CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions.

CONCLUSIONS: In this study, we have identified a new regulatory function for CMTM3 in angiogenesis. CMTM3 is involved in VE-cadherin turnover and is a regulator of the cell surface pool of VE-cadherin. Therefore, CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting. PMID: 28428220 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28428220?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2017 Category: Cardiology Authors: Chrifi I, Louzao-Martinez L, Brandt M, van Dijk CGM, Burgisser P, Zhu C, Kros JM, Duncker DJ, Cheng C Tags: Arterioscler Thromb Vasc Biol Source Type: research

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