Peroxisome proliferator-activated receptor alpha mediates C/EBP homologous protein to protect mice from acute liver failure

ConclusionsHere, we demonstrated that PPAR α activation contributes to liver protection and decreases liver inflammation in ALF, particularly through regulating CHOP. Our findings may provide a rationale for targeting PPARα as a potential therapeutic strategy to ameliorate ALF.
Source: Inflammation Research - Category: Research Source Type: research