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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE161226 HEDGEHOG/GLI Modulates The PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Contributors : Yiyun Sun ; Ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter, and this gene pair synergistically promoted the development of non-small-cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remain obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from the...
Source: GEO: Gene Expression Omnibus - November 10, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE216863 Comparison of gene profiles of human bone marrow stromal stem cell (hBMSCs) transfected by siRNA-Control and siRNA-KIAA1199
Contributor : Li ChenSeries Type : Expression profiling by arrayOrganism : Homo sapienshuman bone marrow stromal stem cells were transfected by siRNA-control (non-target) and siRNA-KIAA1199, after 72 hours, gene profiles were comparedWe used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of up-regulated genes during this process.
Source: GEO: Gene Expression Omnibus - October 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE185368 RNA-Seq of rat cardiac fibroblasts depleted for Yap and Wwtr1
Contributors : Micahel A Flinn ; Xiaoxu Zhou ; Pengyuan Liu ; Caitlin C O'MearaSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPrimary neonatal rat cardiac fibroblasts were isolated and subjected to siRNA mediated Yap and/or Wwtr1 knockdown
Source: GEO: Gene Expression Omnibus - October 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
GSE216519 Effect of depletion of AIM2 on gene expression in psoriatic NETs-treated primary human keratinocytes
Contributors : Xu Yuan ; Tianyu Cao ; Shuai ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of the NET-AIM2 axis on keratinocyte activation during psoriasis, we established psoriatic NETs-treated primary human keratinocytes in which AIM2 has been knocked down by siRNA
Source: GEO: Gene Expression Omnibus - October 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE215344 Characterization of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
Contributors : Jianhua Qu ; Zilong YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the biological function of NEK7 in pyroptosis of pancreatic cancer cells, we manipulate the expression of NEK7 and NEK6 in pancreatic cancer cell lines in which each target gene has been knocked down by siRNA.
Source: GEO: Gene Expression Omnibus - October 14, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE206142 Effect of knockdown of DIO3OS and PTBP1 on gene expression of MCF-7 LTED cells cellseq
Contributors : Xueman Chen ; Man-Li Luo ; Erwei SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of DIO3OS and PTBP1 in the metabolic regulation, we used LNA and siRNA to silence DIO3OS and PTBP1, respectively, in established MCF-7 LTED cell lines. We then performed gene expression profiling analysis using data obtained from RNA-seq of six different cells.
Source: GEO: Gene Expression Omnibus - October 11, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE201426 RNA sequencing of HeLa cells
In this study TOP3A, TOP1MT or both TOP3A and TOP1MT have been knocked down using siRNAs to determine the effect of the topoisomerases on mitochondrial transcription. RNA was isolated from ctrl siRNA, TOP3A siRNA, TOP1MT siRNA and TOP3A + TOP1MT siRNA transfected cells after 6 days of transfection.
Source: GEO: Gene Expression Omnibus - October 11, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE203325 DNA polymerase epsilon interacts with SUVH2/9 to mediate meiotic DSB associated gene silencing beyond DNA methylation in Arabidopsis miRNA-seq
Contributors : Cong Wang ; Chenjiang You ; Yingxiang WangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaMeiotic recombination is initiated from the SPORULATION 11 (SPO11)-triggered formation of double strand breaks (DSBs) that usually occur in open chromatin with active transcriptional features in many eukaryotes. However, gene transcription at meiotic DSB sites appears to be detrimental for repair, and the mechanisms for gene silencing at DSB sites are largely undefined, especially in plants. Here, we demonstrate that the largest DNA polymerase epsilon subunit POL2A inte...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE203263 DNA polymerase epsilon interacts with SUVH2/9 to mediate meiotic DSB associated gene silencing beyond DNA methylation in Arabidopsis BiSulfite-seq
Contributors : Cong Wang ; Chenjiang You ; Yingxiang WangSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaMeiotic recombination is initiated from the SPORULATION 11 (SPO11)-triggered formation of double strand breaks (DSBs) that usually occur in open chromatin with active transcriptional features in many eukaryotes. However, gene transcription at meiotic DSB sites appears to be detrimental for repair, and the mechanisms for gene silencing at DSB sites are largely undefined, especially in plants. Here, we demonstrate that the largest DNA polymerase epsilon subunit POL2A interac...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE185699 NAP1L5 is required for translation activation during cardiomyocyte hypertrophy
Contributors : Ningning Guo ; Di Zheng ; Jiaxin Sun ; Jian Lv ; Shun Wang ; Yu Fang ; Zhenyi Zhao ; Sai Zeng ; Qiuxiao Guo ; Jingjing Tong ; Zhihua WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPathological growth of cardiomyocytes during hypertrophy is characterized by excess protein synthesis; however, the regulatory mechanism remains largely unknown. Using a neonatal rat ventricular myocyte (NRVMs) model, here we find that the expression of nucleosome assembly protein 1 like 5 (Nap1l5) is upregulated in phenylephrine (PE)-induced hypertrophy. Knockdown of Nap1l5 expressi...
