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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE200861 Tumor promoting effect of long non-coding RNA RP11-556E13.1 and its clinical significance as a prognostic factor in hepatocellular carcinoma.
Contributors : Jie Li ; Zhikun Liu ; Jianguo Wang ; Xuyong Wei ; Qiang Wei ; Shusen Zheng ; Xiao XuSeries Type : Expression profiling by arrayOrganism : Homo sapiensObjective: The aim of this study was to reveal the function of the long non-coding RNA (lncRNA) RP11-556E13.1 (RP11) and its clinical significance in hepatocellular carcinoma.Methods: LncRNA and mRNA expression profiling was performed using lncRNA and mRNA microarrays in 5 pairs of HCC and adjacent tissues. 112 paired HCC and adjacent tissue samples were analyzed by semiquantitative real-time polymerase chain reaction (sqRT-PCR) to evaluate the expression of RP...
Source: GEO: Gene Expression Omnibus - April 18, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE200312 Glucocorticoid recptor knockdown in primary amnion epithelial cells treated with MPA and TNFa
Contributors : Sarah J Cunningham ; Terrence K Allen ; Tim E Reddy ; Alejandro BarreraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo analyze the effect of glucocorticoids on primary amnion epthelial cells, we harvested tissue samples from 10 healthy ceseaean section patients. We knocked down the glucocorticoid receptor with an siRNA or used a control siRNA. We treated samples with medroxyprogesterone acetate. Half the cells we subjected to a TNFa challenge
Source: GEO: Gene Expression Omnibus - April 9, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE199944 Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration
In this study, we investigated the functional role of high-mobility group box 2 (HMGB2), a chromatin protein in liver regeneration using wild-type and HMGB2-knockout (KO) mice. Liver tissues were sampled after 70% partial hepatectomy (PHx), and analyzed by immunohistochemistry using various markers of cell proliferation, including Ki-67, PCNA, cyclin D1, cyclin B1, EdU and pH3S10. In WT mice, hepatocyte proliferation was strongly correlated with the spatiotemporal expression of HMGB2; however, cell proliferation was significantly delayed in hepatocytes of HMGB2-KO mice. Quantitative PCR demonstrated that cyclin D1 and cyc...
Source: GEO: Gene Expression Omnibus - April 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE194248 Human prostate cancer cells (VCaP and AIVCaP): siAR alone (single siRNA) vs. siAR plus OPRK1 (combo-siRNA)
Contributors : Yuki Makino ; Takashi KobayashiSeries Type : Expression profiling by arrayOrganism : Homo sapiensThrough comparative genomics using PDX models of androgen-dependent (AD) and castration-resistant (CR) tumors, we identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target.To gain insight with regard to biological function of OPRK1 under androgen-depleted condition, we set up two distinct comparisons us...
Source: GEO: Gene Expression Omnibus - April 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE199026 ATF6 is required for the survival of castration-resistant prostate cancer cells
Contributors : Tingting Zhang ; Faming Zhao ; Xia ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo gain insight into the global ATF6 target gene profile in prostate cancer cells, we performed RNA-seq analysis in DU145 cells upon either ATF6 siRNA-mediated knockdown (siATF6) or Ceapin-A7-mediated ATF6 α inhibition.
Source: GEO: Gene Expression Omnibus - March 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE171974 JMJD6 is a possible epigenetic regulator of PD-L1 expression and an independent favorable prognostic factor of intrahepatic cholangiocarcinoma
Contributors : Yukiko Kosai-Fujimoto ; Daisuke Okuzaki ; Takasuke FukuharaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAssociation of Jumonji domain-containing 6 (JMJD6) with outcomes of various cancers has been shown, however the impact on intrahepatic cholangiocarcinoma (ICC) has never been reported yet. The aim of this study is to clarify the role of JMJD6 in the clinical settings and the impact on the outcomes of ICC. The resected liver specimens of 53 patients who underwent surgery for ICC were analyzed for JMJD6 expression by immunohistochemistry staining. The relationship be...
Source: GEO: Gene Expression Omnibus - March 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE128756 Gene expression data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells 48 hours
Contributors : Juliette Bertrand ; Lionel LarueSeries Type : Expression profiling by arrayOrganism : Mus musculusTo investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells.Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 48 hours after transfection. We analyzed the transcriptome of Melan-a cells 48 hours after transfection with siDicer or siScr to understand the molecular mechanisms involved in Dicer-de...
Source: GEO: Gene Expression Omnibus - March 22, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE128755 Gene expression data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells 24 hours
Contributors : Juliette Bertrand ; Lionel LarueSeries Type : Expression profiling by arrayOrganism : Mus musculusTo investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells.Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 24 hours after transfection. We analyzed the transcriptome of Melan-a cells 24 hours after transfection with siDicer or siScr to understand the molecular mechanisms involved in Dicer-de...
Source: GEO: Gene Expression Omnibus - March 22, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE128754 microRNA levels data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells
Contributors : Juliette Bertrand ; Lionel LarueSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculus ; synthetic constructTo investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells.Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 24 hours after transfection. We analyzed the miRnome of Melan-a cells 24 and 48 hours after transfection with siDicer or siScr to understand the molecular mech...
Source: GEO: Gene Expression Omnibus - March 22, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Mus musculus synthetic construct Source Type: research
GSE165090 Functional role of SERPINA1 in trophoblasts
Contributors : Antti Haapalainen ; Heli Tiensuu ; Pinja TissarinenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the effect of SERPINA1 siRNA experiment
Source: GEO: Gene Expression Omnibus - March 10, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189645 Evolutionary transcriptomics of Eutherian gene expression gains and the origins of decidualization Set 7
Contributors : Mirna Marinic ; Vincent J LynchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used human endometrial stromal fibroblast cell line to perform an siRNA knockdown coupled with RNA-seq screen of a series of transcription factors that gained expression in the endometrial tissue of Eutherian mammals.
Source: GEO: Gene Expression Omnibus - February 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189635 Evolutionary transcriptomics of Eutherian gene expression gains and the origins of decidualization Set 6
Contributors : Mirna Marinic ; Vincent J LynchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used human endometrial stromal fibroblast cell line to perform an siRNA knockdown coupled with RNA-seq screen of a series of transcription factors that gained expression in the endometrial tissue of Eutherian mammals.
Source: GEO: Gene Expression Omnibus - February 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189624 Evolutionary transcriptomics of Eutherian gene expression gains and the origins of decidualization Set 5
Contributors : Mirna Marinic ; Vincent J LynchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used human endometrial stromal fibroblast cell line to perform an siRNA knockdown coupled with RNA-seq screen of a series of transcription factors that gained expression in the endometrial tissue of Eutherian mammals.
Source: GEO: Gene Expression Omnibus - February 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189463 Evolutionary transcriptomics of Eutherian gene expression gains and the origins of decidualization Set 4
Contributors : Mirna Marinic ; Vincent J LynchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used human endometrial stromal fibroblast cell line to perform an siRNA knockdown coupled with RNA-seq screen of a series of transcription factors that gained expression in the endometrial tissue of Eutherian mammals.
Source: GEO: Gene Expression Omnibus - February 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE189448 Evolutionary transcriptomics of Eutherian gene expression gains and the origins of decidualization Set 3
Contributors : Mirna Marinic ; Vincent J LynchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used human endometrial stromal fibroblast cell line to perform an siRNA knockdown coupled with RNA-seq screen of a series of transcription factors that gained expression in the endometrial tissue of Eutherian mammals.
Source: GEO: Gene Expression Omnibus - February 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
