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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE173313 Histone H4 lysine 20 mono-methylation directly facilitates chromatin ‘openness’ and promotes transcription of housekeeping genes (ATAC-seq_DRB)
Contributors : Muhammad Shoaib ; Qinming Chen ; Xiangyan Shi ; Nidhi Nair ; Chinmayi Prasanna ; Renliang Yang ; David Walter ; Klaus S Frederiksen ; Einarsson Hjorleifur ; Peter Svenson ; Chuan-Fa Liu ; Karl Ekwall ; Mads Lerdrup ; Lars Nordenski öld ; Claus S SørensenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo study the role of Histone H4 lysine 20 mono- and tri-methylation (H4K20me1, H4K20me3) in relationship to chromatin accessibility and gene expression, we report the application of high-throughput profiling of these marks in synchronized and asynchronous Hu...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE156216 Histone H4 lysine 20 mono-methylation directly facilitates chromatin ‘openness’ and promotes transcription of housekeeping genes (ChIP-seq)
Contributors : Muhammad Shoaib ; Qinming Chen ; Xiangyan Shi ; Nidhi Nair ; Chinmayi Prasanna ; Renliang Yang ; Chuan F Liu ; David Walter ; Klaus S Frederiksen ; Peter Svenson ; Karl Ekwall ; Mads Lerdrup ; Lars Nordenski öld ; Claus S SørensenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTo study the role of Histone H4 lysine 20 mono- and tri-methylation (H4K20me1, H4K20me3) in relationship to chromatin accessibility and gene expression, we report the application of high-throughput profiling of these marks in Human Osteosarcoma U2OS and Mouse Fibrobl...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE156215 Histone H4 lysine 20 mono-methylation directly facilitates chromatin ‘openness’ and promotes transcription of housekeeping genes (ATAC-seq)
Contributors : Muhammad Shoaib ; Qinming Chen ; Xiangyan Shi ; Nidhi Nair ; Chinmayi Prasanna ; Renliang Yang ; Chuan F Liu ; David Walter ; Klaus S Frederiksen ; Peter Svenson ; Karl Ekwall ; Mads Lerdrup ; Lars Nordenski öld ; Claus S SørensenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTo study the role of Histone H4 lysine 20 mono- and tri-methylation (H4K20me1, H4K20me3) in relationship to chromatin accessibility and gene expression, we report the application of high-throughput profiling of these marks in synchronized and asynchronous Human Osteo...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE151828 Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
Contributors : Carolyn M Phillips ; Dieu H NguyenSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Caenorhabditis elegansCSR-1 is an essential Argonaute protein that binds to a subclass of 22G-RNAs targeting most germline-expressed genes. Here we show that the two isoforms of CSR-1 have distinct expression patterns; CSR-1B is ubiquitously expressed throughout the germline and during all stages of development while CSR-1A expression is restricted to germ cells undergoing spermatogenesis. Furthermore, CSR-1A associates preferentially with 22G-RNAs mapping to spermatogenesis-specific genes whe...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Caenorhabditis elegans Source Type: research
GSE164407 mRNA-seq in siNC and siCNN3 C2C12 cells
Contributors : Rui Chen ; Yanling SheSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe evaluate the effects of CNN3 on myogenesis and further explored its potential molecular mechanisms. C2C12 cells were transfected with siRNA CNN3 and its NC control siRNA. Total mRNA was extracted from cells using TRIZOL reagent in accordance with the manufacturer ’ protocol. And transcriptomes of CNN3 gene silenced C2C12 cells was detected by RNA-Seq.
Source: GEO: Gene Expression Omnibus - June 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE171760 Functional roles of the chromatin remodeler SMARCA5(SNF2H) in mouse and bovine preimplantation embryos
Contributor : Yan ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUpon fertilization, extensive chromatin reprogramming occurs during preimplantation development. Growing evidence reveals species-dependent regulations of this process in mammals. ATP-dependent chromatin remodeling factor SMARCA5 (also known as SNF2H) is required for peri-implantation development in mice. However, the specific functional role of SMARCA5 in preimplantation development and if it is conserved among species remain unclear. Herein, comparative analysis of public RNA-seq datasets reveals that SMARCA5 is un...
