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Condition: Inflammatory Bowel Disease

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Total 147 results found since Jan 2013.

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aime...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis
Publication date: Available online 12 October 2017 Source:Pathology - Research and Practice Author(s): Xian-Qun Chu, Jing Wang, Guang-Xiang Chen, Guan-Qi Zhang, De-Yong Zhang, Yong-Yan Cai We aim to investigate the role of microRNA-495 (miR-495) in the intestinal mucosal barrier by indirectly targeting signal transducer and activator of transcription 3 (STAT3) through the Janus kinase-signal transducer and activator of transcription (JAK)/STAT3 signaling pathway in a mouse model of ulcerative colitis (UC). BALB/c mice were selected for establishing a mice model of UC, and intestinal tissues of normal and UC mice were coll...
Source: Pathology Research and Practice - October 13, 2017 Category: Pathology Source Type: research

BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1
CONCLUSIONS: We found that BMSCs can induce Treg differentiation by inhibiting the Akt/mTOR pathway via PD-L1; this significantly improved symptoms and pathology in our ulcerative colitis rat models.PMID:36261682 | DOI:10.1007/s10529-022-03307-1
Source: Biotechnology Letters - October 19, 2022 Category: Biotechnology Authors: Fei Gao Dandan Cui Dongmei Zuo Zhexing Shou Jia Yang Ting Yu Yujin Liu Si Chu Feng Zhu Chunzhu Wei Source Type: research

Multi-compartmental oral delivery systems for nucleic acid therapy in the gastrointestinal tract.
Abstract Gene and RNA interference therapies have significant potential for alleviating countless diseases, including many associated with the gastro-intestinal (GI) tract. Unfortunately, oral delivery of genes and small interfering RNA (siRNA) is very challenging due to the extracellular and intracellular barriers. In this review, we discuss the utilization of multi-compartmental delivery systems for oral administration of nucleic acid therapies. Some of the illustrative examples of multi-compartmental systems include solid nanoparticles-in-microsphere, solid nanoparticles-in-emulsion, and liquid nanoparticles-in...
Source: Advanced Drug Delivery Reviews - December 7, 2012 Category: Drugs & Pharmacology Authors: Kriegel C, Attarwala H, Amiji M Tags: Adv Drug Deliv Rev Source Type: research

Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice
Conclusions: Nanoparticles containing surface CD98 antibody and loaded with siCD98 reduce expression of this protein by colonic epithelial cells and macrophages, and oral administration decreases the severity of colitis in mice. This nanoparticle in hydrogel (chitosan/alginate) formulation might be developed to treat patients with IBD.
Source: Gastroenterology - February 6, 2014 Category: Gastroenterology Authors: Bo Xiao, Hamed Laroui, Emilie Viennois, Saravanan Ayyadurai, Moiz A. Charania, Yuchen Zhang, Zhan Zhang, Mark T. Baker, Benyue Zhang, Andrew T. Gewirtz, Didier Merlin Tags: Basic and Translational—Alimentary Tract Source Type: research

Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3–induced Enteritis
Conclusions: hnRNP A1 improves intestinal injury in anti-CD3 antibody–induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration, whereas this molecule ameliorates DSS-induced colitis through a different pathway.
Source: Inflammatory Bowel Diseases - June 16, 2015 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research

Chromosome region maintenance-1 (CRM1) regulates apoptosis of intestinal epithelial cells via p27kip1 in Crohn's disease
Conclusions Up-regulated CRM1 may facilitate IEC apoptosis possibly through p27kip1 in CD, indicating an important role of CRM1 in the pathophysiology of CD.
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2017 Category: Gastroenterology Source Type: research

Indirubin regulates T cell differentiation by promoting αVβ8 expression in bone marrow-derived dendritic cells to alleviate inflammatory bowel disease
This study aimed to isolate bone marrow-derived dendritic cells (BMDCs) using lipopolysaccharide (LPS) to obtain mature DCs (mDCs). The expression of CD80, CD86, CD40, and MHC-II was detected using flow cytometry after treatment with IDRB. αVβ8 siRNA was used to knock down αVβ8 in mDCs, and the expression of CD80, CD86, CD40, and MHC-II was detected. Meanwhile, DCs were co-cultured with T cells. Then, T cell differentiation was detected using flow cytometry, and the cytokine levels were detected using enzyme-linked immunosorbent assay. The animal model of dextran sulfate sodium (DSS)-induced inflammatory bowel disease ...
Source: Cell Research - September 26, 2022 Category: Cytology Authors: Tao Zhang Hong Peng Yunxiang Li Xiaoqing Zhou Wenfeng Pu Yan Zhang Zhonghan Du Fuxia Wei Siqing Li Qian Zhou Source Type: research

Effects of mannose density on in vitro and in vivo cellular uptake and RNAi efficiency of polymeric nanoparticles.
Abstract To evaluate the effects of mannose density on in vitro and in vivo cellular uptake and RNA interference (RNAi) efficiency of polymeric nanoparticles (NPs) in macrophages, mannose-modified trimethyl chitosan-cysteine (MTC) conjugates with mannose densities of 4%, 13%, and 21% (MTC-4, MTC-13, and MTC-21) were synthesized. Tumor necrosis factor-alpha (TNF-α) siRNA loaded MTC NPs with particle sizes of ∼150 nm exhibited desired structural stability and effectively protected siRNA from enzymatic degradation. Generally, cellular uptake and RNAi efficiency were affected by mannose density. As expected, MTC...
Source: Biomaterials - April 1, 2015 Category: Materials Science Authors: Chu S, Tang C, Yin C Tags: Biomaterials Source Type: research

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis
Nanomedicine Ahead of Print.
Source: Future Medicine: Nanomedicine - June 30, 2017 Category: Nanotechnology Source Type: research

Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
In conclusion, OXY increases NAD+ levels, resulting in the stimulation of MUC2 expression in LS 174T cells. These findings present a novel role for NAD+ in stimulation of MUC2 expression. PMID: 29935245 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - June 20, 2018 Category: Food Science Authors: Hwang D, Jo H, Ma SH, Lim YH Tags: Food Chem Toxicol Source Type: research

Transforming growth factor β1-induced collagen production in myofibroblasts is mediated by reactive oxygen species derived from NADPH oxidase 4.
In this study, we examined the role of NOX4 in collagen production by intestinal myofibroblasts stimulated with transforming growth factor (TGF)-β1. Using LmcMF cells, an intestinal subepithelial myofibroblast (ISEMF) line, we first examined the induction of collagen production by TGF-β1. Subsequently, we investigated the role of NOX4 in TGF-β1-induced collagen I production in these cells using SB525334 (an SMAD2/3 inhibitor), diphenyleneiodonium (an NOX inhibitor), and Nox4 small interfering RNA (siRNA). Production of collagen was assessed with Sirius red staining, and Nox4 expression was measured by quantitative real-...
Source: Biochemical and Biophysical Research communications - October 23, 2018 Category: Biochemistry Authors: Hotta Y, Uchiyama K, Takagi T, Kashiwagi S, Nakano T, Mukai R, Toyokawa Y, Yasuda T, Ueda T, Suyama Y, Murakami T, Tanaka M, Majima A, Doi T, Hirai Y, Mizushima K, Morita M, Higashimura Y, Inoue K, Fukui A, Okayama T, Katada K, Kamada K, Handa O, Ishikawa Tags: Biochem Biophys Res Commun Source Type: research