Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease

In conclusion, our study demonstrated the key function of the hypoxia-associated transcription factor HIF-1α together with p-STAT3 in driving CD11b transcription in B cells and controlling B cell’s protective activity in experimental inflammatory bowel disease (IBD).
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research