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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE208785 Differentially expressed genes after siRNA transfection in human cancer cell line
Contributors : R Yasudome ; N SekiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by siRNAs transfection in human colon cancer cell line, HCT116 was subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - July 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE189458 The RNA sequencing analysis of nasopharyngeal carcinoma (NPC) cell line S18 upon circIPO7 knockdown
Contributors : X H Hong ; J Ma ; Y Q LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe development of therapeutic resistance and metastatic dissemination takes place in 20-30% patients with nasopharyngeal carcinoma (NPC), resulting in poor survival. Hence, a better understanding of the underlying molecular mechanisms will help improve clinical outcome. We have identified a novel circRNA, circIPO7, as a promoter of metastasis and cisplatin chemoresistance in NPC cells. High-throughput RNA sequencing analysis was performed in the human nasopharyngeal carcinoma cell line S18 after tr...
Source: GEO: Gene Expression Omnibus - July 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE185932 Gene expression changes associated with reducing Sox2 expression in ovarian cancer cell line PA1 under anchorage independence
The objective of this study is to examine the effect of changing Sox2 expression under the conditions of anchorage independent growth that is known to drive the expression of survival genes. We compared genome wide gene expression profiles of the ovarian tumor cell line PA1 upon transient knockdown of Sox2 expression using siRNA and compared to negative silencer control siRNA cells. Cells grown in biological triplicates were transfected under steady state 2D growth conditions and then transferred to poly-hema coated plates to prevent attachment. After 72 hrs, RNA was collected from siSox2 and sicontrol cells followed by ve...
Source: GEO: Gene Expression Omnibus - July 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE183793 Global gene expression of canine bladder K9TCC cells and cancer stem cells after COX-2 inhibition
Contributors : Emma A Hurst ; Lisa Y Pang ; David J ArgyleSeries Type : Expression profiling by arrayOrganism : Canis lupus ; Canis lupus familiarisCancer stem cells (CSCs) are fundamental to bladder cancer progression and the cyclooxygenase-2 (COX-2) pathway has a pro-tumorigenic role in CSC function. Naturally occurring bladder cancer in dogs has the potential to be a natural model of the human disease. Here, we used canine specific microarrays to determine changes in global gene expression of canine bladder cancer cells (the K9TCC cell line) and bladder cancer stem cells isolated from the K9TCC cell line after treatment...
Source: GEO: Gene Expression Omnibus - July 20, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Canis lupus Canis lupus familiaris Source Type: research
GSE208171 Loss of protein function of ZC4H2 gene causing severe phenotypes of female-restricted Wieacker Wolff Syndrome
Conclusions: Down-regulation of genes related to the oxidative phosphorylation pathway might be involved in the pathogenity of the disease. Keywords: Female-restricted Wieacker-Wolff Syndrome (WRWF), Wieacker-Wolff Syndrome (WRWFFR), ZC4H2, Arthrogryposis multiplex congenita (AMC), nonsense mutation
Source: GEO: Gene Expression Omnibus - July 17, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE207658 Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Contributors : Georg Vogler ; Alexandre R ColasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identified. Postulating that impaired cardiomyocyte proliferation as a likely important contributing mechanism to HLHS pathogenesis, and we conducted a genome-wide siRNA screen to identify genes affecting proliferation of human iPSC-derived cardiomyocy...
Source: GEO: Gene Expression Omnibus - July 14, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189462 LncRNA SPRY4-IT1 Facilitates Cell Proliferation and Angiogenesis of Glioma by the miR-101-3p/EZH2/VEGFA Signaling Axis
Contributors : Ji Wang ; Yanming Chen ; Qing LanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSPRY4-IT1 (SPRY4 intronic transcript 1) is a long non-coding RNA (lncRNA) that was identified as a novel oncogene in various human cancers, including glioma. However, its function and the further mechanism in glioma remain largely unclear. Here, we aimed to investigate the role of SPRY4-IT1 in the development of glioma and its underlying molecular mechanism. We identify that SPRY4-IT1 is overexpressed in patients with glioma from the TCGA database and own cohort, and correlated with poor pr...
