Filtered By:
Condition: Thrombosis

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 185 results found since Jan 2013.

Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2.
CONCLUSIONS: HDAC2 is a critical regulator of Arg2 expression and thereby endothelial nitric oxide and endothelial function. Overexpression or activation of HDAC2 represents a novel therapy for endothelial dysfunction and atherosclerosis. PMID: 24833798 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 15, 2014 Category: Cardiology Authors: Pandey D, Sikka G, Bergman Y, Kim JH, Ryoo S, Romer L, Berkowitz D Tags: Arterioscler Thromb Vasc Biol Source Type: research

Oestrogen induced downregulation of TFPI expression is mediated by ERα
Conclusion: Our data establish a direct and time dependent regulation of TFPI expression by oestrogens through the ERα at the transcriptional level.
Source: Thrombosis Research - April 30, 2014 Category: Hematology Authors: Huda Omar Ali, Benedicte Stavik, Elisabeth Dørum, Nina Iversen, Per Morten Sandset, Grethe Skretting Tags: Coagulation and Fibrinolysis Source Type: research

Generation of transgenic pigs carrying siRNA vector directed against human tissue factor expression
ConclusionsThe AVR is currently the bottleneck in porcine‐to‐primate organ xenotransplantation. Controlling TF‐induced coagulation might provide protective effects for porcine xenografts. Thus, TF knockdown pigs could be critical in producing the ultimate multi‐transgenic pig as organ donor for human patients. References[1] Toomey J, Kratzer K, Lasky N, Stanton J, Broze GJ. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. 1996; 88(5): 1583–1587.
Source: Xenotransplantation - April 19, 2014 Category: Transplant Surgery Authors: Hellen Ahrens, Björn Petersen, Doris Herrmann, Andrea Lucas‐Hahn, Petra Hassel, Maren Ziegler, Wilfried Kues, Heiner Niemann Tags: Program and Abstracts Source Type: research

PI3K/p110{alpha} inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design
Conclusion Following vascular injury, PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization. Hence, PI3K/p110α represents an attractive new target in DES design.
Source: European Heart Journal - March 21, 2014 Category: Cardiology Authors: Holy, E. W., Jakob, P., Eickner, T., Camici, G. G., Beer, J. H., Akhmedov, A., Sternberg, K., Schmitz, K.-P., Luscher, T. F., Tanner, F. C. Tags: FASTTRACK CLINICAL RESEARCH Source Type: research

Interferon-Induced Transmembrane Protein 1 Regulates Endothelial Lumen Formation During Angiogenesis.
CONCLUSIONS: IFITM1 is essential for the formation of functional blood vessels and stabilizes EC-EC interactions during endothelial lumen formation by regulating tight junction assembly. PMID: 24603679 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 6, 2014 Category: Cardiology Authors: Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, Hughes CC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Targeting A549 lung adenocarcinoma cell growth and invasion with protease‑activated receptor‑1 siRNA.
In conclusion, the present study demonstrated that the progression of A549 cells is able to be inhibited by knockdown of PAR1 expression. Efficient delivery of the specific siRNA targeting PAR1 may be used for further study in clinical cancer therapy. PMID: 24604247 [PubMed - as supplied by publisher]
Source: Molecular Medicine - March 6, 2014 Category: Molecular Biology Authors: Wu Z, Zeng Y, Zhong M, Wang B Tags: Mol Med Rep Source Type: research

Gas6‐induced tissue factor expression in endothelial cells is mediated through caveolin‐1–enriched microdomains
Summary BackgroundGas6 has been shown to interact with Axl in endothelial cells and to induce several signaling pathways involved in cell survival and proliferation. However, the interaction of Gas6/Axl with lipid raft/caveolin‐1 in endothelial cells and its role in thrombosis are unknown. ObjectivesWe tested whether Axl and/or caveolin‐1 is involved in Gas6–induced Akt, ERK1/2, and c‐Src activation leading to altered tissue factor expression in endothelial cells. MethodsGas6‐treated endothelial cells were transfected with small interfering RNA (siRNA) for Axl, caveolin‐1, c‐Src, and Akt or treated with pharm...
Source: Journal of Thrombosis and Haemostasis - March 5, 2014 Category: Hematology Authors: S. Laurance, M. N. Aghourian, Z. Jiva Lila, C. A. Lemarié, M. D. Blostein Tags: Original Article Source Type: research

Rubbing salt into wounded endothelium: Sodium potentiates proatherogenic effects of TNF-α under non-uniform shear stress.
In conclusion, elevated sodium has a direct effect on endothelial activation under atherogenic shear-stress in vitro and in vivo, and promotes the endothelial-leukocyte interactions even in the absence of increased lipid concentrations. PMID: 24573382 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 27, 2014 Category: Hematology Authors: Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I Tags: Thromb Haemost Source Type: research

