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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE227774 Differential gene expression profile analysis of parental, Cas9-p15 control, and MELK knockout cells
Contributor : Chandra BartholomeuszSeries Type : Expression profiling by arrayOrganism : Homo sapiensTriple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSCs), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase of the Snf1/AMPK kinase family, is known to promote CSC maintenance and malignant transformation. Our study showed that MELK knockdown using siRNA or MELK inhibition using the MELK inhibitor MELK-In-17 significantly reduced invasiveness, reversed epithelial-to-mesenchymal t...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE204969 MED12 Mutation Activates Tryptophan-Kynurenine-AHR pathway and Promotes Cell Growth in Human Uterine Leiomyoma RNA-seq
Contributors : Azna Zuberi ; Yongchao Huang ; Ariel J Dotts ; John S Coon V ; Shimeng Liu ; Takashi Lizuka ; Yang Dai ; Ping Yin ; Priyam Patel ; Serdar E BulunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUterine leiomyoma (LM) is the most common tumor in women. Estrogen and progesterone, via their receptors ER α and PR, play essential roles in LM growth. Mediator complex subunit 12 (MED12) mutations occur in 70% of all LM and are thought to drive tumor growth in a steroid hormone-dependent manner; however, the mechanisms remain unclear. Here, we performed ChIP-seq (ERα, PR, and ...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE204968 MED12 Mutation Activates Tryptophan-Kynurenine-AHR pathway and Promotes Cell Growth in Human Uterine Leiomyoma ChIP-seq
Contributors : Azna Zuberi ; Yongchao Huang ; Ariel J Dotts ; John S Coon V ; Shimeng Liu ; Takashi Lizuka ; Yang Dai ; Ping Yin ; Priyam Patel ; Serdar E BulunSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensUterine leiomyoma (LM) is the most common tumor in women. Estrogen and progesterone, via their receptors ER α and PR, play essential roles in LM growth. Mediator complex subunit 12 (MED12) mutations occur in 70% of all LM and are thought to drive tumor growth in a steroid hormone-dependent manner; however, the mechanisms remain unclear. Here, we performed ChIP-seq (...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149867 AHR regulated genes in Colorectal Cancer
Contributor : Yan TingtingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global genes regulated by AHR, high-throughput mRNA sequencing (RNA-Seq) was performed to compare the expression profile between DLD-1 cells transfected with control siRNA or AHR siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE149783 lncSLCC1(RP11-400N13.2)-regulated genes in Colorectal Cancer
Contributor : Yan TingtingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the global genes regulated by lncRNA-SLCC1(RP11-400N13.2), high-throughput mRNA sequencing (RNA-Seq) was performed to compare the expression profile between DLD-1 cells transfected with control siRNA or lncSLCC1 siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE222571 Haploinsufficiency of NFKBIA reshapes the epigenome and imparts disease fate in diffuse gliomas
Contributors : Markus Bredel ; Llu ís Espinosa ; Teresa Lobo-JarneSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis dataset used H3K27me3 ChIP-seq profiling of normal immortalized human astrocytes that are wild-type or have been genetically modified to by CRISPR to knockout NFKBIA or by siRNA to mimic a hemizygous NFKBIA loss
Source: GEO: Gene Expression Omnibus - April 28, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE160638 MYC induces immunotherapy and interferon- γ resistance through downregulation of JAK2
Contributors : Ettai Markovits ; Ran Elkon ; Michal J Besser ; Gal MarkelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmunotherapy revolutionized the treatment of advanced melanoma. As the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of pre-immunotherapy tumor biopsies from melanoma patients that received PD-1 blockade (n=36) or adoptive cell therapy with tumor infiltrating lymphocytes (n=37). We identified two melanoma-intrinsic mutually exclusive gene programs, which are controlled by interferon- γ and MYC, and determi...
Source: GEO: Gene Expression Omnibus - April 24, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE219162 MLX siRNA knockdown in primary human hepatocytes
Contributors : Shilpa R Nagarajan ; Eilidh J Livingstone ; Thomas Monfeuga ; Lara C Lewis ; Shahul H Liyakath Ali ; Anandhakumar Chandran ; David J Dearlove ; Matt J Neville ; Lingyan Chen ; Cyrielle Maroteau ; Maxwell Ruby ; Leanne HodsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens3' mRNA-sequencing of primary human hepatocytes treated with either non-targeting (siNT) or targeted siRNA against MLX (siMLX) (3 independent replicates with different PHH donors, n=5 prepared per donor and treatment; one siMLX sample was excluded from analysis due to low quality)
Source: GEO: Gene Expression Omnibus - April 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE229291 Gene expression profiling of Cav1 knock down in murine hepatic stellate cell
Contributors : Yan Zhang ; Yijie Zhang ; Tingting Chen ; Yin Ling ; Jiacheng Gong ; Jun Wang ; Jierui Li ; Qihan Xu ; Ying Meng ; Yang Li ; Xu LiSeries Type : Expression profiling by arrayOrganism : Mus musculusActivated primary murine hepatic stellate cells were transfected with siRNA targeting Caveolin-1 directly after attachment (o/n). Experiment was performed in triplicate using primary cells from 3 donor mice.
Source: GEO: Gene Expression Omnibus - April 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE229206 RNA-sequencing analysis of Nrf2 target genes in rat pulmonary arterial smooth muscle cells and endothelial cells
Contributors : Ang Luo ; Haiyang Tang ; Yangfan JiaSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTo investigate the genes regulated by Nrf2 in rat PASMC and PAEC, Nrf2 was knockdown by using siRNA. 48h after siRNA transfection ， cells were collected for RNA-sequencing.
Source: GEO: Gene Expression Omnibus - April 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
GSE223652 Hepatocyte mARC1 Promotes Fatty Liver Disease
ConclusionsCollectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - April 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE146975 EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Contributors : Michael Rose ; Bernd Denecke ; Nadine T GaisaSeries Type : Expression profiling by arrayOrganism :Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle invasive bladder cancer (MIBC). However, impact on bladder cancer with substantial squamous differentiated (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n=125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urin...
Source: GEO: Gene Expression Omnibus - March 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
GSE204771 RNA sequencing of CTRL and siFBLN4 HAECs
Contributor : Yoshito YamashiroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibulin-4 (Fbln4) is an extracellular protein, expressed throughout the aortic wall including endothelial cells (EC), smooth muscle cells (SMC) and fibroblasts. SMC-specific deletion of Fbln4 in mice led to formation of ascending aortic aneurysm with disruption of elastic fibers and Fbln4 is known to play role in elastic fiber formation. However, the function of Fbln4 in EC is unknown. To examine if Fbln4 deletion induces any changes in cellular phenotype of EC, we knocked down FBLN4 in human aortic endothe...
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE185232 RNA-seq for siRpl14+siDux/siRpl11
Contributors : Y YI ; Y Y Zeng ; H Li ; Y LohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA-seq were performed on E14 cells knockdown with siRNA; siRpl14+siDux; siRpl14+siRpl11
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE179124 RNA-seq for siRNA 48h
Contributors : Yao Yi ; Y Y Zeng ; H Li ; Y LohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA-seq were performed on E14 cells knockdown with siRNA
Source: GEO: Gene Expression Omnibus - March 8, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
