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Condition: Inflammatory Bowel Disease

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Total 147 results found since Jan 2013.

Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism
AbstractThe pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn ’s disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. However, expression of all theREG family genes in IBD is still unclear. Here, we analyzed expression of all theREG family genes (REGI α,REGI β,REG III,HIP/PAP, andREG IV) in biopsy specimens of UC and CD by real-time RT-PCR.REG I α,REG I β, andREG IV genes were overexpressed in CD samples.REG IV ge...
Source: Immunologic Research - January 29, 2019 Category: Allergy & Immunology Source Type: research

Intestinal Epithelial Tight Junction Barrier regulation by Autophagy related protein ATG6/beclin 1.
Abstract Defective tight junction (TJ) barrier is a key pathogenic factor for Inflammatory Bowel Disease. Previously, we have shown that autophagy, a cell survival mechanism, enhances intestinal epithelial TJ barrier function. Autophagy related protein ATG6/beclin 1, a key protein in the autophagy pathway, also plays a role in the endocytic pathway. The constitutive role of beclin 1 in intestinal TJ barrier is not known. In Caco-2 cells, beclin 1 was found to be co-immunoprecipitated with the TJ protein occludin and co-localized with occludin on the membrane. Treatment of Caco-2 cells with beclin 1 peptide (Tat-be...
Source: Am J Physiol Cell Ph... - March 19, 2019 Category: Cytology Authors: Wong M, Ganapathy AS, Suchanec E, Laidler L, Ma T, Nighot PK Tags: Am J Physiol Cell Physiol Source Type: research

Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR ‑16‑1/HSP70 pathway.
Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR‑16‑1/HSP70 pathway. Mol Med Rep. 2019 Apr 03;: Authors: Chen M, Wang JM, Wang D, Wu R, Hou HW Abstract Anastomotic fibrosis is highly likely to lead to reoperation in Crohn's disease (CD) patients. Triptolide (TPL) is considered to have anti‑inflammatory and antifibrotic effects in a variety of autoimmune diseases, including CD. The present study aimed to investigate the effects of TPL on fibroblasts from strictured ileocolonic anastomosis of patients...
Source: Molecular Medicine Reports - April 5, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease
In conclusion, our study demonstrated the key function of the hypoxia-associated transcription factor HIF-1α together with p-STAT3 in driving CD11b transcription in B cells and controlling B cell’s protective activity in experimental inflammatory bowel disease (IBD).
Source: Molecular Immunology - May 8, 2019 Category: Allergy & Immunology Source Type: research

Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity.
Abstract Eos (lkzf4) is a member of the Ikaros family of transcription factors and is preferentially expressed in T-regulatory (Treg) cells. However, the role of Eos in Treg function is controversial. One study using siRNA knock down of Eos demonstrated that it was critical for Treg suppressor function. In contrast, Treg from mice with a global deficiency of Eos had normal Treg function in vitro and in vivo. To further dissect the function of Eos in Tregs, we generated mice with a conditional knock out of Eos in Treg cells (lkzf4fl/fl X Foxp3YFP-cre, Eos cKO). Deletion of Eos in Treg resulted in activation of CD4+...
Source: Journal of Autoimmunity - July 7, 2019 Category: Allergy & Immunology Authors: Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM, Shevach EM Tags: J Autoimmun Source Type: research

IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway
This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in regulating MUC5AC production in chronic rhinosinusitis (CRS). We analyzed the expression of mucin and MUC5AC in the nasal mucosa of patients with CRS by periodic acid Schiff (PAS) staining and immunohistochemical examination. Real-time quantitative PCR, ELISA, confocal microscopy and western blotting were used to measure MUC5AC expression in primary human nasal epithelium cells (PHNECs) stimulated with recombinant human IL-19 (rhIL-19), IL-19 receptor siRNA transfection or control. The involvement of the STAT3 signa...
Source: Frontiers in Immunology - July 16, 2019 Category: Allergy & Immunology Source Type: research

Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ
Publication date: Available online 3 August 2019Source: Pharmacological ResearchAuthor(s): Ming Yue Li, Zhi Hong Zhang, Zhe Wang, Hong Xiang Zuo, Jing Ying Wang, Yue Xing, Cheng Hua Jin, Guang Hua Xu, Lian Xun Piao, Juan Ma, Xuejun JinAbstractConvallatoxin (CNT) is a cardiac glycoside isolated from Adonis amurensis Regel et Radde and has both anti-inflammatory and anti-proliferative properties. In the present study, the anti-inflammatory mechanisms of action of CNT was investigated in vitro and in vivo. Stimulation of mouse macrophages with lipopolysaccharide induced secretion of proinflammatory cytokines via suppression o...
Source: Pharmacological Research - August 5, 2019 Category: Drugs & Pharmacology Source Type: research

Analgesic effect of resveratrol on colitis-induced visceral pain via inhibition of TRAF6/NF- κB signaling pathway in the spinal cord.
In conclusion, our results suggest that RSV exerts the effects of antinociception on colitis-induced visceral hyperalgesia through inhibition of spinal TRAF6/NF-κB signaling pathway and the production of inflammatory mediators in the spinal cord, suggesting a new application of RSV for the treatment of visceral pain. PMID: 31536729 [PubMed - as supplied by publisher]
Source: Brain Research - September 15, 2019 Category: Neurology Authors: Lu Y, Xu HM, Han Y, Zhang YL Tags: Brain Res Source Type: research

Overexpression of interleukin-20 receptor subunit beta (IL20RB) correlates with cell proliferation, invasion and migration enhancement and poor prognosis in papillary renal cell carcinoma.
Authors: Cui XF, Cui XG, Leng N Abstract Papillary renal cell carcinoma (PRCC) accounts for about 10 percent of all renal cell carcinomas, and the prognosis is poor for people with advanced disease. Interleukin-20 receptor subunit beta (IL20RB) is a single-pass type I membrane protein of the type II cytokine receptor family and is related to the pathogenesis of chronic inflammation and autoimmune diseases, including psoriasis, glaucoma, vitiligo, rheumatoid arthritis, and inflammatory bowel disease. However, little has been reported on IL20RB with respect to cancer, especially in PRCC. Thus, we performed this study...
Source: Journal of Toxicologic Pathology - November 14, 2019 Category: Toxicology Tags: J Toxicol Pathol Source Type: research

Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene therapy: A comprehensive review
This article will give a new perspective on understanding immunopathogenesis of autoimmune diseases not only in animals but also in human. Emerging approaches to investigate cytokine regulation through gene therapy may be a potential approach for the tailored immunomodulation of some autoimmune diseases near in the future.
Source: Autoimmunity Reviews - January 7, 2020 Category: Allergy & Immunology Source Type: research

Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review
This article will give a new perspective on understanding immunopathogenesis of autoimmune diseases not only in animals but also in human. Emerging approaches to investigate cytokine regulation through gene modulation may be a potential approach for the tailored immunomodulation of some autoimmune diseases near in the future.
Source: Autoimmunity Reviews - February 6, 2020 Category: Allergy & Immunology Source Type: research

Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis.
Conclusions: HSF2 may be a predictor of MH in UC patients. HSF2 inhibited inflammation and promoted mucosal repair. PMID: 32538201 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - June 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling
ConclusionsOur results indicate that the effects of vitamin D on Cl-2 and Cl-4 are mediated by p-Stat-6 and Smad-7 signal, respectively. The study suggests that vitamin D administration to UC patients could be a useful therapeutic intervention, given that vitamin D deficiency is found in these patients.
Source: International Journal of Colorectal Disease - June 26, 2020 Category: Gastroenterology Source Type: research

Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?
AbstractPurpose of ReviewUlcerative colitis (UC) is a chronic inflammatory bowel disorder that causes inflammation in the colon and rectum and can be lethal to the patients. The dysbiotic intestinal microbiome is considered a major factor of UC, yet it needs more evidences. As there is no cure for UC, anti-inflammatory drugs, potent steroids, immunomodulatory drugs, or even surgery is used to manage the disease. The purpose of this review is to focus on the underlying factors involved in the disease pathogenicity, including host gut microbiome and novel therapies for treatment of UC.Recent FindingsDue to disruption of inte...
Source: Current Pathobiology Reports - January 6, 2021 Category: Laboratory Medicine Source Type: research