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Condition: Depression

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Total 164 results found since Jan 2013.

Inhibition of Proliferation, Migration, and Invasion by Knockdown of Pyruvate Kinase-M2 (PKM2) in Ovarian Cancer SKOV3 and OVCAR3 Cells.
Authors: Miao Y, Lu M, Yan Q, Li S, Feng Y Abstract Pyruvate kinase (PK) is a key enzyme in the process of glycolysis, catalyzing phosphoenolpyruvate (PEP) into pyruvate. Currently, PK isozyme type M2 (PKM2), one subtype of PK, has been proposed as a new tumor marker with high expression in various tumor tissues. Here we aimed to explore the effects of siRNA-PKM2 on ovarian carcinoma (OC) cell lines SKOV3 and OVCAR3, in which PKM2 was notably expressed. PKM2 gene interference lentivirus vectors were built by miRNA transfection assay. siRNA-PKM2-transfected SKOV3 and OVCAR3 cells were evaluated for cell proliferatio...
Source: Oncology Research - March 12, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression.
We examined the ability of the neuropeptide Galanin(1-15) [GAL(1-15)] to modulate the behavioral effects of FLX in the forced swimming test (FST) and studied feasible molecular mechanisms. The data show that GAL(1-15) enhances the antidepressant-like effects induced by FLX in the FST, and we demonstrate the involvement of GALR1/GALR2 heteroreceptor complex in the GAL(1-15)-mediated effect using in vivo rat models for siRNA GALR1 or GALR2 knockdown. Importantly, 5-HT1A receptors (5HT1AR) also participate in the GAL(1-15)/FLX interactions since the 5HT1AR antagonist WAY100635 blocked the behavioral effects in the FST induced...
Source: Neuropharmacology - March 9, 2017 Category: Drugs & Pharmacology Authors: Flores-Burgess A, Millón C, Gago B, Narváez M, Borroto-Escuela DO, Mengod G, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z Tags: Neuropharmacology Source Type: research

MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3).
CONCLUSIONS: These results indicate that circulating miR-15b-5p is a suitable biomarker for discriminating between patients with well-developed or poorly developed collaterals. Moreover, miR-15b-5p is a key regulator of arteriogenesis and angiogenesis, which may represent a potential therapeutic target for ischemic disease. PMID: 28254819 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 1, 2017 Category: Cardiology Authors: Zhu LP, Zhou JP, Zhang JX, Wang JY, Wang ZY, Pan M, Li LF, Li CC, Wang KK, Bai YP, Zhang GG Tags: Arterioscler Thromb Vasc Biol Source Type: research

NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers.
Authors: Xu X, Yan Q, Wang Y, Dong X Abstract Metastasis is the leading cause of death for breast cancer patients. Nerve guidance factor 4 (Netrin-4, NTN4) is reduced in variety of malignancies and involved in tumor metastasis. However, the functions of NTN4 and related molecular mechanisms in breast cancer are poorly understood. Oncomine data revealed that NTN4 was decreased in breast cancer compared with normal breast tissues. For fresh frozen breast cancer samples, significantly depressed expression of NTN4 mRNA was observed in lesion tissues compared with that in adjacent tissues. Afterwards, NTN4 protein level...
Source: Oncology Reports - November 16, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.
Abstract The Nuclear factor (erythroid 2-derived)-like 2 (Nrf2) plays a key role in inflammation which is implicated in the pathophysiology of depression. The Nrf2 activators have antidepressant effects in animal models of depression. The present study was undertaken to examine whether TBE-31 [(±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile] and MCE-1 [(±)-3-ethynyl-3-methyl-6-oxocyclohexa-1,4-dienecarbonitrile], the novel Nrf2 activator, could show antidepressant effects in inflammation model of depression. We found that TBE-31 and MCE-1 si...
Source: European Journal of Pharmacology - October 31, 2016 Category: Drugs & Pharmacology Authors: Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K Tags: Eur J Pharmacol Source Type: research

Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress
AbstractInterleukin-18 (IL18) is a multifunctional cytokine that has been implicated in increased susceptibility to depression; however, the underlying mechanism remains unknown. We found that the IL18 system in the basolateral amygdala (BLA) determined susceptibility to chronic stress. Mice subjected to chronic restraint stress or chronic foot-shock stress demonstrated increased expression of IL18 in the BLA, and exhibited depression-like behaviors, whereas IL18 knockout (KO) mice were resilient to these chronic stresses. IL18 and IL18 receptors in the BLA were expressed in glutamatergic and GABAergic neurons in addition ...
Source: Molecular Neurobiology - September 1, 2016 Category: Neurology Source Type: research

