells. This provides a possible mechanism to account for the differential responsiveness of MCL patients to treatment with the Bruton ’s Tyrosine Kinase inhibitor, Ibrutinib, an inhibitor of BCR signaling that is clinically approved for MCL.
Source: GEO: Gene Expression Omnibus - September 9, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE172014 Transcriptome analysis of primary microglia defecting ASD-related genes.
We report the transcriptome analysis by RNAseq for primary microglia defecting ASD-related genes by siRNA treatment.
Source: GEO: Gene Expression Omnibus - September 8, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE174741 LINC01133 inhibits invasion and promotes proliferation in an endometriosis epithelial cell line
Contributors : Quanah J Hudson ; Iveta Yotova ; Florian M Pauler ; Rene WenzlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndometriosis is a common gynecological disorder characterized by ectopic growth of endometrium outside the uterus and associated with chronic pain and infertility. We investigated the role of LINC01133 in endometriosis, an lncRNA that has been implicated in several types of cancer. We found that LINC01133 is upregulated in ectopic endometriosis lesions. As expression appeared higher in the epithelial endometrial layer, we performed an siRNA knockdown of LINC011...
Source: GEO: Gene Expression Omnibus - August 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE181078 RNA sequencing of DDX23 knockdown by siRNA in ovarian cancer cells
In this study, DDX23 was first identified as a key DEAD-box RNA helicase in ovarian cancer, and its overexpressed was associated with poor clinical outcomes. High expression of DDX23 was involved in the malignant proliferation and aggressiveness of ovarian cancer.
Source: GEO: Gene Expression Omnibus - July 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE179496 Targeting the Viral Suppressor of RNAi Provides a Novel Strategy for Antiviral Therapy
Contributors : Yuan Fang ; Zezhong Liu ; Yang Qiu ; Jing Kong ; Yuhong Fu ; Yujie Liu ; Chong Wang ; Jia Quan ; Qian Wang ; Wei Xu ; Lei Yin ; Jie Cui ; Yi Xu ; Stephen Curry ; Shibo Jiang ; Lu Lu ; Xi ZhouSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Enterovirus A71RNA interference (RNAi) is an antiviral immunity conserved in diverse eukaryotes including mammals, while viruses encodes viral suppressors of RNAi (VSRs) as countermeasures. However, the physiological impact of RNAi on viral infection in mammals has not been fully assessed, and it also remains unknown whether antiviral RNAi can...
Source: GEO: Gene Expression Omnibus - July 31, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Enterovirus A71 Source Type: research
GSE180273 Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of the host cell DNA and chromatin
Contributors : Robert Lodge ; Alexandre Deshiere ; Corinne Barat ; Michel J TremblaySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt has been proposed that macrophages could serve as long-lived compartments for HIV-1 infection under in vivo situations because these cells are resistant to the virus-mediated cytopathic effect, produce progeny virus over extended periods of time and are localized in tissues that are often less accessible by treatment. Comprehensive experimental studies are thus needed to characterize the HIV-1-induced modulation of host genes in these myeloid lineage c...
Source: GEO: Gene Expression Omnibus - July 21, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE180131 Sequencing of siRNA from soybean containing silencing vectors and empty vectors
Contributors : Megan McCaghey ; Dandan Shao ; Kurcezewski Kurcezewski ; Ally Lindstrom ; Ashish Ranjan ; Steven Whitham ; Shawn Conley ; Brett Williams ; Damon Smith ; Mehdi KabbageSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Glycine maxA cDNA library was constructed by Novogene (CA, USA) using a Small RNA Sample Pre Kit, and Illumina sequencing was conducted according to company workflow, using 20 million reads. Raw data were filtered for quality as determined by reads with a quality score> 5, reads containing N
Source: GEO: Gene Expression Omnibus - July 21, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Glycine max Source Type: research
GSE171715 High-throughput sequencing analyze the differentially expressed miRNA of HUVECs after lncRNA uc003pxg.1 knockdown by siRNA compared with NC group
This study provides a theoretical basis for the study of the molecular mechanism of uc003pxg.1 in HUVECs.
Source: GEO: Gene Expression Omnibus - July 14, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE169322 Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma
Conclusion: These novel findings demonstrated that STRAP plays a role in tumorigenesis and maintenance of neuroblastoma stemness.
Source: GEO: Gene Expression Omnibus - July 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE158710 The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice
Contributors : Kezhi Zheng ; Dong-Lei YangSeries Type : Methylation profiling by high throughput sequencingOrganism : Oryza sativaRNA-directed DNA methylation (RdDM) functions in de novo methylation in CG, CHG, and CHH contexts. Here, we performed map-based cloning of OsNRPE1, which encodes the largest subunit of Pol V, a key regulator of gene silencing and reproductive development in rice. We found that rice Pol V is required for CHH methylation on RdDM loci by transcribing long non-coding RNAs. Pol V influences the accumulation of 24-nt siRNAs in a locus-specific manner. Biosynthesis of 24-nt siRNAs on loci with high CHH...
Source: GEO: Gene Expression Omnibus - July 7, 2021 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Oryza sativa Source Type: research