Source: GEO: Gene Expression Omnibus - May 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE158135 Role of RUVBL2 in LPS-induced proinflammatory gene expression of RAW264.7 cells
Series Type : Expression profiling by arrayOrganism : Mus musculusThe aim of this experiment is to compare gene expression proflies of RAW264.7 cells trasnfected with non-targeting siRNA or siRNA against RUVBL2, in the presence or absence of LPS.
Source: GEO: Gene Expression Omnibus - May 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE175404 The RNA binding protein MEX3A controls G1/S transition via regulating RB/E2F pathway in clear cell renal cell carcinoma RNA-Seq
Contributor : Meng MengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-Seq was performed after siRNA transfection in ACHN cells.
Source: GEO: Gene Expression Omnibus - May 25, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE174530 ZGA-Timer: a framework for the identification of key zygotic genome activation genes from time-series RNA-seq data
Contributors : Hao Li ; Qiu XieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusZygotic genome activation (ZGA) is a complex process which denotes the initiation of gene expression after fertilization. Deciphering the proper timing and genes involved in ZGA program is still a fundamental challenge in early embryo development. Here, we present a new ZGA gene identification framework, named ZGA-Timer, based on the timecourse pattern from RNA-seq data. By performing ZGA-Timer and siRNA technology, we confirmed Uqcc3 as a novel ZGA gene in mice. As a unique feature of ZGA-Timer, time-serie...
Source: GEO: Gene Expression Omnibus - May 18, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE164413 RNAseq in JARID2 siRNA-treated in vitro differentiated human primary adipocytes
Contributors : N Subramanian ; J Laurencikiene ; C Bj örkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNAseq was performed in siJARID2 and control siRNA-treated human adipose tissue derived stem cells (hASC). The tretment of siRNA was performed by electroporation one day before induction of differentiation in vitro. The cells were lyzed and RNA was purified on day 6 (mid differentiation) and day 13 (full differentiation) from differentiation start.
Source: GEO: Gene Expression Omnibus - May 18, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149640 Functional role of CPPED1 in trophoblasts.
Contributors : Antti Haapalainen ; Ravindra DaddaliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the effect of CPPED1 siRNA experiment with and without P4
Source: GEO: Gene Expression Omnibus - May 12, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE131084 Coordinate regulation of ELF5 and EHF at the chr11p13 modifier region
Contributors : Ann Harris ; Shiyi Yin ; Jenny L KerschnerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensE74-like factor 5 (ELF5) and ETS-homologous factor (EHF) are epithelial selective ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic fibrosis (CF) lung disease severity. EHF controls many key processes in lung epithelial function so its regulatory mechanisms are important. Using CRISPR/Cas9 technology, we removed three cis-regulatory elements (CREs) from the chr11p13 region in airway epithelial cells. Deletion of two e...
Source: GEO: Gene Expression Omnibus - May 11, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE155231 RNA-seq data of prefoldin subunits PFDN2 and PFDN5 knockdowns in HCT116 human colon carcinoma cells
We report gene expression data from total RNA-seq of HCT116 human colon carcinoma cells treated with siRNA against PFDN2 and PFDN5 (both part of a complex known as prefoldin). Cells were independently treated with one of the previously mentioned siRNAs or with an exogenous control siRNA (luciferase GL2). All cells were treated with the different siRNAs for 24 hours, then serum-starved them for 48 hours, and finally stimulated by adding serum for 90 minutes. Samples were taken before and after serum stimulation. Prefoldin depletion provoked transcriptional alterations across the genome of human cells. Severe pre-mRNA splici...
Source: GEO: Gene Expression Omnibus - May 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE165289 Genome wide expression change by RNF31 knocking down in MCF-7 cells
Contributor : Jian ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aim to the investigate the role of RNF31 in breast cancer progression. MCF-7 cells were used as the model and RNF31 was silenced by siRNA.
Source: GEO: Gene Expression Omnibus - April 30, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE173433 Single-cell RNA-seq following APE1/Ref-1 knockdown in Pancreatic Ductal Adenocarcinoma
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAPE1 was knocked down using siRNA in low passage patient-derived PDAC cells and the resulting cells, along with control cells were analysed using scRNA-seq to identify differentially expressed genes and pathways as a result of APE1 knock-down.
Source: GEO: Gene Expression Omnibus - April 28, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
