Filtered By:
Condition: Depression

This page shows you your search results in order of date. This is page number 8.

Order by Relevance | Date

Total 164 results found since Jan 2013.

The Involvement of Cytochrome c Oxidase in Mitochondrial Fusion in Primary Cultures of Neonatal Rat Cardiomyocytes.
This study thus demonstrates that copper-dependent CCO is critical for mitochondrial fusion in the regression of cardiomyocyte hypertrophy. PMID: 29396798 [PubMed - as supplied by publisher]
Source: Cardiovascular Toxicology - February 2, 2018 Category: Cardiology Authors: Yin W, Li R, Feng X, James Kang Y Tags: Cardiovasc Toxicol Source Type: research

Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression
Publication date: 21 February 2018 Source:Neuroscience, Volume 372 Author(s): Wei-jie Zhang, Hua-hua Wang, Yi-dong Lv, Cai-cai Liu, Wen-yao Sun, Liu-jun Tian Ketamine is a non-competitive antagonist of N-methyl-D-aspartate receptors (NMDARs). Growing evidence suggests that a single dose of ketamine produces a series of rapid and remarkable antidepressant properties. However, the mechanisms remain unclear. In our study, the antidepressant properties of a single dose of ketamine (10 mg/kg, i.p.) in mice exposed to chronic unpredictable stress (CUS) were assessed using the open-field test (OFT) and the forced swimming test...
Source: Neuroscience - January 17, 2018 Category: Neuroscience Source Type: research

Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells.
Authors: Xing CY, Zhang DX, Gui SQ, Tao MF Abstract Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage. Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts. In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells. Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, an...
Source: Evidence-based Complementary and Alternative Medicine - December 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Advanced glycation end ‐products increase IL‐6 and ICAM‐1 expression via RAGE, MAPK and NF‐κB pathways in human gingival fibroblasts
ConclusionAGEs increase IL‐6 and ICAM‐1 expression via the RAGE, MAPK and NF‐κB pathways in HGFs and may exacerbate the progression of the pathogenesis of periodontal diseases.
Source: Journal of Periodontal Research - November 30, 2017 Category: Dentistry Authors: K. Nonaka, Y. Kajiura, M. Bando, E. Sakamoto, Y. Inagaki, J. H. Lew, K. Naruishi, T. Ikuta, K. Yoshida, T. Kobayashi, H. Yoshie, T. Nagata, J. Kido Tags: ORIGINAL ARTICLE Source Type: research

GALR1/GALR2 Knockdown rats block the Depression and Anxiogenic effects induced by GAL(1-15): The Heterodimer GALR1/GALR2 as a target of GAL(1-15)
The Galanin N-terminal fragment(1-15) [GAL(1-15)] induces depressant-and anxiogenic-like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) and Open Field Test (OFT) using siRNA GALR2 and GALR1 knockdown rats.
Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Carmelo Mill ón, Flores-Burgess Antonio, Narvaez Manuel, O Borroto-Escuela Dasiel, Santín Luis, Parrado Concención, Narvaez Jose Angel, Fuxe Kjell, Diaz-Cabiale Zaida Source Type: research

A role for Galanin N-terminal fragment (1-15) In anxiety and depression in rats
Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been proposed. In this work we have analysed if GAL(1-15) contributes to depression- and anxiety -related behaviours using the forced swimming test, tail suspension test, open field and light/dark test. We tested the involvement of the GAL receptor 2 (GALR2) in GAL(1-15) effects with the GAL receptor antagonist M871 and with an in vivo model of siRNA GALR2 knockdown rats.
Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Carmelo Mill ón, Antonio Flores-Burguess, Manuel Narváez, Dasiel Borroto-Escuela, Luis Santín, Jose Angel Narváez, Kjell Fuxe, Zaida Díaz-Cabiale Source Type: research

Overexpression of LAMC1 predicts poor prognosis and enhances tumor cell invasion and migration in hepatocellular carcinoma
LAMC1 encodes an extracellular matrix protein, laminin γ1 chain, which is involved in several biological and pathological processes including tissue development, tumor cell invasion and metastasis. In present study, we demonstrated that both LAMC1 protein and mRNA levels were elevated in HCC tissue samples compared with non-cancerous tissue samples according to western blot analyses, immunohistochemistry (IHC) and microarray. Moreover, high LAMC1 expression was positively correlated with incomplete encapsulation (p=0.014), poor overall (OS, p=0.02) and disease-free survival (DFS, p=0.014). Using cell lines, we demonst...
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Yaojun Zhang, Shaoyan Xi, Jinbin Chen, Dongsheng Zhou, Hengjun Gao, Zhongguo Zhou, Li Xu, Minshan Chen Tags: Research Paper Source Type: research

Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus
Publication date: November 2017 Source:Molecular Immunology, Volume 91 Author(s): Zhen Zhang, Zhimeng Lv, Zhixin Wei, Chenghua Li, Yina Shao, Weiwei Zhang, Xuelin Zhao, Jinbo Xiong Microsomal glutathione transferase 2 (mGST2) is an integral membrane protein involved in detoxication of xenobiotics, and has also been suggested to catalyze the biosynthesis of pro-inflammatory mediator leukotriene C4 (LTC4) as homologous to LTC4 synthase (LTC4S) in mammals. In the present study, a novel mGST2 homology was identified from Apostichopus japonicus (designated as AjmGST2) by RACE approaches. The full-length cDNA of AjmGST2 was of ...
Source: Molecular Immunology - September 9, 2017 Category: Allergy & Immunology Source Type: research

SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway
AbstractSpalt-like transcription factor 4 (SALL4), a oncogene, is known to participate in multiple carcinomas, and is up-regulated in glioma. However, its actual role and underlying mechanisms in the development of glioma remain unclear. The present study explored the molecular functions of SALL4 in promoting cell proliferation in glioma. The expression level of SALL4 in 69  human glioma samples and six non-tumor brain tissues was determined using real-time polymerase chain reaction (PCR). Then, we transfected U87 and U251 cell lines with siRNA, and assessed cellular proliferation and cell cycle to understand the function...
Source: Journal of Neuro-Oncology - September 8, 2017 Category: Cancer & Oncology Source Type: research

Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation.
Abstract MicroRNAs are considered to play critical roles in the pathogenesis of human inflammatory arthritis, including rheumatoid arthritis (RA). The purpose of this study was to determine the relationship between miR-10a-5p and TBX5 in synoviocytes and evaluate their contribution to joint inflammation. The expression of miR-10a-5p and TBX5 in the synovium of RA and human synovial sarcoma cell line SW982 stimulated by IL-1β was determined by RT-qPCR and Western blotting. The direct interaction between miR-10a-5p and TBX5 3'UTR was determined by dual-luciferase reporter assay in HeLa cells. Mimics and inhibitors ...
Source: J Cell Mol Med - August 7, 2017 Category: Molecular Biology Authors: Hussain N, Zhu W, Jiang C, Xu J, Wu X, Geng M, Hussain S, Cai Y, Xu K, Xu P, Han Y, Sun J, Meng L, Lu S Tags: J Cell Mol Med Source Type: research

Down ‐regulation of miR‐10a‐5p in synoviocytes contributes to TBX5‐controlled joint inflammation
Abstract MicroRNAs are considered to play critical roles in the pathogenesis of human inflammatory arthritis, including rheumatoid arthritis (RA). The purpose of this study was to determine the relationship between miR‐10a‐5p and TBX5 in synoviocytes and evaluate their contribution to joint inflammation. The expression of miR‐10a‐5p and TBX5 in the synovium of RA and human synovial sarcoma cell line SW982 stimulated by IL‐1β was determined by RT‐qPCR and Western blotting. The direct interaction between miR‐10a‐5p and TBX5 3′UTR was determined by dual‐luciferase reporter assay in HeLa cells. Mimics and ...
Source: Journal of Cellular and Molecular Medicine - August 7, 2017 Category: Molecular Biology Authors: Nazim Hussain, Wenhua Zhu, Congshan Jiang, Jing Xu, Xiaoying Wu, Manman Geng, Safdar Hussain, Yongsong Cai, Ke Xu, Peng Xu, Yan Han, Jian Sun, Liesu Meng, Shemin Lu Tags: Original Article Source Type: research

HPI/AMF inhibition halts the development of the aggressive phenotype of breast cancer stem cells
Publication date: Available online 23 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Alvaro Marín-Hernández, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez Cancer stem cells are responsible for tumor recurrence and metastasis. A new highly reproducible procedure for human breast cancer MCF-7 stem cells (BCSC) isolation and selection was developed by using a combination of hypoxia/hypoglycemia plus taxol and adriamycin for 24h. The BCSC enriched fraction (i) expressed (2–15 times) the typical stemness protein ma...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 23, 2017 Category: Molecular Biology Source Type: research

Peroxisome proliferator-activated receptor alpha mediates C/EBP homologous protein to protect mice from acute liver failure
ConclusionsHere, we demonstrated that PPAR α activation contributes to liver protection and decreases liver inflammation in ALF, particularly through regulating CHOP. Our findings may provide a rationale for targeting PPARα as a potential therapeutic strategy to ameliorate ALF.
Source: Inflammation Research - June 9, 2017 Category: Research Source Type: research

PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication.
Abstract Activation of PI3K/Akt signaling, leading to upregulation of nitric oxide synthase II (NOS II)/peroxynitrite cascade in the rostral ventrolateral medulla (RVLM), the brain stem site that maintains blood pressure and sympathetic vasomotor tone, underpins cardiovascular depression induced by the organophosphate pesticide mevinphos. By exhibiting dual-specificity protein- and lipid-phosphatase activity, phosphatase and tensin homolog (PTEN) directly antagonizes the PI3K/Akt signaling by dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate, the lipid product of PI3K. Based on the guiding hypothesis t...
Source: Neuropharmacology - June 7, 2017 Category: Drugs & Pharmacology Authors: Tsai CY, Wu JCC, Fang C, Chang AYW Tags: Neuropharmacology Source Type: research

Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway.
This study provides novel insights into the molecular mechanisms of Cr(VI)-induced cytotoxicity. PMID: 28323103 [PubMed - as supplied by publisher]
Source: Toxicology in Vitro - March 17, 2017 Category: Toxicology Authors: Zhang Y, Xiao F, Liu X, Liu K, Zhou X, Zhong C Tags: Toxicol In Vitro Source Type: research