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Condition: Thrombosis

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Total 185 results found since Jan 2013.

Ex vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele-Specific Small-Interfering RNA.
Abstract Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is an endothelial protein that is secreted to the circulation upon endothelial activation. Once secreted, VWF multimers bind platelets and chaperone coagulation factor VIII in the circulation. Treatment of VWD focuses on increasing VWF plasma levels, but production and secretion of mutant VWF remain uninterrupted. Presence of circulating muta...
Source: Thrombosis and Haemostasis - August 14, 2020 Category: Hematology Authors: de Jong A, Dirven RJ, Boender J, Atiq F, Anvar SY, Leebeek FWG, van Vlijmen BJM, Eikenboom J Tags: Thromb Haemost Source Type: research

Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
AbstractIntracerebral hemorrhage is the most dangerous complication in tPA thrombolytic therapy for ischemic stroke, which occurs as a consequence of endothelial cell death at the blood brain barrier (BBB) during thrombolytic reperfusion. We have previously shown that cerebral ischemia induced rapid occludin degradation and BBB disruption. Here we demonstrated an important role of occludin degradation in facilitating the evolution of ischemic endothelial cells towards death. Cultured brain microvascular endothelial cells (bEnd.3 cells) were exposed to oxygen ‐glucose deprivation (OGD) or incubated with occludin siRNA or ...
Source: Journal of Neurochemistry - June 11, 2020 Category: Neuroscience Authors: Yuan Zhang, Xiaofeng Li, Shanshan Qiao, Dexin Yang, Zongyang Li, Ji Xu, Weiping Li, Li Su, Wenlan Liu Tags: ORIGINAL ARTICLE Source Type: research

Hypoxia induced up-regulation of tissue factor is mediated through extracellular RNA activated Toll-like receptor 3-activated protein 1 signalling.
Abstract Sterile Inflammation (SI), a condition where damage associated molecular patterns (DAMPs) released from dying cells, leads to TLR (Toll-like receptor) activation and triggers hypoxemia in circulation leading to venous thrombosis (VT) through tissue factor (TF) activation, but its importance under acute hypoxia (AH) remains unexplored. Thus, we hypothesized that eRNA released from dying cells under AH activates TF via the TLR3-ERK1/2-AP1 pathway, leading to VT. Animals were exposed to stimulate hypoxia for 0-24 h at standard temperature and humidity. RNaseA and DNase1 were injected immediately before expo...
Source: Blood Cells, Molecules and Diseases - June 10, 2020 Category: Hematology Authors: Bhagat S, Biswas I, Ahmed R, Khan GA Tags: Blood Cells Mol Dis Source Type: research

MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor- α-induced protein 8.
CONCLUSIONS: MiR-379 has a binding site with TNFAIP8 and can inhibit its activity by binding to TNFAIP8 mRNA. SiRNA-TNFAIP8 can inhibit the NF-κB signaling pathway and protect myocardial cells from AMI-induced myocardial damage by reducing the apoptosis level of myocardial cells. PMID: 32414226 [PubMed - as supplied by publisher]
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis.
CONCLUSIONS: These studies corroborate the original GWAS findings and establish a contributing role for SLC44A2 during the initiation of VT, with indications that this may be related to platelet-neutrophil interaction. The precise mechanism however remains elusive and warrants further investigation. PMID: 32297475 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - April 14, 2020 Category: Hematology Authors: Tilburg J, Coenen DM, Zirka G, Dólleman S, van Oeveren-Rietdijk AM, Karel MFA, de Boer HC, Cosemans JMEM, Versteeg HH, Morange PE, van Vlijmen BJM, Maracle CX, Thomas GM Tags: J Thromb Haemost Source Type: research

Transcriptome analysis of Klf15 ‑mediated inhibitory functions in a mouse deep venous thrombosis model.
Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model. Int J Mol Med. 2020 Mar 13;: Authors: Zhou J, Zhao X, Xie S, Zhou R Abstract Krüppel‑like family (KLF) members are important regulators of proinflammatory activation in the vasculature. A transcriptome study involving RNA sequencing (RNA‑seq) and quantitative PCR (qPCR) was performed to investigate Klf15 and Klf15‑regulated gene levels in C57BL/6 mice with inferior vena cava thrombi and in control (Blank) mice. A total of 2,206 differentially expressed genes (DEGs), including 1,330 upregul...
Source: International Journal of Molecular Medicine - March 12, 2020 Category: Molecular Biology Authors: Zhou J, Zhao X, Xie S, Zhou R Tags: Int J Mol Med Source Type: research

