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Condition: Thrombosis

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Total 185 results found since Jan 2013.

Filamin A Modulates Store-Operated Ca2+ Entry by Regulating STIM1 (Stromal Interaction Molecule 1)-Orai1 Association in Human Platelets.
CONCLUSIONS: Our results indicate that FLNA modulates SOCE and then the correct platelet function, by fine-tuning the distribution of STIM1 in the cytoskeleton and the interaction with Orai1 channels. PMID: 29284605 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2017 Category: Cardiology Authors: Lopez JJ, Albarrán L, Jardín I, Sanchez-Collado J, Redondo PC, Bermejo N, Bobe R, Smani T, Rosado JA Tags: Arterioscler Thromb Vasc Biol Source Type: research

MicroRNA ‐335‐5p Suppresses Lower Extremity Deep Venous Thrombosis by Targeted Inhibition of PAI‐1 via the TLR4 Signaling Pathway
Conclusion: miR‐335‐5p may suppress the occurrence and development of LEDVT in rats by repressing the activation of the TLR4 signaling pathway by targeted inhibition of PAI‐1. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - December 27, 2017 Category: Biochemistry Authors: Cui ‐Xia Bao, Dong‐Xia Zhang, Na‐Na Wang, Xiang‐Kui Zhu, Qi Zhao, Xiao‐Lei Sun Tags: Article Source Type: research

European Society of Cardiology (ESC) Annual Congress Report From Barcelona 2017.
This report briefly introduces some late-breaking registry results, late-breaking clinical trials, and ESC Guidelines from the ESC 2017 Congress. PMID: 29093432 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 2, 2017 Category: Cardiology Authors: Satoh K, Takahashi J, Matsumoto Y, Tatebe S, Aoki T, Kikuchi Y, Hao K, Ohyama K, Nogi M, Suda A, Kasahara S, Sato K, Ichijo S, Shimokawa H Tags: Circ J Source Type: research

Plasminogen Activator Inhibitor-1 Regulates the Vascular Expression of Vitronectin.
CONCLUSIONS: PAI-1 stimulates SMC VN expression by binding LRP1 and controls vascular VN expression in vivo. Autocrine regulation of vascular VN expression by PAI-1 may play important roles in vascular homeostasis and pathological vascular remodeling. This article is protected by copyright. All rights reserved. PMID: 29028290 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - October 13, 2017 Category: Hematology Authors: Luo M, Ji Y, Luo Y, Li R, Fay WP, Wu J Tags: J Thromb Haemost Source Type: research

Plasminogen Activator Inhibitor ‐1 Regulates the Vascular Expression of Vitronectin
ConclusionsPAI‐1 stimulates SMC VN expression by binding LRP1 and controls vascular VN expression in vivo. Autocrine regulation of vascular VN expression by PAI‐1 may play important roles in vascular homeostasis and pathological vascular remodeling.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - October 1, 2017 Category: Hematology Authors: M. Luo, Y. Ji, Y. Luo, R. Li, W. P. Fay, J. Wu Tags: Original Article ‐ Vascular Biology Source Type: research

The heterotrimeric G protein G{beta}1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets Cell Biology
Thrombosis is caused by the activation of platelets at the site of ruptured atherosclerotic plaques. This activation involves engagement of G protein–coupled receptors (GPCR) on platelets that promote their aggregation. Although it is known that protein kinases and phosphatases modulate GPCR signaling, how serine/threonine phosphatases integrate with G protein signaling pathways is less understood. Because the subcellular localization and substrate specificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dictated by PP1c-interacting proteins, here we sought to identify new PP1c interactors. GPCRs signal vi...
Source: Journal of Biological Chemistry - August 11, 2017 Category: Chemistry Authors: Subhashree Pradhan, Tanvir Khatlani, Angus C. Nairn, K. Vinod Vijayan Tags: Signal Transduction Source Type: research

Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
CONCLUSIONS: These in vitro and in vivo studies suggest that JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth. PMID: 28705794 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 13, 2017 Category: Cardiology Authors: Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI Tags: Arterioscler Thromb Vasc Biol Source Type: research

Androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription
In this study, we identified the molecular mechanism by which androgen regulates ADTRP expression and tested the hypothesis that androgen plays a protective role in cardiovascular disease by activating ADTRP expression. Luciferase assays with an ADTRP promoter luciferase reporter revealed that androgen regulated ADTRP transcription in a dose-and time-dependent manner, and the effect was abolished by three different androgen inhibitors, including pyrvinium pamoate, bicalutamide, and cyproterone acetate. Chromatin-immunoprecipitation showed that the androgen receptor bound to a half androgen response element (ARE, TGTTCT) lo...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - June 20, 2017 Category: Molecular Biology Source Type: research

CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions.
CONCLUSIONS: In this study, we have identified a new regulatory function for CMTM3 in angiogenesis. CMTM3 is involved in VE-cadherin turnover and is a regulator of the cell surface pool of VE-cadherin. Therefore, CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting. PMID: 28428220 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2017 Category: Cardiology Authors: Chrifi I, Louzao-Martinez L, Brandt M, van Dijk CGM, Burgisser P, Zhu C, Kros JM, Duncker DJ, Cheng C Tags: Arterioscler Thromb Vasc Biol Source Type: research

MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3).
CONCLUSIONS: These results indicate that circulating miR-15b-5p is a suitable biomarker for discriminating between patients with well-developed or poorly developed collaterals. Moreover, miR-15b-5p is a key regulator of arteriogenesis and angiogenesis, which may represent a potential therapeutic target for ischemic disease. PMID: 28254819 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 1, 2017 Category: Cardiology Authors: Zhu LP, Zhou JP, Zhang JX, Wang JY, Wang ZY, Pan M, Li LF, Li CC, Wang KK, Bai YP, Zhang GG Tags: Arterioscler Thromb Vasc Biol Source Type: research

JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress.
Abstract Junctional adhesion molecule-C (JAM-C) has been shown to play critical roles during development and in immune responses. However, its role in adult eyes under oxidative stress remains poorly understood. Here, we report that JAM-C is abundantly expressed in adult mouse retinae and choroids in vivo and in cultured retinal pigment epithelium (RPE) and photoreceptor cells in vitro. Importantly, both JAM-C expression and its membrane localisation are downregulated by H2O2-induced oxidative stress. Under H2O2-induced oxidative stress, JAM-C is critically required for the survival of human RPE cells. Indeed, los...
Source: Thrombosis and Haemostasis - February 15, 2017 Category: Hematology Authors: Jia X, Zhao C, Chen Q, Du Y, Huang L, Ye Z, Ren X, Wang S, Lee C, Tang Z, Li X, Ju R Tags: Thromb Haemost Source Type: research

AUP1 (Ancient Ubiquitous Protein 1) Is a Key Determinant of Hepatic Very-Low-Density Lipoprotein Assembly and Secretion.
CONCLUSIONS: In summary, our findings reveal an important role for AUP1 as a regulator of apoB100 stability, hepatic LD metabolism, and intracellular lipidation of VLDL particles. AUP1 may be a crucial factor in apoB100 quality control, determining the rate at which apoB100 is degraded or lipidated to enable VLDL particle assembly and secretion. PMID: 28183703 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2017 Category: Cardiology Authors: Zhang J, Zamani M, Thiele C, Taher J, Amir Alipour M, Yao Z, Adeli K Tags: Arterioscler Thromb Vasc Biol Source Type: research

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
CONCLUSIONS: Our results provide evidence for an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFα and TNFR2, thereby preventing overactivation of endogenous TNFR2 signaling in cells of the vasculature. PMID: 28062509 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 21, 2016 Category: Cardiology Authors: Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Endothelin-1-Induced Cell Hypertrophy in Cardiomyocytes is Improved by Fenofibrate: Possible Roles of Adiponectin.
CONCLUSIONS: Our study shows that fenofibrate may protect against ET-1-induced cardiomyocyte hypertrophy and enhanced adiponectin expression through modulation of PPARα expression in vitro and limitation of daunorubicin cardiotoxicity in vivo, suggesting a novel mechanistic insight into the role of PPARα and adiponectin in cardiac hypertrophy and heart failure. PMID: 27629528 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - September 19, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Inorganic polyphosphate promotes cyclin D1 synthesis through activation of mTOR/Wnt/ β-catenin signaling in endothelial cells.
CONCLUSION: We conclude that a RAGE-dependent polyP-mediated crosstalk between mTOR and GSK-3/Wnt/β-catenin signaling network can modulate important physiological processes in endothelial cells. This article is protected by copyright. All rights reserved. PMID: 27546592 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 21, 2016 Category: Hematology Authors: Hassanian SM, Ardeshirylajimi A, Dinarvand P, Rezaie AR Tags: J Thromb Haemost Source Type: research