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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE196283 BRG1-dependent regulation of Wnt signaling pathway during skeletal muscle differentiation
Contributors : Anthony N Imbalzano ; Tapan SharmaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq analysis for C2C12 myoblasts knocked down for either only-BRG1 or only-BRM or both BRG1 and BRM. Cells were treated with an siRNA SMARTpools of four oligos each targeting either BRG1 (siGENOME mouse Smarca4 pool #M-041135-01-0020) or BRM (siGENOME mouse Smarca2 pool #M-056591-00-0020) or both. Control samples were treated with non-targeting scrambled oligos (siRNA SMARTpool ON-TARGETplus scrambled non-targeting pool # D-001810-10-20). siRNA pools were purchased from Dharmacon, Hori...
Source: GEO: Gene Expression Omnibus - June 24, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE223836 Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival
Contributors : Vinay K Sharma ; Kiersten Campbell ; Xuyu Yang ; Ryan Dale ; Y.P LohSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the cellular regulators of ERK and cAMP signaling pathways in response to serotonin induced 5-HTR1E activation in 5-HTR1E overexpressing HEK293 cells. We found that Pertussis Toxin (PTX) treatment co...
Source: GEO: Gene Expression Omnibus - June 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE152863 MCF10A cells expressing empty vector, siRNA-resistant wild-type and siRNA-resistant catalytically dead TIP60 treated with control or TIP60 siRNA
This study suggests that alternative s plicing of ITGA6 exon 25 is regulated by the TIP60-ESRP2 axis.
Source: GEO: Gene Expression Omnibus - June 19, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE234780 Knockdown TIMM13 in A549 lung cancer cell line
Contributors : Zhaozhao Zhao ; Ting NiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe depleted TIMM13 using short interfering RNA (siRNA) in A549 lung cancer cells, and found that silencing of TIMM13 could significantly inhibit A549 cell proliferation. Thus, we conducted RNA-seq in the A549 cells transduced with either nontargeting siRNA or two distinct TIMM13-specific siRNAs. We observed widespread gene expression change in A549 cells upon TIMM13 knockdown.
Source: GEO: Gene Expression Omnibus - June 17, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE209802 Mettl3 mediated m6A methylation in human bronchial epithelial cells exposed to cigarette smoke extract
Contributors : Yaping Zhang ; Lixing Wang ; Xiangdong Wang ; Yiming ZengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the mRNA m6A modification profiling in 16-HBE cells with or without siRNA-mediated Mettl3 knockdown exposed to cigarette smoke extract, we performed m6A MeRIP-seq with the total RNA extracted from two samples.
Source: GEO: Gene Expression Omnibus - June 7, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE222598 Effect of SF3B4 depletion on gene expression of A549 lung cancer cell
Contributor : Tao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function SF3B4 during the progression of lung cancer, A549 cells with either SF3B4 siRNA or scramble siRNA were used for RNA-seq.
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE175671 U2AF1 plays a critical role in global co-transcriptional splicing (Fraction chrRNA-seq)
Contributors : Yajing Hao ; Changwei Shao ; Xiang-Dong FuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to measure the impact of U2AF1 on co-transcriptional splicing, we treated HeLa cells with control siRNA or U2AF1 siRNA. To measure co-transcriptional splicing, we fractionated HeLa cells into cytosolic (Cyt), nucleoplasm (NP), and chromatin/particle (Chr) fractions. We purified total RNA from Chr compartment, spiked in with in vitro transcribed EGFP and FireFly luciferase RNA for data normalization, depleted ribosomal RNAs, and constructed two independent libraries for RNA-seq.
Source: GEO: Gene Expression Omnibus - May 27, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE209768 Gene expression in AML12 cells after Uhrf2 knock-down
Contributors : Coenraad F Slabber ; Andrii Kuklin ; Sabine WernerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe identified the ubiquitin ligase Uhrf2 as a key regulator of liver regeneration. To determine the underlying mechanisms of action, we performed siRNA-mediated knockdown of Uhrf2 in AML12 cells and analysed the transcriptome of the Uhrf2-deficient cells.
Source: GEO: Gene Expression Omnibus - May 25, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE232483 Effect of SRCAP on gene expression during PRRSV infection of Marc-145 cells.
Contributors : Yihong Xiao ; Guofei DingSeries Type : Expression profiling by high throughput sequencingOrganism : Chlorocebus sabaeusTo investigate the SRCAP regulation of gene transcription during PRRSV infection, we established Marc-145 cell lines in which SRCAP gene has been knocked down by siRNA.We then performed gene expression profiling analysis using data obtained from RNA-seq.
Source: GEO: Gene Expression Omnibus - May 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Chlorocebus sabaeus Source Type: research
GSE231942 MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres
Contributors : Kausika K Malik ; Deepshika Pulimamidi ; Shweta TyagiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of KMT2A and KMT2F in the regulation of gene transcriptiom,siRNA based knock-down of KMT2A and KMT2F was performed in U2OS cells.
Source: GEO: Gene Expression Omnibus - May 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE150260 FTO regulated genes in Hepatocellular Carcinoma
Contributor : Shen YinghaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global genes regulated by FTO high-throughput mRNA sequencing (RNA-Seq) was performed to compare the expression profile between HepG2 cells transfected with control siRNA or FTO siRNA.
Source: GEO: Gene Expression Omnibus - May 10, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE231670 Targeted suppression of siRNA biogenesis in Arabidopsis pollen
Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE231669 Targeted suppression of siRNA biogenesis in Arabidopsis pollen RNA-seq
Contributor : Filipe BorgesSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe used the RNaseIII-like protein RTL1 to suppress siRNA biogenesis specifically in Arabidopsis pollen, and found distinct siRNA subsets produced in the sperm and vegetative cell lineages via the RNA polymerase IV (Pol IV).
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE231668 Targeted suppression of siRNA biogenesis in Arabidopsis pollen small RNA-seq
Contributor : Filipe BorgesSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe used the RNaseIII-like protein RTL1 to suppress siRNA biogenesis specifically in Arabidopsis pollen, and found distinct siRNA subsets produced in the sperm and vegetative cell lineages via the RNA polymerase IV (Pol IV).
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE231667 Targeted suppression of siRNA biogenesis in Arabidopsis pollen bisulfite-seq
Contributor : Filipe BorgesSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe used the RNaseIII-like protein RTL1 to suppress siRNA biogenesis specifically in Arabidopsis pollen, and found distinct siRNA subsets produced in the sperm and vegetative cell lineages via the RNA polymerase IV (Pol IV).
Source: GEO: Gene Expression Omnibus - May 7, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
