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Total 164 results found since Jan 2013.

Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3 β/Nrf2 axis
In conclusion, Dex protects hearts against MIRI-induced ferroptosis via activation of Nrf2 through AMPK/GSK-3β signaling pathway.PMID:35988428 | DOI:10.1016/j.biopha.2022.113572
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 21, 2022 Category: Drugs & Pharmacology Authors: Zhuoran Wang Mengran Yao Leyu Jiang Lingyan Wang Yuqiao Yang Quan Wang Xi Qian Yu Zhao Jinqiao Qian Source Type: research

Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn
In this study, we discovered that chrysin, a natural flavonoid compound, suppressed the activation of Fyn kinase and further alleviated neuroinflammation-induced neuron damage and behavior deficits. Functionally, chrysin improved lipopolysaccharide (LPS)-induced memory impairment and depressive behaviors in mice, it also protected against LPS-induced neuronal degeneration and loss and synaptic defects in mice. Our study demonstrated that chrysin inhibited the activation of microglia and reduced the expression of NLRP3 and IL-1β. Furthermore, our data indicated that chrysin blocked phosphorylation of Fyn and activation of ...
Source: International Immunopharmacology - August 13, 2022 Category: Allergy & Immunology Authors: Qingchen Wang Zhiping Yang Xintong Wu Xiao Zhang Feng Geng Qiaoyun Wang Zikai Geng Chen Yu Zhipeng Li Source Type: research

The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice
In conclusion, this research demonstrated that Palmatine attenuated depressive like behavior by modulating microglia polarization via PDE4B/KLF4 signaling.PMID:35917005 | DOI:10.1007/s11064-022-03672-3
Source: Neurochemical Research - August 2, 2022 Category: Neuroscience Authors: Lei Wang Min Li Cuiping Zhu Aiping Qin Jinchun Wang Xianni Wei Source Type: research

Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells
In this study, Neuro-2a cells were used to be our object of study for determining the mechanism by which gelsenicine induced neurotoxicity. We found that gelsenicine is neurotoxic to Neuro-2a cells; indeed cell proliferation was inhibited and apoptosis was induced in a dose-dependent manner. Meanwhile, gelsenicine markedly promoted autophagy and activated autophagic flux. Additionally, promoting autophagy with rapamycin decreased apoptosis, whereas blocking autophagy with 3-methyladenine (3-MA) increased apoptosis. Furthermore, the protein kinase ribose nucleic acid (RNA)-like endoplasmic reticulum kinase (PERK)/eukaryotic...
Source: Toxicology - May 19, 2022 Category: Toxicology Authors: Yu-Juan Li Pei-Pei Hu Zhiqiang Zhang Zhi-Hang Yuan Kun Yang Zhi-Liang Sun Source Type: research

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non –Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway
This study mainly focused on the discovery of the molecular basis of the inhibitory effect of fluoxetine in lung cancer. The specific anti-proliferation effect and autophagy induced by fluoxetine on lung cancer cell were shown in CCK8 and immunofluorescence. The RNA sequence hinted that the endoplasmic reticulum (ER) stress-related protein and mTOR pathway were enriched after fluoxetine treatment. Western blot results revealed that the ER stress pathway was activated by fluoxetine, including PERK, ATF4, and CHOP, while the AKT/mTOR pathway was inhibited. In addition, the transfection of ATF4 siRNA further discovered that E...
Source: Frontiers in Pharmacology - May 10, 2022 Category: Drugs & Pharmacology Source Type: research

Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor < sub > 1/3 < /sub > , Src, and extracellular signal-regulated kinase
Eur J Pharmacol. 2022 Apr 28:174986. doi: 10.1016/j.ejphar.2022.174986. Online ahead of print.ABSTRACTConnexin 43 (Cx43) expression is decreased in the prefrontal cortex of patients with depression, but its significance is still unknown. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), are involved in the effects of antidepressant. However, the relationship between Cx43 expression and induction of brain-derived neurotrophic factor production by antidepressants is unknown. On the basis of our previous study, which showed that adrenergic receptors stimulation results in potentiation of BDNF expression ...
Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Nozomi Tokunaga Tomoyo Takimoto Yoki Nakamura Kazue Hisaoka-Nakashima Norimitsu Morioka Source Type: research

Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF- κB/NLRP3 Signaling Pathway
Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear and the options of drug treatments are limited. Here, we explored the role of pyroptosis, a novel pro-inflammatory programmed cell death process, in depression as well as the anti-depression effects and mechanisms of salidroside (Sal), a bioactive extract from Rhodiola rosea L. We established a corticosterone (CORT)-induced or lipopolysaccharide (LPS)-induced mice in vivo, and CORT, or nigericin (NLRP3 agonist)-induced PC12 cells in vitro. Our findings demonstrated that Sal profoundly mediated CORT or LPS-induced depressive behavior...
Source: Frontiers in Pharmacology - April 12, 2022 Category: Drugs & Pharmacology Source Type: research

LINC00488 Induces Tumorigenicity in Retinoblastoma by Regulating microRNA-30a-5p/EPHB2 Axis
CONCLUSION: LINC00488 induces tumorigenicity in RB by binding to miR-30a-5p to target EPHB2, which may offer a new clue of RB treatment from an lncRNA-miRNA-mRNA network.PMID:35404750 | DOI:10.1080/09273948.2022.2037659
Source: Ocular Immunology and Inflammation - April 11, 2022 Category: Allergy & Immunology Authors: Xuehao Cui Tingyi Liang Xunda Ji Yan Shao Peiquan Zhao Xiaorong Li Source Type: research

GSK-3 β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation
CONCLUSIONS: We identified a novel mechanism by which GSK-3β localizes to the myofilament to modulate LDA. Importantly, z-disc GSK-3β levels were reduced in patients with heart failure, indicating z-disc localized GSK-3β is a possible therapeutic target to restore the Frank-Starling mechanism in patients with heart failure.PMID:35168370 | DOI:10.1161/CIRCRESAHA.121.319491
Source: Circulation Research - February 16, 2022 Category: Cardiology Authors: Marisa J Stachowski-Doll Maria Papadaki Thomas G Martin Weikang Ma Henry M Gong Stephanie Shao Shi Shen Nitha Aima Muntu Mohit Kumar Edith Perez Jody L Martin Christine S Moravec Sakthivel Sadayappan Stuart G Campbell Thomas Irving Jonathan A Kirk Source Type: research

The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior
Cell Death & Disease, Published online: 12 November 2021; doi:10.1038/s41419-021-04361-9The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior
Source: Cell death and disease - November 12, 2021 Category: Internal Medicine Authors: Yufeng Jia Xiao Zhuang Yi Zhang Ming Zhao Nuo Chen Wen Li Faliang Zhu Chun Guo Yan Li Qun Wang Yuan Li Lining Zhang Source Type: research