miR210 modulates respiratory burst in Apostichopus japonicus coelomocytes via targeting Toll-like receptor.
Abstract Immune responses of species in Echinodermata remains mysterious due to the lack of efforts made in the study of host defense mechanism in these species. More researches start focusing on this ancient immune system with the recognition the economic values of several species in this phylum, especially sea cucumbers. Here, we reported a study in the innate immunity of a sea cucumber species (Apostichopus japonicus) in response to infection of Vibrio splendidus. A novel differential expressed miRNA (miR-210) from the diseased sea cucumber coelomocytes was identified in our study. This miRNA molecule modulates...
Source: Developmental and Comparative Immunology - August 17, 2016 Category: Allergy & Immunology Authors: Li C, Zhao M, Zhang C, Zhang W, Zhao X, Duan X, Xu W Tags: Dev Comp Immunol Source Type: research

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition
Publication date: Available online 16 August 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Steven F. Grieco, Yuyan Cheng, Hagit Eldar-Finkelman, Richard S. Jope, Eléonore Beurel An antidepressant dose of the rapidly-acting ketamine inhibits glycogen synthase kinase-3 (GSK3) in mouse hippocampus, and this inhibition is required for the antidepressant effect of ketamine in learned helplessness depression-like behavior. Here we report that treatment with an antidepressant dose of ketamine (10mg/kg) increased expression of insulin-like growth factor 2 (IGF2) in mouse hippocampus, an ef...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 15, 2016 Category: Psychiatry Source Type: research

SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line.
Authors: Musavi Shenas SM, Mansoori B, Mohammadi A, Salehi S, Kaffash B, Talebi B, Babaloo Z, Shanehbandi D, Baradaran B Abstract Snail-1 known as one of the important transcription factor is a mediator of survival and cell migration, and expression is raised in numerous cancer types. Snail-1 gene may show a role in recurrence of several cancers including bladder cancer by down-regulating E-cadherin, inducing an epithelial to mesenchymal transition (EMT) and its related microRNAs (miRNAs). The aim of this study was to investigate the effect of a specific Snail-1 siRNA on apoptosis and alter EMT related miRNAs of EJ...
Source: Artificial Cells, Nanomedicine and Biotechnology - June 22, 2016 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway.
In this study, we discovered that LGS exerted potent anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation. We found that LGS significantly depressed the production of IL-6 and TNF-α in LPS-stimulated RAW 264.7 macrophage cells. The degradation and phosphorylation of IκBα and the nuclear translocation of NF-κB p65 were also inhibited. Moreover, LGS activated α7 nicotinic cholinergic receptor (α7nAchR). The blockage of α7nAchR by selective inhibitor methyllycaconitine (MLA) or α7nAchR siRNA attenuated the inhibitory effects of LGS on IκBα, NF-κB p65, IL-6 and TNF-α. Critically, LGS significa...
Source: Oncotarget - April 3, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

P.4.014 siRNA-mediated suppression of astroglial glutamate transporters in infralimbic cortex induces depressive-like behaviours
Source: European Neuropsychopharmacology - February 27, 2016 Category: Psychiatry & Psychology Authors: M.N. Fullana Llinàs, A. Bortolozzi, F. Artigas Tags: The flip side of the brain, glia and their significance Source Type: research

SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway.
In conclusion, SEPT7 is involved in glioma cell migration with the assistance of cofilin phospho‑mediated cytoskeleton locomotion. PMID: 26846171 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 9, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BDNFVal66met polymorphism: a potential bridge between depression and thrombosis
Conclusion</div>Activation of platelets, alteration in coagulation pathways, and changes in vessel wall protein expression in BDNF<sup>Met/Met</sup> mice recapitulate well the features occurring in the anxiety/depression condition. Furthermore, our data suggest that the BDNFVal66Met polymorphism contribute to the individual propensity for arterial thrombosis related to AMI.</span>
Source: European Heart Journal - December 26, 2015 Category: Cardiology Source Type: research

Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization
Conclusions: We demonstrated that in mouse trigeminal neurons endogenous BNP acts on NPR-A receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A/PKG pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments. This novel mechanism of receptor control might be a target for future studies aiming at decreasing dysregulated P2X3 receptor activity in chronic pain.
Source: Molecular Pain - November 14, 2015 Category: Molecular Biology Authors: Anna MarchenkovaSandra VilottiElsa FabbrettiAndrea Nistri Source Type: research

Cystine accumulation attenuates insulin release from the pancreatic beta-cell due to elevated oxidative stress and decreased ATP levels.
This article is protected by copyright. All rights reserved. PMID: 26482480 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - October 20, 2015 Category: Physiology Authors: McEvoy B, Sumayao R, Slattery C, McMorrow T, Newsholme P Tags: J Physiol Source Type: research