Source: GEO: Gene Expression Omnibus - October 9, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
GSE214842 ATF6 αis required for the inflammation and survival in rheumatoid arthritis fibroblast-like synoviocytes
Contributors : L Ge ; L Wang ; Y ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize transcriptome changes upon ATF6 α knockdown by the siRNA in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs)
Source: GEO: Gene Expression Omnibus - October 6, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE214453 Alphavirus infection triggers antiviral RNAi immunity in mammals
Contributors : Jing Kong ; Yuanyuan Bie ; Wenting Ji ; Jiuyue Xu ; Bao Lyu ; Xiaobei Xiong ; Yang Qiu ; Xi ZhouSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Aedes aegypti ; Homo sapiens ; Mus musculusRNA interference (RNAi) functions as an antiviral immune response in plants and invertebrates, whereas mammalian RNAi response has been found so far only in undifferentiated cells and in differentiated cells inactive in interferon (IFN) system or in infections with viruses disabling viral suppressors of RNAi (VSRs), thereby leading to questio...
Source: GEO: Gene Expression Omnibus - October 4, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Aedes aegypti Homo sapiens Mus musculus Source Type: research
GSE186225 CUT-tag analysis of T24 cells treated with a control scramble (scr) siRNA or a si-circSLC38A1
This study aims to investigate whether circSLC38A1 could affect the enrichment of downstream genes by the transcription factor ILF3.T24 cells were treated with a control scramble (scr) siRNA or a siRNA that specifically knock down the expression of circSLC38A1, 48h after ttansfection, cells were collected and treated for CUT-tag.CUT-tag-Seq analysis provided evidence of ILF3 enrichment of downstream genes changes between si-NC and si-circSLC38A1 T24 cells.
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE210922 FOXM1-mediated regulation of reactive oxygen species and radioresistance in oral squamous cell carcinoma cells
Contributors : Hisashi Takeshita ; Ryoji Yoshida ; Junki Inoue ; Mayumi Hirayama ; Toru Oyama ; Ryuta Kubo ; Keisuke Yamana ; Yuka Nagao ; Shunsuke Gohara ; Junki Sakata ; Masatoshi Hirayama ; Kenta Kawahara ; Nozomu Takahashi ; Akiyuki Hirosue ; Yoshikazu Kuwata ; Manabu Fukumoto ; Ryo Toya ; Ryuji Murakami ; Hideki NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRadioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) cell lines, generated by irradiating parental...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE206084 RNA-seq on primary human kidney epithelial cells with oleate treatment and PLIN2 knockdown
Contributors : Haikuo Li ; Benjamin D HumphreysSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we investigated the transcriptomic changes induced by oleic acid treatment on human Primary Renal Proximal Tubule Epithelial Cells (RPTECs) with RNA-seq. We also profiled cells with oleic acid treatment after PLIN2 gene knockdown with siRNA treatment.
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
