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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE233806 RNA N6-methyladenosine methyltransferase METTL3 drives NAFLD-HCC and is a therapeutic target for boosting immunotherapy RNA-Seq
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNon-alcoholic fatty liver disease (NAFLD) is an emerging risk factor of hepatocellular carcinoma (HCC). However, the mechanism and target therapy on NAFLD-HCC are still unclear. Here, we identify that the N6-methyladenosine (m6A) methyltransferase METTL3 promotes NAFLD-HCC. Hepatocyte-specific Mettl3 knockin exacerbated NAFLD-HCC formation while Mettl3 knockout exerted an opposite effect in mice. Single-cell RNA-seq revealed that METTL3 suppressed antitumor immune response by reducing infiltration of Gzmb+ and IFN- γ+ CD8+ T-cell, there...
Source: GEO: Gene Expression Omnibus - August 23, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE224479 Genome-wide analysis of INO80 knockdown
This study provides novel insights into the chromatin remodeling factors regulated by INO80 in renal epithelial cells.
Source: GEO: Gene Expression Omnibus - August 23, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE197650 RNA BS-seq of Nocodazole treated HeLa cells with NSUN family member deficiency
Contributors : Tao Huang ; Jianheng Liu ; Rui ZhangSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensm5C accumulates on mRNAs in Nocodazole (Noc) treated cells. To figure out which m5C writer is responsible for these m5C sites, we generated three KO cell lines (NSUN2, NSUN5, and NSUN6) with CRISPR induced mutagenesis. We also used siRNA to suppress the expression of Nop2 (NSUN1) in wild-type HeLa cells. Then we performed mRNA BS-seq on the cells harvested after 48 hours Noc-treatment (for siRNA experiments, cells were treated with siRNA for 48 hours first).
Source: GEO: Gene Expression Omnibus - August 20, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
GSE240039 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein ATAC
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of ...
Source: GEO: Gene Expression Omnibus - August 10, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE182050 C-X-C chemokine receptor 4 ablation-driven transcriptional changes in monocyte-derived macrophage in response to lipopolysaccharide
Conclusions: Our study reveals that CXCR4 orchestrated the pro-inflammatory cytokine and decorin production in macrophages.
Source: GEO: Gene Expression Omnibus - August 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE236275 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of PVRL4 are elev...
Source: GEO: Gene Expression Omnibus - July 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE210879 Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity ChIP-seq
Contributors : Sara Rohban ; Mahmoud R Rafiee ; Jernej Ule ; Nicholas LuscombeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of catalytic subunit of the Integrator complex, INTS11, during the transcription cycle, we established U2OS cell line in which INTS11 has been knock down by siRNA.
Source: GEO: Gene Expression Omnibus - July 27, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE210878 Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity DRB/TT-seq
Contributors : Sara Rohban ; Mahmoud R Rafiee ; Jernej Ule ; Nicholas LuscombeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of catalytic subunit of the Integrator complex, INTS11, during the transcription cycle, we established U2OS cell line in which INTS11 has been knock down by siRNA.
Source: GEO: Gene Expression Omnibus - July 27, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE210877 Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity TT-seq
Contributors : Sara Rohban ; Mahmoud R Rafiee ; Jernej Ule ; Nicholas LuscombeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of catalytic subunit of the Integrator complex, INTS11, during the transcription cycle, we established U2OS cell line in which INTS11 has been knock down by siRNA.
Source: GEO: Gene Expression Omnibus - July 27, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE228651 Knockdown of LTB4R, HCAR3, GPR153, and GPR137 in primary human keratinocytes
Contributors : Ramiro Iglesias-Bartolome ; Pilar M Pedro ; Ting ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA sequencing (RNAseq) of primary neonatal human keratinocytes transduced with pooled siRNAs targeting LTB4R, HCAR3, GPR153, and GPR137, or non-targeting control siRNA (siCon)
Source: GEO: Gene Expression Omnibus - July 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE214742 CRISPR and siRNA manipulation of SOX17 in human pulmonary artery endothelial cells HPAEC
Contributors : Christopher J Rhodes ; Rachel Walters ; Jurjan AmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHPAEC were treated with either siRNA to SOX17 or CRISPR activating or inhibiting the promoter or an enhancer region associated with pulmonary hypertension and sequenced.
Source: GEO: Gene Expression Omnibus - July 10, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE209814 Gene expression profiles in gastric cancer cells with TM4SF1-AS1 knockdown
Contributors : Hiromu Suzuki ; Hiroshi KitajimaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo clarify the function of a long noncoding RNA TM4SF1-AS1 in gastric cancer (GC), we carried out a gene expression microarray analysis using GC cell lines HSC45 transfected with a siRNA targeting TM4SF1-AS1 or a control siRNA. Gene ontology analysis revealed that genes associated with interferon signaling and immune response were significantly enriched among downregulated genes.
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE207250 MiRNA array analysis of VMRC-LCD cells following ASCL1 knockdown function.
Contributors : Takayoshi Enokido ; Naoya Miyashita ; Akira SaitoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructTo investigate the function of ASCL1 in ASCL1-positive lung adenocarcinoma, we established VMRC-LCD cell line in which the target gene has been knocked down by siRNA.We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different cells.
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
GSE181249 Transcriptional effects of siRNA-mediated AhR knockdown on TLR7 activation of M-CSF-derived macrophages
Contributors : Miriam Sim ón Fuentes ; Ángeles Domínguez Soto ; Miguel A Vega ; Angel L CorbíSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the role of AhR on the transcriptional signature of TLR7-activated human M-CSF-dependent monocyte-derived macrophages. Methods: Human Peripheral Blood Mononuclear Cells (PBMC) were isolated from buffy coats from donors over a Lymphoprep gradient according to standard procedures. Monocytes were purified from PBMC by magnetic cell sorting using anti-CD14 microbeads (>95% CD14+ cells). Monocytes from three independent donors (0.5 x ...
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE174495 Next Generation Sequencing of si-NC and si-circFAM120A Transcriptomes
Conclusions: Our study represents the detailed analysis of decidualized hESCs transcriptomes between si-NC and si-circFAM120A groups.
Source: GEO: Gene Expression Omnibus - June 30, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
