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Condition: Thrombosis
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Total 185 results found since Jan 2013.
EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
CONCLUSIONS: We identified EVA1A as a novel flow-sensitive gene that mediates the effects of proatherogenic DF on EC dysfunction by regulating autophagy.PMID:36794585 | DOI:10.1161/ATVBAHA.122.318110
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 16, 2023 Category: Cardiology Authors: Lindsay Canham Sam Sendac Mannekomba R Diagbouga Elena Wolodimeroff Daniela Pirri Blanca Tardajos Ayllon Shuang Feng Celine Souilhol Timothy J A Chico Paul C Evans Jovana Serbanovic-Canic Source Type: research
Assessment of breast cancer progression and metastasis during a hypercoagulable state induced by silencing of antithrombin in a xenograft mouse model
Local coagulation activation has been shown to impact both primary tumor growth and metastasis in mice. It is well known that components of the blood clotting cascade such as tissue factor and thrombin play a role in tumor progression by activating cellular receptors and local formation of fibrin. However, whether venous thromboembolism (VTE) or a hypercoagulable state has a direct impact on cancer progression is unknown. Here we have combined an orthotopic murine breast cancer model, using female Nod-SCID mice, with siRNA-mediated silencing of antithrombin (siAT) leading to the induction of a systemic hypercoagulable state.
Source: Thrombosis Research - November 24, 2022 Category: Hematology Authors: J.T. Buijs, B. Ünlü, E.H. Laghmani, M. Heestermans, B.J.M. van Vlijmen, H.H. Versteeg Tags: Full Length Article Source Type: research
Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies
CONCLUSIONS: Consistent with prior studies, Fib𝛾390-396A mice were significantly protected from increased adiposity, NAFLD, hypercholesterolemia and diabetes while Fib- and siFga-treated mice gained as much weight and developed obesity-associated pathologies identical to wildtype mice. FibAEK and FXIII- mice displayed an intermediate phenotype with partial protection from some obesity-associated pathologies. Results here indicate that fibrin(ogen) lacking αM β2 binding function offers substantial protection from obesity and associated disease that is partially recapitulated by preventing fibrin polymer formation or cr...
Source: Thrombosis and Haemostasis - September 16, 2022 Category: Hematology Authors: Woosuk S Hur Katharine C King Yesha N Patel Y-Van Nguyen Zimu Wei Yi Yang Lih Jiin Juang Jerry Leung Christian J Kastrup Alisa S Wolberg James P Luyendyk Matthew J Flick Source Type: research
Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury
CONCLUSION: Chronic reduction of PTP1B in SMCs promotes dedifferentiation, perivascular fibrosis, and adverse remodeling following vascular injury by mechanisms involving an ERK1/2 phosphorylation-driven shift from SMAD2 to KLF4-regulated gene transcription.PMID:36075234 | DOI:10.1055/s-0042-1755329
Source: Thrombosis and Haemostasis - September 8, 2022 Category: Hematology Authors: Rajinikanth Gogiraju Sogol Gachkar David Velmeden Magdalena L Bochenek Konstantinos Zifkos Astrid Hubert Thomas M ünzel Stefan Offermanns Katrin Sch äfer Source Type: research
The X box binding protein 1/C/EBP homologous protein pathway induces apoptosis of endothelial cells under hyperglycemia
Exp Ther Med. 2022 May 18;24(1):454. doi: 10.3892/etm.2022.11381. eCollection 2022 Jul.ABSTRACTVenous endothelial cell apoptosis can be induced by endoplasmic reticulum (ER) stress, thus serving an important role in the formation of deep venous thrombosis. X-box binding protein 1 (XBP1) is a protein associated with ER. The present study aimed to explore the function of XBP1/C/EBP homologous protein (CHOP) pathway in the process of endothelial cell apoptosis under hyperglycemia. Small interfering (si)RNAs targeting XBP1 and CHOP were designed to downregulate the expression of XBP1 and CHOP in human umbilical vein endothelia...
Source: Experimental and Therapeutic Medicine - June 20, 2022 Category: General Medicine Authors: Maoshun Tang Yi Zheng Jianping Li Yuanlang Hu Source Type: research
Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization
CONCLUSIONS: The above observations clearly reveal that PLCβ3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.PMID:35236105 | DOI:10.1161/ATVBAHA.121.317182
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 3, 2022 Category: Cardiology Authors: Raj Kumar Gadiparthi N Rao Source Type: research