Source: GEO: Gene Expression Omnibus - June 30, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE164834 Mitochondrial protease Lonp1 localizes to the nucleus in response to heat shock
Contributors : Marcello Pinti ; Lara Gibellini ; Rebecca Borella ; Mattia Forcato ; Giada ZaniniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe analyzed the effects of Lonp1 silencing on the response to heat shock by analyzing the transriptomic profile of SW620 colon cancer cells undergoing heat shock. Briefly, Lonp1 has been silenced by using a specific siRNA, then cells have been kept at 42 °C for 1 hour, and left at 37°C for one hour.
Source: GEO: Gene Expression Omnibus - June 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE154529 Identification of ALKBH5 targets in osteosarcoma by methyl RNA immunoprecipitation MeRIP-seq
Contributors : Pooja Yadav ; Manjeet Rao ; Yidong Chen ; Zhao LaiSeries Type : OtherOrganism : Homo sapiensTo identify potential target mRNAs that are demethylated by ALKBH5, meRIP-seq with a m6A antibody was conducted in 143B osteosarcoma cells transfected with scrambled or ALKBH5-siRNA.
Source: GEO: Gene Expression Omnibus - June 28, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE206100 Direct conversion of rod to cone-like photoreceptors by NRL knockdown with cell-penetrating siRNA
Contributors : Hyungwoo Lee ; Hyoik Jang ; Jae-Byoung Chae ; Dong Ki Lee ; Hyewon ChungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the retinal transcriptome in which Nrl gene is knocked down by cp-asiRNA (cp-asiNRL) in wildtype C57BL/6J mouse and laser-induced CNV model.
Source: GEO: Gene Expression Omnibus - June 24, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE133012 Measuring the transcriptomic response to targeting kinases correlated with estrogen receptor activity in Breast Cancer
Contributors : Simona Schindler ; Amy Cullen ; Helen V Cook ; Florian Markowetz ; Andrew N HoldingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe undertook a phosophotranscriptomic network analysis of published patient tumour RNA-seq and phosphoproteomic data to identify kinases that correltated with Estrogen Receptor activity in Breast Cancer. The most sucessful canidates were selected for targeting by siRNA and the effects monitored by RNA-seq.
Source: GEO: Gene Expression Omnibus - June 18, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE206103 Human skin specific long noncoding RNA HOXC13-AS regulates keratinocyte differentiation by inferfering with Golgi-ER retrograde transport
Contributors : Ning X Land én ; Letian ZhangSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn an RNAseq analysis, we have identified the HOXC13-AS significantly downregulated in wound biopsies and epidermal cells compared to skin counterparts.To study the genes regulated by HOXC13-AS, we transfected HOXC13-AS siRNA pool into human primary epidermal keratinocytes to knockdown HOXC13-AS and induced cell differentiation for 3 days by 1.5 mM calcium. We performed a global transcriptome analysis of keratinocytes upon the HOXC13-AS knockdown using Affymetrix arrays.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE178243 Evaluation of ATAD2 as a potential target in hepatocellular carcinoma
Contributor : Mehmet OzturkSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe evaluated differentially expressed genes (DEGs) between hepatocellular carcinoma cell lines (Hep3B, SNU449, and PLC/PRF/5) treated with ATAD2 siRNA or control using Affymetrix array data whether ATAD2 could be potential target in hepatocellular carcinoma.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE148795 Study of transcriptional effects of FOXS1 silencing and TGF-beta treatment in SNU-449 hepatocellular carcinoma cell line
Conclusions: FOXS1 is a novel TGFβ target and a key mediator of EMT. Its induction in cancer is associated with a poor prognosis. Thus, determining the exp ression of FOXS1 in advanced tumors in which the pro-metastatic arm of TGFβ is activated could help to identify patients who may benefit from targeted therapies using TGFβ inhibitors.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE180897 Transcriptional effects of siRNA-mediated STAT3 knockdown on LPS-activated M-CSF-derived macrophages
Contributors : Miriam S Fuentes ; Ángeles D Soto ; Miguel A Vega ; Angel L CorbíSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the role of STAT3 on the transcriptional signature of LPS-activated human M-CSF-dependentmonocyte-derived macrophages. Methods: Human Peripheral Blood Mononuclear Cells (PBMC) were isolated from buffy coats from donors over a Lymphoprep gradient according to standard procedures.monocytes were purified from PBMC by magnetic cell sorting using anti-CD14 microbeads (>95% CD14+ cells).monocytes from three independent donors (0.5 x 106 cells/ml,>95%...
Source: GEO: Gene Expression Omnibus - June 8, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