NF‐B is Activated from Endosomal Compartments in Antiphospholipid Antibodies‐treated Human Monocytes
ConclusionWe show that TLR2 and its co‐receptors, TLR1 and TLR6, contribute to the pathogenicity of aPLA, that aPLA are internalized via clathrin‐ and CD14‐dependent endocytosis and that endocytosis is required for NF‐B activation. Our results contribute to a better understanding of the APS and provide a possible therapeutic approach.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - February 24, 2014 Category: Hematology Authors: Karim J. Brandt, Céline Fickentscher, Françoise Boehlen, Egbert K.O. Kruithof, Philippe Moerloose Tags: Original Article Source Type: research

Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor α dependent pathway.
Abstract Restenosis is an adverse outcome of angioplasty, characterized by vascular smooth muscle cell (VSMC) hyperplasia. However, therapies targeting VSMC proliferation delay re-endothelialization, increasing the risk of thrombosis. Resveratrol (RESV) inhibits restenosis and promotes re-endothelialization after arterial injury, but in vitro studies assessing RESV-mediated effects on endothelial cell growth contradict these findings. We thus hypothesized that fluid shear stress, mimicking physiological blood flow, would recapitulate RESV-dependent endothelial cell wound healing. Since RESV is an estrogen receptor...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 24, 2014 Category: Physiology Authors: Yurdagul A, Kleinedler J, McInnis MC, Khandelwal AR, Spence A, Orr AW, Dugas TR Tags: Am J Physiol Heart Circ Physiol Source Type: research

Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians.
Abstract The 9p21.3 locus is the best replicated region to date for coronary artery disease (CAD). We investigated the association of 9p21.3 common variants with CAD, candidate gene expression including ANRIL, a non-coding RNA, followed by in vitro validation. Five variants, rs10757278, rs10757274, rs2383206, rs1333049 and rs4977574 were genotyped in 1,034 cases and 1,034 controls. Gene expression of C9orf5, MTAP1, MTAP 2, p16INK4a, p14ARF, p15INK4b and two ANRIL splice variants, NR_003529 and EU741058, were measured in 100 cases and 100 controls. Human aortic smooth muscle cells (HuAoSMCs) were transfected with s...
Source: Thrombosis and Haemostasis - January 23, 2014 Category: Hematology Authors: Shanker J, Arvind P, Jambunathan S, Nair J, Kakkar VV Tags: Thromb Haemost Source Type: research

G protein-dependent basal and evoked endothelial cell vWF secretion
von Willebrand factor (vWF) secretion by endothelial cells (ECs) is essential for hemostasis and thrombosis; however, the molecular mechanisms are poorly understood. Interestingly, we observed increased bleeding in EC-Gα13–/–;Gα12–/– mice that could be normalized by infusion of human vWF. Blood from Gα12–/– mice exhibited significantly reduced vWF levels but normal vWF multimers and impaired laser-induced thrombus formation, indicating that Gα12 plays a prominent role in EC vWF secretion required for hemostasis and thrombosis. In isolated buffer-perfused mouse lun...
Source: Blood - January 16, 2014 Category: Hematology Authors: Rusu, L., Andreeva, A., Visintine, D. J., Kim, K., Vogel, S. M., Stojanovic-Terpo, A., Chernaya, O., Liu, G., Bakhshi, F. R., Haberichter, S. L., Iwanari, H., Kusano-Arai, O., Suzuki, N., Hamakubo, T., Kozasa, T., Cho, J., Du, X., Minshall, R. D. Tags: Thrombosis and Hemostasis, Vascular Biology Source Type: research

Inhibition of Arthritis in the Lewis Rat by Apolipoprotein A-I and Reconstituted High-Density Lipoproteins.
CONCLUSIONS: Apolipoprotein A-I and reconstituted HDLs attenuate PG-PS-induced arthritis in the rat. Studies in human monocyte-derived macrophages indicate that this benefit may be because of the inhibition of toll-like receptor 2 expression and decreased nuclear factor-κB activation in macrophages. PMID: 24357062 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2013 Category: Cardiology Authors: Wu BJ, Ong KL, Shrestha S, Chen K, Tabet F, Barter PJ, Rye KA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.
CONCLUSIONS: Our large-scale proteomics study identified novel candidate regulators or markers for osteoclastogenesis and demonstrated that CSE may act in early stages of osteoclastogenesis. PMID: 24357058 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2013 Category: Cardiology Authors: Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E Tags: Arterioscler Thromb Vasc Biol Source Type: research

Tissue factor/factor VIIa induces cell survival and gene transcription by transactivation of the insulin-like growth factor 1 receptor.
Abstract The insulin-like growth factor 1 receptor (IGF-1R) is known to promote survival and has also been implicated in the pathogenesis of several disease states, including cardiovascular disorders and cancer. Recently, we showed that binding of coagulation factor VIIa (FVIIa) to its receptor tissue factor (TF) protects cancer cells from TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis. Here we present evidence that this biological function of TF/FVIIa is dependent on the IGF-1R. IGF-1R inhibitors AG1024 and PPP as well as siRNA-mediated downregulation of IGF-1R, abolished the TF/FVIIa-mediated pr...
Source: Thrombosis and Haemostasis - December 12, 2013 Category: Hematology Authors: Aberg M, Eriksson O, Mokhtari D, Siegbahn A Tags: Thromb Haemost Source Type: research