Plasmodium falciparum histidine rich protein HRPII inhibits the antiinflammatory function of antithrombin.
CONCLUSION: We postulate that Pf-derived HRPII and polyphosphate can contribute to the pathogenesis of malaria infection by downregulating the AT-dependent antiinflammatory and anticoagulant pathways. PMID: 31858717 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 18, 2019 Category: Hematology Authors: Dinarvand P, Yang L, Biswas I, Giri H, Rezaie AR Tags: J Thromb Haemost Source Type: research

Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
CONCLUSIONS: These results establish retinoid regulation of human cardiovascular calcification, provide new insight into mechanisms involved in these responses, and suggest selective retinoid modulators, like acyclic retinoids may allow for treating cardiovascular calcification without the adverse effects associated with cyclic retinoids. PMID: 31852220 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 18, 2019 Category: Cardiology Authors: Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J Tags: Arterioscler Thromb Vasc Biol Source Type: research

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates.
CONCLUSIONS: We present a mechanism in which interaction of macrophages with agLDL initiates a TLR4 signaling pathway, resulting in formation of the lysosomal synapse, catabolism of agLDL, and lipid accumulation in vitro and in vivo. PMID: 31597445 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 9, 2019 Category: Cardiology Authors: Singh RK, Haka AS, Asmal A, Barbosa-Lorenzi VC, Grosheva I, Chin HF, Xiong Y, Hla T, Maxfield FR Tags: Arterioscler Thromb Vasc Biol Source Type: research

P14. Abstract Title: Modulating Fibrinolysis using siRNA against Coagulation Factor XIII
High specificity, easy reversibility, and a half-life on the order of weeks; these are all major advantages that gene therapy has over traditional anticoagulants, add to that a strategy that weakens clots rather than preventing clotting altogether and prophylaxis of thrombosis may become much safer. Currently, anticoagulant drugs are used as a preventative measure for people susceptible to developing disease causing thrombi (which manifest as heart attacks, strokes, and pulmonary embolism), but they require frequent administration and their strict inhibition of clotting increases the risk of uncontrolled bleeding.
Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: A. Strilchuk, E. Conway, E. Pryzdial, P. Cullis, C. Kastrup Source Type: research

Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.
CONCLUSIONS: Our glycoproteomics analysis revealed that MFAP4 glycosylation is enhanced, as well as its expression during the advanced, aneurysmal stages of MFS compared with control aneurysms from patients without MFS. PMID: 31315432 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 17, 2019 Category: Cardiology Authors: Yin X, Wanga S, Fellows A, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M Tags: Arterioscler Thromb Vasc Biol Source Type: research

A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process.
CONCLUSION: Our study identified PLXDC2 as a new molecular player of the coagulation process. This article is protected by copyright. All rights reserved. PMID: 31271701 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 3, 2019 Category: Hematology Authors: Thibord F, Hardy L, Ibrahim-Kosta M, Saut N, Pulcrano-Nicolas AS, Goumidi L, Civelek M, Eriksson P, Deleuze JF, Le Goff W, Trégouët DA, Morange PE Tags: J Thromb Haemost Source Type: research

Mitigating placental injuries through up-regulating DAF in experimental APS mice:new mechanism of progesterone.
This article is protected by copyright. All rights reserved. PMID: 31091357 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - May 14, 2019 Category: Allergy & Immunology Authors: Zhang Y, Jin S Tags: Clin Exp Immunol Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages.
Abstract The prevalence of atherosclerosis has increased significantly in the recent years due to sedentary lifestyle and high-fat diet. However, the association between saturated fat intake and the increased risk for atherosclerotic cardiovascular diseases remains heavily debated. Lauric acid belongs to the saturated fatty acid group and its unique medium chain fatty acid properties are proven to be beneficial to humans in many ways. Thus, the aim of this project is to investigate the effect of lauric acid on the expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes-ADAMTS-1,...
Source: Molecular Biology Reports - April 14, 2019 Category: Molecular Biology Authors: Ong MH, Wong HK, Tengku-Muhammad TS, Choo QC, Chew CH Tags: Mol Biol Rep Source Type: research